Результаты поиска

A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-Inflammatory, and Anticancer Activities.

Curcumin, as the main active component of turmeric (Curcuma longa), has been demonstrated with various bioactivities. However, its potential therapeutic applications are hindered by challenges such as poor solubility and bioavailability, rapid metabolism, and pan-assay interference properties. Recent advancements have aimed to overcome these limitations by developing novel curcumin analogues and modifications. This brief review critically assesses recent studies on synthesising different curcumin analogues, including metal complexes, nano particulates, and other curcumin derivatives, focused o

Совпадение в полном тексте источника
… Novel Drug Delivery Systems To increase the stability of curcumin, novel drug delivery systems such as nanoparticles, metal complexes, liposomes, solid dispersion, microemulsion, micelles, nano gels, and dendrimers have been explored to increase the absorption and bioavailability of curcumin [ 17 ]. … Wang and co-workers have developed curcumin micelles for the stabilisation of curcumin by a mixture of surfactant molecules, such as sodium dodecyl sulphate, cetyltrimethylammonium bromide (CTAB), Tween 80, Triton X-100, and pluronic polymers [ 18 ]. …

Tumor Targeting with Peptide-Drug Conjugates: Showcasing Key Progress and Hurdles.

Peptide-drug conjugates (PDCs) are modular, targeted therapeutics composed of a homing peptide linked to a cytotoxic or modulating drug payload via a cleavable/non-cleavable linker. PDCs utilize peptide targeting to enhance the delivery of potent drugs to tumors, providing advantages such as superior tissue penetration, reduced immunogenicity, and simpler manufacture compared to antibody-drug conjugates (ADCs). A comparison of PDCs versus ADCs highlights that PDCs' small size (~1-3 kDa) enables deeper tumor penetration and faster clearance, whereas ADCs (~150 kDa) benefit from prolonged circul

Совпадение в полном тексте источника
… Hydrophobic drugs and amphiphilic peptide motifs can drive PDCs to form nanostructures (micelles, fibers, vesicles) in an aqueous milieu. … One such approach involves designing PDCs that can self-assemble into nanostructures, such as fibers, micelles, or hydrogels, thereby creating a drug depot effect and prolonged local release. …

Drug delivery for age-related bone diseases: From therapeutic targets to common and emerging therapeutic strategies.

With the accumulation of knowledge on aging, people have gradually realized that among the many factors that cause individual aging, the accumulation of aging cells is an essential cause of organ degeneration and, ultimately, age-related diseases. Most cells present in the bone microenvironment gradually age over time, leading to an imbalance of osteogenesis, osteoclastogenesis, adipogenesis, and chondrogenesis. This imbalance contributes to age-related bone loss and the development of age-related bone diseases, such as osteoporosis. Bone aging can prolong the lifespan and delay the developmen

Совпадение в полном тексте источника
… Bioequivalence assessment of high-capacity polymeric micelle nanoformulation of paclitaxel and Abraxane® in rodent and non-human primate models using a stable isotope tracer assay. Biomaterials. 2021;278 doi: 10.1016/j.biomaterials.2021.121140. Hwang D., Ramsey J.D., Kabanov A.V. … Polymeric micelles for the delivery of poorly soluble drugs: from nanoformulation to clinical approval. Adv. Drug Deliv. Rev. 2020;156:80–118. doi: 10.1016/j.addr.2020.09.009. Jadzinsky P.D., et al. Structure of a thiol monolayer-protected gold nanoparticle at 1.1 A resolution. …

Recent Advances on the Pathobiology and Treatment of Multiple Myeloma.

Worldwide experts in the field of multiple myeloma (MM) have promptly answered to the call in the Special Issue entitled "Recent advances on the pathobiology and treatment of multiple myeloma", submitting basic, translational or clinical works under the form of original article, review or perspective [...].

Совпадение в полном тексте источника
… To overcome these drawbacks, Iannazzo et al. highlighted the potential usefulness of liposomes, micelles, polymeric nanoparticles, inorganic nanoparticles and carbon-based nanomaterials that have been successfully tested in MM preclinical models to improve targeting of tumor PCs [ 18 ]. …

Keyword Index for Volume 93

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Anti-PEG Antibodies and Their Biological Impact on PEGylated Drugs: Challenges and Strategies for Optimization.

