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The prince and the pauper. A tale of anticancer targeted agents.

Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of two treatment eras. The so-called pregenomic therapy which names the traditional cancer drugs, mainly cytotoxic drug types, and post-genomic era-type drugs referring to rationally-based designed. Although there are successful examples of this newer drug discovery approach, most target-specific agents only provide small gains in symptom control and/or survival, whereas others have consiste

Резюме ЭСП 2013.

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… Method: Pretherapeutic biopsies and resection specimen of 41 hSTS (14 pleomorphic sarcomas, 9 myxofibrosarcomas, 5 synovial sarcomas, 7 dedifferentiated liposarcomas (DLS), 3 myxoid/roundcell liposarcomas, 1 epitheloid sarcoma, 1 rhabdomyosarcoma, 1 leiomyosarcoma) after preoperative IMRT were included … Results: The most frequent tumor types were alveolar rhabdomyosarcoma (ARMS) (33.3 %), embryonal rhabdomyosarcoma (ERMS) (14,6 %), unclassified sarcoma (14.6 %) and leiomyosarcoma (12,5 %). All “round cells” sarcomas were rhabdomyosarcoma. …

Резюме: 32 Второй Конгресс ЭСП и Международный конгресс XXXIII МПД.

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A Natural Organic Compound "Decursin" Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma.

Osteosarcoma is a rare malignant tumor that commonly occurs in children. Anticancer drugs, for example, cisplatin, aid in postsurgery recovery but induce side effects such as renal damage, affecting the life prognosis of patients. Decursin which is one of the bioactive components has been reported for its anti-inflammatory, antioxidant, and antitumor effects, but the effect on osteosarcoma is unexplained. In this study, the research theme was to examine the sensitizing effect of decursin and its influence on cisplatin-induced nephrotoxicity. The cell viability and half maximal inhibitory conce

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… Efficacy and safety of trabectedin as an early treatment for advanced or metastatic liposarcoma and leiomyosarcoma. Future Oncology . 2014;10(1):59–68. doi: 10.2217/fon.13.163. 12. Seetharam M., Kolla K. R., Chawla S. P. …

Risk Factors Analysis of Phantom Limb Pain in Amputees with Malignant Tumors.

PurposePostamputation neuropathic pain is a common disease in patients with malignant tumor amputation, seriously affecting amputees' quality of life and mental health. The objective of this study was to identify independent risk factors for phantom limb pain in patients with tumor amputation and to construct a risk prediction model.MethodsPatients who underwent amputation due to malignant tumors from 2013 to 2023 were retrospectively analyzed and divided into phantom limb pain group and non-phantom limb pain group. To determine which preoperative factors would affect the occurrence of phantom

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… Abbreviations : PENT, primitive neuroectodermal tumor; OMGCT, Osteoclastic malignant giant cell tumor; Soft tissue sarcomas includes the following; UPS, Pleomorphic undifferentiated sarcoma; LS, liposarcoma; RS, rhabdomyosarcoma; LMS, leiomyosarcoma; SS, synovial sarcoma; AS, angiosarcoma; FS, fibrosarcoma …

Proximal femur replacement in oncologic lesion: hemiarthroplasty vs total hip arthroplasty-a multicentric retrospective study.

IntroductionThis study aimed to evaluate the outcomes and complications associated with proximal femur replacement (PFR) in patients undergoing treatment for primary bone tumors or metastatic lesions. This research specifically compared modular hemiarthroplasty (HA) and total hip arthroplasty (THA) to ascertain the optimal approach regarding functionality and postoperative complications.Materials and methodsA retrospective multicenter review was conducted involving 85 patients who underwent prosthetic femoral reconstruction (PFR) between the years 2015 and 2022 at two specialized medical cente

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… ), lung cancer (6 cases; including 1 squamous cell carcinoma and 5 adenocarcinomas), bladder cancer (2 cases), rectal adenocarcinoma (1 case), hematological tumors (1 case of multiple myeloma and 1 case of large B-cell lymphoma), pancreatic cancer (1 case), prostate adenocarcinoma (1 case), uterine leiomyosarcoma …

Age-related sarcoma patient experience: results from a national survey in England.

