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Sorcin: a novel potential target in therapies of cancers.

Soluble resistance-related calcium-binding protein (sorcin) is a member of the penta-EF-hand protein family. Sorcin is widely distributed in normal human tissues, such as the brain, heart, lymphocytes, kidneys, breast and skin. Findings suggest that sorcin is associated with the regulation of calcium homeostasis, cell cycle and vesicle trafficking. It has been reported that many types of non-neoplastic diseases such as diabetes, viral infection, infertility, and nervous system diseases were affected by the expression of sorcin. One of the main issues is the role of sorcin in neoplastic disease

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… Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine . 2010;6(6):714–729. doi: 10.1016/j.nano.2010.05.005 6. Gothwal A, Khan I, Gupta U. Polymeric micelles: recent advancements in the delivery of anticancer drugs. … Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors. Colloids Surf B . 2019;173:581–590. doi: 10.1016/j.colsurfb.2018.10.022 8. Yousefi B, Azimi A, Majidinia M, et al. …

Review on Bortezomib Resistance in Multiple Myeloma and Potential Role of Emerging Technologies.

Multiple myeloma is a hematological cancer type. For its treatment, Bortezomib has been widely used. However, drug resistance to this effective chemotherapeutic has been developed for various reasons. 2D cell cultures and animal models have failed to understand the MM disease and Bortezomib resistance. It is therefore essential to utilize new technologies to reveal a complete molecular profile of the disease. In this review, we in-depth examined the possible molecular mechanisms that cause Bortezomib resistance and specifically addressed MM and Bortezomib resistance. Moreover, we also included

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… Nanoparticles are the encapsulation of a drug or a new chemical agent through micelles, liposomes, dendrimers, nanospheres, etc. [ 146 ]. Liposomes have more success because of their higher biocompatibility [ 147 ]. … Polymer-based ones include dendrimers, nanoparticles, micelles, and nanogels, while the most notable ones among non-polymer-based ones are silica-based, metallic nanoparticles, and nanotubes [ 145 ]. …

Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research.

Active targeting is a valuable and promising approach with which to enhance the therapeutic efficacy of nanodelivery systems, and the development of tumor-targeted nanoparticles has therefore attracted much research attention. In this field, the research carried out in Italian Pharmaceutical Technology academic groups has been focused on the development of actively targeted nanosystems using a multidisciplinary approach. To highlight these efforts, this review reports a thorough description of the last 10 years of Italian research results on the development of actively targeted nanoparticles t

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… Then, the derivative was used to prepare the mixed micelles, which showed higher uptake in cancer cells than untargeted carriers and provided gradual drug release, at the same time. Peptides and proteins have been conjugated to polymer NPs as well. … Dual-targeted hyaluronic acid/albumin micelle-like nanoparticles for the vectorization of doxorubicin Pharmaceutics 2021 13 304 10.3390/pharmaceutics13030304 33652648 PMC7996918 62. Cosco D. Mare R. Paolino D. Salvatici M.C. Cilurzo F. Fresta M. …

The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation.

Heat-shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the critical challenges posed by its aggressive nature and therapeutic resistance. HSP70's dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target. This review explores the innovative integration of HSP70 with nanotechnology, emphasising advancements in imaging, drug delivery and combination therapies. Nanoparticles, including SPIONs, liposomes, gold nanoparticles and metal-organic framework

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… Combining methoxy-polyethylene-glycol-coated-gold-nanorods (MPEG-AuNR) with VER-155008-micelles in PTT enhances heat sensitivity of tumour cells. VER-155008 micelles downregulate HSP70 expression, attenuating heat resistance in HCT116 cells. … Tan and his colleagues explored the efficacy of combined chemo-PTT using IR780-CSOSA/DOX micelles in MCF-7 tumour-bearing mice. The results demonstrated significant tumour volume reduction and scar recovery in the IR780-CSOSA/DOX group with laser irradiation. …

Nanoparticle Strategies for Bone Metastasis Immunotherapy: Targeting, Immune Reprogramming and Combination Therapy.

Bone metastases remain one of the most clinically devastating complications of advanced cancer, particularly in breast, prostate, and lung malignancies, where they drive pain, fractures, hypercalcemia, and progressive functional decline. Their management is further complicated by a highly immunosuppressive bone microenvironment characterized by osteoclast-driven bone destruction, myeloid cell dominance, impaired antigen presentation, and weak effector T-cell infiltration, all of which limit the activity of conventional immunotherapies. In this setting, nanoparticles are emerging not merely as

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… Moreover, the tumor-binding phage peptide (DP 8) within ALN/DP 8 micelles is engineered to ensure ALN targets osteoclast-rich metastatic bone, while DP 8, which binds to surface nucleolin, enhances micelle concentration on breast cancer cells. … MMP-cleavable linkers integrated into polymeric micelles or dendrimers facilitate fast payload release solely in enzyme-dense tumor environments [ 81 , 94 ]. …

Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets.

Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across the globe for its therapeutic and medicinal benefits. The active moiety of Curcuma longa is curcumin and has gained importance in various treatments of various disorders such as antibacterial, antiprotozoal, cancer, obesity, diabetics and wound healing applications. Several techniques had been exploited as reported by researchers for increasing the therapeutic potential and its pharmacological activity. Here, the dictum is the new room for the development of physicochemical, as well as biolo

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… Various types of curcumin nanocarriers, which include dendrimers, nanoparticle conjugates, micelles, and bio-based nanomaterials and their associated properties such as solubility, stability, etc., were studied in [ 59 ]. … Murthy et al. prepared nano-micelle containing curcumin for oral use, and in the clinical trial of the study, it was found that the nanocurcumin acts as a potent agent for the reduction in the different parameters of the lipid profile [ 63 ]. …

Bisphosphonate conjugation for bone specific drug targeting.

Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved delivery of drugs to bone remains an important goal for achieving effective treatments. Drug targeting strategies have improved drug localization to bone by taking advantage of the high mineral concentration unique to the bone hydroxyapatite matrix, as well as tissue-specific cell types. The bisphosphonate molecule class binds specifically to hydroxyapatite and inhibits

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… With a different polymer strategy, an alendronate-paclitaxel conjugate was formed with self-assembling PEG micelles also with improved safety and efficacy over free paclitaxel ( Miller et al., 2013 ). … Instead of polymers, liposomes and micelles can also be bone-targeted with BP. …

Изучение точных методов лечения иммунизированных подстрекательских заболеваний: использование бесконечного потенциала доставки нуклеиновой кислоты.

Неизлечимые подстрекательские заболевания (ИМИД) создают неизмеримое бремя для отдельных лиц и общества. В то время как традиционное использование иммунодепрессантов и лекарственных средств для борьбы с заболеваниями обеспечивает частичную помощь и контроль, их неизбежные побочные эффекты и ограниченная эффективность ставят под сомнение возможность найти лекарство. Перспективные лекарства от нуклеиновой кислоты продемонстрировали способность оказывать точное воздействие на молекулярном уровне, при этом различные классы нуклеиновых кислот выполняют регулирующие функции с помощью различных механ

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… For example, Zhu et al. developed biodegradable cationic micelles composed of poly(2‐dimethylaminoethyl methacrylate)‐PCL‐poly(2‐dimethylaminoethyl methacrylate) (PDMAEMA‐PCL‐PDMAEMA) blocks with varying molecular weights, enabling the efficient co‐delivery of siRNA and doxorubicin to cancer cells. … Chen et al. developed low molecular weight PEI‐based micelles (LPCE) to deliver NF‐κB RelA siRNA (siRelA), significantly downregulating NF‐κB RelA mRNA and TNF‐α mRNA levels and promoting M1‐to‐M2 macrophage polarization. [ 187 ] The intraarticular administration of siRelA/LPCE inhibited synovial …

Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges.

Early detection, right therapeutic intervention, and simultaneous effectiveness mapping are considered the critical factors in successful cancer therapy. Nevertheless, these factors experience the limitations of conventional cancer diagnostics and therapeutics delivery approaches. Along with providing the targeted therapeutics delivery, advances in nanomedicines have allowed the combination of therapy and diagnostics in a single system (called cancer theranostics). This paper discusses the progress in the pre-clinical and clinical development of therapeutics, diagnostics, and theranostics canc

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… Drug carriers of nano dimension that include liposomes, dendrimers, polymer-drug conjugates, polymer micelles, and inorganic NPs are widely studied in drug delivery for this particular approach in cancer chemotherapy [ 19 ]. … More recently, researchers are also exploring the potential of different forms of organic nanomedicine such as liposomes, SLN, polymeric nanoparticles, and polymeric micelles, etc., for cancer-targeted delivery of diagnostics. …

Nanotechnology-Driven Cancer Therapies for Precision Oncology: Advances and Clinical Outlook.

