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The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults.

Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing

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… In preliminary results, a single intracolonic administration combination of XG with Bifidobacterium animalis was found to be effective in inducing mucosal healing in patients with ulcerative colitis [ 86 ]. … Bozkurt HS Kara B A new treatment for ulcerative colitis: Intracolonic Bifidobacterium and xyloglucan application Eur J Inflamm 2020 18 1 7 87. …

Инфекционные кишечные заболевания повышают риск нейродегенеративных заболеваний на основе общенационального исследования групп населения.

Инфекционные кишечные заболевания (МИЗ) создают значительное бремя для здоровья и экономики во всем мире. Недавние наблюдения в больнице общего профиля " Три сервис " (Тайван) указывают на потенциальную связь между МИС и нейродегенеративными заболеваниями, что подтолкнуло к изучению этих отношений. В ходе этого исследования были изучены взаимосвязи между МИС и нейродегенеративными заболеваниями. Мы провели ретроспективный когортный анализ на основе данных Национальной научно-исследовательской базы данных о медицинском страховании (NHIRD) Тайваня. Пациенты, у которых диагностированы И

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… Kobayashi Y Sugahara H Shimada K Mitsuyama E Kuhara T Yasuoka A Kondo T Abe K Xiao JZ Therapeutic potential of bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease Sci. Rep. 2017 7 1 13510 10.1038/s41598-017-13368-2 29044140 PMC5647431 Kobayashi, Y. et al. … Therapeutic potential of bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease. Sci. …

Механизмы и новые регулирующие органы нейроинфламмации: изучение новых терапевтических стратегий в отношении неврологических расстройств.

Нейроинфламмация представляет собой сложную и динамичную реакцию центральной нервной системы (КНС) на травмы, инфекцию и болезни. В то время как острая нейроинфламмация играет защитную роль, облегчая расчистку патогенов и восстановление тканей, хроническая и дисрегулированная воспаление в значительной степени способствует развитию таких нейродегенеративных расстройств, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз. В рамках этого обзора изучаются клеточные и молекулярные механизмы, лежащие в основе нейроинфламмации, с уделением особого внимания роли микроглий, астроцитов

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… For instance, it has been demonstrated that probiotics such as Bifidobacterium and Lactobacillus species reduce inflammation by improving the generation of SCFAs and modifying immune responses. …

BLAB2CancerKD: a knowledge graph database focusing on the association between lactic acid bacteria and cancer, but beyond.

In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB i

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… For example, eating Bifidobacterium Longum SPM1207 can help to improve mild to moderate hypercholesterolemia to prevent CRC ( 30 ). …

Immunodiagnosis - the promise of personalized immunotherapy.

Immunotherapy showed remarkable efficacy in several cancer types. However, the majority of patients do not benefit from immunotherapy. Evaluating tumor heterogeneity and immune status before treatment is key to identifying patients that are more likely to respond to immunotherapy. Demographic characteristics (such as sex, age, and race), immune status, and specific biomarkers all contribute to response to immunotherapy. A comprehensive immunodiagnostic model integrating all these three dimensions by artificial intelligence would provide valuable information for predicting treatment response. H

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… Specifically, Bifidobacterium may improve the activation of DCs and tumor-specific CD8+T cell responses ( 63 ), while B fragilis may increase the activation of TH1 cells ( 62 ). … Commensal bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy . Science ( 2015 ) 350 ( 6264 ): 1084–9 . doi: 10.1126/science.aac4255 PMC4873287 26541606 64 Uribe-Herranz M Bittinger K Rafail S Guedan S Pierini S Tanes C . …

Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives.

Sex differences play a crucial role in determining tumor incidence, treatment sensitivity, and prognosis among men and women. However, current clinical cancer treatment strategies fail to account for these differences. Furthermore, the underlying mechanisms of tumor disparities between sexes remain elusive. Sex differences in sex chromosomes, hormone levels, metabolism, and immunity synergistically contribute to tumor-related disparities. As the demand for precision medicine escalates, there is an urgent need to conduct further exploration and research to address the tumor differences between

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… Sex-specific microbial profiles are shaped by the interplay of genetic factors and sex hormones, with premenopausal women generally exhibiting higher microbial diversity and greater abundance of beneficial taxa (e.g., Bifidobacterium) than men [ 135 , 136 ]. …

Гут Микробиота как ключевой модулятор хронических заболеваний: последствия для диабета, автономного иммунитета и рака.

