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Review of Adoptive Cellular Therapies for the Treatment of Sarcoma.

Sarcomas are a heterogeneous group of malignancies with limited therapeutic options, particularly in the metastatic setting. Adoptive cellular therapies (ACTs), including tumor-infiltrating lymphocyte (TIL) therapy, chimeric antigen receptor (CAR) T-cell therapy, and T-cell receptor (TCR) gene-modified T-cell therapy, offer promising novel approaches for these refractory tumors. TIL-based therapy has demonstrated early efficacy in melanoma and myeloma, with ongoing trials exploring its role in sarcoma. CAR T-cell strategies targeting HER2, GD2, and B7-H3 antigens are in development, though cha

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… Six patients were included in the trial: two with desmoplastic round cell tumors, two with solitary fibrous tumors, one with leiomyosarcoma, and one with sclerosing epithelial fibrosarcoma. … Safety and clinical activity of TTI-621 in combination with doxorubicin in patients with unresectable or metastatic high-grade leiomyosarcoma: Results from the low-dose expansion cohort. JCO. 2023;41:11508. doi: 10.1200/JCO.2023.41.16_suppl.11508. 66. Poh A.R., Ernst M. …

Recent topics in diagnosis and treatment of malignant spinal tumors.

The diagnosis and treatment of malignant spinal tumors are complex and require an integrated approach known as Jaffe's triangle. This review discusses recent topics in the diagnosis and treatment of primary and metastatic malignant spinal tumors. Integrated diagnostic methods, including the development of a dumbbell scoring system for benign-malignant differentiation and the use of positron emission tomography and magnetic resonance imaging (PET-MRI), have improved diagnostic accuracy. Curative resection techniques such as vertebrectomy, sagittal resection, and posterior resection are crucial

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… An 82-year-old male with multiple spinal metastases from leiomyosarcoma. (a) Sagittal T2-weighted fat-suppressed MRI image. (b, c) Multilevel posterior fixation surgery using PPS: (b) Postoperative AP X-ray. (c) Postoperative lateral X-ray. 5. …

Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study.

BACKGROUND & AIMS: Brown adipose tissue (BAT) has been mainly investigated as a potential target against cardiometabolic disease, but it has also been linked to cancer-related outcomes. Although preclinical data support that BAT and the thermogenic adipocytes in white adipose tissue may play an adverse role in the pathogenesis of cancer cachexia, results from studies in patients have reported inconsistent results. The purpose of this study was to examine the interrelationship between presence of detectable BAT, changes in body weight, and cachexia in patients with cancer. We hypothesized that

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… breast tissue malignancy, in situ/ invasive ductal carcinoma); 7) head and neck (squamous cell carcinoma with origin in the head or neck region, basaloid squamous cell carcinoma, adenoid cystic carcinoma); and 8) other cancer types of various origins (neurofibroma, paraganglioma, myxoid liposarcoma, leiomyosarcoma …

Real-World Outcomes of Incurable Cancer Patients Treated with Unlisted Anticancer Treatments in an Academic Center in Quebec, Canada.

Medical oncology is a rapidly evolving field, with new medications being discovered yearly, contributing to increased survival rates. However, accessing drugs in a timely manner can be challenging. In Quebec, Canada, a physician can prescribe an unlisted anticancer treatment through a regulated pathway under exceptional circumstances. We conducted a quality improvement study describing the outcomes of incurable cancer patients receiving unlisted anticancer therapy at the Jewish General Hospital between 2018 and 2019. Though our study did not include a comparator arm, unlisted anticancer therap

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… malignancy | 59 (52%) Breast | 10 (9%) Pancreatic | 8 (7%) Colorectal | 7 (6%) Ovarian | 6 (5%) Skin, melanoma | 6 (5%) Renal cell | 6 (5%) Lung cancer, non-small cell lung cancer | 4 (4%) Skin, squamous carcinoma | 3 (3%) Head and neck, squamous carcinoma | 2 (2%) Bladder | 2 (2%) Angiosarcoma, prostate, leiomyosarcoma …

Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw.

