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[Fatal complications in pre-eclampsia and eclampsia].

OBJECTIVE: Analysis of preeclampsia and eclampsia--one of the major contributor to life-threatening maternal morbidity frequently leading to maternal mortality in the Czech Republic till late 70's. Our goal was to mention major causal links in clinical courses of individual maternal death and to highlight main mistakes and faults, and to provide frequencies and basic characteristics of risk groups. DESIGN: Retrospective epidemiological study. SETTING: Department of Obstetrics and Gynecology of the 1st Medical School of Charles University and General University Hospital, Prague. Institute for

A Review on Probable Causes of Cardiotoxicity Caused by Common Cancer Drugs and the Role of Traditional Chinese Medicine in Prevention and Treatment.

Cancer is a widespread disease in our nation, characterized by a high occurrence rate. The use of tumor medications has been linked to an increased chance of cardiovascular complications, including a notable occurrence of heart toxicity. This has caused significant concern among healthcare professionals. This article provides a comprehensive compilation of drugs recognized for their potential to cause heart toxicity. Furthermore, extensive research has been conducted to investigate and categorize the effects of heart toxicity, with the purpose of promoting awareness, facilitating early interve

Fetal cardiac and neonatal cerebral hemodynamics and oxygen metabolism in transposition of the great arteries.

OBJECTIVES: Hemodynamic abnormalities and brain development disorders have been reported previously in fetuses and infants with transposition of the great arteries and intact ventricular septum (TGA-IVS). A ventricular septal defect (VSD) is thought to be an additional risk factor for adverse neurodevelopment, but literature describing this population is sparse. The objectives of this study were to assess fetal cardiac hemodynamics throughout pregnancy, to monitor cerebral hemodynamics and oxygen metabolism in neonates, and to compare these data between patients with TGA-IVS, those with TGA-VS…

Risk factors for syphilis in women: case-control study.

OBJECTIVE: To determine the sociodemographic, behavioral, and health care factors related to the occurrence of syphilis in women treated at public maternity hospitals. METHODS: This is a case-control study (239 cases and 322 controls) with women admitted to seven maternity hospitals in the municipality of Recife, Brazil, from July 2013 to July 2014. Eligible women were recruited after the result of the VDRL (Venereal Disease Research Laboratory) under any titration. The selection of cases and controls was based on the result of the serology for syphilis using ELISA (enzyme-linked immunosorben

Long Rectal Cuff and Remnant Mesorectum Are Major Preventable Causes of Ileal Pouch Failure.

BACKGROUND: Long rectal cuff (>2 cm) and remnant mesorectum are known causes of pouch dysfunction because of obstructive defecation as well as pelvic sepsis after prolonged obstruction. OBJECTIVE: The aim of this study was to report the rates and management of patients who underwent redo IPAA because of pouch failure associated with a retained mesorectum and long rectal cuff. DESIGN: This is a retrospective study. SETTINGS: The investigation is based on data from a quaternary IBD center. PATIENTS: Patients undergoing redo IPAA surgery with a long rectal cuff and/or remnant mesorectum betwe

Relationship between sodium and diffusion MRI metrics in multiple sclerosis.

Sodium MRI can measure in vivo sodium concentrations in people with multiple sclerosis, but the extent to which these alterations reflect metabolic dysfunction in the absence of tissue damage or neuroaxonal loss remains uncertain. Increases in total sodium concentration and extracellular sodium concentration are believed to be indicative of tissue disruption and extracellular space expansion. Conversely, increase in intracellular sodium concentration may represent early and transient responses to neuronal insult, preceding overt tissue damage. Here, we explored the relationship between total s

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… dispersion index, isotropic volume fraction (ISOVF) and ICVF. 20 These maps were obtained using the AMICO software. 31 Mean dMRI metrics values were extracted from WM lesions and NAWM, which were registered to the diffusion space through rigid transformation and nearest-neighbor interpolation using ANTs … Voxel-based analysis The voxel-based analysis of 23 Na and dMRI maps was conducted using the threshold-free cluster enhancement method (part of FSL, number of permutation = 5000). 32 These maps were registered to the MNI space with affine and non-linear transformations using ANTs. …

Возрастающая роль адропина в неврологическом здоровье: систематический обзор.