Кишечная микробиота (ГМ) представляет собой сложную, динамичную и сложную экосистему. Она играет ключевую роль в области здравоохранения и болезней. ГМ взаимодействует с принимающей стороной и модифицирует различные физиологические функции, включая метаболизм, иммунное регулирование и неврологическую функцию. В настоящем описательном обзоре всесторонне анализируется роль ГМ в развитии и развитии three Основные хронические заболевания, а именно диабет, аутоиммунные расстройства и рак. Используя структурированную стратегию поиска литературы в таких базах данных, как Google Scientist, PubMed, Sco

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… short-chain fatty acid;  References: [ 21 - 27 ] Therapeutic Approach Mechanism/Effect Examples Dietary Interventions Promotes microbial diversity and SCFA production High fiber diets, whole grains, vegetables Probiotics and Prebiotics Improve insulin sensitivity and reduce inflammation Lactobacillus, Bifidobacterium …

The roles of microRNA families in hepatic fibrosis.

The Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008 (JCMWDDT 2008) was held from September 29 to October 1, 200 … e worldwide supply by Motomu Kanai (The University of Tokyo, Japan) ● Clinical effects of probiotic bifidobacterium in the prevention of influenza virus infections and allergic diseases by Jin-zhong Xiao (Morinaga Milk Industry Co., Ltd., Japan) ● Production of anti-influenza PR8-scFv using a phage display by Normaiza Zamri (Tokai University, Japan) Session V. An …

A narrative review of the epidemiological and mechanistic associations between ABO blood groups and diseases: focusing on cardiovascular diseases, cancers, diabetes, malaria, COVID-19 and rheumatic diseases.

BACKGROUND: The ABO blood group system is one of the most clinically significant human blood group systems and is closely associated with pathogenesis, progression, and prognosis of numerous diseases. This narrative review synthesizes recent epidemiological evidence and explores potential mechanisms linking ABO to cardiovascular diseases, malignancies, diabetes, Plasmodium falciparum malaria, COVID‑19, and rheumatic diseases. METHODS: We searched PubMed and CNKI up to September 2025. RESULTS: Epidemiological studies consistently show non‑O blood groups have significantly elevated cardiovascu

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… Bifidobacterium) and influence bacterial growth by regulating carbon sources such as GalNAc [ 94 , 95 ]. This evidence forms a new microbiota-immune pathway connecting blood groups to disease risk. …

Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review.

Immunotherapy is emerging as a promising avenue in oncology, gaining increasing importance and offering substantial advantages when compared to chemotherapy or radiotherapy. However, in the context of immunotherapy, there is the potential for the immune system to either support or hinder the administered treatment. This review encompasses recent and pivotal studies that assess the influence of dietary elements, including vitamins, fatty acids, nutrients, small dietary molecules, dietary patterns, and caloric restriction, on the ability to modulate immune responses. Furthermore, the article und

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… In the case of PD-1 blockade, the gut microbiome profiling showed an increase in Bifidobacterium species in mice with delayed tumor growth and effective response to anti-PD-1 therapy [ 64 ]. … Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science. 2015;350:1084–9. doi: 10.1126/science.aac4255. 65. Routy B, Le Chatelier E, Derosa L, Duong CPM, Tidjani Alou M, Daillère R, et al. …

Current Advancement of Immunomodulatory Drugs as Potential Pharmacotherapies for Autoimmunity Based Neurological Diseases.

