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Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.

In the last few years, monoclonal antibodies (mAbs) such as elotuzumab and daratutumab have brought the treatment of multiple myeloma (MM) into the new era of immunotherapy. More recently, chimeric antigen receptor (CAR) modified T cell, a novel cellular immunotherapy, has been developed for treatment of relapsed/refractory (RR) MM, and early phase clinical trials have shown promising efficacy of CAR T cell therapy. Many patients with end stage RRMM regard CAR T cell therapy as their "last chance" and a "hope of cure". However, severe adverse events (AEs) and even toxic death related to CAR T

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… If elevated ICP/cerebral edema, consider hyperosmolar therapy with mannitol and hyperventilation. Methylprednisolone IV 1,000 mg/d. … As papilledema is often a sign of increased ICP, hyperosmolar therapy with mannitol and/or hyperventilation are advised in these patients ( 22 , 135 ). Another major issue in ICANS is the management of seizure. …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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… effects of β-agonists in patients with COPD and: a meta-analysis, 2309 childhood, increase in alveolar nitric oxide in the presence of symptoms in, 1012 cigarette smoking, emphysema, and, vol. 124:2408; erratum, vol. 125:1175 clinical significance of elevated diffusing capacity, 446 coughing during mannitol … , May Supp., 95S tracheobronchial adenoid cystic carcinoma: a clinicopathologic study of 14 cases, 1160 Bronchial provocation, coughing during mannitol challenge is associated with asthma, 1985 geographic and gender variability in the prevalence of bronchial responsiveness in Canada, 1657 methacholine …

Инженерная иммунологическая ниша направляет терапевтическое развитие в модели прогрессивного множественного склероза.

Первичный прогрессивный множественный склероз (MS) представляет собой аутоиммунное заболевание, вызывающее демиелионацию и имеющее лишь один класс лечения, одобренного УЛХ, — истощение клеток В. Новейшее лечение может возникнуть в результате более глубокого понимания взаимодействия между различными типами клеток в заболевших тканях на протяжении всего процесса развития. Первоначально мы описываем инженерную иммунологическую нишу (ИН) на основе биоматериалов как суррогатную для заболевших тканей функцию иммунных клеток и фенотипную динамику на протяжении хронической прогрессивной модели MS мыши

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… This double emulsion was stirred in 0.5% PEMA overnight to form particles, particles were washed, and lyophilized in a sucrose/mannitol (3/4% w/v) cryoprotectant solution. NP Characterization. …

Effect of β2-microglobulin in evaluating the severity and prognosis of brain injury: a clinical study.

Backgroundβ2-microglobulin has been showing to be vital that associated with brain function and neurological diseases. This study aimed to explore the expressions of β2-microglobulin in blood and urine of the patients with brain injury, and the effect of hyperbaric oxygen therapy on the content of β2-microglobulin.MethodsThis prospective study included 54 patients with brain injury and 11 healthy controls. The patients were further assigned to two groups: the conscious disturbance group (n = 32) and the non-conscious disturbance group (n = 22) depending on the Glasgow Coma Scale (GCS). The pat

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… Secondly, after admission, the use of vasoactive drugs, mannitol or diuretics and other drugs affected the glomerular filtration rate and renal tubular reabsorption function. …

ZHX2 inhibits diabetes-induced liver injury and ferroptosis by epigenetic silence of YTHDF2.

ObjectiveMetabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication of type 2 diabetes mellitus (DM). The transcription factor zinc fingers and homeoboxes 2 (ZHX2) has been implicated in the pathogenesis of chronic liver diseases, yet its precise role and underlying mechanism in DM-induced hepatic injury remain poorly elucidated.MethodsTo investigate this, we used a high-fat diet (HFD) and streptozotocin (STZ) administration to create a DM model in mice, while high glucose (HG) exposure was used to simulate DM in vitro. Through various experiments such as lucifer

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… To establish a cellular model of DM, the Huh7 cells were exposed to high glucose conditions (HG; 30 mM D-glucose), while normal glucose conditions (NG; 5.6 mM D-glucose and 24.4 mM mannitol) served as the control group. …

Centella Asiatica поощряет антиоксидантное гениевые экспрессии и митохондриальное окисляющее дыхание в экспериментальном аутоиммунном энцефаломелите.

