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Аутоиммунные заболевания 30,340 Датские женщины с полициклическим оварским синдромом (ПОС) по сравнению с 151,520 Контроль. Национальное кохартовое исследование.

ЦЕЛЬ: Автоиммунитет может быть частью патогенез полициклического яичного синдрома (ПХОС), однако перспективных исследований аутоиммунных заболеваний в группах населения не проводится. Это исследование было направлено на изучение показателей заболеваемости аутоиммунной болезнью у датских женщин с ПХОС до и после диагностики ПХОС по сравнению с мерами контроля. DESIGN: Национальное исследование на основе регистров. ПАТИЕНТЫ: Датские женщины диагностировали ПХОС (N = 30,340) и совпадающие по возрасту органы управления (N = 151,520). ОСНОВНЫЕ МЕРЫ ПО ИТОГАМ: Аутоиммунная болезнь является результат

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… In Denmark, citizens receive a social security number at birth or upon immigration, allowing for the linkage of individual‐level data from various national health and social care registers [ 14 ]. …

Ассоциация < < Между воздействием Солнца и риском возврата > > в педиатрии-посете с множественным склерозом.

ОБСТАНОВКА И ЗАДАЧИ: Облучение с низким Солнцем и ультрафиолетовым излучением (УВР) связано с повышенным риском развития педиатрического многоразового склероза (МС); однако их влияние на курс болезни не является достаточно наглядным. В первую очередь мы изучили, существует ли связь между временем, проведенным на солнце в раннем детстве, и риском рецидива в педиатрии MS. Во-вторых, мы изучали последствия воздействия солнца в последние периоды с точки зрения риска рецидива. МЕТОДЫ: Мы провели многоцентральное когортное исследование участников с педиатрической системой MS, нанятых в 18 детских кл

Market Access Challenges and Solutions in Cell and Gene Therapy in The Netherlands.

With the increasing pipeline of cell and gene therapies (CGTs) and the expected surge in the number of approvals, understanding the market access landscape becomes crucial for timely patient access. This study evaluates the challenges Dutch stakeholders encounter in CGT market access, offering insights for improving time-to-patient access. A traditional literature review was conducted to identify market access challenges and solutions for CGTs. Based on the findings, participants for semi-structured interviews, designed using an interview guide adapted to the Dutch context, were selected to ca

Interventions to improve cancer survivorship among Indigenous Peoples and communities: a systematic review with a narrative synthesis.

PurposeThe purpose of this systematic review is to synthesize the evidence on the types of interventions that have been utilized by Indigenous Peoples living with cancer, and report on their relevance to Indigenous communities and how they align with holistic wellness.MethodsA systematic review with narrative synthesis was conducted.ResultsThe search yielded 7995 unique records; 27 studies evaluating 20 interventions were included. The majority of studies were conducted in USA, with five in Australia and one in Peru. Study designs were cross-sectional (n=13); qualitative (n=5); mixed methods (

Physical Activity and Quality of Life in Cancer Survivors: A Meta-Synthesis of Qualitative Research.

Qualitative research on the impact of physical activity on quality of life (QoL) in adults diagnosed with cancer is accumulating. However, the field of physical activity and cancer survivorship lack a synthesis of this research to reliably understand the implications for future research and practice. The aim of this meta-synthesis was to identify, appraise, and synthesize qualitative research on cancer survivors' perspectives of the impact of physical activity on their QoL. Seven electronic databases were searched for original studies published in English, and reference lists of relevant studi

ICIMH 2022 Abstracts

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Use of real-world evidence in the Medicare Drug Price Negotiation Program: A checklist for the Centers for Medicare and Medicaid Services and manufacturers.