Dramatic advancement has been made in recent decades to understand the basis of autoimmunity-mediated neurological diseases. These diseases create a strong influence on the central nervous system (CNS) and the peripheral nervous system (PNS), leading to various clinical manifestations and numerous symptoms. Multiple sclerosis (MS) is the most prevalent autoimmune neurological disease while NMO spectrum disorder (NMOSD) is less common. Furthermore, evidence supports the presence of autoimmune mechanisms contributing to the pathogenesis of amyotrophic lateral sclerosis (ALS), which is a neurodeg

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… Fermentation is mostly mediated by Bifidobacterium , Eubacterium , Roseburia , Bacteroides , Lactobacillus , and Propionibacterium, which results in the production of metabolites including butyrate, acetate, and propionate short chain fatty acid (SCFAs) [ 185 ]. …

Chronic stress: a fourth etiology in tumorigenesis?

Chronic stress, driven by persistent psychological, environmental, or physiological factors, is a prolonged heightened state of stress response that disrupts homeostasis. When unmanaged, it will lead to sustained negative emotions such as depression, loneliness, anxiety, and emotional adversity. This persistent emotional distress not only exacerbates mental health disorders but also poses significant risks to physical health. Increasing evidence suggests a strong link between chronic stress, stress-related hormones, and the rising incidence of malignancies. As a result, chronic stress might be

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… Chronic stress via glucocorticoids, leading to decreased luminal guanine and subsequent suppression of Bifidobacterium proliferation. The resulting impairment in Bifidobacterium -mediated oleic acid degradation elevates serum oleic acid levels, thereby facilitating tumor metastasis [ 185 ]. …

Совпадающие результаты исследования клинических характеристик и факторов риска герпеса-зостера в злокачественной опухоли.

СВЯЗЬ: герпес-зостр (HZ) вызван возобновлением скрытого вируса варицелла-зостера (VZV). Раковые больные в результате иммунного подавления подвергаются повышенному риску воздействия HZ. Однако точная связь между раком и возникновением HZ остается неясной. МЕТОДЫ: В ходе этого ретроспективного исследования были собраны данные о больных раком, диагностированных 01/01/2020, и 30/09/2024. Для резюмирования клинических характеристик пациентов из числа ВЗ использовались описательные статистические данные. Для сопоставления групп HZ и неHZ в а) была применена система сопоставления показателей прибыльн

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… Mechanism of the immunomodulatory effect of the combination of live bifidobacterium, lactobacillus, enterococcus, and bacillus on immunocompromised rats. Front Immunol. (2021) 12:694344. doi: 10.3389/fimmu.2021.694344. PMID: 6. Pan QZ, Zhao JJ, Yang CP, Zhou YQ, Lin JZ, Tang Y, et al. …

Ассоциация < < Средиземное питание > > и < < Развитие множественного склероза: систематический обзор и мета-анализ > > .

Множественный склероз (MS) является хроническим воспалительным заболеванием центральной нервной системы. С учетом противоречивых данных о влиянии соблюдения средиземноморской диеты (MedDiet) на развитие НР и отсутствия систематического обзора по этой теме цель настоящего исследования состояла в изучении этой ассоциации. МЕТОДЫ: В соответствии с методами PrISMA и JBI до марта был проведен поиск электронных баз данных через PubMed, Embase, Web of Science и Scopus 2024. В него были включены первоначальные клинические исследования по оценке связи между присоединением к MedDiet и разработкой MS. Ри

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… Higher adherence to the MedDiet is suggested to be linked with Bifidobacterium animalis , a potential probiotic strain, which is proposed to be involved in the disease pathogenesis (Nitzan et al. 2023 , Toghi et al. 2019 ). …

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collect

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… One microbiota-aimed intervention for dysbiosis is probiotic supplementation containing mainly Bifidobacterium and Lactobacillus species. 181 , 182 Another microbiota-aimed intervention is fecal microbiota transplantation which is a procedure used to restore the intestinal ecosystem through transferring … One such study sponsored by Clasado discovered that their Bimuno galacto oligosaccharide (GOS) mixture product has the potential to increase Bacteroides and Bifidobacterium fecal bacteria during an early phase I clinical trial ( NCT01303484 ). …

Natural extract-derived compounds for the treatment of hematological diseases through modulation of the bone marrow microenvironment.