BackgroundSarcomas are rare, heterogeneous tumours affecting patients of any age. Previous surveys describe that sarcoma patients report a significantly worse experience than those with common cancers. Consequently, Sarcoma UK conducted a national survey and these data were examined for age- and tumour-related differences in patients' experiences.MethodsPatients were randomly selected from respondents to National Cancer Patient Experience Surveys (n = 900). Differences between patient groups according to age (Adolescents and Young Adults [AYA] 18-39 years, middle-aged 40-64 years, elderly 65 +

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… Adult sarcoma patients most commonly develop undifferentiated sarcomas, gastrointestinal stromal tumours, leiomyosarcomas and liposarcomas requiring surgery, often radiotherapy and on indication chemotherapy [ 11 ]. …

Symptoms and patient factors associated with longer time to diagnosis for colorectal cancer: results from a prospective cohort study.

BACKGROUND: The objective of this study is to investigate symptoms, clinical factors and socio-demographic factors associated with colorectal cancer (CRC) diagnosis and time to diagnosis. METHODS: Prospective cohort study of participants referred for suspicion of CRC in two English regions. Data were collected using a patient questionnaire, primary care and hospital records. Descriptive and regression analyses examined associations between symptoms and patient factors with total diagnostic interval (TDI), patient interval (PI), health system interval (HSI) and stage. RESULTS: A total of 2677

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… Other cancers include ( n =1): leiomyosarcoma, appendix, peritoneal, melanoma, cholangiocarcinoma. a Percentages add to >100%, because 54 patients have more than one diagnosis. More than one diagnosis in the same category (e.g., miscellaneous) was counted only once. …

Molecular Evaluation of Low-grade Low-stage Endometrial Cancer With and Without Recurrence.

Low-grade, low-stage endometrioid carcinomas (LGLS EC) demonstrate 5-yr survival rates up to 95%. However, a small subset of these tumors recur, and little is known about prognostic markers or established mutation profiles associated with recurrence. The goal of the current study was to identify the molecular profiles of the primary carcinomas and the genomic differences between primary tumors and subsequent recurrences. Four cases of LGLS EC with recurrence and 8 cases without recurrence were evaluated via whole-exome sequencing. Three of the 4 recurrent tumors were evaluated via Oncomine Com

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… Uterine leiomyosarcomas express KIT protein but lack mutation(s) in exon 9 of c-KIT. Gynecol Oncol 2005;98:334–5. 56. Lee CH, Hoang LN, Yip S, et al. Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement. Mod Pathol 2014;27:751–7. 57. …

Метастазы мужской груди: систематический обзор.

Фон/цели: Метастазы молочной железы, возникающие в результате злокачественных опухолей, представляют собой исключительно редкое клиническое существо, особенно у мужского населения. Цель этого исследования состоит в том, чтобы проанализировать соответствующую литературу по вопросу о вторичном вовлечении в грудь пациентов мужского пола с уделением особого внимания клиническому представлению, характеристикам изображений, гистологическим и иммунохимическим характеристикам и стратегиям управления. До настоящего времени в международной литературе не было опубликовано какого-либо систематического обз

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… Breast metastasis from testicular leiomyosarcoma Breast J. 2013 19 336 337 10.1111/tbj.12116 23600884 123. Alacacioglu A. Unal S. Canpolat S. Yurt A. Oztekin O. Coskun A. Karatas A. Postaci H. Sop G. …

The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials.

