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Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality.

BackgroundConsensus statements and clinical practice guidelines are widely available for enhancing the care of cancer patients. Despite subtle differences in their definition and purpose, these terms are often used interchangeably. We systematically assessed the methodological quality of consensus statements and clinical practice guidelines published in three commonly read, geographically diverse, cancer-specific journals. Methods Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal o

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… Gupta AA, Yao X, Verma S, Mackay H, Hopkins L (2013) Chemotherapy (gemcitabine, docetaxel plus gemcitabine, doxorubicin, or trabectedin) in inoperable, locally advanced, recurrent, or metastatic uterine leiomyosarcoma: a clinical practice guideline. Curr Oncol 20: e448–454. 46. …

Combination radiofrequency ablation and vertebral cement augmentation for spinal metastatic tumors: A systematic review and meta-analysis of safety and treatment outcomes.

BACKGROUND: The treatment of spine metastases continues to pose a significant clinical challenge, requiring the integration of multiple therapeutic modalities to address the multifactorial aspects of this disease process. Radiofrequency ablation (RFA) and vertebral cement augmentation (VCA) are 2 less invasive modalities compared to open surgery that have emerged as promising strategies, offering the potential for both pain relief and preservation of vertebral stability. The utility of these approaches, however, remains uncertain and subject to ongoing investigation.This systematic review and

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… Kidney, 2 Liver, 1 Lymphatic, 1 Thyroid Gland Madani et al 2022 | R | 18 Patients (24 Lesions) | 9,9 | 53.9 +/_ 13.5 | 14 Thoracic, 10 Lumbar | n/s | 24/24 | 17 Osteolytic, 7 Mixed | 1 Breast, 1 Melanoma, 2 Medullary Thyroid, 6 Clear Cell Renal Carcinoma, 3 Intracanalicular Breast, 1 Adrenocortical, 1 Leiomyosarcoma …

Infections in Hospitalized Cancer Patients.

Cancer patients are at an increased risk of developing infections that are primarily treatment-driven but may also be malignancy-driven. While cancer treatments such as chemotherapy, radiotherapy, and surgery have been known to improve malignancy morbidity and mortality, they also have the potential to weaken immune defenses and induce periods of severe cytopenia. These adverse effects pave the way for opportunistic infections to complicate a hospitalized cancer patient's clinical course. Understanding the risk each patient inherently has for developing a bacterial, fungal, or viral infection

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… Scalp leiomyosarcoma: diagnosis and treatment during a global pandemic with COVID-19. World J Oncol. 2021;12(4):132–136. doi: 10.14740/wjon1393. 81. Bow EJ. Fluoroquinolones, antimicrobial resistance and neutropenic cancer patients. …

Bendamustine: safety and efficacy in the management of indolent non-hodgkins lymphoma.

Bendamustine (Treanda, Ribomustin) was recently approved by the US Food and Drug Administration (FDA) for treatment of patients with rituximab refractory indolent lymphoma and is expected to turn into a frontline therapy option for indolent lymphoma. This compound with amphoteric properties was designed in the former Germany Democratic Republic in 1960s and re-discovered in 1990s with multiple successive well-designed studies. Bendamustine possesses a unique mechanism of action with potential antimetabolite properties, and only partial cross-resistance with other alkylators. Used in combinatio

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… Clinical trials appear to also indicate some activity of bendamustine in breast cancer, small-cell lung cancer, and leiomyosarcomas. …

Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention.

The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone deacetylases (HDAC) have been reported in hematologic and solid types of cancer. In this sense, the cancer-associated epigenetic alterations are promising targets for anticancer therapy and chemoprevention. HDAC inhibitors (HDACi) induce histone hyperacetylation within target proteins, altering cell cycle and proliferation, cell differentiation, and the regulation of cell death pr

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… Additionally, mocetinostat, administered with gemcitabine, seems a valuable therapeutic strategy to reverse chemoresistance in gemcitabine-resistant metastatic leiomyosarcoma patients [ 121 ]. … SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy Sarcoma 2018 2018 2068517 10.1155/2018/2068517 30473623 PMC6220374 122. Batlevi C.L. …

Prognostic and functional role of the nuclear export receptor 1 (XPO1) in gastrointestinal cancers: a potential novel target?