Справочная информация/задачи: Centella asiatica (L.) — традиционная ботаническая медицина, применяемая при старении и слабоумии. Водные выдержки из C. asiatica (CAW) использовались для лечения нейропсихиатрических симптомов в соответствующих моделях животных и связаны с увеличением генов антиоксидантов (ARE) и улучшением митохондриальной дыхательной функции и нейронного здоровья. Поскольку множественный склероз (MS) разделяет ее нейрогенеративную патологию окислительного стресса и митохондриальной дисфункции со старением и слабоумием, нейропсихиатрические симптомы в MS могут также выиграть от

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… A total of 10 ug of synaptosomal protein diluted in 25 uL mitochondrial assay solution (MAS; 70 mM sucrose, 220 mM mannitol, 10 mM KH 2 PO 4 , 5 mM MgCl 2 , 2 mM HEPES, 1 mM EGTA, 0.2% BSA) was plated in each well of a polyethylenimine (PEI)-coated 96-well Seahorse plate (5–6 replicate wells for each …

A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure.

Acute liver failure (ALF) is a rare and specific form of severe hepatic dysfunction characterized by coagulopathy and hepatic encephalopathy in a patient with no known liver disease. ALF carries a high morbidity and mortality. Careful attention should be given to hemodynamics and metabolic parameters along with the active surveillance of infections. Timely transfer and supportive management are important in an intensive care unit in a liver transplant center. Identifying patients who will and will not improve with medical management and may need emergent liver transplantation is critical. In t

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… Empiric use of treatments to reduce ICP, including hypertonic saline, l-ornithine l-aspartate (LOLA), mannitol, hyperventilation, or moderate hypothermia, has not been shown to improve mortality in ALF [ 2 , 21 ]. Benzodiazepines and opioids should be avoided and sedation should be minimized. …

Characteristics and Outcomes of Intracranial Hemorrhage in Cancer Patients Visiting the Emergency Department.

Intracranial hemorrhage (ICH) is a dreaded complication of both cancer and its treatment. To evaluate the characteristics and clinical outcomes of cancer patients with ICH, we identified all patients with ICH who visited The University of Texas MD Anderson Cancer Center emergency department between 1 September 2006 and 16 February 2016. Clinical and radiologic data were collected and compared. Logistic regression analyses were used to determine the association between clinical variables and various outcomes. During the period studied, 704 confirmed acute ICH cases were identified. In-hospital,

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… 17.6) | 109 (18.9) | 15 (11.7) | Discontinue anticoagulant | 56 (8.0) | 49 (8.5) | 7 (5.5) | Antihypertensive medications | 60 (8.5) | 48 (8.3) | 12 (9.4) | FFP | 56 (8.0) | 38 (6.6) | 18 (14.1) | Intubation/hyperventilation | 37 (5.3) | 33 (5.7) | 4 (3.1) | XRT | 19 (2.7) | 19 (3.3) | 0 (0.0) | Mannitol …

Анатомические и морфологические вариации, связанные с микрографированием в оливках in vitro с использованием клональных корнеплодов.

Микрографтация является мощным биотехнологическим инструментом для микропродукции фруктовых деревьев и может применяться для клонального распространения непристойных видов, искоренения вирусов, управления патогенами, раннего выявления совместимости с скионом/кротовым скотом и размножения. Однако в оливках этот метод по-прежнему недостаточно изучен, особенно в том, что касается пересадки на полностью клональные корнеплоды. В этом исследовании мы разработали протокол in vitro микрографирования (IVM), основанный исключительно на клонально распространяемом материале. Two Культиваторы: "Galega" и "

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… After establishment and multiplication as described by Jouini et al. (2024) and Granata et al. (2023) , micro-scions and micro-rootstocks were multiplicated in Rugini Olive medium (OM) supplemented with 10 µM Zeatin, 7 g L -1 agar, 30 g L -1 mannitol, and pH was adjusted at 5.8 prior to autoclaving. …

Nephrology in Veterinary Medicine.