Under the Inflation Reduction Act's (IRA's) - Medicare Drug Price Negotiation Program, the Centers for Medicare & Medicaid Services' (CMS's) "maximum fair price" must be informed by evidence on factors such as therapeutic advance of the selected drug compared with its alternative, comparative effectiveness across clinical and patient-reported outcomes, the impact on specific populations, and the ability to address unmet medical needs. This paper describes how real-world evidence could improve CMS decision-making and creates a best practices checklist to help CMS evaluate the quality of any man

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… Medicare drug price negotiation program: final guidance, implementation of sections 1191–1198 of the social security act for initial price applicability year 2027 and manufacturer effectuation of the maximum fair price in 2026 and 2027. 2024. …

Distress prior to undergoing hematopoietic stem cell transplantation: demographic and symptom correlations and establishing a baseline.

BackgroundDistress can arise from physical and/or psychosocial impairments and has been documented in patients after hematopoietic stem cell transplantation in the outpatient setting. It has not been evaluated in inpatients admitted to undergo the transplant, nor has potential correlations with length of hospital stay, physical function, and pain after receiving the transplant.ObjectivesTo measure distress in patients admitted to the hospital to undergo hematopoietic stem cell transplantation, and to evaluate potential correlations with length of hospital stay, physical function, pain, and dep

Effect of Paget's disease of bone (osteitis deformans) on the progression of prostate cancer bone metastasis.

BackgroundPatients with prostate cancer tend to die from bone metastases. Until now, no evidence has shown that Paget's disease of bone (PDB) affects the progression of bone metastasis or overall survival of patients with prostate cancer.MethodsWe searched our patient database for men who had presented with prostate cancer and PDB between June 1993 and March 2009, and identified best-matched control patients according to stage, grade, age, date of diagnosis, treatment, and race.ResultsAmong 1346 consecutive patients with prostate cancer diagnosed before 2008, 15 were confirmed to have comorbid

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… To determine the exact date of death, we used the scanned documents in our ClinicStation database or the Social Security Death Index ( http://ssdi.rootsweb.ancestry.com/ ). …

Действенность и безопасность цифрового таперинга для пациентов, которым предписывается опиоид после хирургической операции: протокол для перспективного исследования кохарта.

Предыстория 300 million Каждый год во всем мире проводятся хирургические операции, и опиоиды по-прежнему являются одним из основных методов борьбы с острой послеоперационной болью. Исследования показали, что значительное число пациентов не прекращают опиоидное лечение и продолжают использовать опиоиды в течение месяцев или даже лет после операции. Известная практика применения опиоидов рецептурного отпуска и управления ими является частью нынешних клинических руководящих принципов безопасного прописывания. Каждый пациент должен получать тщательный контроль, образование и план скрининга, когда

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… When onboarding patients onto the app, the clinician creates the patient profile using the patient’s social security number, phone number, and name. During onboarding, the clinician must set up a plan that can be adjusted later. …

Пациенты, которые потенциально нуждаются в паллиативном уходе в Германии - региональная оценка малых районов на основе данных регистрации смерти.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Демографические изменения и растущая распространенность хронических заболеваний приводят к повышению спроса на паллиативный уход. В настоящее время мало что известно о потенциальной необходимости паллиативного ухода на уровне малых районов в Германии. Однако это имеет решающее значение для планирования услуг. Мы стремились рассчитать долю населения, потенциально нуждающегося в паллиативном уходе, на уровне малых районов и проиллюстрировать различия в масштабах всей страны. МЕТОДЫ: Ретроспективное межсекторальное исследование на основе статистических данных о причинах сме

Exploring the impact of opioid use on outcomes in allogeneic hematopoietic stem cell transplantation.

IntroductionHematological malignancies and allogeneic hematopoietic cell transplantation (alloHCT) often necessitate the use of opioids due to significant pain. This study aimed to investigate the impact of opioid use on the clinical outcomes of patients undergoing alloHCT.MethodsA retrospective cohort study was conducted by merging data from our local transplant database with anonymized pharmacy records obtained from the Institute for Clinical Evaluative Sciences (ICES). We analyzed 681 patients who underwent alloHCT at Princess Margaret Cancer Centre between January 2010 and December 2019. P

Development and validation of new multimorbidity-weighted index for ICD-10-coded electronic health record and claims data: an observational study.

