Результаты поиска

Physical activity programming and counseling preferences among cancer survivors: a systematic review.

BackgroundPhysical activity (PA) participation and adherence among cancer survivors is low, despite research indicating numerous physical, psychological and emotional health benefits of exercise. Tailoring exercise programs specific to the PA preferences in cancer survivors has merit for increasing PA participation and adherence to accrue these benefits. This systematic review identifies and differentiates PA programming and counseling preferences of adult cancer survivors across various cancer survivor groups.MethodsPubMed, SPORTDiscus, Scopus, PsycINFO, EMBASE, Web of Science and CINAHL were

Совпадение в полном тексте источника
… Of the studies assessing mixed cancer survivors, survivors were diagnosed with a wide range of cancer types including breast, prostate, colorectal, lymphoma, gynecological, hematological, sarcoma, lung, head and neck, non-Hodgkin lymphoma, leiomyosarcoma, genitourinary, gastrointestinal, melanoma, prostate …

Primary hyperhidrosis: an updated review.

BACKGROUND: Hyperhidrosis (HH) is a condition characterized by excessive sweating beyond the physiological needs of thermoregulation. HH can be classified as primary (idiopathic) hyperhidrosis (PHH) or secondary hyperhidrosis (SHH), which is associated with underlying medical conditions, medications or systemic disorders. This narrative review provides an updated overview of PHH, with a focus on epidemiology, aetiopathogenesis, clinical manifestations, diagnostic approaches and current management strategies, particularly highlighting pharmacological and procedural treatment options. METHODS:

Совпадение в полном тексте источника
… Lung cancer, renal cancer, melanoma, carcinoid tumours, pheochromocytomas, histiocytosis, systemic mastocytosis, metastatic chondroblastoma, breast carcinoma, cholangiocarcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, prostate adenocarcinoma, hepatocellular carcinoma, Kaposi sarcoma, leiomyosarcoma …

Interpreting clinical assays for histone deacetylase inhibitors.

As opposed to genetics, dealing with gene expressions by direct DNA sequence modifications, the term epigenetics applies to all the external influences that target the chromatin structure of cells with impact on gene expression unrelated to the sequence coding of DNA itself. In normal cells, epigenetics modulates gene expression through all development steps. When "imprinted" early by the environment, epigenetic changes influence the organism at an early stage and can be transmitted to the progeny. Together with DNA sequence alterations, DNA aberrant cytosine methylation and microRNA deregulat

Совпадение в полном тексте источника
… Prostate, colorectal, leiomyosarcoma, and esophageal cancers were treated in combination with 5-aza ( Table 3, C ), 68 metastatic colorectal cancer with fluorouracil 5-FU as a 24-hour continuous intravenous infusion (CIV). 69 With 5-aza, no re-expression of E-cadherin, endothelin B, and glutathione S …

A Review on Curability of Cancers: More Efforts for Novel Therapeutic Options Are Needed.

Cancer remains a major cause of death globally. Given its relapsing and fatal features, curing cancer seems to be something hardly possible for the majority of patients. In view of the development in cancer therapies, this article summarizes currently available cancer therapeutics and cure potential by cancer type and stage at diagnosis, based on literature and database reviews. Currently common cancer therapeutics include surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy. However, treatment with curative intent by these methods are mainly eligible for patients with loca

Совпадение в полном тексте источника
… In addition, chemotherapy is associated with a higher risk of a secondary malignancy, with increased risk of bone tumours and leiomyosarcoma after addition of an alkylating agent to radiotherapy for treatment of hereditary retinoblastoma [ 135 ]. …

Материалы Международного общества по картированию раковых заболеваний (ИСИС) 18th Ежегодный учебный курс: Ментон, Франция. 7-9 октябрь 2018

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Exploring viral mimicry combined with epigenetics and tumor immunity: new perspectives in cancer therapy.

Viral mimicry refers to an active antiviral response triggered by the activation of endogenous retroviruses (ERVs), usually manifested by the formation of double-stranded RNA (dsRNA) and activation of the cellular interferon response, which activates the immune system and produces anti-tumor effects. Epigenetic studies have shown that epigenetic modifications (e.g. DNA methylation, histone modifications, etc.) play a crucial role in tumorigenesis, progression, and treatment resistance. Particularly, alterations in DNA methylation may be closely associated with the suppression of ERVs expressio

Совпадение в полном тексте источника
… inhibitors improve the effect of chemotherapeutic agents in SW48 and HT-29 colorectal cancer cells PLoS One 2014 9 e92305 24676085 10.1371/journal.pone.0092305 PMC3967992 173 De Carvalho Fischer C Hu Y Morreale M Lin WY Wali A Thakar M Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma …

Proteasome Inhibitors and Their Potential Applicability in Osteosarcoma Treatment.