Polyethylene glycol (PEG) has been widely utilized in optimizing therapeutics due to its excellent biocompatibility and chemical stability. However, multiple dosing of PEGylated drugs may result in toxicity due to PEG accumulation in tissues, leading to the formation of anti-PEG antibodies (APAs), which can accelerate drug clearance, reduce efficacy, and alongside enhanced side effects, such as allergic reactions. Notably, pre-existing APAs have also been detected in individuals with no prior exposure to PEGylated drugs, raising additional clinical concerns. This review summarizes the mechanis

Совпадение в полном тексте источника
… Shiraishi et al. [ 42 ] evaluated the toxicity of polymeric micelles made from PEG-b-polyaspartate block copolymers in Donryu rats. The number of foam cells in the lungs and lymph nodes increased after five intravenous injections of 20 mg/kg and significantly increased in the spleen with 200 mg/kg. … Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: A review Sci. Technol. Adv. Mat. 2019 20 324 336 10.1080/14686996.2019.1590126 31068982 PMC6493319 43. Zhou Z.H. Cortese M.M. Fang J.L. Wood R. Hummell D.S. Risma K.A. Norton A.E. KuKuruga M. Kirshner S. Rabin R.L. …

Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core.

Engineering of a "smart" drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosing the right cancer surface biomarker are critical for a targeted treatment to work. Currently, the available delivery systems use a two-dimensional monolayer of cancer cells to test the efficacy of the drug delivery system, but designing a "smart" drug delivery system to be specific for a tumour in vivo and to penetrat

Совпадение в полном тексте источника
… Self-Assembled Biodegradable Micelles Based on Star-Shaped Pcl-b-peg Copolymers for Chemotherapeutic Drug Delivery. Coll. Surf. A Physicochem. Eng. Aspects. 2010;358:128–134. doi: 10.1016/j.colsurfa.2010.01.037. 32. Kim C.K., Ghosh P., Pagliuca C., Zhu Z.-J., Menichetti S., Rotello V.M. … Thiol and pH Dual-Responsive Dynamic Covalent Shell Cross-Linked Micelles for Triggered Release of Chemotherapeutic Drugs. Polym. Chem. 2013;4:695–706. doi: 10.1039/C2PY20701J. 34. …

Мукоадгезивные наноэмульсии для доставки нозы в мозг диметилфумарат: разработка, характеристика и доказательство согласия

Фон. Диметилфумарат (ДМП) является утвержденным терапевтическим агентом для лечения множественного склероза, известным своими противовоспалительными и нейрозащитными свойствами. Однако его пероральное управление часто сопровождается побочными эффектами желудочно-кишечного кишечника, что ограничивает его терапевтический потенциал. В настоящем исследовании была разработана новая формула наноэмульсии (NE), которая была охарактеризована с целью усиления воздействия ДМП в цереброспинарной жидкости (CSF) после внутринационального администрирования. Методы: Состав был подготовлен методом самоэмульсиф

Совпадение в полном тексте источника
… Among its derivatives, chitosan oleate (CSOA), an amphiphilic ionic complex of chitosan and oleic acid, has previously demonstrated suitability as both a self-assembling carrier to obtain polymeric micelles [ 47 ] and a stabilizer for NE systems [ 33 ]. …

Recent Trends in anti-tumor mechanisms and molecular targets of celastrol.

Celastrol, a compound derived from traditional Chinese medicine, has therapeutic effects and has been used to treat inflammation-related diseases, cancer, cardiovascular diseases, and neurodegenerative diseases. However, current reviews lack a comprehensive and systematic summary of the anti-tumor mechanisms and molecular targets of celastrol. For this reason, this paper reviews the anticancer properties of celastrol and the molecular mechanisms underlying its anticancer effects. This paper primarily focuses on the mechanism of action of celastrol in terms of inhibition of cell proliferation a

Совпадение в полном тексте источника
… In addition, celastrol and siRNA have been delivered to retinoblastoma cells in the form of polymeric micelles to achieve synergistic anti-tumor and anti-angiogenic effects. … It has been demonstrated that micelles enable rapid release of celastrol into mitochondria, reduce drug leakage into the cytoplasm and lysosomes, and improving the anti-tumor capacity of celastrol 151 . …

Repositioning of drugs for Parkinson's disease and pharmaceutical nanotechnology tools for their optimization.