BackgroundCardiotoxicity is one of the most common adverse events of the chemotherapy. Physical exercise was shown to be cardioprotective. We aim to estimate the efficacy and safety of exercise in cancer patients receiving cardiotoxic chemotherapy.MethodsWe conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), which were retrieved by systematically searching PubMed, Web of Science, SCOPUS, Cochrane, Clinical Trials.gov, and MedRxiv through July 17th, 2023. We used RevMan V. 5.4 to pool dichotomous data using risk ratio (RR) and continuous data using mean diffe

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… (aerobic) | 10 | 2 to 3 | 40—50 | moderate- to high-intensity exercise | Usual care | doxorubicin and/or trastuzumab | breast cancer stages I-IV and leiomyosarcoma | 59% | Our primary aim was to determine whether CR improves exercise capacity in patients who have exhibited subclinical markers of myocardial …

Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine.

The treatment of neoplastic spine metastases requires multi-faceted assessment and an interdisciplinary approach to patients. The metastases do not show specific symptoms but are often the first confirmation of the presence of a primary tumor in a patient. The diagnostic process includes imaging and invasive procedures, e.g., biopsy. It is essential to qualify the patient for an appropriate treatment using dedicated scales. Decompression of the spinal cord is a critical issue to save or restore neurological function in a patient with spine metastases. Surgical treatment ought to meet three cri

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… Clinical outcomes and survivals after total en bloc spondylectomy for metastatic leiomyosarcoma in the spine. Eur. Spine J. 2020;29:3237–3244. doi: 10.1007/s00586-020-06461-0. 70. Shimizu T., Murakami H., Sangsin A., Demura S., Kato S., Shinmura K., Yokogawa N., Oku N., Kitagawa R., Tsuchiya H. …

Basket Trials for Intractable Cancer.

Currently, genomic characterization has become standard of care for tumor types such as non-small cell lung cancer, breast cancer, melanoma, and colorectal cancer. A deep understanding of genomic alterations in different tumor types would help identify potentially actionable genomic changes which occur across a wide variety of tumor types. A basket trial is a new type of clinical trial for which eligibility is based on the presence of a specific genomic alteration, irrespective of histology. Basket trials are phase II screening trials for the off-label use of a targeted drug in patients with t

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… Primary pulmonary leiomyosarcoma: a population-based study. Lung Cancer. (2018) 116:67–72. 10.1016/j.lungcan.2017.12.015 16. Qin BD, Jiao XD, Liu K, Wu Y, He X, Liu J, et al. …

The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer.

BackgroundFatigue is a prevalent and complex condition with significant impacts on well-being. Existing fatigue assessments often lack comprehensiveness or practicality for general population studies.MethodsThis study validated the REST Questionnaire, a novel fatigue assessment tool, in a sample of 268 adults. Psychometric properties, including internal consistency and construct validity, were evaluated. REST scores were correlated with WHO-5 well-being, BMI, self-rated health, and chronic conditions. Exploratory factor analysis identified underlying dimensions of fatigue.ResultsThe REST Quest

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… carcinoma Hepatocellular carcinoma Esophageal carcinoma Bladder carcinoma Renal cell carcinoma Cervical carcinoma Endometrial carcinoma Ovarian carcinoma Thyroid carcinoma Melanoma Basal cell carcinoma Squamous cell carcinoma Osteosarcoma, chondrosarcoma, sarcoma of Ewing, rhabdomyosarcoma, leiomyosarcoma …

FDA-Approved Small Molecule Compounds as Drugs for Solid Cancers from Early 2011 to the End of 2021.

Solid cancers are the most common types of cancers diagnosed globally and comprise a large number of deaths each year. The main challenge currently in drug development for tumors raised from solid organs is to find more selective compounds, which exploit specific molecular targets. In this work, the small molecule drugs registered by the Food and Drug Administration (FDA) for solid cancers treatment between 2011 and 2022 were identified and analyzed by investigating a type of therapy they are used for, as well as their structures and mechanisms of action. On average, 4 new small molecule agent

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… phosphokinase | [ 245 , 246 , 247 ] Trabectedin is a tetrahydroisoquinoline alkaloid obtained from the marine tunicate Ecteinascidia turbinate registered by the FDA in 2015, 8 years after its approval in Europe, for the treatment of specific soft tissue sarcomas (STS)—unresectable or advanced liposarcoma and leiomyosarcoma …

Antibodies to watch in 2020.

