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Interventions for replacing missing teeth: management of soft tissues for dental implants.

BACKGROUND: Dental implants are usually placed by elevating a soft tissue flap, but in some instances, they can also be placed flapless reducing patient discomfort. Several flap designs and suturing techniques have been proposed. Soft tissues are often manipulated and augmented for aesthetic reasons. It is often recommended that implants are surrounded by a sufficient width of attached/keratinised mucosa to improve their long-term prognosis. OBJECTIVES: To evaluate whether (1a) flapless procedures are beneficial for patients, and (1b) which is the ideal flap design; whether (2a) soft tissue c

From Development, Disease, and Decline: A Review of What Defines an Osteoclast Progenitor.

Our understanding of the different developmental origins of osteoclast progenitors and their respective roles during homeostatic bone remodeling at different skeletal sites as well as their roles within bone regeneration and degenerative conditions is evolving. In this narrative review article, we summarize what is known about the developmental origins, anatomical sources, and markers of osteoclast progenitors. We touch on how osteoclast progenitors vary during different disease contexts, including periodontitis, rheumatoid arthritis, and osteoarthritis. In addition, we also characterize osteo

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… Oxidized Titanium Implants Enhance Osseointegration via Mechanisms Involving RANK/RANKL/OPG Regulation Clin. Implant. Dent. Relat. Res. 2015 17 (Suppl. 2) e486 e500 10.1111/cid.12276 25536123 111. Makishi S. Watanabe T. Saito K. Ohshima H. … Effect of Hydroxyapatite/beta-Tricalcium Phosphate on Osseointegration after Implantation into Mouse Maxilla Int. J. Mol. Sci. 2023 24 3124 10.3390/ijms24043124 36834535 PMC9965049 112. Shirakura M. Fujii N. Ohnishi H. Taguchi Y. Ohshima H. Nomura S. Maeda T. …

Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis.

Osteoblasts are mainly derived from mesenchymal stem cells in the bone marrow. These stem cells can differentiate into osteoblasts, which have the functions of secreting bone matrix, promoting bone formation, and participating in bone remodeling. The abnormality of osteoblasts can cause a variety of bone-related diseases, including osteoporosis, delayed fracture healing, and skeletal deformities. In recent years, with the side effects caused by the application of PTH drugs, biphosphonate drugs, and calmodulin drugs, people have carried out more in-depth research on the mechanism of osteoblast

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… Ke Yu et al. identified circRNA422 in rat bone marrow mesenchymal stem cells (BMSC), which can promote BMSC proliferation and osteogenic differentiation by regulating the expression of SP7 and LRP5, and has a facilitating effect on the early osseointegration process (Yu et al. 2022 ). … osteoblast differentiation Ambrosetti et al. ( 2008 ) Sp1 Fzd1 Increase differentiation and mineralization of osteoblasts in vitro Yu et al. ( 2016 ) miR-129-5p Fzd4 and β-catenin Inhibits osteoblast differentiation Wang et al. ( 2021 ) circRNA422 LRP5 Promotes osteoblast differentiation and facilitates osseointegration …

Bone cements for percutaneous vertebroplasty and balloon kyphoplasty: Current status and future developments.

Osteoporotic vertebral compression fractures (OVCFs) have gradually evolved into a serious health care problem globally. In order to reduce the morbidity of OVCF patients and improve their life quality, two minimally invasive surgery procedures, vertebroplasty (VP) and balloon kyphoplasty (BKP), have been developed. Both VP and BKP require the injection of bone cement into the vertebrae of patients to stabilize fractured vertebra. As such, bone cement as the filling material plays an essential role in the effectiveness of these treatments. In this review article, we summarize the bone cements

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… The supplementation of strontium to CPCs causes the release of biologically effective doses of Sr 2+ , which stimulates bone formation in and around the implant and enhances osseointegration. … Strontium enhances osseointegration of calcium phosphate cement: a histomorphometric pilot study in ovariectomized rats J Orthopaed Surg Res 8 2013 16 10.1186/1749-799X-8-16 PMC3680072 23758869 50 Schumacher M. Henss A. Rohnke M. Gelinsky M. …

Терапевтический потенциал моделей Purmorphamine через болезни.

Purmorphamine (PUR) — тройная субституция пурина, которая выборочно активирует сгущенный рецептор, тем самым инициируя Sonic Hedgehog (Shhh) сигнализирующий путь, имеющий решающее значение для эмбриональной модели, нейронной спецификации и регенерации тканей в различных системах различных органов. Регулирование сигнала " Шш " причастно к дегенеративным заболеваниям, однако терапевтические меры, направленные на этот путь, по-прежнему ограничены. PUR демонстрирует широкую терапевтическую эффективность различных моделей предклинических заболеваний путем активации как транскрипции с помо

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… This synergy enhances the therapeutic potential of PUR in orthopaedic and dental applications, including osseointegration of implants. … Brett , “ Small Molecule Stimulation Enhances Bone Regeneration but Not Titanium Implant Osseointegration ,” Bone 57 , no. 2 ( 2013 ): 405 – 412 . 24076022 10.1016/j.bone.2013.09.012 64 V. Pota , P. Sansone , S. …

Clinical effect of Zoledronic Acid in the treatment of Senile Osteoporosis.

