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Natural products targeting ferroptosis in cancer: molecular mechanisms and applications.

Ferroptosis is a novel class of programmed cell death that is mainly dependent on intracellular iron accumulation and lipid peroxidation. Ferroptosis is closely related to a variety of human diseases, especially different kinds of cancer. Several small molecule inducers have been developed to induce ferroptosis in tumor cells, some of which have been used in clinical studies. However, these chemical small molecules have toxic effects that limit its wide application. Natural products, however, have a natural advantage in cancer therapy due to their low toxicity and side effects. Some natural pr

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… Many small molecules have been reported, such as the small molecule drugs emodin ( 2 – 4 ), shikonin ( 5 , 6 ), and tanshinol A ( 7 ), which target necroptosis, and the small molecules berberine, fluoxetine, and ABTL081, which target ADCD. …

Chronic stress: a fourth etiology in tumorigenesis?

Chronic stress, driven by persistent psychological, environmental, or physiological factors, is a prolonged heightened state of stress response that disrupts homeostasis. When unmanaged, it will lead to sustained negative emotions such as depression, loneliness, anxiety, and emotional adversity. This persistent emotional distress not only exacerbates mental health disorders but also poses significant risks to physical health. Increasing evidence suggests a strong link between chronic stress, stress-related hormones, and the rising incidence of malignancies. As a result, chronic stress might be

Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features.

The indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we conducted a review on the antitumor mechanisms of aminoquinolines, focusing on the responses and differences of tumor histological tissues and toxicity related to pharmacokinetics. This well-defined analysis shows similar mechanistic forms triggered by aminoquinolines in different histological tumor tissues and under coexposure conditions, although different pharmacological potencies also occur. These molecules are lysosomotropic amines th

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… Higher lysosomal pH was observed after 4 h of treatment with known alkalinizer drugs (fluoxetine, imipramine, dimebon, tamoxifen, chlorpromazine, amitriptyline, and verapamil), including chloroquine. …

Chronic Psychological Stress in Oncogenesis: Multisystem Crosstalk and Multimodal Interventions.

Malignant tumors constitute a major global public health burden. Chronic psychological stress (CPS) manifests as sustained dysregulation arising from prolonged adaptive responses to chronic endogenous and exogenous stimuli. Clinical evidence indicates that CPS markedly influences cancer progression, with most oncology patients developing detectable stress-related psychological disorders during disease management. This review synthesizes recent advances in understanding CPS-mediated oncogenic mechanisms and evaluates current intervention approaches. Mechanistically, CPS compromises immune surve

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… In inducing tumor cell apoptosis and cycle arrest, fluoxetine activates the ATF4-AKT-mTOR signaling axis, triggering endoplasmic reticulum stress and protective autophagy, which blocks NSCLC at the G0/G1 phase without damaging normal lung epithelial cells [ 32 ]. …

Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016-2022).

Fluorine is characterized by high electronegativity and small atomic size, which provide this molecule with the unique property of augmenting the potency, selectivity, metabolic stability, and pharmacokinetics of drugs. Fluorine (F) substitution has been extensively explored in drug research as a means of improving biological activity and enhancing chemical or metabolic stability. Selective F substitution onto a therapeutic or diagnostic drug candidate can enhance several pharmacokinetic and physicochemical properties such as metabolic stability and membrane permeation. The increased binding a

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… Since the introduction of the first fluorocorticosteroid, namely fludrocortisone, in 1954 [ 9 ], the fluorinated drug market has grown exponentially, with these medicines accounting for 20% of those on the market, and approximately 30% of them becoming blockbusters, such as Lipitor, Fluoxetine, Linezolid …

Primed for global coronavirus pandemic: Emerging research and clinical outcome.