This 2020 installment of the annual 'Antibodies to Watch' series documents the antibody therapeutics approved in 2019 and in regulatory review in the United States or European Union, as well as those in late-stage clinical studies, as of November 2019*. At this time, a total of 5 novel antibody therapeutics (romosozumab, risankizumab, polatuzumab vedotin, brolucizumab, and crizanlizumab) had been granted a first approval in either the US or EU, and marketing applications for 13 novel antibody therapeutics (eptinezumab, teprotumumab, enfortumab vedotin, isatuximab, [fam-]trastuzumab deruxtecan,

Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal.

Cancer stem-like cells (CSC) represent a subpopulation of tumor cells with elevated tumor-initiating potential. Upon differentiation, they replenish the bulk of the tumor cell population. Enhanced tumor-forming capacity, resistance to antitumor drugs, and metastasis-forming potential are the hallmark traits of CSCs. Given these properties, it is not surprising that CSCs have become a therapeutic target of prime interest in drug discovery. In fact, over the last few years, an enormous number of articles describing compounds endowed with anti-CSC activities have been published. In the meanwhile,

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… This pathway is also involved in the biology of CSCs of several tumor types, such as bladder cancer ( 148 ), colon cancer ( 149 ), and leiomyosarcoma ( 150 ). In some cases, a coordinate activation of the PI3K–AKT–mTOR and RAS–RAF–MEK–ERK has been demonstrated ( 150 , 151 ). …

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

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… Curcumin has been reported to induce autophagy in chronic myeloid leukemia, malignant glioma, esophageal cancer, colon cancer, uterine leiomyosarcoma, ovarian cancer and lung adenocarcinoma via mechanisms related to the reduction in cell viability, proliferation, migration and invasion [ 119 ]. … Besides activating autophagy, curcumin also exhibits time- or concentration-dependent inhibition of cell proliferation, autophagy and apoptosis in K562 cells, SKN and SK-UT-1 uterine leiomyosarcoma cells [ 236 ]. …

Psychometric properties and clinical utility of the EORTC QLQ-BM22 in patients with bone metastases: a systematic review.

BackgroundThe European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for bone metastases 22 (EORTC QLQ-BM22) is a site-specific health-related quality-of-life instrument for patients with bone metastases. However, modern treatments and extended survivorship have introduced new toxicity profiles and clinical challenges. We systematically assessed the measurement performance of QLQ-BM22 to determine if contemporary evidence supports updating the module.MethodsA search was conducted using Medline, Embase, and Cochrane Central Register of Controlled Trials from in

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… Study | 198 | Prostate (40%), Breast (21%), and Others (lung, bladder, and others) | 1, 2, 3, 6, and 12 months | No Niu, 2023 51 | 2018–2019 | China | Chinese Mandarin (China) | Prospective Interventional Study | 39 | Liver, lung, breast, kidney, thyroid, renal, prostate, cervix, rectum, urothelial, leiomyosarcoma …

Gene and Cell Therapy for Sarcomas: A Review.

Background: The heterogeneity of sarcomas and resulting distinct sub-type specific characteristics, their high recurrence rates, and tendency for distant metastasis, continue to present significant challenges to providing optimal treatments. Objective: To provide a comprehensive review of current literature and clinical trials in gene and cell therapies for sarcomas. Methods: A comprehensive literature search was conducted utilizing the following databases: PubMed, Medline, Google Scholar and clinicaltrials.gov. Search terms included "gene therapy", "cell therapy", "NK cell therapy, "CAR-T the

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… Nine patients with metastatic sarcomas (subtypes included osteosarcoma, small round cell desmoplastic tumor, chondrosarcoma, malignant peripheral nerve sheath tumor, uterine leiomyosarcoma, and dedifferentiated liposarcoma) were treated with either DNG64 monotherapy or DNG64+ (DNG64 with an FDA approved …