Cancer continues to pose a global health challenge, with conventional therapies often limited by non-specific toxicity, drug resistance, and an inadequate therapeutic index. Nanotechnology offers transformative opportunities by enabling targeted drug delivery, improved pharmacokinetics, and integrated diagnostic-therapeutic platforms (termed nanotheranostics). This review highlights key nanocarrier systems including liposomes, polymeric nanoparticles, dendrimers, inorganic nanostructures, carbon-based materials, extracellular vesicles, and hybrid platforms with a focus on human studies and cli

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… Another trend includes pH/redox dual-responsive polymeric micelles that remain intact when exposed to acidic tumor vicinities and conditions of high glutathione concentrations but will release a drug in a site-specific manner. 35 Recently, there have been bioresponsive polymers that can change according … One has been the derivation of hybrid systems whereby Genexol-PM (polymeric micelle for paclitaxel; NCT01249293) is derived of micelles assembled with a liposomal shell in a way such that tumor retention is enhanced whilst limiting burst release. 70 Another popular design is core-shell NPs. …

Bispecific antibodies and nanotechnology: a strategic alliance in cancer immunotherapy.

Bispecific antibodies (bsAbs), designed to recognize two distinct antigens or epitopes, enable innovative mechanisms of action for emerging generations of cancer immunotherapies. Despite their potential, bsAb therapeutics face several challenges related to their biodistribution and pharmacokinetics, which often result in a suboptimal efficacy/toxicity balance. Starting with a brief description of the relevance of bsAbs in cancer immunotherapy, this review aims to critically analyze the synergistic potential of nanotechnology and bsAb technology oriented to enhance therapeutic efficiency while

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… This approach has been applied to several PEGylated nanocarriers, including liposomes, micelles, nanoemulsions, polymeric NPs, quantum dots and AuNPs [ 24 – 30 , 41 ] and, also, to approved PEGylated nanomedicines such as liposomal doxorubicin (Doxil, Caelyx) [ 21 , 22 , 42 , 43 ]. … Lecithin micelles prepared with DSPE-PEG2K or DSPE-PEG5K were compared for cellular uptake following bsAb (anti HER or DNS x PEG) binding. …

Stochasticity of anticancer mechanisms underlying clinical effectiveness of vorinostat.

The Food and Drug Administration (FDA) has approved vorinostat, also called Zolinza®, for its effectiveness in fighting cancer. This drug is a suberoyl-anilide hydroxamic acid belonging to the class of histone deacetylase inhibitors (HDACis). Its HDAC inhibitory potential allows it to accumulate acetylated histones. This, in turn, can restore normal gene expression in cancer cells and activate multiple signaling pathways. Experiments have proven that vorinostat induces histone acetylation and cytotoxicity in many cancer cell lines, increases the level of p21 cell cycle proteins, and enhances p

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… Consequently, vorinostat-loaded PEG-PLGA (Vorinostat-PEG-PLGA) micelles exhibited superior apoptotic activity and enhanced cytotoxic effects compared to free vorinostat. … After 24 h MDA MB 231 cell treatment with Vorinostat-PEG-PLGA micelles, the percentage of cell destruction was approximately 55 % compared to 36 % for the free agent. …

Подготовка и характеристика повода для высвобождения PVA: Na-Alg Микросфера, содержащая фамфридин.

ЦЕЛИ: В настоящем исследовании основное внимание уделяется как формулированию микросфер на основе биоизоляции, содержащих фэмфридин, для лечения множественного склероза, так и альтернативе коммерчески доступному продукту (Fampyra 10 мг, Biogen). МАТЕРИАЛЫ И МЕТОДЫ: Инкапсулирование фамфридина было достигнуто с использованием поливинил-алкоголиков (PVA) и алгинатов натрия (Na-Alg). Глутаральдегид (ГА) и соляная кислота (ГКИ) использовались в качестве связующих веществ. Проведена оценка полимерного соотношения (PVA: Na-Alg), лекарственного средства: полимерного соотношения (d:p), перекрестного с

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… 6 , 7 In the treatment of MS, even though many molecules are used in various segments, the extended-release 10 mg fampridine tablet, taken twice daily, is the only approved pharmacological drug for improving walking ability in adults with MS. 8 Injectable hydrogels, direct implantation, crosslinked micelles … Reversible coreshell crosslinked micelles for controlled release of bioactive agents In: Grumezescu AM, ed. Nanoarchitectonics Biomed, 1st edition, Romania. 2019;119-167. 12. Hyland SJ, Deliberato DG, Fada RA, Romanelli MJ, Collins CL, Wasielewski RC. …

Nanogel-Based Precision Bone Regeneration: Rational Design, Biological Barrier Penetration, and Osteoporotic Microenvironment Remodeling.

The pathogenesis of osteoporosis is primarily associated with impaired communication between osteoblasts and osteoclasts, leading to disrupted bone homeostasis. Conventional biomaterials mainly rely on macroscopic structural support and are limited in their ability to precisely regulate the complex bone microenvironment and overcome biological barriers. As representative soft matter nanoplatforms, nanogels possess unique viscoelastic mechanical properties and adaptive biointerfacial properties, offering new opportunities to overcome physical barriers within bone tissues. Moving beyond previous

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… stable delivery within complex bone microenvironments. 9 , 10 Liposomes and micelles primarily rely on molecular self-assembly to maintain their structural integrity. … Alendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats. Drug Delivery . 2022;29(1):2386–2402. doi: 10.1080/10717544.2022.2086942 83. Wang W, Cui X, Wei H, et al. …

Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders.