Osteosarcoma (OS) is the most common type of bone cancer, with ~30% of patients developing secondary/metastatic tumors. The molecular complexity of tumor metastasis and the lack of effective therapies for OS has cultivated interest in exploiting the proteasome as a molecular target for anti-cancer therapy. As our understanding towards the behavior of malignant cells expands, it is evident that cancerous cells display a greater reliance on the proteasome to maintain homeostasis and sustain efficient biological activities. This led to the development and approval of first- and second-generation

Совпадение в полном тексте источника
… Only one patient with leiomyosarcoma confirmed a partial response [ 83 ]. One OS patient was included but their response was not specified [ 83 ]. Two pediatric OS patients received bortezomib in a different phase I dose escalation study without experiencing objective responses [ 102 ]. …

Emergency Care

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Biomaterials from the sea: Future building blocks for biomedical applications.

Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in t

Совпадение в полном тексте источника
… In this clinical trial, patients with metastatic leiomyosarcoma or liposarcoma after failure of conventional chemotherapy were included. Recall after ten years of treatment demonstrated acceptable treatment outcomes without detrimental side effects. …

The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.

The bidirectional crosstalk between the nervous system and tumors has emerged as a transformative new frontier in both precision oncotherapy and mechanism-driven cancer pain management. Marine natural products with inherent neuroactive properties exhibit unparalleled intervention advantages for targeting this complex pathophysiological axis. Herein, we systematically and prospectively dissect the multi-layered bidirectional communication between the nervous system and malignancies, comprehensively summarize the pivotal contributions of marine-derived bioactive molecules to advances in neurosci

Совпадение в полном тексте источника
… Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules. J. Clin. Oncol. 2009;27:4188–4196. doi: 10.1200/jco.2008.21.0088. 88. …

Chronic Psychological Stress in Oncogenesis: Multisystem Crosstalk and Multimodal Interventions.

Malignant tumors constitute a major global public health burden. Chronic psychological stress (CPS) manifests as sustained dysregulation arising from prolonged adaptive responses to chronic endogenous and exogenous stimuli. Clinical evidence indicates that CPS markedly influences cancer progression, with most oncology patients developing detectable stress-related psychological disorders during disease management. This review synthesizes recent advances in understanding CPS-mediated oncogenic mechanisms and evaluates current intervention approaches. Mechanistically, CPS compromises immune surve

Совпадение в полном тексте источника
… In soft-tissue sarcomas (leiomyosarcoma, liposarcoma, angiosarcoma, and solitary fibrous tumor), propranolol synergistically inhibits multidrug resistance and survival pathways to overcome β-adrenergic signaling-linked chemotherapy resistance, demonstrating enhanced tumor control with doxorubicin or …

Antibody drug conjugates in the clinic.

Antibody-drug conjugates (ADCs), chemotherapeutic agents conjugated to an antibody to enhance their targeted delivery to tumors, represent a significant advancement in cancer therapy. ADCs combine the precise targeting capabilities of antibodies and the potent cell-killing effects of chemotherapy, allowing for enhanced cytotoxicity to tumors while minimizing damage to healthy tissues. Here, we provide an overview of the current clinical landscape of ADCs, highlighting 11 U.S. Food and Drug Administration (FDA)-approved products and discussing over 500 active clinical trials investigating newer

Совпадение в полном тексте источника
… advanced nonsmall cell nonsquamous lung cancer | MMAE | 1 | NCT05652868 SHR‐A1403 | Advanced solid tumor | Undisclosed Microtubule Inhibitor | 1 | NCT03856541 AXL | CAB‐AXL‐ADC | Nonsmall‐cell lung cancer | MMAE | 2 | NCT04681131 Solid tumor; NSCLC; melanoma; sarcoma; sarcoma, ewing; osteosarcoma; leiomyosarcoma …

Терапевтические и диагностические проблемы передневременного слабоумия.

В поисках терапевтических модификаторов фронтовременное слабоумие (ФТР) традиционно омрачалось другими заболеваниями, такими, как болезнь Альцгеймера (AD). Будучи клиническим и патологическим по своему характеру заболеванием, ПТО было вызвано рядом недавних открытий, таких, как новые генетические варианты семейных и спорадических форм заболеваний и выявление белка, связывающего ДНК с ДНК. 43 kDa (kDa)TDP-43) в качестве определяющего компонента включения более чем в половине случаев. В сочетании с постоянно расширяющимися знаниями о функции и дисфункции белка тау-а, который патологически агреги

mRNA Vaccines: Current Applications and Future Directions.