Адропин, гормон пептида играет роль в различных физиологических процессах, включая метаболическое регулирование и сердечно-сосудистое здоровье. Цель этого систематического обзора заключалась в обобщении результатов наблюдений по вопросу об участии адропина в неврологических расстройствах и когнитивных характеристиках. Были отобраны и проанализированы исследования, опубликованные в период с 2020 по 2024 год. Процесс поиска и отбора соответствовал Руководящим принципам по предпочтительным элементам отчетности для системных обзоров и мета-анализов (PRISMA). Из 127 отобранных статей 5 удовлетворяю

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy.

Background: Cancer has become a major disease endangering human health around the world. Conventional chemotherapy suffers from many side effects including pain, cardiotoxicity, hepatotoxicity, and renal toxicity. This review aims to describe a natural product of resveratrol as a chemoprotective and synergistic agent in the modulation of cancer chemotherapy. Methods: The publications were identified by comprehensive searching of SciFinder, PubMed, Web of Science, and our own reference library. Search terms included combinations of "resveratrol," "cancer," "natural products," "chemotherapy," an

Ultrasound-guided intrapleural positioning of pleural catheters: influence on immediate lung expansion and pleurodesis in patients with recurrent malignant pleural effusion.

OBJECTIVE:: To evaluate the role of intrapleural positioning of a pleural catheter in early lung expansion and pleurodesis success in patients with recurrent malignant pleural effusion (RMPE). METHODS:: This was a retrospective study nested into a larger prospective cohort study including patients with RMPE recruited from a tertiary university teaching hospital between June of 2009 and September of 2014. The patients underwent pleural catheter insertion followed by bedside pleurodesis. Chest CT scans were performed twice: immediately before pleurodesis (iCT) and 30 days after pleurodesis (CT3

[Mid-term results of 360-degree lumbar spondylodesis with the use of a tantalum implant for disc replacement].

PURPOSE OF THE STUDY: The study presents the mid-term results in patients treated with circumferential, i.e., 360-degreee, fusion of the lumbar spine carried out by posterolateral instrumented spondylodesis and anterior intersomatic fusion using a tantalum implant for replacement of an intervertebral disc. The aim of the study was to verify tantalum implant quality, to evaluate segment fusion and to assess the outcome of this method by patients' subjective findings. MATERIAL AND METHODS: The prospective non-randomised study included the implantation of 47 tantalum cages in 40 patients by the

Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries.

BACKGROUND:: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted. OBJECTIVE:: To investigate whether acute ethanol intake activates the vascular RhoA/Rho kinase pathway in resistance arteries and the role of NAD(P)H oxidase-derived reactive oxygen species (ROS) on such response. We also evaluated the requirement of p47phox translocation for ethanol-induced NAD(P)H oxidase activation. METHODS:: Male Wistar rats were orally treated with ethanol (1g/kg, p.o

Магнитизация передачи изображений с использованием несбалансированного SSPF на сверхнизком поле.

ЦЕЛЬ: Углубленные полевые сканеры МРТ способны повысить качество медицинского обслуживания как за счет улучшения доступа в тех районах, где мало сканеров МРТ, так и за счет обеспечения более частого мониторинга динамики заболеваний и реагирования на них. Это, возможно, особенно относится к расстройствам, связанным с белым веществом, включая лейкодистрофии и множественный склероз, при которых частые снимки, чувствительные к миелину, такие, как снимки передачи магнитизации (MT), могут улучшить клиническую помощь и результаты лечения пациентов. Методика: Мы применяли подход, основанный на чувстви

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… Images of MT low and MT high were denoised using ANTs non‐local means (NLM) denoising. 45 MTR maps were then calculated as MTR = (MT low  – MT high )/MT low  × 100%. … Magnitude images of MT low and MT high were denoised with ANTs NLM denoising as before, and MTR maps were calculated. T 2 ‐weighted images were brain‐extracted and used to generate white matter masks as in Section  2.2 . …

The Impact of Preoperative Serum High-Mobility Group Box 1 on Recurrence in Patients With Colorectal Cancer: A Prospective Observational Study.

BACKGROUND: High-mobility group box 1 can serve as a follow-up marker for postoperative GI cancer progression. However, we do not know the role of preoperative high-mobility group box 1 measurement in an observation of longer-term recurrence of cancer and for colorectal cancer. OBJECTIVE: This study aimed to evaluate the prediction of high-mobility group box 1 on long-term recurrence in patients with colorectal cancer. DESIGN: This was a prospective cohort study. SETTINGS: A single tertiary hospital in Japan. PATIENTS: A cohort of 95 patients who underwent surgery for colorectal cancer bet

[“Dum spiro spero”: clinicopathologic characteristics of SARS-CoV-2 infection].