Nanoparticles (NPs) provide a versatile toolkit for psychiatry and neurology by leveraging tunable size, surface chemistry, and payload control to overcome long-standing barriers in central nervous system (CNS) therapy. Lipid, polymeric, inorganic, and hybrid NPs can be engineered to traverse the blood-brain barrier (BBB) via receptor/transporter pathways, target specific cell types, and deliver sustained or stimuli-responsive release. Beyond drug delivery, NPs improve imaging, enable gene/RNA therapeutics, and support anti-inflammatory and neuroprotective strategies, advancing precision medic

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… This versatility supports subclasses such as polymeric micelles, polymersomes, and dendrimers (Fig. 1B ) [ 23 – 25 ]. Polymeric micelles are spherical nanostructures with a monolayer shell, featuring a hydrophobic core and hydrophilic corona [ 26 , 27 ]. … Polymeric micelles for drug delivery. Curr Pharm Des. 2006;12:4669–84. 10.2174/138161206779026245 27. Kuperkar K, Patel D, Atanase LI, Bahadur P. Amphiphilic block copolymers: their structures, and self-assembly to polymeric micelles and polymersomes as drug delivery vehicles. …

Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment.

Cancer is still one of the leading causes of death worldwide. This great mortality is due to its late diagnosis when the disease is already at advanced stages. Although the efforts made to develop more effective treatments, around 90% of cancer deaths are due to metastasis that confers a systemic character to the disease. Likewise, matrix metalloproteinases (MMPs) are endopeptidases that participate in all the events of the metastatic process. MMPs' augmented concentrations and an increased enzymatic activity have been considered bad prognosis markers of the disease. Therefore, synthetic inhib

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… In contrast, NMs such as liposomes, lipid micelles, polymers, dendrimers, CNTs, CO, NDs, ribonucleic acid NPs (RNPs), and protein constructs have been used mainly in vaccines and drug delivery systems ( Anselmo and Mitragotri, 2016 ; Pelaz et al., 2017 ; Khan et al., 2018 ; Lee et al., 2021 ; Seaberg … Then, the DGL-DOX is conjugated to poly(ethylene glycol)-poly(caprolactone) (PP) micelles by the MMP-2 sensitive peptide EGPLGVRGK (@) ( Cun et al., 2018 ). The DGL/DOX@PP size is ∼103 nm, and when incubated with MMP-2, DGL/DOX fragments with a size of ∼30 nm are released. …

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects.

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest develo

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… To overcome these limitations, Guo and colleagues developed a self-assembled amphiphilic micelle that is sensitive to lipase, enabling efficient delivery of HA. … The micelles composed of mPEG-PCL/HA demonstrated promising antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) ( 58 ). …

Cancer Vaccines and Beyond: The Transformative Role of Nanotechnology in Immunotherapy.

Cancer is one of the leading causes of morbidity and mortality globally, responsible for approximately 10 million deaths in 2022 and an estimated 21 million new cases in 2024. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy often present limitations in efficacy and side effects. However, immunotherapeutic vaccines have emerged as a promising approach, leveraging the body's immune system to target and eliminate cancer cells. This review examines the evolving landscape of cancer vaccines, differentiating between preventive and therapeutic strategies and highlig

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… These micelles, formed from amphiphilic block copolymers, have the capacity to increase the stability of the mRNA and facilitate its intracellular delivery. … By optimizing their composition, polymeric micelles can enhance the biodistribution and targeting of the vaccine while minimizing potential side effects. …

The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases.

PurposeIn 2007 the two senior authors wrote a review on the structure and function of the endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9:121-167, 2007). Since then there has been an explosion of interest in this hydrated gel-like structure that coats the luminal surface of endothelial cells that line our vasculature due to its important functions in (A) basic vascular physiology and (B) vascular related diseases. This review will highlight the major advances that have occurred since our 2007 paper.MethodsA literature search mainly focusing on the role of the glycocalyx in the

Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom.

A multidrug combination strategy is an important mean to improve the treatment of cancer and is the mainstream scheme of clinical cancer treatment. The active ingredients of traditional Chinese medicine, represented by toad skin and toad venom, have the advantages of high efficiency, low toxicity, wide action and multiple targets and have become ideal targets in combined treatment strategies for tumors in recent years. Toad skin and toad venom are traditional Chinese animal medicines derived from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider that have shown excellent therapeutic