ObjectiveTo investigate the clinical efficacy of zoledronic acid in the treatment of senile osteoporosis.MethodsOne hundred and six cases of senile osteoporosis who visited to our hospital from August 2017 to December 2018 for treatment were selected and randomly divided into a control group and an observation group. The control group was treated with conventional therapy, while the observation group was treated with zoledronic acid in addition to the treatment of the control group. Bone mineral density, pain degree, therapeutic effect and adverse reactions of the two groups were compared.Resu

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… P Phenotypic research on senile osteoporosis caused by SIRT6 deficiency Int J Oral Sci 2016 8 2 84 92 doi:10.1038/ijos.2015.57 27357320 10.1038/ijos.2015.57 PMC4932771 5 Beppu K Kido H Watazu A Teraoka K Matsuura M Peri-implant bone density in senile osteoporosis-changes from implant placement to osseointegration …

BDNF improves the survival of mesenchymal stem cells cultured on pre-structured gelatin material containing strontium and calcium phosphates for bone regeneration.

INTRODUCTION: The treatment of osteoporotic fractures is still challenging and may be improved using materials for bone regeneration, such as pre-structured gelatin with calcium and strontium phosphates (PPGC+S), combined with brain-derived neurotrophic factor (BDNF). Recently, it was shown that PPGC+S stimulates bone formation, and BDNF improves cell survival. This study aimed to analyze the combined effect of PPGC+S and BDNF on the survival of mesenchymal stem cells (MSCs) from osteoporotic and non-osteoporotic female donors. METHODS: In our study, cells were seeded on PPGC+S plates with th

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… Depending on the concentration, degradation, resorbability, and the degree of osseointegration and bone formation increased ( Christoffersen et al., 1997 ; Verberckmoes et al., 2003 ). … Strontium enhances osseointegration of calcium phosphate cement: a histomorphometric pilot study in ovariectomized rats. J. Orthop. Surg. Res. 8, 16. 10.1186/1749-799X-8-16 Borciani G., Montalbano G., Melo P., Baldini N., Ciapetti G., Vitale-Brovaron C. (2021). …

An Approach for the Prevention, Diagnosis, and Treatment of Jaw Osteonecrosis: Report of a Case Associated with Zoledronic Acid.

BACKGROUND Osteonecrosis of the jaw is a condition manifesting as necrotic bone for 8 weeks or more, with no history of radiotherapy. It is linked to the use of antiresorptive drugs, such as bisphosphonates and denosumab. We discuss in this case report the importance of infection control during clinical procedures in patients taking antiresorptives. CASE REPORT Our case report describes a 52-year-old woman who had received zoledronic acid injections for 7 years, who presented with osteonecrosis of the jaw in the region of teeth 24, 25, and 26, with no local trauma. The report proceeds to descr

Advance in the application of organoids in bone diseases.

Bone diseases such as osteoporosis and osteoarthritis have become important human health problems, requiring a deeper understanding of the pathogenesis of related diseases and the development of more effective treatments. Bone organoids are three-dimensional tissue masses that are useful for drug screening, regenerative medicine, and disease modeling because they may mimic the structure and physiological activities of organs. Here, we describe various potential methods for culturing bone-related organoids from different stem cells, detailing the construction processes and highlighting the main

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… In 2020, a new method has been proposed utilizing human trabecular bone explants filled with chitosan/gel/hydroxyapatite biomaterials to determine the osseointegration process in vitro and in vivo ( Przekora et al., 2021 ). … Ex vivo determination of chitosan/curdlan/hydroxyapatite biomaterial osseointegration with the use of human trabecular bone explant: new method for biocompatibility testing of bone implants reducing animal tests . Mater. Sci. Eng. C 119 , 111612 . 10.1016/j.msec.2020.111612 33321655 Qing J. Guo Q. …

Conventional free-hand, dynamic navigation and static guided implant surgery produce similar short-term patient-reported outcome measures and experiences.

