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The influence of experimentally induced osteoarthrosis on articular nerve fibers of the sheep temporomandibular joint.

AIMS: To study the effect of experimentally induced osteoarthrosis, or non-inflammatory degenerative changes, on the innervation of the sheep temporomandibular joint (TMJ) through the use of indirect immunohistochemistry and image analysis quantification. METHODS: Bilateral condylar scarification was performed in 8 sheep, which were killed at 16 weeks post-operation; 3 unoperated sheep served as controls. Tissues from 8 osteoarthrotic joints and 4 control joints were processed for the immunostaining with antisera for protein gene product 9.5 (PGP 9.5), substance P (SP), calcitonin gene-relate

[Submental island flap for repair of oral defects after radical resection of early-stage oral squamous cell carcinoma].

OBJECTIVE: To evaluate the effectiveness of the submental island flap for repair of oral defects after radical resection of early-stage oral … superficial necrosis of the flap, which was cured after conservative treatment. Temporary marginal mandibular nerve palsy occurred in 1 case, and was cured after 3 months; submandibular effusion was observed in 3 cases, and was cured after expectant treatment. The follow-up period ranged from 8 to 15 months (mean, 10.5 months) in 14 cases undergoing repair with s …

Autogeneous coronoid process as free graft for reconstruction of mandibular condyle in patients with temporomandibular ankylosis.

OBJECTIVE: This study was conducted to determine the efficacy of using the autogeneous coronoid process as free graft for reconstruction of mandibular condyle and to achieve structural, functional, as well as esthetic rehabilitation of patients with temporomandibular joint (TMJ) ankylosis. MATERIALS AND METHODS: This article presents the clinical results of an evaluation of ten cases of TMJ ankylosis treated by using autogeneous coronoid process as free graft for reconstruction of mandibular condyle after resection of ankylotic mass. RESULTS: Satisfactory mouth opening were obtained in all t

Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves.

To investigate whether or not N-methyl-D-aspartate (NMDA)/nitric oxide (NO) pathway in the trigeminal system is involved in the development and/or maintenance of such pathological pain states as the hyperalgesia and allodynia observed after dental surgery, we examined the alteration patterns of excitatory amino acid (EAA) level in the superficial layer of subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex (SpVc-I,II) by in vivo microdialysis. A very high EAA release response was observed immediately after the start of the perfusion in ligated animals compared with sham-op

Prospective clinical assessment of pulp sensitivity after chin bone harvesting.

PROPOSAL: Evaluate pulp vitality of mandibular teeth after chin bone harvesting. MATERIALS AND METHODS: Thirty patients underwent chin bone harvesting and accompanied for 12 months, being submitted to testing for pulp vitality with Endo Ice refrigerant spray to produce a local temperature of -50 °C. The statistical analysis was executed with McNemar test with P value < 0.05. RESULTS: Results show that canine teeth are most susceptible to alterations; 68.82% (181) of the teeth tested showed no loss of pulp sensitivity to cold 30 days after surgery (P < 0.05), and at the end of the study, that

Complication rates associated with different treatments for mandibular fractures.

PURPOSE: This study compared the complication rate with different types of mandibular fracture treatment (maxillomandibular fixation, 2-mm miniplates, 2.4-mm AO plates, and 2.7-mm AO plates). PATIENTS AND METHODS: A total of 245 patients who presented with 386 fractures were retrospectively analyzed. Patient characteristics, type of fracture, severity of fracture, type of treatment used, and occurrence of complications were recorded. Statistical analysis was used to compare complication rates, fracture severity, and type of treatment. RESULTS: There were no differences in the complication ra

Treatment of mandibular fractures with rigid osteosynthesis: using the AO system.

PURPOSE: This study evaluated the results achieved in the surgical treatment of all mandibular fractures at two university centers using the 2.7 AO mandibular system. PATIENTS AND METHODS: A total of 227 patients presenting with 180 single fractures and 47 with double fractures (274 osteosyntheses) were included in this prospective study. RESULTS: During a mean follow-up of 27.5 months (minimum, 12 months), an overall complication rate of 7% was observed. No infection justified early removal of the osteosynthesis material. CONCLUSIONS: The systematic use of the technique recommended by AO f

Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline.

