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Assessment of TSPAN Expression Profile and Their Role in the VSCC Prognosis.

The role and prognostic value of tetraspanins (TSPANs) in vulvar squamous cell carcinoma (VSCC) remain poorly understood. We sought to primarily determine, at both the molecular and tissue level, the expression profile of the TSPANs CD9, CD63, CD81, and CD82 in archived VSCC samples (n = 117) and further investigate their clinical relevance as prognostic markers. Our studies led us to identify CD63 as the most highly expressed TSPAN, at the gene and protein levels. Multicomparison studies also revealed that the expression of CD9 was associated with tumor size, whereas CD63 upregulation was ass

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… Let-7 miRNA’s expression profile and its potential prognostic role in uterine leiomyosarcoma. Cells. 2019;8:1452. doi: 10.3390/cells8111452. 88. Kumari S., Nie J., Chen H.-S., Ma H., Stewart R., Li X., Lu M.-Z., Taylor W.M., Wei H. …

Neurobiology of Cancer: Introduction of New Drugs in the Treatment and Prevention of Cancer.

Research on the neurobiology of cancer, which lies at the border of neuroscience and oncology, has elucidated the mechanisms and pathways that enable the nervous system to modulate processes associated with cancer initiation and progression. This research has also shown that several drugs which modulate interactions between the nervous system and the tumor micro- and macroenvironments significantly reduced the progression of cancer in animal models. Encouraging results were also provided by prospective clinical trials investigating the effect of drugs that reduce adrenergic signaling on the co

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… Moreover, propranolol exerted a synergic effect with doxorubicin in inhibiting the viability of liposarcoma and leiomyosarcoma cells and increased the response to docetaxel in angiosarcoma and solitary fibrous tumor patient-derived cells. …

Management of skeletal metastases: An orthopaedic surgeon's guide.

Skeletal metastasis is a common cause of severe morbidity, reduction in quality of life (QOL) and often early mortality. Its prevalence is rising due to a higher rate of diagnosis, better systemic treatment, longer lives with the disease and higher disease burden rate. As people with cancer live longer and with rising sensitivity of body imaging and surveillance, the incidence of pathological fracture, metastatic epidural cord compression is rising and constitutes a challenge for the orthopedic surgeon to maintain their QOL. Metastatic disease is no longer a death sentence condemning patients

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… In patients with long expected survival, primary resection may obviate need for more surgery in future Figure 9 A solitary diaphyseal metastasis from uterine leiomyosarcoma treated with resection and diaphyseal prosthesis. …

Rare central nervous system lymphomas.

Central nervous system (CNS) lymphomas are rare malignancies characterised by lymphoid infiltration into the brain, spinal cord, cranial nerves, meninges and/or eyes in the presence or absence of previous or concurrent systemic disease. Most CNS lymphomas are of the diffuse large B-cell lymphoma (DLBCL) subtype for which treatment strategies, particularly the use of high-dose methotrexate-based protocols and consolidation with autologous stem cell transplantation, are well established. Other histopathological subtypes of CNS lymphoma are comparatively less common with published data on these r

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… matter. 37 Given their anatomical predilection for the dura, CNS‐MZL are commonly mistaken for meningiomas on initial diagnostic imaging. 38 , 39 , 40 However, the differential diagnosis for dural‐based lesions is wide, encompassing subdural haematomas, other tumours (e.g. dural metastases, glioma, leiomyosarcoma …

Pericytes as targets in hereditary hemorrhagic telangiectasia.

Defective paracrine Transforming Growth Factor-β (TGF-β) signaling between endothelial cells and the neighboring mural cells have been thought to lead to the development of vascular lesions that are characteristic of Hereditary Hemorrhagic Telangiectasia (HHT). This review highlights recent progress in our understanding of TGF-β signaling in mural cell recruitment and vessel stabilization and how perturbed TGF-β signaling might contribute to defective endothelial-mural cell interaction affecting vessel functionalities. Our recent findings have provided exciting insights into the role of thalid

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… Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease . Oncology 16 , 21 – 24 . 11831608 Larrivée B. Prahst C. Gordon E. del Toro R. Mathivet T. Duarte A. . ( 2012 ). ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway . Dev. …

Обязательный экзамен по патологии: лишний или необходимый?

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34th Европейский конгресс патологии - резюме.

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RNA modifications in cancer.

RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6-methyladenosine (m6A) and 5-methylcytosine (m5C), are implicated in various cellular processes. These modifications are regulated by proteins that write, erase, and read RNA and modulate RNA stability, splicing, translation, and degradation. Recent studies have highlighted their roles in metabolic reprogramming, signaling pathways, and cell cycle control, which are essential for tumor proliferation and survival. Despite these scientific advances, the precise

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… The upregulation of FTO may promote uterine leiomyosarcoma cell proliferation. 188 ALKBH5 demethylates m 6 A modifications, influencing gene expression and cell processes, including proliferation. …

Резюме

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The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinflammatory phenomena. On account of this fact, the identification of novel pathomechanisms targeting neuroinflammation seems to be crucial in terms of yielding successful individual therapeutic strategies. In recent years, the pleiotropic growth factor progranulin (PGRN) has attracted significant atten

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… The overexpression of PGRN was observed in several cancer types and cell lines, including ovarian, breast, bladder, liver, adrenal, prostate, kidney, multiple myeloma, leiomyosarcoma and mesothelioma [ 17 ]. …

Childhood Cancer: Occurrence, Treatment and Risk of Second Primary Malignancies.

Cancer represents the leading cause of disease-related death and treatment-associated morbidity in children with an increasing trend in recent decades worldwide. Nevertheless, the 5-year survival of childhood cancer patients has been raised impressively to more than 80% during the past decades, primarily attributed to improved diagnostic technologies and multiagent cytotoxic regimens. This strong benefit of more efficient tumor control and prolonged survival is compromised by an increased risk of adverse and fatal late sequelae. Long-term survivors of pediatric tumors are at the utmost risk fo

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… heterogeneous group of rare mesenchymal tumors encompassing more than 50 different subtypes with distinct genetic profiles and phenotypes including tumors of the connective tissue (e.g., desmoid-type fibromatosis), peripheral nervous system (e.g., malignant peripheral nerve sheath tumor), smooth muscle (e.g., leiomyosarcoma …

Immune Checkpoint Molecules: A Review on Pathways and Immunotherapy Implications.

BackgroundToday, treating cancer patients with monoclonal antibodies (mAbs), by targeting immune checkpoints, is one of the most outstanding immunotherapeutic methods. Immune checkpoints are special molecules having regulatory role in immune system responses. Once these molecules are presented on cancer cells, these cells will be capable of evading the immune system through their own specific pathways. This Evasion can be prevented by counterbalancing immune system responses with immune checkpoints related antibodies.AimsThe current study aimed to highlight immunotherapy and its methods, descr

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… Solomon , et al., “ Immunotherapy With Single Agent Nivolumab for Advanced Leiomyosarcoma of the Uterus: Results of a Phase 2 Study ,” Cancer 123 , no. 17 ( 2017 ): 3285 – 3290 . 28440953 10.1002/cncr.30738 PMC5762200 132 B. A. Inman , T. A. Longo , S. Ramalingam , and M. R. …

Proceedings of ICIS SGCR-WIRES 2024, held jointly with the 23rd International Cancer Imaging Society Annual Conference, collaborating with the Singapore Radiological Society and College of Radiologists Singapore.

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… Other rare intravascular tumours and their imaging features, including pulmonary artery sarcomas, intravascular leiomyomatosis, and vascular leiomyosarcomas. Background / Outline: Tumours located within the cardiovascular system are rare, regardless if they originated there or from elsewhere. …

Current Overview of Treatment for Metastatic Bone Disease.

The number of patients with bone metastasis increases as medical management and surgery improve the overall survival of patients with cancer. Bone metastasis can cause skeletal complications, including bone pain, pathological fractures, spinal cord or nerve root compression, and hypercalcemia. Before initiation of treatment for bone metastasis, it is important to exclude primary bone malignancy, which would require a completely different therapeutic approach. It is essential to select surgical methods considering the patient's prognosis, quality of life, postoperative function, and risk of pos

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… Enhancement of antitumor effect of bleomycin by low-voltage in vivo electroporation: A study of human uterine leiomyosarcomas in nude mice Int. J. Cancer 2000 88 640 644 10.1002/1097-0215(20001115)88:4<640::AID-IJC19>3.0.CO;2-K 11058883 178. Kotnik T. Pucihar G. Miklavcic D. …

Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.

Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack by the immune system, but cells that do survive change their phenotypes to reduce their immunogenicity. The resultant cells evade the attack by the immune system and form clinically discernible tumors. Tumor microenvironments simultaneously contain a wide variety of immune suppre

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… non-Hodgkin lymphoma Cell 2010 142 699 713 20813259 10.1016/j.cell.2010.07.044 PMC2943345 108 Edris B Weiskopf K Volkmer AK Volkmer JP Willingham SB Contreras-Trujillo H Liu J Majeti R West RB Fletcher JA Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma …

Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious Diseases.

Aurora kinase A (AURKA) is crucial in regulating cell division and maintaining genomic stability, making it significant in cancer biology. This review explores AURKA's structural and functional roles, emphasizing its involvement in cell cycle progression. Beyond cancer, AURKA emerges as a multifaceted player in host cell modulation, exerting influence over inflammatory responses, cell death mechanisms, and autophagy pathways. Moreover, recent research highlights its involvement in viral and bacterial infections. Numerous viruses, for their replication and assembly, modulate host cell cycle pro

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… Dual targeting of mTOR and aurora-A kinase for the treatment of uterine Leiomyosarcoma. Clin Cancer Res. 2012;18(17):4633–4645. doi: 10.1158/1078-0432.CCR-12-0436. 119. Kozyreva VK, Kiseleva AA, Ice RJ, Jones BC, Loskutov YV, Matalkah F, Smolkin MB, Marinak K, Livengood RH, Salkeni MA, et al. …

Vincristine in Combination Therapy of Cancer: Emerging Trends in Clinics.

Treatment of blood malignancies and other cancer diseases has been mostly unfeasible, so far. Therefore, novel treatment regimens should be developed and the currently used ones should be further elaborated. A stable component in various cancer treatment regimens consists of vincristine, an antimitotic compound of natural origin. Despite its strong anticancer activity, mostly, it cannot be administered as monotherapy due to its unspecific action and severe side effects. However, vincristine is suitable for combination therapy. Multidrug treatment regimens including vincristine are standardly a

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… FDA approval summary: Trabectedin for unresectable or metastatic liposarcoma or leiomyosarcoma following an anthracycline-containing regimen Clin. Cancer Res. 2017 23 7448 7453 10.1158/1078-0432.CCR-17-0898 28774898 24. Lossignol D. A little help from steroids in oncology J. Transl. Int. …

Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials.

Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated toxicity due to the non-tumor-associated effects, development of secondary malignancies, infertility, radiation-induced fibrosis and resistance to treatment limit the effectiveness and safety of treatment. In addition, these multiple factors significantly impact quality of life. Over the last decades, our increased understanding of cancer epigenetics has led to new therapeutic approaches and the promise of improved patient outcomes. Epigenetic alterations are commonly foun

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… Givinostat combined with doxorubicin (a dual topoisomerase inhibitor I and II and DNA damage agent) has shown significant potential in improving sensitization in different preclinical models of sarcoma such as osteosarcoma, liposarcoma, synovial sarcoma, rhabdomyosarcoma, leiomyosarcoma, or fibrosarcoma …

Marine Bioactive Compounds from Functional Seafoods: Pharmacological Mechanisms and Health Applications.

Functional seafoods derived from marine organisms, including fish, shellfish and algae, are gaining increasing attention due to their high content of bioactive compounds, such as omega-3 fatty acids, peptides, polysaccharides and antioxidants, which provide health benefits beyond basic nutrition. These marine-derived compounds exhibit a wide range of biological activities and have been investigated for their potential roles in the prevention and management of chronic diseases, including cardiovascular, neurodegenerative, cancer and gastrointestinal disorders. Their effects are largely mediated

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… FDA approved trabectedin for patients with unresectable or metastatic liposarcoma or leiomyosarcoma previously treated with anthracycline-based chemotherapy. …

Expert consensus on resection of chest wall tumors and chest wall reconstruction.

Chest wall tumors are a relatively uncommon disease in clinical practice. Most of the published studies about chest wall tumors are usually single-center retrospective studies, involving few patients. Therefore, evidences regarding clinical conclusions about chest wall tumors are lacking, and some controversial issues have still to be agreed upon. In January 2019, 73 experts in thoracic surgery, plastic surgery, science, and engineering jointly released the Chinese Expert Consensus on Chest Wall Tumor Resection and Chest Wall Reconstruction (2018 edition). After that, numerous experts put forw

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… Some soft tissue sarcomas, including leiomyosarcoma, synoviosarcoma, fibrosarcoma, primitive neuroectodermal tumor, hemangiosarcoma and so on, can be staged according to the 8th edition TNM staging criteria of soft tissue sarcomas (trunk and extremities) ( 4 ). …