The global effort to combat and contain the coronavirus disease 2019 (COVID-19) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now proceeding on a war footing. The world was slow to react to the developing crisis, but once the contours of the impending calamity became evident, the different state and non-state actors have raced to put their act together. The COVID-19 pandemic has blatantly exposed the shortcomings of our healthcare system and the limitations of medical science, despite considerable advances in recent years. To effectively tack

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… ClinicalTrials.gov ) | Interacts with the ubiquitin E3 ligase cereblon 92 | Ivermectin ( 95 ) | Qazvin University of Medical Sciences, Iran | Phase-III IRCT20200408046987N1(ICTPR) | Anti-parasitic 93 | Ibrutinib ( 96 ) | AbbVie Inc., USA | Phase-II NCT04375397 ( ClinicalTrials.gov ) | Protein kinase inhibitor 94 | Fluoxetine …

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

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… . | Curcumin as nutraceutical in patients of depression | Major depressive disorder | Dietary Supplement: Curcumin Drug: Fluoxetine | Completed 2. | Premedication with curcumin on post-endodontic pain | Acute pulpitis | Drug: Curcumin | Completed Dietary Supplement: 400 mg starch 3. | Curcumin during …

Mechanisms of Chemotherapy-Induced Neurotoxicity.

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been extensively used in the clinic as the main cancer treatment either alone or as an adjuvant therapy before and after surgery. Although the use of chemotherapeutic drugs improved the survival of cancer patients, these drugs are notorious for causing many severe side effects that significantly reduce the efficacy of anti-cancer treatment and patients' quality of life. Many widely used chemotherapy drugs including platinum-based agents, taxanes, vinca alkaloids, proteasome inhibitors, and thalidomide ana

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… The selective serotonin reuptake inhibitors that are safe to use with tamoxifen include citalopram, sertraline, and escitalopram ( Barton et al., 2010 , Freeman et al., 2011 , Loprinzi et al., 2009 ); paroxetine and fluoxetine should be avoided because they inhibit the cytochrome P450 2D6 pathway ( Carris …

A comprehensive review on pain: Model, target, therapy, and prospect (Review).

Pain serves as both a protective physiological response essential for species survival and a global health issue affecting human well‑being and societal development. The present review systematically summarized and analyzed the research progresses on pain through a multidimensional analytical framework encompassing animal models, molecular targets, therapeutic approaches and future prospects. In animal modeling, neuropathic pain paradigms have evolved from traditional mechanical compression to composite models that combine dynamic displacement and chemical stimulation. Cancer‑induced pain mode

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… Common agents included tricyclic anti-depressants (TCAs), selective serotonin reuptake inhibitors (fluoxetine, sertraline) and serotonin-norepinephrine reuptake inhibitors (venlafaxine, duloxetine). …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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… related to SJS/TEN and comparison with US FDA label Anti-epileptic drugs/antipsychotics US FDA n (%) Carbamazepine Labeled 268 26.07 Phenytoin Labeled 137 13.33 Lamotrigine Labeled 104 10.12 Phenobarbital Labeled 21 2.04 Oxcarbazepine Labeled 18 1.75 Valproic acid Labeled 2 0.19 Bupropion Labeled 1 0.10 Fluoxetine … Anti-epileptic drugs/antipsychotics | US FDA | n | (%) Carbamazepine | Labeled | 268 | 26.07 Phenytoin | Labeled | 137 | 13.33 Lamotrigine | Labeled | 104 | 10.12 Phenobarbital | Labeled | 21 | 2.04 Oxcarbazepine | Labeled | 18 | 1.75 Valproic acid | Labeled | 2 | 0.19 Bupropion | Labeled | 1 | 0.10 Fluoxetine …

Clinical Practice Guidelines for Menopause: An Executive Summary and Recommendations: Indian Menopause Society 2026.

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Кровавая добавка и болезни человека: обзор клинических испытаний.

Медицинальные свойства турмеров (Curcuma longa L.) — растения, использовавшегося на протяжении веков в качестве противовоспалительного средства, объясняются его полифеноловыми каркуминоидами, где преобладает кёркумин. Хотя «куркуминовые» добавки являются топ-продаваемыми ботаническими с перспективными доклиническими эффектами, остаются вопросы о биологической активности у человека. Для решения этой проблемы был проведен обзор аналитического исследования с целью оценки клинических испытаний человека, в ходе которых сообщалось о пероральном воздействии каркумина на результаты лечения. Eight :: п

Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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15th Конгресс Европейской ассоциации клинической фармакологии и терапии (ЕАКПТ)

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Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs.

Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enh

The Clinical Application of Ozonetherapy

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ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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