In the last decades the survival of metastatic gastrointestinal (GI) cancer patients could have been significantly extended due to the introduction of targeted- and immunotherapy. However, only the minority of patients will experience long-lasting survival. Hence, novel therapeutics are clearly necessary for GI cancer patients. Molecular high-throughput profiling techniques have revealed potential novel targetable molecular alterations, emphasizing the necessity for tailored therapeutic approaches. Nuclear export proteins, particularly Exportin-1 (XPO1), have emerged as promising targets in ca

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… daratumumab/pomalidomide/dexamethasone (DPD) Drug: isatuximab/carfilzomib/dexamethasone (Isa-KD) Drug: selinexor/bortezomib/dexamethasone (SVD) A study of different dosing schedules of selinexor in sarcoma patients Phase I–II NCT04811196 Soft tissue sarcoma Malignant peripheral nerve sheath tumor (MPNST) Leiomyosarcoma … pomalidomide/dexamethasone (DPD) Drug: isatuximab/carfilzomib/dexamethasone (Isa-KD) Drug: selinexor/bortezomib/dexamethasone (SVD) | A study of different dosing schedules of selinexor in sarcoma patients | Phase I–II | NCT04811196 | Soft tissue sarcoma Malignant peripheral nerve sheath tumor (MPNST) Leiomyosarcoma …

Alcohol use, intentions to reduce consumption, and perceived motivations and barriers among cancer survivors.

PurposeTo characterize alcohol use patterns, awareness of alcohol's oncologic risks, and efforts and intentions to reduce consumption among cancer survivors in New Hampshire and Vermont.MethodsCross-sectional survey of 471 cancer survivors aged ≥21 years enrolled in two state-wide, online panels. Participants reported their current or former alcohol use, completed the Alcohol Use Disorders Identification (AUDIT), and replied to a series of items regarding any efforts to reduce consumption and related motivations and barriers.ResultsAmong 471 survivors, 34.2% of which had an alcohol-related can

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… carcinoma of the eyelid ( n = 2, 0.4%), anal cancer ( n = 1, 0.2%), brain cancer ( n = 1, 0.2%), chondrosarcoma ( n = 1, 0.2%), chronic myeloid leukemia ( n = 1, 0.2%), dermatofibrosarcoma ( n = 1, 0.2%), epithelioid hemangioendothelioma ( n = 1, 0.2%), gastrointestinal stromal tumor ( n = 1, 0.2%), leiomyosarcoma …

Radiosurgery to the Medial Thalamus for Chronic Pain: A Single Group Experience and Review of Literature.

Introduction Chronic pain presents a significant challenge in achieving effective treatment and can greatly reduce patients' quality of life. Many individuals can undergo multiple therapies with limited success. Stereotactic medial thalamotomy is a treatment option for certain types of chronic pain when other measures have failed. This study aims to assess the efficacy and safety of radiosurgical medial thalamotomy based on nearly a decade of experience in managing chronic intractable pain of both malignant and non-malignant origins. Methods This retrospective study included 56 patients who un

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… included adenocarcinoma of the colon (n=1, 9.1%), stomach (n=1, 9.1%), esophagus (n=1, 9.1%), pancreas (n=1, 9.1%), breast (with or without metastatic disease, n=2, 18.2%), metastatic cervical cancer (n=1, 9.1%), metastatic multiple myeloma (n=1, 9.1%), recurrent Ewing’s sarcoma (n=1, 9.1%), thigh leiomyosarcoma …

Comprehensive understanding of the adverse effects associated with temozolomide: a disproportionate analysis based on the FAERS database.

BACKGROUND: Temozolomide, which is the standard drug for glioma treatment, has several Adverse events (AEs) in the treatment of gliomas and other tumors that are not yet fully understood. This is due to the pharmacological nature of the alkylating agent. A significant proportion of these effects have not been systematically documented or reported. METHODS: We selected data from the United States FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2004 to the fourth quarter of 2023. Four algorithms were used for disproportionate analysis, with the objective of assessi

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… Phase II study of olaparib and temozolomide for advanced uterine leiomyosarcoma (NCI protocol 10250). J. Clin. Oncol. 41, 4154–4163. 10.1200/JCO.23.00402 Iturrioz-RodríGUEZ N., Sampron N., Matheu A. (2023). …

Canine Gastric Cancer: Current Treatment Approaches.