PURPOSE: The treatment of advanced stages of medication-related osteonecrosis of the jaw (MRONJ) remains challenging. In order to improve decision making concerning the therapy, we examined the change of patients' quality of life (QoL) after surgical treatment of MRONJ stage III. METHOD: The primary outcome variable was patients' QoL. It was preoperative (T0), 6 weeks postoperative (T1) and 6 months postoperative (T2) assessed by the European Organisation for Research and Treatment of Cancer QoL-H&N35 (EORTC QoL-H&N35) and the Oral Health Impact Factor-G14 (OHIP-G14) questionnaire in a prospe

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… denosumab they also appear as bisphosphonate or denosumab patients Number of patients | 43 | • Male | 21 | 48.8% • Female | 22 | 51.2% Primary malignant disease | 36 | 83.7% • Mamma carcinoma | 11 | 30.6% • Prostate carcinoma | 14 | 38.9% • Multiple myeloma | 8 | 22% • Lung carcinoma | 2 | 5.6% • Leiomyosarcoma …

Clinical management and therapeutic development for the rare disease rhabdomyosarcoma.

Rhabdomyosarcoma (RMS) is a rare disease that arises from skeletal muscle mainly affects children and adolescents. Patients with RMS have diverse symptoms and prognosis based on tumor sizes, tumor anatomical locations, histological subtypes of the tumors and genetic testing of paired-box-forkhead box O1 (PAX-FOXO1) fusion gene. The 4 subtypes of RMS include embryonal RMS (eRMS), alveolar RMS (aRMS), spindle cell/sclerosing RMS (scRMS) and pleomorphic RMS (pRMS). Treatment for RMS patients remains challenging due to its heterogeneous nature. Thus, a combinatory approach is likely to warrant bet

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… Uncontrolled cell growth arising from bones or muscles will lead to musculoskeletal cancers, which are often rare cancers, such as osteosarcoma, Ewing sarcoma, chondrosarcoma, rhabdomyosarcoma (RMS), leiomyosarcoma. …

Scleroderma-Specific Autoantibodies and Disease Trajectories in Early Systemic Sclerosis: Insights From a Single-Center Prospective Registry.

OBJECTIVE: Early diffuse cutaneous systemic sclerosis (dcSSc) is associated with substantial disease-specific mortality.  Scleroderma-specific autoantibodies (SSc-Ab) may influence disease course, but their prognostic value in very early dcSSc remains unclear. We examined associations between autoantibody profiles and disease trajectories for clinical events in a prospective single-center cohort. METHODS: We retrospectively analyzed prospectively collected data from a subset of patients enrolled in an early SSc registry between October 2012 and July 2021, including those with early dcSSc or i

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… diagnosis; IQR, interquartile range; NA, not available or not applicable; RNAP3, RNA polymerase III antibody; SCC, squamous cell carcinoma; Scl70, anti‐topoisomerase I antibody; SSc, systemic sclerosis. a Other cancers included bladder cancer (RNAP3, n = 1), esophageal adenocarcinoma (negative, n = 1), leiomyosarcoma …

A review of immunotherapy for bone tumors.

This article reviews the latest research progress in immunotherapy for bone tumors. Bone tumors are a serious threat to human health, and traditional treatments have limitations. Recently, immunotherapy, as an emerging treatment method, has shown great potential in the treatment of bone tumors. This article systematically introduces the pathological features, traditional treatment methods and limitations of bone tumors, and focuses on the principles, application status and challenges of immune checkpoint inhibitors, CAR-T cell therapy, tumor vaccines and other immunotherapies. At the same time

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… Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: results of a phase III randomized multicenter clinical trial . …

Presenting characteristics, histological subtypes and outcomes of adult central nervous system tumours: retrospective review of a surgical cohort.

IntroductionThe most recent local study on the incidence of histological subtypes of all brain and spinal tumours treated surgically was published in 2000. In view of the outdated data, we investigated the presenting characteristics, histological subtypes and outcomes of adult patients who underwent surgery for brain or spinal tumours at our institution.MethodsA single-centre retrospective review of 501 patients who underwent surgery for brain or spinal tumours from 2016 to 2020 was conducted. The inclusion criteria were (a) patients who had a brain or spinal tumour that was histologically ver

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… 1.5) | 3 (0.6) Non-small cell lung carcinoma, undefined | 1 (0.2) | 0 (0.0) | 1 (0.2) Colorectal adenocarcinoma | 8 (1.8) | 1 (1.5) | 9 (1.8) Renal clear cell carcinoma | 6 (1.4) | 1 (1.5) | 7(1.4) Melanoma | 2(0.5) | 0 (0.0) | 2 (0.4) Alveolar soft part sarcoma | 2(0.5) | 0 (0.0) | 2 (0.4) Gastric leiomyosarcoma …

Nationwide Longitudinal Annual Survey of HIV/AIDS Referral Hospitals in Japan From 1999 to 2021: Trend in Non-AIDS-defining Cancers Among Individuals Infected With HIV-1.