Messenger RNA (mRNA) vaccines, as a novel class of biotherapeutics, leverage mRNA technology to instruct cells to produce specific antigens, thereby inducing an immune response. In recent years, significant progress has been made in applying these vaccines to infectious disease prevention and cancer treatment. Compared with traditional vaccines, mRNA vaccines offer high programmability, as well as greatly enhanced stability and immunogenicity, achieved through nucleotide modifications and advanced delivery systems such as lipid nanoparticles. However, many challenges remain in the design and d

Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach.

Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation or suppression of immune components such as CD4+ T cells, CD8+ T cells, B cells, monocytes, macrophages, dendritic cells, and natural killer cells. By targeting several immune checkpoint inhibitors or blockers (e.g., PD-1, PD-L1, PD-L2, CTLA-4, LAG3, and TIM-3) expressed on the surface of immune cells, several monoclonal antibodies and polyclonal antibodies have been develop

Совпадение в полном тексте источника
… Zatersky et al. reported that the JAK1 and JAK2 mutations and the β2M mutation led to defects in interferon signaling and antigen presentation, respectively, in melanoma patients, and the same was true for the PTEN mutation in uterine leiomyosarcoma patients who initially responded to Pembrolizumab [ …

NRF2: A crucial regulator for mitochondrial metabolic shift and prostate cancer progression.

Metabolic alterations are a common survival mechanism for prostate cancer progression and therapy resistance. Oxidative stress in the cellular and tumor microenvironment dictates metabolic switching in the cancer cells to adopt, prosper and escape therapeutic stress. Therefore, regulation of oxidative stress in tumor cells and in the tumor-microenvironment may enhance the action of conventional anticancer therapies. NRF2 is the master regulator for oxidative stress management. However, the overall oxidative stress varies with PCa clinical stage, metabolic state and therapy used for the cancer.

Совпадение в полном тексте источника
… Advanced solid tumors ARQ 501 in subjects with cancer | Cancer ARQ 501 in combination with gemcitabine in subjects with pancreatic cancer | Pancreatic cancer ARQ-761 treatment in pancreatic cancer in gemcitabine/Nab-paclitaxel chemotherapy | Pancreatic cancer Safety and Efficacy Study of ARQ 501 | Leiomyosarcoma …

What Zebrafish and Nanotechnology Can Offer for Cancer Treatments in the Age of Personalized Medicine.

Cancer causes millions of deaths each year and thus urgently requires the development of new therapeutic strategies. Nanotechnology-based anticancer therapies are a promising approach, with several formulations already approved and in clinical use. The evaluation of these therapies requires efficient in vivo models to study their behavior and interaction with cancer cells, and to optimize their properties to ensure maximum efficacy and safety. In this way, zebrafish is an important candidate due to its high homology with the human genoma, its large offspring, and the ease in developing specifi

Совпадение в полном тексте источника
… Embryos developed mainly hepatic and mesenchymal neoplasms, including chondroma, hemangioma, hemangiosarcoma, leiomyosarcoma, and rhabdomyosarcoma. …

Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review.

Cancer immunotherapy-including immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT)-has become a standard, potentially curative treatment for a subset of advanced solid and liquid tumors. However, most patients with cancer do not benefit from the rapidly evolving improvements in the understanding of principal mechanisms determining cancer immune responsiveness (CIR); including patient-specific genetically determined and acquired factors, as well as intrinsic cancer cell biology. Though CIR is multifactorial, fundamental concepts are emerging that should be considered for the desi

Advances and clinical applications of immune checkpoint inhibitors in hematological malignancies.

Immune checkpoints are differentially expressed on various immune cells to regulate immune responses in tumor microenvironment. Tumor cells can activate the immune checkpoint pathway to establish an immunosuppressive tumor microenvironment and inhibit the anti-tumor immune response, which may lead to tumor progression by evading immune surveillance. Interrupting co-inhibitory signaling pathways with immune checkpoint inhibitors (ICIs) could reinvigorate the anti-tumor immune response and promote immune-mediated eradication of tumor cells. As a milestone in tumor treatment, ICIs have been first

Tumour-associated macrophages: versatile players in the tumour microenvironment.

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and anti-cancer activities are reported, including not only angiogenesis, extracellular matrix remodeling, immunosuppression, drug resistance but also phagocytosis and tumour regression. Interestingly, TAMs are highly dynamic and versatile in solid tumours. They show anti-cancer or pro-tumour activities, and interplay between the tumour microenvironment and cancer stem cells and under specific conditions. In addition to the c

Совпадение в полном тексте источника
… Recruiting | NCT04126876 | 2019 Phase1 | Pancreatic Cancer and Metastatic Pancreatic Cancer | Recruiting | NCT04612530 | 2020 Phase1 | Lung Cancer and Hepatocellular Carcinoma and Solid Tumour | Recruiting | NCT04952272 | 2021 Poly(I:C) | Phase1 | Prostate Cancer | Completed | NCT03412786 | 2018 Phase1 | Leiomyosarcoma …