Human gastric cancer (GC) ranks as the fifth most prevalent cancer worldwide, and is the third leading cause of cancer-related death. The incidence of GC is lower in dogs than in humans, accounting for less than 1% of all canine malignancies. In recent years, efforts have been made to understand the pathogenesis of GC and in find an appropriate therapy to maximize curative results, such as adjuvant chemotherapy treatments in addition to surgery. Although surgery is the first-line treatment, it is associated with several complications. In terms of chemotherapeutic intervention, canine gastric c

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… Canine Gastric Adenocarcinoma and Leiomyosarcoma: A Retrospective Study of 21 Cases (1986–1999) and Literature Review J. Am. Anim. Hosp. Assoc. 2002 38 157 164 10.5326/0380157 11908834 5. Seim-Wikse T. Jörundsson E. Nødtvedt A. Grotmol T. Bjornvad C.R. Kristensen A.T. Skancke E. …

Proceedings of the International Cancer Imaging Society Meeting and 21st Annual Teaching Course : Boston, MA, USA. 12-14 September 2022

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… These were endometrial stromal sarcoma, pericardial angiosarcoma, suprarenal leiomyosarcoma, retroperitoneal sarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma, epithelioid angiosarcoma, retroperitoneal and mediastinal Ewing’s sarcoma and retroperitoneal liposarcoma. …

Cementoplasty to cryoablation: review and current status.

Recent advances in percutaneous image-guided techniques have empowered interventional radiologists with diverse treatment options for the management of musculoskeletal lesions. Of note, there is growing utility for cementoplasty procedures, with indications ranging from stabilization of bone metastases to treatment of painful vertebral compression fractures. Likewise, cryoablation has emerged as a viable adjunct in the treatment of both primary and secondary bone and soft tissue neoplasms. These treatment options have been progressively incorporated into the multidisciplinary approach to holis

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… Soft tissue tumour Soft tissue sarcomas are rare tumours with multiple subtypes, the most common of which are liposarcomas and leiomyosarcomas. 116 There is emerging evidence of cryoablation as a feasible and safe treatment option for these tumours, especially in recurrent or metastatic disease. 117 …

Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management.

We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as "sternal", "manubrium", and "metastasis" within the title and/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports). A prior unpublished case in point is also introduced (percutaneous incisio

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… Development of primary leiomyosarcoma of the sternum postirradiation: Report of a case Surg. Today 1998 28 1326 1328 10.1007/BF02482828 9872562 95. Hayashi K. Fujioka T. Hara M. Kumaki Y. Oda G. Yamaga E. Mori M. Ohnishi I. Kubota K. Nakagawa T. …

Development and Preliminary Psychometric Evaluation of the ACRIS-CS: A Theory-Based Measure of Prospective Acceptability of Cognitive Rehabilitation in Cancer Survivors.

Background/Objectives: Cancer-related cognitive impairment (CRCI) is a prevalent survivorship concern associated with functional limitations and reduced quality of life. Although cognitive rehabilitation shows beneficial effects, implementation depends not only on efficacy but also on survivors' anticipated willingness to engage. No psychometrically validated instrument currently exists to assess prospective acceptability of cognitive rehabilitation among cancer survivors. This study aimed to: (1) develop the Acceptability of Cognitive Rehabilitation Interventions Survey-Cancer Survivors (ACRI

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… Table 1 Sample characteristics ( N = 154). 1 Note: Includes multiple myeloma, lung, thyroid, bone, stomach, skin, cervical, endometrial, head and neck cancer, and leiomyosarcoma. 2 Includes sedatives and hypnotics, antidepressants, anxiolytics, and antipsychotics. …

Defining the Role of Oral Pathway Inhibitors as Targeted Therapeutics in Arteriovenous Malformation Care.