BackgroundNon-AIDS-defining cancers (NADCs) in patients infected with HIV have recently attracted attention because of the improved survival of this patient population. To obtain accurate data, a longitudinal study is warranted for the nationwide surveillance of the current status and national trend of NADCs in patients infected with HIV in Japan.SettingAn annual nationwide surveillance of NADCs in patients infected with HIV-1 in Japan from 1999 to 2021.MethodsAn annual questionnaire was sent to 378 HIV/AIDS referral hospitals across Japan to collect data (clusters of differentiation 4-positiv

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… hepatitis B virus, hepatitis C virus, Epstein–Barr virus, human herpesvirus 8, human T-cell lymphotropic virus, and Merkel cell polyomavirus. 31 Epstein–Barr virus has been implicated in the pathogenesis of Burkitt lymphoma, Hodgkin disease, non-Hodgkin lymphoma, nasopharyngeal carcinoma, lymphomas, and leiomyosarcomas …

Evaluation of circulating PD-1 and PD-L1 as diagnostic biomarkers in dogs with tumors.

BackgroundProgrammed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) have important roles in tumor evasion of the immune system.ObjectivesThis study aimed to assess the diagnostic utility of circulating PD-1 and PD-L1 levels in healthy dogs and dogs with tumors.MethodsCirculating PD-1 and PD-L1 levels in the serum of 71 dogs with tumors were compared with those of 52 healthy dogs by performing enzyme-linked immunosorbent assay (ELISA).ResultsThe ELISA results revealed higher circulating PD-1 and PD-L1 levels in dogs with tumors (2.9 [2.2-3.7] ng/mL; median [IQR] and 2.4

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… | Nasal adenocarcinoma (n = 2) | | Rectal adenocarcinoma (n = 1) Mesenchymal (n = 14) | Benign (n = 4) | | Lipoma (n = 4) | Malignant (n = 10) | | Melanoma (n = 5) | | Osteosarcoma (n = 1) | | Liposarcoma (n = 1) | | Cutaneous hemangiosarcoma (n = 1) | | Fibrosarcoma (n = 1) | | Leiomyosarcoma …

Incidence of atypical femoral fractures in the treatment of bone metastasis: An alert report.

BackgroundAs the life expectancy of cancer-bearing patients has increased, more patients with bone metastasis are receiving long-term treatment with bone-modifying agents (BMAs; e.g., zoledronate and denosumab), which are a risk factor for developing atypical femoral fracture (AFF). In this study, we surveyed the risk of iatrogenic AFF using a clinical database on treatment of bone metastasis in the past 10 years.MethodsFrom April 2011 through October 2019, 721 patients with bone metastasis (436 men, 285 women; mean age, 65.7 ± 12.4 years) were registered under the bone metastasis consultation

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… Others ( n = 31) were uterine cancer, uterine sarcoma, ovarian cancer, testicular cancer, adrenal cancer, malignant pleural mesothelioma, thymic carcinoma, thymic carcinoid, angiosarcoma, hemangiopericytoma, leiomyosarcoma, malignant insulinoma, duodenal cancer, and small intestinal cancer (each <1%) …

Резюме: 31 Европейский конгресс патологии.

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The progress and perspective of nanomedicine in modulating the tumor immune microenvironment.

The widespread application of nanomedicine in oncology is reshaping cancer treatment paradigms. Using the precise targeting mechanisms and the rapid advancements in nanoscale materials, nanomedicine is driving progress in cancer therapy, particularly within the complex landscape of the tumor immune microenvironment (TIM). This review provides a comprehensive overview of recent studies elucidating the critical role of nanomedicine in modulating the TIM, augmenting the efficacy of immunotherapies, and overcoming therapeutic resistance. Emphasis is placed on the significance of targeted drug deli