Design A randomised controlled trial study comparing patient-reported outcome measures (PROMs) and experiences (PREs) using conventional brain-guided (free-hand), dynamic computer-assisted implant surgery (dCAIS) and static computer-assisted implant surgery (sCAIS) for dental implant placement.Case selection Ninety subjects who met the inclusion criteria (that is, at least 20 years of age interested in dental implant treatment) accepted to participate in the trial and were randomly allocated to three groups between August 2019 and October 2020, according to the dental implant placement protoco

Anti-resorptive therapy in the osteometabolic patient affected by periodontitis. A joint position paper of the Italian Society of Orthopaedics and Traumatology (SIOT) and the Italian Society of Periodontology and Implantology (SIdP).

This joint report from the Italian Society of Orthopaedics and Traumatology (SIOT) and the Italian Society of Periodontology and Implantology (SIdP) aims for a consensus around the scientific rationale and clinical strategy for the management of osteoporotic patients affected by periodontitis who are undergoing anti-resorptive (AR) therapy to manage the risk of the occurrence of a medication-related osteonecrosis of the jaws (MRONJ). Osteoporosis and periodontitis are chronic diseases with a high prevalence in aging patients, and they share some of the same pathogenetic mechanisms based upon i

Systematic Review of Case Reports and Case Series Published Between 2015 and 2025 on the Use of Biomaterials for Closure of Oroantral Fistula.

Oroantral fistulas (OAFs) challenge the clinical decision-making of oral surgeons, requiring selection of an effective biomaterial for successful closure. This systematic review aims to evaluate recent biomaterials and techniques for closing oroantral fistulas, as reported in case reports and series. The goal of this review was to assess how different biomaterials affect the clinical closure of OAFs and oroantral communication. This systematic review followed PRISMA guidelines. Multiple scientific databases (Scopus, Web of Science, Cochrane Library) were comprehensively searched using relevant

The Effect of Perioperative Radiation Therapy on Spinal Bone Fusion Following Spine Tumor Surgery.

INTRODUCTION: Perioperative irradiation is often combined with spine tumor surgery. Radiation is known to be detrimental to healing process of bone fusion. We tried to investigate bone fusion rate in spine tumor surgery cases with perioperative radiation therapy (RT) and to analyze significant factors affecting successful bone fusion. METHODS: Study cohort was 33 patients who underwent spinal tumor resection and bone graft surgery combined with perioperative RT. Their medical records and radiological data were analyzed retrospectively. The analyzed factors were surgical approach, location of

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… Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic. J Orthop Res. 2016 Jan 30; doi: 10.1002/jor.23179. [Epub] 22. Sherman RM, Waddell JP. Laminectomy for metastatic epidural spinal cord tumors. …

Printing the Pathway Forward in Bone Metastatic Cancer Research: Applications of 3D Engineered Models and Bioprinted Scaffolds to Recapitulate the Bone-Tumor Niche.

Breast cancer commonly metastasizes to bone, resulting in osteolytic lesions and poor patient quality of life. The bone extracellular matrix (ECM) plays a critical role in cancer cell metastasis by means of the physical and biochemical cues it provides to support cellular crosstalk. Current two-dimensional in-vitro models lack the spatial and biochemical complexities of the native ECM and do not fully recapitulate crosstalk that occurs between the tumor and endogenous stromal cells. Engineered models such as bone-on-a-chip, extramedullary bone, and bioreactors are presently used to model cellu

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… Osteomyelitis typically occurs from chronic inflammation as a result of osseointegrated implants (e.g., dental implants or femoral implants (i.e., artificial hip)) [ 64 , 65 , 66 ]. … Osteomyelitis risk in patients with transfemoral amputations treated with osseointegration prostheses Clin. Orthop. Relat. Res. 2017 475 3100 3108 10.1007/s11999-017-5507-2 28940152 PMC5670076 65. Kellesarian S.V. Javed F. Romanos G.E. …

Nanogel-Based Precision Bone Regeneration: Rational Design, Biological Barrier Penetration, and Osteoporotic Microenvironment Remodeling.

The pathogenesis of osteoporosis is primarily associated with impaired communication between osteoblasts and osteoclasts, leading to disrupted bone homeostasis. Conventional biomaterials mainly rely on macroscopic structural support and are limited in their ability to precisely regulate the complex bone microenvironment and overcome biological barriers. As representative soft matter nanoplatforms, nanogels possess unique viscoelastic mechanical properties and adaptive biointerfacial properties, offering new opportunities to overcome physical barriers within bone tissues. Moving beyond previous

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… This markedly enhances osteoconductivity and osseointegration, thereby promoting efficient new bone formation. 64 , 65 In addition, nanostructured ceramic materials possess a high specific surface area and strong surface catalytic activity. … Layered double hydroxide modified bone cement promoting osseointegration via multiple osteogenic signal pathways. ACS Nano . 2021;15(6):9732–9745. doi: 10.1021/acsnano.1c00461 65. Ben Braham M, Trunfio-Sfarghiu AM, Brizuela L, et al. …

Medication related osteonecrosis (MRONJ) in the management of CTIBL in breast and prostate cancer patients. Joint report by SIPMO AND SIOMMMS.