Veterinary nephrology is a specialized field of veterinary medicine providing a high level of care for animals with all types of kidney disease. Veterinarians complete extensive training to become board-certified in veterinary nephrology-urology. Companion animal nephrology is the most advanced field; however, all species are afflicted by a variety of renal disorders. Most naturally occurring animal kidney diseases have similar disorders found in people; where veterinary research is lacking, clinical management is often modified from standard of care in people. Veterinarians have become adept

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… Dialysis disequilibrium syndrome has been observed in cats and dogs; symptoms include disorientation, vocalization, seizures, and acute death. 9 , 81 To help prevent such consequences, initial ERRT treatments will deliver conservative solute clearances, and prophylactic administration of mannitol is …

Platinum-induced ototoxicity and hearing impairment in children and adolescents.

Platinum compounds play a crucial role in the treatment of solid tumours in paediatric patients, significantly improving survival rates. However, these treatments can result in hearing loss as a side-effect that can significantly impact the quality of life of young cancer survivors. Whilst the therapeutic benefits of platinum compounds in paediatric oncology are indisputable, addressing the challenge of ototoxicity remains a priority. Early and regular auditory function assessments, with tools such as audiometry, otoacoustic emissions and auditory brainstem response testing, are critical durin

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… The ability of mannitol to decrease cisplatin-induced nephrotoxicity in children: real or not? Cancer Chemother Pharmacol. 2016;77(1):19–26. doi: 10.1007/s00280-015-2913-6. 50. Meijer AJM, Li KH, Brooks B, et al. …

Liposomes for the Treatment of Brain Cancer-A Review.

Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood-brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consol

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… Infusing a hyperosmotic solution, such as mannitol, is the most clinically utilized approach. This method has been investigated in adult patients with supratentorial malignant gliomas. … Another method was proposed by Skalko-Basnet et al. [ 103 ], where the lipid–organic mixture was prepared by dissolving dry lipid powders with mannitol in chloroform; then, the mixture was spray-dried. …

Update on Contrast-Induced Nephropathy: Recent Developments in Its Prevention, Early Diagnosis, and Therapy.

Contrast-induced nephropathy (CIN), now more accurately referred to as contrast-induced acute kidney injury (CI-AKI), remains a major cause of hospital-acquired acute kidney injury (AKI) and is associated with increased morbidity and mortality, particularly in high-risk patients. This condition occurs following the intravascular administration of iodinated radiocontrast media (RCM), especially in individuals with pre-existing chronic kidney disease (CKD), diabetes mellitus, heart failure, advanced age, or exposure to high contrast volumes. The pathophysiology of CI-AKI is multifactorial and in

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… Forced euvolemic diuresis with mannitol and furosemide for prevention of contrast-induced nephropathy in patients with CKD undergoing coronary angiography: A randomized controlled trial Am. J. Kidney Dis. 2009 54 602 609 10.1053/j.ajkd.2009.03.024 19535188 145. Solomon R. Werner C. Mann D. … Effects of saline, mannitol, and furosemide on acute decreases in renal function induced by radiocontrast agents N. Engl. J. Med. 1994 331 1416 1420 10.1056/NEJM199411243312104 7969280 146. Briguori C. Visconti G. Ricciardelli B. Condorelli G. …

Decoding the mechanisms underlying breast cancer brain metastasis: paving the way for precision therapeutics.

The development of brain metastasis is a major cause of significantly reduced survival in breast cancer patients. The initiation and progression of breast cancer brain metastasis (BCBM) involve multiple distinct molecular pathways and reprogramming of the tumor microenvironment (TME). This review systematically summarizes key mechanisms underlying BCBM, including epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) remodeling, and the spatiotemporal dynamics of metabolic reprogramming regulated by critical signaling pathways during brain colonization. In particular, we highlight

Следует ли улучшить сопоставление между рационами питания?