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… pathway inhibitor) Combined chemotherapy (Pegylated liposomal doxorubicin/Paclitaxel) Ovarian cancer I 2021 NCT03639246 155 R484/Resiquimod (TLR7/8 agonist) Monotherapy CTCL I/II 2015 NCT01676831 147 Olaparib (PARP inhibitor) Combined immunotherapy (Durvalumab) and angiogenesis (Cediranib) Advanced leiomyosarcoma … chemotherapy (Pegylated liposomal doxorubicin/Paclitaxel) | Ovarian cancer | I | 2021 | NCT03639246 | 155 | R484/Resiquimod (TLR7/8 agonist) | Monotherapy | CTCL | I/II | 2015 | NCT01676831 | 147 | Olaparib (PARP inhibitor) | Combined immunotherapy (Durvalumab) and angiogenesis (Cediranib) | Advanced leiomyosarcoma …

Zusanli (ST36) Acupoint Injection With Dexamethasone for Chemotherapy-Induced Myelosuppression: A Systematic Review and Meta-Analysis.

ObjectiveMyelosuppression is the most common adverse reaction of chemotherapy, which seriously affects the course of treatment. Zusanli (ST36) acupoint injection with dexamethasone has achieved good clinical efficacy in China. This study aimed to systematically evaluate the efficacy of ST36 acupoint injection with dexamethasone in the treatment of chemotherapy-induced myelosuppression (CIM).MethodsRandomized controlled trials of CIM treated with ST36 acupoint injection with dexamethasone were retrieved from eight electronic databases. We used the Cochrane Collaboration tool to assess the risk

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… (oral) | DMX(im) + Chinese herb (oral) | 7 | 1.Effective Rate 2.Blood routine Levels | Malignant lymphoma, lung cancer, colorectal cancer, breast cancer, ovarian cancer, nasopharyngeal cancer, cervical cancer, esophageal cancer, stomach cancer, larynx cancer, renal cancer, cancerous pleural fluid, leiomyosarcoma …

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations.

Cancer cells support their growth and proliferation by reprogramming their metabolism in order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to tumorigenesis, a common alteration in tumors occurs in pathways that upregulate nutrient acquisition. A central signaling pathway that controls metabolic processes is the mTOR pathway. The elucidation of the regulation and functions of mTOR can be traced to the discovery of the natural compound, rapamycin. Studies using rapamycin have unraveled the role of mTOR in the control of cell growth and metabolism. By sen

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… Ridaforolimus had an overall PFS rate at 6 months of 23.4% for soft tissue and bone sarcomas, including primary bone sarcomas, leiomyosarcomas, and liposarcomas in a phase II study [ 182 ]. … However, the combination treatment seems to have better efficacy for leiomyosarcoma, thus warranting further investigation [ 259 ]. It is notable that previous studies have reported that over 70% of primary leiomyosarcoma tumors have increased Akt/mTOR signaling [ 298 ]. …

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review.

ObjectiveOsteoradionecrosis (ORN) is a recognized complication of radiotherapy. However, calvarial ORN (ORNC) following treatment for cutaneous malignancies is poorly understood. Shedding light on the limited evidence to date, this study aims to summarize existing evidence and highlight the research gaps.Data sourcesPubMed and Embase.Review methodsA systematic search of PubMed and Embase was conducted up to May 2024, using relevant keywords to identify papers on ORNC. Data on the definition, incidence, risk factors, radiotherapy parameters, diagnostic methods, and management strategies were co

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… | 1 | 87 | M | Renal transplantation for PKD | Melanoma | 60 Gy in 30 fractions | Excision Kwee et al 21 | Australia | 2012 | CR | 1 | 83 | M | NR | MM | NR | Excision Local transposition flap STSG Selber et al 22 | United States | 2016 | CR | 1 | 55 | M | T1DM Kidney and pancreas transplantation | Leiomyosarcoma …

Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response.

Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune response. The inhibition and reprogramming of the immune system play critical roles in tumor initiation and progression. Immunotherapy aims to reactivate antitumor immune cells and overcome the immune escape mechanisms of tumors. Represented by immune checkpoint blockade and adoptive cell transfer, tumor immunotherapy has seen tremendous success in the clinic, with the capability to induce long-term regression of some tumors that are refractory to all other treatm

Unraveling the Anticancer Effect of Curcumin and Resveratrol.

Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unr

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… mTOR, an Akt upstream modulator, was inhibited in vitro by curcumin using uterine leiomyosarcoma cells. Western Blot data revealed that curcumin has restrained p70S6 and S6 phosphorylations; both ribosomal proteins are downstream targets of mTOR. …