CLINICAL QUESTION: What is the comparative effectiveness of available therapies for chronic pain associated with temporomandibular disorders (TMD)? CURRENT PRACTICE: TMD are the second most common musculoskeletal chronic pain disorder after low back pain, affecting 6-9% of adults globally. TMD are associated with pain affecting the jaw and associated structures and may present with headaches, earache, clicking, popping, or crackling sounds in the temporomandibular joint, and impaired mandibular function. Current clinical practice guidelines are largely consensus-based and provide inconsistent

Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells.

BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency. METHODS: Scar

Navigation-guided resection with immediate functional reconstruction for high-grade malignant parotid tumour at skull base.

The authors report a case of navigation-guided tumour ablation of a high-grade epithelial-myoepithelial carcinoma of the right parotid gland extending to the skull base. Immediate functional reconstruction of the mandible with a prosthetic temporomandibular joint and facial nerve was performed. Postoperative follow-up showed no evidence of local tumour recurrence or distant metastasis with satisfactory temporomandibular and facial nerve function.

Oculo-auriculo-vertebral spectrum: clinical and molecular analysis of 51 patients.

INTRODUCTION: Oculo-auriculo-vertebral spectrum (OAVS OMIM 164210) is a craniofacial developmental disorder affecting the development of the structures derived from the 1st and the 2nd branchial arches during embryogenesis, with consequential maxillary, mandibular, and ear abnormalities. The phenotype in OAVS is variable and associated clinical features can involve the cardiac, renal, skeletal, and central nervous systems. Its aetiology is still poorly understood. METHODS: We have evaluated the clinical phenotypes of 51 previously unpublished patients with OAVS and their parents, and performe

Modified Neumann incision for implant placement in overdentures: Case series of a less invasive alternative.

BACKGROUND: Conventional envelope flap techniques for implant placement in edentulous mandibles are associated with greater postoperative morbidity, especially in elderly patients or those with anatomical limitations. Minimally invasive alternatives aim to preserve soft tissues and reduce complications, enhancing clinical predictability. METHODS: A clinical study was conducted with ten fully edentulous patients, in whom 20 regular implants were placed in the interforaminal region without surgical guides. A modified Neumann incision with a mesial relaxing cut and partial-thickness "L"-shaped f

Metastatic gallbladder cancer presenting as numb chin syndrome: A case report and literature review.

Gallbladder cancer (GBC) is an uncommon malignancy that is highly aggressive in the advanced stages. However, it rarely metastasizes to the mandible. Numb chin syndrome (NCS) is a rare neurological manifestation associated with various underlying causes, including occult primary cancers and distant metastases. It is often considered to be a significant indicator of malignancy, and thorough investigation is essential in the presence of unclear etiology. The current study reported on the case of a 69-year-old Japanese woman who presented with numbness and mild pain in the lower lip and chin area

Effect of sleep apnoea interventions on multiple health outcomes: an umbrella review of meta-analyses of randomised controlled trials.

BACKGROUND: Obstructive sleep apnoea (OSA) is a prevalent chronic condition that is associated with cardiometabolic and neurocognitive complications. While continuous positive airway pressure (CPAP) remains the first-line therapy, suboptimal adherence limits its effectiveness, highlighting the need to evaluate alternatives such as mandibular advancement devices (MADs), hypoglossal nerve stimulation (HNS), physical activity, different modalities of weight loss management including glucagon-like peptide-1 (GLP-1) agonists and combination therapies. METHODS: We conducted an umbrella review to sy

Отологические проявления временных нарушений.

Фон/цели: Временное расстройство (ТМО) затрагивает треть взрослого населения и связано с отологическими симптомами. Эти симптомы часто недооцениваются первичными отологическими заболеваниями, что приводит к задержкам в диагностике и лечении. Цель этого обзора состоит в обобщении сообщаемых данных о распространенности, предлагаемых патофизиологических механизмов и стратегий управления отологическими проявлениями у пациентов с ТМР. Методы: Был проведен обзор литературы с использованием терминов MESH "временная болезнь сустава" и "отологические симптомы". Five Дополнительные обыски проводились с

Graft interposition for preventing Frey's syndrome in patients undergoing parotidectomy.