BACKGROUND: Low-doses of bone modifying agents (LD-BMAs) compared to those used to treat bone metastases are used in breast or prostate cancer patients on adjuvant endocrine therapy to prevent Cancer Treatment Induced Bone Loss (CTIBL). Their use is associated with an increased risk of developing Medication-Related Osteonecrosis of the Jaw (MRONJ). However, there is not clarity about strategies aimed to minimize the MRONJ risk in cancer patients at different conditions as low- vs high-doses of BMA. This joint report from the Italian Societies of Oral Pathology and Medicine (SIPMO) and of Itali

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… than 3 years or those exposed to BPs for less than 3 years but with other systemic diseases, BPs could be discontinued 1 week before the dental surgical procedure and resumed once the oral mucosa is completely healed (typically 4–6 weeks surgery) [68] ; in the case of dental implant placement, the osseointegration … In the case of dental implant placement, the osseointegration process should be monitored and documented [90] . A 1-month delay of DNB must be authorized by the bone specialist. …

Platelet rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw: personal experience and review of the literature.

Bisphosphonates (BPs) are a class of synthetic drugs commonly used to treat bone metastasis and various bone diseases that cause osseous fragility (such as osteoporosis). Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a common complication in patients who received BPs, especially intravenously. Recently, osteonecrosis of the jaw (ONJ) caused by chemotherapeutic not belonging to BPs drug class has been reported. For this reason, it has been proposed recently to rename BRONJ in antiresorptive agents related osteonecrosis of the jaw (ARONJ), to include a wider spectrum of drugs that m

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… bone formation: a radiological and histomorphometric study in New Zealand rabbits Brazilian Oral Research 2009 23 3 275 280 2-s2.0-72449150588 19893962 10.1590/s1806-83242009000300009 52 Anitua E Orive G Pla R Roman P Serrano V Andía I The effects of PRGF on bone regeneration and on titanium implant osseointegration …

Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force.

With a rapidly aging population and increasing use of antiresorptive agents, medication-related osteonecrosis of the jaw (MRONJ) represents a growing clinical challenge worldwide. To address the need for tailored clinical guidance, a multidisciplinary task force was convened. Five Korean academic societies-the Korean Society for Bone and Mineral Research, the Korean Association of Oral and Maxillofacial Surgeons, the Korean Society of Maxillofacial Plastic and Reconstructive Surgeons, the Korean Osteoporosis Society, and the Korean Endocrine Society-collaborated to develop this position statem

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… Furthermore, MRONJ can manifest years after successful implant osseointegration, a phenomenon termed ‘late implant-associated MRONJ [ 103 ].’ This condition is pathologically distinct from conventional peri-implantitis, although it is often precipitated by it [ 104 ]. … Consequently, the presence of an osseointegrated implant, particularly one with suboptimal oral hygiene, constitutes a long-term local risk factor that requires meticulous professional maintenance and patient surveillance [ 106 ]. …

The Synthetic Collagen-Binding Peptide NIPEP-OSS Delays Mouse Myeloma Progression.

Multiple myeloma (MM) is the second most common hematological malignancy. It is a clonal B-cell disorder characterized by the proliferation of malignant plasma cells in the bone marrow, the presence of monoclonal serum immunoglobulin, and osteolytic lesions. An increasing amount of evidence shows that the interactions of MM cells and the bone microenvironment play a significant role, suggesting that these interactions may be good targets for therapy. The osteopontin-derived collagen-binding motif-bearing peptide NIPEP-OSS stimulates biomineralization and enhances bone remodeling dynamics. Due

The potential therapeutic role of extracellular vesicles in critical-size bone defects: Spring of cell-free regenerative medicine is coming.

In recent years, the incidence of critical-size bone defects has significantly increased. Critical-size bone defects seriously affect patients' motor functions and quality of life and increase the need for additional clinical treatments. Bone tissue engineering (BTE) has made great progress in repairing critical-size bone defects. As one of the main components of bone tissue engineering, stem cell-based therapy is considered a potential effective strategy to regenerate bone tissues. However, there are some disadvantages including phenotypic changes, immune rejection, potential tumorigenicity,

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… In addition, they are the only metals that have been proven to have osseointegration characteristics ( Briguglio et al., 2019 ). Similar to polymers, many studies that used metals as scaffold materials for EVs have focused on improving their biological functions. … Thus, this system was better at promoting osseointegration by regulating inflammatory responses. Detailed mechanisms include blocking nuclear factor-κB (NF-κB) signalling and enhancing macrophage M2 polarization, and these two processes are reversible ( Wei R. et al., 2019 ). …