Питание считается возможным кофактором, который влияет на иммунную систему и потенциально вызывает дисрегулирование кишечного гомеостаза и воспаления. Цель этого исследования заключалась в анализе качества данных о воздействии конкретного состава рациона питания на симптомы иммунопосредованных подстрекательских заболеваний (ИМИД), включая ревматоидный артрит (RA), спондилоартрит, множественный склероз (MS), воспалительный кишечник (IBD) [восстановление болезни Крона и язвительный колит], псориоз и псориатический артрит у взрослых пациентов. Мы провели обзор метаанализов и систематических обзор

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… A low-FODMAP diet can be considered an anti-inflammatory diet because it includes the withdrawal of potentially inflammatory foods, such as fructose (sugar), sorbitol or mannitol (derived from sugar), lactose (dairy), fructans (wheat, rye, and oats), and galactans (chickpeas, rye, and oats). …

Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial.

CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the best standard of care (SOC). To improve current SOC, we evaluated the added value of weekly bortezomib (V) to isatuximab plus lenalidomide and dexamethasone (IsaRd versus Isa-VRd). This Intergroupe Francophone of Myeloma phase 3 study randomized 270 patients with NDMM that were TI, aged 65-79 years, to IsaRd versus Isa-VRd arms. The primary endpoint was a minimal residual disease (MRD) nega

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… Subject has known allergies, hypersensitivity or intolerance to steroids, mannitol, pregelatinized starch, sodium stearyl fumarate, histidine (as base and hydrochloride salt), arginine hydrochloride, poloxamer 188, sucrose or any of the other components of study intervention that are not amenable to …

Neurologic adverse events of cancer immunotherapy.

Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers. However, it is not without side effects. Several neurological adverse events have been recognized associated with immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T-cell therapy, the two main classes of cancer immunotherapy. With the increase in the prevalence of oncological diseases and this type of therapy, it is improbable that neu

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… If elevated ICP/cerebral edema, consider hyperosmolar therapy with mannitol and hyperventilation. Methylprednisolone IV 1,000 mg/d. …

Связанный с воспалением IncRNA вызывает нейронные повреждения в результате митохондриальной дисфункции.

В качестве ключевых факторов в регулировании генов появляются некодирующие SNP, которые часто находят свое отражение в специфических для тканей регулятивных элементах. Среди этих элементов длинные некодирующие РНК (lncRNA) участвуют во многих клеточных процессах, и их характеристики делают эти молекулы привлекательными для терапевтических целей. В этом исследовании мы изучили IncRNA LOC339803 в контексте нейронных клеток, которые расположены в районе 2p15, связанном с автоиммунитетом, и недавно описываем, что они играют провоспалительную роль в кишечных расстройствах. Используя образцы мозга ч

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… For the quantification of RNA and protein amounts in mitochondrial and cytoplasmic compartments, cells were resuspended in MIB buffer (210 mM Mannitol, 70 mM sucrose, 10 mM HEPES pH 7.5, and 1 mM EDTA) + PI and homogenized in ice using a 25-gauge needle fitted on a syringe. …

Advances in Drug Delivery and Biomaterials: Facts and Vision.

Drug delivery and biomaterials are different fields of science but, at the same time, are tightly related and intertwined. The 2018 CRS Italy Chapter Annual Workshop aims to explore recent advances in design and development in these areas. Many colleagues from Europe participated to the Workshop, stimulating the discussion. To foster the discussion on recent research and networking opportunities, especially among younger attendees, all poster-presenting authors were asked to provide a short talk. The very friendly and stimulating atmosphere allowed the attendees to explore new frontiers and ta

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… Here, nano into micro (NiMs) formulations based on mannitol or a mixture between mannitol (Man) and different helping materials, have been prepared for containing just mucus-penetrating nanocomplexes loaded with tobramycin for the treatment of Pseudomonas aeruginosa infections or containing mucus and …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… Case presentation: A 2-year-old boy with type I diabetes mellitus admitted for coma due to cerebral oedema and treated successfully with insulin, dexamethasone, mannitol and KCl, on the tenth day presented with fever of 40°C, agitation, restlessness, lack of appetite, somnolence, fatigue. …