The bone marrow microenvironment comprises a complex network of hematopoietic stem cells, immune cells, stromal cells, and non-cellular components such as the extracellular matrix and soluble factors, collectively maintaining the homeostasis of hematopoietic stem and progenitor cells. It is highly vulnerable to pathological perturbations induced by hematologic malignancies, solid tumors, inflammatory stress, and therapeutic exposure, which collectively destabilize microenvironmental homeostasis and promote hematopoietic failure, malignant progression, and immune dysregulation. Natural products

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… Furthermore, metabolites derived from fungi and marine organisms, such as Bifidobacterium longum , have been shown to synergize with anti-PD-L1 immunotherapy to enhance antitumor efficacy ( Sivan A et al., 2015 ). Recent research has further expanded the concept of natural products. … Commensal bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy . Sci. (New York, N.Y.) 350 ( 6264 ), 1084 – 1089 . 10.1126/science.aac4255 26541606 PMC4873287 Sottile R. Federico G. Garofalo C. Tallerico R. Faniello M. C. Quaresima B. ( 2019 ). …

Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study.

Elderly people are at high risk of suffering from infection and being affected by severe forms of disease because their immunosystem suffers from aging. The alteration of normal immune functions causes the increase of pro-inflammatory cytokines which can expose these people to increased risk of developing pathologies as cancer, diabetes, and/or arthritis. Some supplements could be helpful for restoring normal immune functions. We conducted a case-control study to evaluate the efficacy of a supplement containing Sambucus nigra, zinc, tyndallized Lactobacillus acidophilus (HA122), arabinogalacta

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… Effect of Bifidobacterium bifidum and Lactobacillus acidophilus on gut mucosa and peripheral blood B lymphocytes. Immunopharmacol. Immunotoxicol. 1992;14:331–340. doi: 10.3109/08923979209009228. 34. Muhamed P.K., Vadstrup S. Zinc is the most important trace element. Ugeskr. …

Ось Гут-Брэйна и взаимодействие мозга с помощью микробиома с медицинской точки зрения.

Фон: кишечный микробиом непосредственно влияет на здоровье и активность мозга, что означает, что они тесно связаны между собой. Эта взаимосвязь предполагает наличие связи между микробными диспропорциями и болезнями, такими, как болезнь Альцгеймера, хотя здесь также играют свою роль и многочисленные другие факторы, способствующие этому, такие, как генетика. Кроме того, недавние исследования показали, что цереброспинальная жидкость содержит микробную дезоксирибонуклеиновую кислоту (ДНК), которая может быть истолкована как означающая наличие микробиома в мозгу. Вагустный нерв и центральная нервна

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… These bacteria include bifidobacterium, lactobacillus, and others [ 77 , 78 , 79 , 80 ]. This information can be used to develop effective treatments such as FMT for brain-related disorders [ 40 , 81 , 82 ]. …

Rethinking corticosteroids use in oncology.

Corticosteroids (CSs), widely used in oncology for their anti-inflammatory and immunosuppressive properties, help manage cancer-related symptoms and side effects. However, their long-term use may negatively affect patient survival and exacerbate tumor progression. Elevated glucose and glutamine metabolism, disruption of vitamin D levels, and alterations in the microbiome are some of the key factors contributing to these adverse outcomes. Approaches such as ketogenic diets, fasting, sartans, and vitamin D supplementation have shown promise in providing similar benefits to CSs while mitigating t

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… Meanwhile, IBS patients using inhaled CSs showed an increased abundance of Streptococcus mutans and Bifidobacterium dentium ( Vich Vila et al., 2020 ). …

Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study.

AIM: Comparing oral and gut microbiome profiles between patients with and without ulcerative mucositis during allogeneic stem cell transplantation (aSCT). MATERIALS AND METHODS: Specimens from oral mucosa, saliva, and stool were collected pre-(T0) and post- (T0 +28d ± 14d) aSCT (T1). Microbiome structure differences were analyzed by 16S-rRNA-gene sequencing, and associations to patients' clinical characteristics were investigated. RESULTS: Ten of 25 included patients developed ulcerations. The α-diversity decreased between T0 and T1, independent of ulcerations. PERMANOVA revealed differences

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… The most abundant taxa belonged to the genera Bacteroides , Enterococcus , Bifidobacterium , and Blautia (Figure 4a ). …