ObjectiveMap multimorbidity-weighted index (MWI) conditions to International Classification of Diseases, 10th Revision (ICD-10), expand the conditions and codes to develop a new ICD-10-coded MWI (MWI-ICD10) and updated MWI-ICD9, and assess their consistency.DesignPopulation-based retrospective cohort.SettingLarge medical centre between 2013 and 2017.ParticipantsAdults ≥18 years old with encounters in each of 4 years (2013, 2014, 2016, 2017).Main outcome measuresMWI conditions mapped to ICD-10 codes, and additional conditions and codes added to produce a new MWI-ICD10 and updated MWI-ICD9. We c

The impact of telemonitoring on correct drug use, complications and quality of life among patients with multiple myeloma (ITUMM): A study protocol for an open-label, parallel-group, randomized controlled trial.

INTRODUCTION: Multiple myeloma (MM) is the second most common hematologic malignancy. MM is associated with significant morbidity due to its end-organ destruction and is a disease of the older population. Although survival rates for MM have improved over the last decade, due to an increase in treatment options, the disease remains incurable. Expensive (oral) agents are widely used in MM patients; however, tools for supporting patients in complex treatment regimens are scarce. To investigate if a tool will support MM patients and healthcare professionals, the MM e-coach was developed and tested

Implementation of patient-reported outcome measures and patient-reported experience measures in melanoma clinical quality registries: a systematic review.

ObjectivesTo identify patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) in clinical quality registries, for people with cutaneous melanoma, to inform a new Australian Melanoma Clinical Outcomes Registry; and describe opportunities and challenges of routine PROM/PREM collection, especially in primary care.DesignSystematic review.Primary and secondary outcome measuresWhich PROMs and PREMs are used in clinical quality registries for people with cutaneous melanoma, how they are collected, frequency of collection, participant recruitment methods and funding

Myeloma Patient Value Mapping: A Discrete Choice Experiment on Myeloma Treatment Preferences in the UK.

BackgroundMyeloma is an incurable life-threatening hematological cancer. Recent treatment developments have seen improvements in survival; however, while patients are living longer, they are living with symptoms and treatment side effects.ObjectiveTo evaluate myeloma patients' preferences for treatment using a discrete choice experiment (DCE). This study set out to define the relative importance of key treatment attributes, characterize the risk-benefit trade-offs in patients' decision-making, and to analyze the predictive power of basic demographic factors.MethodsFour hundred seventy-five mye

Clinical Genetics of Cancer 2017 : Szczecin, Poland. 21-22 September 2017

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Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.

Marine macroalgae, microalgae, and associated microorganisms are increasingly recognised as valuable sources of bioactive compounds with applications across biotechnology and health. The environmental and ecological conditions they inhabit shape their metabolite diversity, leading to the production of high-value compounds such as sulphated polysaccharides, lipids, pigments, phenolics, and peptides. These compounds exhibit conserved biological activities that underpin potent antioxidant, anti-inflammatory, cytotoxic, and pro-regenerative effects with strong potential for translation. Although e

Population health impacts from the taxation of salt and sugar in the United Kingdom.

ObjectiveTo estimate the potential health benefits from the reduction in consumption of salt and sugar following the introduction of a proposed tax on salt and sugar in the United Kingdom (UK).DesignEpidemiological modelling study. Life table modelling was used to estimate the expected population health benefits from the reduction in consumption of salt and sugar for four scenarios, each reflecting different manufacturer and consumer responses the proposed tax. Relative risks for twenty-four disease-risk pairs were applied, exploring different pathways between salt and sugar consumption, and m

Physical function in patients newly diagnosed with multiple myeloma; a Danish cohort study.

BACKGROUND: Multiple myeloma is a cancer in the bone marrow causing bone destruction. Patients experience various symptoms related to the disease and/or treatment, such as pain and fatigue, leading to poorer quality of life. The symptom burden might affect physical function and physical activity levels, posing a risk of physical deterioration. The aim was to investigate whether physical function in newly diagnosed patients with multiple myeloma differs from the reference values of the normal population and other cancer patients. METHODS: The study is a cross sectional descriptive analysis of