BACKGROUND: Frey's syndrome is characterised by transient flushing and sometimes facial sweating in the area of the auriculotemporal nerve. It most commonly occurs after parotidectomy, but other causes may include submandibular gland surgery, mandibular condylar fracture, obstetric (forceps) trauma, sympathectomy and metabolic disease. Although the pathophysiology of Frey's syndrome remains controversial, the generally accepted hypothesis is that it occurs as the result of injury to the auriculotemporal nerve.There is currently no clear evidence to establish the efficacy and safety of the diff

Радиологическое и патологическое восприятие остеонекроза, связанного с лекарственными препаратами, у &lt; &lt; Жо &gt; &gt; , больного миеломой: доклад 3 Дела.

Связанный с лекарственными препаратами остеонекроз челюсти (MRONJ) является редким побочным эффектом некоторых лекарственных средств, главным образом тех, которые используются при лечении конкретных раковых заболеваний и при первоначальном лечении ненеопластических заболеваний. Первые случаи остеонекроза челюсти были зарегистрированы в ходе 2 десятилетия назад у пациентов, употребляющих бисфофонаты (БП). После идентификации номенклатура перешла от остеонекроза челюсти (BRONJ) к MRONJ, поскольку другие лекарства могут вызвать такую же реакцию. Инвазивные стоматологические услуги, такие, как экс

Bilateral jaw involvement of Burkitt's lymphoma in a 5-year-old: Rare pediatric case with review of the literature.

INTRODUCTION AND IMPORTANCE: Burkitt lymphoma (BL) is a rapidly progressing tumor that requires urgent diagnosis and treatment. It is the first human neoplasm linked to a viral cause and is classified into three subtypes: sporadic, endemic, and immunodeficiency-associated. CASE PRESENTATION: We report a rare case of a 5-year-old boy who presented to the Oral and Maxillofacial Surgery Department with a two-month history of bilateral maxillary swelling and pain. He had no significant medical history. An incisional biopsy confirmed the diagnosis of Burkitt's lymphoma. The patient underwent chemo

Three-dimensional bone evaluation after surgical treatment with plasma rich in growth factors of Medication Related Osteonecrosis of the Jaw (MRONJ): A report of 3 cases.

INTRODUCTION: Medication Related Osteonecrosis of the Jaw (MRONJ) is an adverse effect of antiresorptive and antiangiogenic agents that consists of progressive bone destruction in the maxillofacial area. The purpose of this study is to analyze the effect on bone volume of a surgical protocol using plasma rich in growth factors (PRGF) for successfully treating MRONJ. METHODS: Three patients were treated combining surgical debridement with PRGF. Cone bean computed tomography scans were taken prior to surgery and 12 months after to measure bone volume changes. Biopsies were taken for histology a

Chinese expert consensus on the diagnosis and clinical management of medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is a side effect that occurs after treatment for systemic diseases. However, most institutions currently rely on empirical methods to make diagnosis and treatment plans, and there is a lack of consensus or guidelines for the classification, staging and treatment of MRONJ in China. To address this gap and improve prognosis, an expert panel representing 11 renowned domestic medical colleges and affiliated hospitals in China was convened. The panel made a comprehensive literature review of previous treatment experiences and research findings to

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… Conservative therapies or local debridement Stage Ⅰ Radiographic manifestations are as follows: bone abnormalities above mandibular nerve tube or the line connecting two mental holes in the mandible; bone abnormalities not penetrating into maxillary floor or nasal floor in the maxilla Stage ⅠA Localized … Clinical manifestations include unhealing extraction sockets, loose teeth or bone exposure in the premise of excluding periodontal diseases. | Conservative therapies or local debridement Stage Ⅰ | Radiographic manifestations are as follows: bone abnormalities above mandibular nerve tube or the line connecting …