UNLABELLED: Összefoglaló. Bevezetés: A kórboncolás hozzájárul a súlyos akut légzőszervi szindrómát okozó koronavírus-2 (SARS-CoV-2-) fertőzés klinikopatológiai vonatkozásainak megismeréséhez. Célkitűzés: A SARS-CoV-2-fertőzöttek boncolása során gyűjtött tapasztalatok bemutatása. Módszer: Egymást követően boncolt, védőoltásban nem részesült, SARS-CoV-2-fertőzött elhunytak klinikai adatait, makro- és mikroszkópos észleleteit összegeztük; a tüdőkimetszéseket SARS-CoV-2-nukleokapszid-immunfestéssel vizsgáltuk. Eredmények: A boncolást a halálok megállapítására (n = 14), tumorgyanú (n = 9), illetve

[Observations on injuries by blunt objects].

Based on my personal experience publishing case reports on blunt injuries, I hereby focus on issues that have recently come to my attention. 1. Abrasions: 1) As to whether they occurred ante-mortem or post-mortem; those reddish in color cannot always have occurred antemortem. When they overlap with reddish (-purple) discoloration, as in hypostasis, post-mortem abrasions look reddish as well. Abrasions larger than the tip of the finger or the palm of the hand are often seen post-mortem and are thought to occur due to the touching of putrefied skin post-mortem. 2) There are cases where the direc

Расширенная техническая и клиническая проверка сегментации глубокого мозга на основе изучения для применения в нейродегенеративных заболеваниях.

Дефекты центральной нервной системы, включая нейродегенеративные заболевания, часто влияют на мозговую стержень и могут вызывать атрофию. Это исследование преследовало следующие цели:1) оптимизация сегментации мозга на основе глубокого обучения для широкого круга патологий и T1-weighted параметры для получения изображения,2) проводить систематическую техническую и клиническую проверку (;3) повышать качество сегментации в присутствии повреждений головного мозга; и4) создать оптимизированный инструмент сегментации мозга для общественного пользования. Набор преднамеренно неоднородных наземных дан

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… The brainstem was segmented on T1‐weighted images with the MD‐GRU 2024 and nnU‐Net models before and after filling lesions with FSL or ANTs, respectively. … ANTs lesion filling performed slightly better than FSL and the nnU‐Net model performed generally better than the MD‐GRU 2024 model. Also, the percentage of lesion volume covered by the inferred brainstem mask improved with lesion filling, especially when using ANTs. Lesion filling. …

Arrhythmias, conduction disorders and sudden cardiac death in cancer patients and survivors: expert opinion of the working groups on cardio-oncology and on electrophysiology of the hellenic cardiac society.

Advances in cancer therapeutics have significantly improved patient survival; however, cardiotoxic effects-including arrhythmias-have emerged as a growing clinical concern. This expert opinion, developed by the Working Groups on Cardio-Oncology and Electrophysiology of the Hellenic Cardiological Society, aims to raise awareness of the increasing burden of arrhythmias in cancer patients and survivors. This document explores the multifactorial etiology of arrhythmias in this population, including patient-related factors, the direct effects of malignancy, and the arrhythmogenic potential of thera

Preoperative Magnetic Resonance Enterography to Predict Pathological Specimen Length in Crohn's Disease.

BACKGROUND: The European Crohn's and Colitis Organization guidelines have highlighted the importance of the preoperative evaluation of the affected segment length in patients with ileocolic Crohn's disease to determine the best surgical approach. OBJECTIVE: This study aimed to evaluate the accuracy of preoperative magnetic resonance enterography in assessing the length of the affected segment in patients with ileocolic Crohn's disease. DESIGN: This observational study was conducted with a prospectively maintained database and retrospective analysis. SETTINGS: This study was conducted in a t

Brazilian Position Statement on the Use Of Multimodality Imaging in Cardio-Oncology - 2021.

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Assessment of evidence from teeth and the alveolar bone of skulls.

A notable lack of agreement on a standardised criterion for representing changes in alveolar bone persists, which limits its application in forensic dentistry. This study aimed to describe the data on loss of tooth substance and alveolar bone in skulls. Dental and trabecular bone information from 28 skulls from the German Helmer skull collection was collected through dental charting, intraoral photographs taken with a DSLR camera (Nikon D5600, Nikon Corporation, Japan), and small radiographs obtained using a handheld dental X-ray device (Nomad Pro 2, Kavo Kerr, Biberach, Germany). Adobe Photos