Arteriovenous malformations (AVMs) are vascular malformations that are prone to rupturing and can cause significant morbidity and mortality in relatively young patients. Conventional treatment options such as surgery and endovascular therapy often are insufficient for cure. There is a growing body of knowledge on the genetic and molecular underpinnings of AVM development and maintenance, making the future of precision medicine a real possibility for AVM management. Here, we review the pathophysiology of AVM development across various cell types, with a focus on current and potential druggable

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… Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease Oncology 2002 16 21 24 11831608 40. Edwards E.A. Phelps A.S. Cooke D. Frieden I.J. Zapala M.A. Fullerton H.J. Shimano K.A. …

Disorders of the Gastrointestinal System

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Mitophagy related gene signature for prognosis and therapeutic evaluation in KIRC.

This study conducted a comprehensive investigation of the prognostic significance and immunological features associated with mitophagy-related gene signatures in clear cell renal cell carcinoma (KIRC). Our primary aim was to establish an optimized predictive model for precise prognosis stratification and treatment response prediction in KIRC patients. Through LASSO Cox regression analysis, we systematically identified mitophagy-related genes (MRGs) and implemented them to develop a prognostic risk stratification model. The model's reliability was rigorously validated using both internal cohort

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… PTX3 functions as an extrinsic tumor suppressor, mediating complement-dependent inflammatory responses in malignancies including leiomyosarcoma and colorectal cancer 38 . …

Прогнозирующие биомаркеры для общего выживания пациентов, проходящих операцию на метастазах костей: исследование пан-ракера.

Быстрое диагностирование и прогнозируемая оценка метастаза костей (БМ) по-прежнему сопряжены с трудностями, поскольку большинство исследований и перспективных моделей концентрируются на одной первичной опухоли и пренебрегают биомаркерами, связанными с принимающей страной. Таким образом, это панраковое исследование было направлено на оценку метаболизма костей, провокационных и гематологических биомаркеров у пациентов, проходящих хирургическую операцию для БМ, выявление факторов риска для развития БМ и создание прогнозной номограммы. Потенциальная группа взрослых пациентов с гистологическим подт

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… Patients were stratified according to the primary tumor as follows: breast, kidney, lung and other tumors (including prostate, uterine, urothelial, thyroid, Merkel cell neuroendocrine, salivary gland, and squamous cell carcinomas, adenoid cystic carcinoma of the mandible, leiomyosarcoma, lymphoma, melanoma …

A new era in the management of spinal metastasis.

Despite the recent advances in cancer treatment, the incidence of patients with spinal metastases continues to grow along with the total number of cancer patients. Spinal metastases can significantly impair activities of daily living (ADL) and quality of life (QOL), compared with other types of bone metastases, as they are characterized with severe pain and paralysis caused by skeletal-related events. Reduced ADL can also lead to treatment limitations as certain anticancer agents and radiation therapy are not compatible treatments; thus, leading to a shorter life expectancy. Consequently, main

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… Clinical outcomes and survivals after total en bloc spondylectomy for metastatic leiomyosarcoma in the spine. Eur Spine J. (2020) 29:3237–44. doi: 10.1007/s00586-020-06461-0 72. Li Z, Lv Z, Li J. Total en bloc spondylectomy for the fifth lumbar solitary metastasis by a posterior-only approach. …

Chemotherapy-Associated Thrombotic Microangiopathy.

Thrombotic microangiopathy (TMA) is a syndrome of microangiopathic hemolytic anemia and thrombocytopenia with end-organ dysfunction. Although the advent of plasma exchange, immunosuppression, and complement inhibition has improved morbidity and mortality for primary TMAs, the management of secondary TMAs, particularly drug-induced TMA, remains less clear. TMA related to cancer drugs disrupts the antineoplastic treatment course, increasing the risk of cancer progression. Chemotherapeutic agents such as mitomycin-C, gemcitabine, and platinum-based drugs as well as targeted therapies such as anti

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… wk, 18 due to progression Wen, 2003 13 | 1 | 58 y/o, gastric ca, HTN, edema, AKI, + schistocytes, proteinuria 0.8 g/d, ↓hgb, ↓plt, ↑LDH | 10 mo, 100 mg | None | Yes | TPE + antiplatelets | No MAHA at baseline | CKD—Cr 4 mg/dl | Alive at 4 yr with no progression Shiiki, 1992 14 | 1 | 65 y/o gastric leiomyosarcoma …