Parkinson's disease (PD) significantly affects patients' quality of life and represents a high economic burden for health systems. Given the lack of safe and effective treatments for PD, drug repositioning seeks to offer new medication alternatives, reducing research time and costs compared to the traditional drug development strategy. This review aimed to collect evidence of drugs proposed as candidates to be reused in PD and identify those with the potential to be reformulated into nanocarriers to optimize future repositioning trials. We conducted a detailed search in PubMed, Web of Science,

Совпадение в полном тексте источника
… Reformulation in NPs could facilitate absorption and control the dosage and release at the specific site of action Nilotinib | 1 – Active 2 – Terminated | Low permeability | Polymeric micelles/Styrene-co-maleic acid [ 141 ] | Low exposure to CSF limits its use in PD. … To overcome this limitation and optimize future PD repositioning studies, we propose using lipid and polymeric nanosystems: lipid-based NP (SLN, micelles and LP) and polymeric-based NP (nanocapsules, nanospheres and polymeric micelles). …

Keyword Index for Volume 95

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review.

In the dynamic realm of healthcare, the convergence of engineering and biomedical sciences has emerged as a pivotal frontier. In this review we go into specific areas of innovation, including medical imaging and diagnosis, developments in biomedical sensors, and drug delivery systems. Wearable biosensors, non-wearable biosensors, and biochips, which include gene chips, protein chips, and cell chips, are all included in the scope of the topic that pertains to biomedical sensors. Extensive research is conducted on drug delivery systems, spanning topics such as the integration of computer modelin

Совпадение в полном тексте источника
… Medicine delivery systems can also refer to how pharmaceuticals are ‘packaged,’ such as in a micelle or nanoparticle, which keeps the medicine from breaking down and enables it to enter the body where it is needed [ 158 ]. … Utilizing thermosensitive polymers, a variety of thermo-responsive nanocarrier forms, including hydrogels, microbeads, micelles, polymeric nanotubes, core-shell thermo-responsive nanoparticles, and layer-by-layer constructed nanocapsules, have been created and are being employed as SDDS [ 186 ]. …

Innovative Biomaterials for the Treatment of Bone Cancer.

Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients' survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop

Совпадение в полном тексте источника
… For example, Mao et al. [ 62 ] prepared micelles based on CaCO 3 -crosslinked methoxy poly(ethylene glycol)-block-poly (L-glutamic acid) (mPEG-b-PGA) for the release of MCSF, which is able to inhibit tumor growth by activating the immune response. … Intratumoral delivery of M-CSF by calcium crosslinked polymer micelles enhances cancer immunotherapy Biomater. Sci. 2019 7 2769 2776 10.1039/C9BM00226J 31012882 63. Zhang Y. Cai L. Li D. Lao Y.-H. Liu D. Li M. Ding J. Chen X. …

Hepatocellular carcinoma: Understanding molecular mechanisms for defining potential clinical modalities.

Liver cancer is the sixth most commonly occurring cancer and costs millions of lives per year. The diagnosis of hepatocellular carcinoma (HCC) has relied on scanning techniques and serum-based markers such as α-fetoprotein. These measures have limitations due to their detection limits and asymptomatic conditions during the early stages, resulting in late-stage cancer diagnosis where targeted chemotherapy or systemic treatment with sorafenib is offered. However, the aid of conventional therapy for patients in the advanced stage of HCC has limited outcomes. Thus, it is essential to seek a new tr

Совпадение в полном тексте источника
… Other materials such as dendrimers, micelles, polysaccharides, and silica are also used as carrier molecules[ 98 - 100 ]. Still, the hunt for an effective delivery system continues for targeted delivery. CONCLUSION Existing diagnostic methods are inadequate for the early detection of HCC. … 21240457 10.3892/ijo.2011.902 98 Madaan K Kumar S Poonia N Lather V Pandita D Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues J Pharm Bioallied Sci 2014 6 139 150 25035633 10.4103/0975-7406.130965 PMC4097927 99 Zhang N Wardwell PR Bader RA Polysaccharide-based micelles …

Keyword Index for Volume 104

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Recent Review on Biological Barriers and Host-Material Interfaces in Precision Drug Delivery: Advancement in Biomaterial Engineering for Better Treatment Therapies.

Preclinical and clinical studies have demonstrated that precision therapy has a broad variety of treatment applications, making it an interesting research topic with exciting potential in numerous sectors. However, major obstacles, such as inefficient and unsafe delivery systems and severe side effects, have impeded the widespread use of precision medicine. The purpose of drug delivery systems (DDSs) is to regulate the time and place of drug release and action. They aid in enhancing the equilibrium between medicinal efficacy on target and hazardous side effects off target. One promising approa

Совпадение в полном тексте источника
… To facilitate the targeted delivery of anticancer medicines, aptamers are functionalised onto nanocarriers such as liposomes, polymeric micelles, and biomimetic nanocarriers [ 120 ]. …

The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.

The bidirectional crosstalk between the nervous system and tumors has emerged as a transformative new frontier in both precision oncotherapy and mechanism-driven cancer pain management. Marine natural products with inherent neuroactive properties exhibit unparalleled intervention advantages for targeting this complex pathophysiological axis. Herein, we systematically and prospectively dissect the multi-layered bidirectional communication between the nervous system and malignancies, comprehensively summarize the pivotal contributions of marine-derived bioactive molecules to advances in neurosci

Совпадение в полном тексте источника
… Studies have utilized ImI to functionalize PEG-DSPE drug-loaded micelles (ImI-PMs) for paclitaxel encapsulation, facilitating a more rapid and extensive internalization into MCF-7 cells via targeted recognition of α7-nAChR. …

Emerging advances in drug delivery systems (DDSs) for optimizing cancer complications.

The management and treatment of tumor complications pose continuous challenges due to the inherent complexity. However, the advent of drug delivery systems (DDSs) brings promising opportunities to address the tumor complications using innovative technological approaches. This review focuses on common oncological complications, including cancer thrombosis, malignant serous effusion, tumor-associated infections, cancer pain, and treatment-related complications. Emphasis was placed on the application and potential of DDSs in mitigating and treating these tumor complications, and we delved into th

Совпадение в полном тексте источника
… Currently, various types of delivery systems are based on chemical materials such as lipid nanoparticles, liposomes, and lipid micelles. … For example, liposomes and micelles can enhance drug solubility and stability by encapsulating them into microparticles, while polymer carriers can modulate the release rate and targeting of drugs. …

Nanomedicine and Onco-Immunotherapy: From the Bench to Bedside to Biomarkers.

The broad relationship between the immune system and cancer is opening a new hallmark to explore for nanomedicine. Here, all the common and synergy points between both areas are reviewed and described, and the recent approaches which show the progress from the bench to the beside to biomarkers developed in nanomedicine and onco-immunotherapy.

Совпадение в полном тексте источника
… Polymeric micelles are also used for drug delivery, which involves the self-assembly of amphiphilic molecules. The encapsulation of the anti-tumoral drug in these micelles reduces toxicity and improves circulation [ 7 ]. … An example is the loading of cisplatin into micelles formed by polyethylene glycol (PEG), which increases the time of drug circulation by reducing acute renal accumulation of polymeric micelles [ 21 ]. …

Уникальные диагностические и терапевтические функции порфиринов и фтальокянинов в области фотодинамической терапии, визуализации и термостимы.

Порфиринические молекулы играют уникальную тераностическую роль в лечении болезней; они используются для отображения, обнаружения и лечения различных форм заболевших тканей, в том числе в связи с возрастной маркулярной дегенерацией и рядом различных видов рака. В настоящее время основное внимание уделяется клинической съемке опухолей; целенаправленной доставке фотосенитеров и потенциалу фотоэнцедентов в мультимодальных биомедицинских наноплатформах. В настоящем Обзоре подчеркиваются роли порфириновых молекул в области съемки и пдта, а также исследования по совершенствованию их селективного пог