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Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery.

Drug repurposing is a method of investigating new therapeutic applications for previously approved medications. This repurposing approach to "old" medications is now highly efficient, simple to arrange, and cost-effective and poses little risk of failure in treating a variety of disorders, including cancer. Drug repurposing for cancer therapy is currently a key topic of study. It is a way of exploring recent therapeutic applications for already-existing drugs. Theoretically, the repurposing strategy has various advantages over the recognized challenges of creating new molecular entities, inclu

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… When the pH was altered to highly acidic, as in tumor extracellular pH, the hydrophobic nature of the flower-like micelles altered, causing the microsphere core to rupture and enabling rapid release of drugs. 158 For doxorubicin, we also created adjacent fluorescent probes on reduction-sensitive polymeric … A Smart Flower-Like Polymeric Micelle for pH-Triggered Anticancer Drug Release . J. International Journal of Pharmaceutics 2009 , 375 , 163 – 169 . 10.1016/j.ijpharm.2009.04.005 . 19481702 Xing T. ; Mao C. Q. ; Lai B. ; Yan L. F. …

Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective.

Cancer stem cells (CSCs) are characterized by intrinsic self-renewal and tumorigenic properties, and play important roles in tumor initiation, progression, and resistance to diverse forms of anticancer therapy. Accordingly, targeting signaling pathways that are critical for CSC maintenance and biofunctions, including the Wnt, Notch, Hippo, and Hedgehog signaling cascades, remains a promising therapeutic strategy in multiple cancer types. Furthermore, advances in various cancer omics approaches have largely increased our knowledge of the molecular basis of CSCs, and provided numerous novel targ

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… In recent decades, a wide variety of lipid-based nanoparticles have been reported, including solid lipid nanoparticles, liposomes, micelles, and emulsions [ 144 , 145 , 146 ]. … Mixed Nanosized Polymeric Micelles as Promoter of Doxorubicin and miRNA-34a Co-Delivery Triggered by Dual Stimuli in Tumor Tissue Small 2016 12 4837 4848 10.1002/smll.201600925 27432595 PMC5157154 84. Ortega M. Bhatnagar H. Lin A.P. Wang L. Aster J.C. Sill H. Aguiar R.C. …

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines.

Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional

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… To overcome the problem, OST was successfully loaded into N-caprinoyl-N-trimethyl chitosan (CA-TMC, an amphiphilically modified chitosan derivative) as micelles, and the results showed that OST/CA-TMC micelles exhibited significant anticancer activity with potent cytotoxicity and apoptosis induction …

Обычные, биоаналогичные и последующие небиологические сложные лекарственные средства для многоразового склероза: наглядный обзор нормативных и клинических последствий для европейских нееврологий.

Множественный склероз (МС) создает для пациентов значительное социально-экономическое бремя в связи с его ранним наступлением и прогрессивным характером, однако на системы здравоохранения также влияют высокие издержки, связанные с лечением болезней (ДМТ). Использование непатентованных (для обычных лекарственных средств), биоаналогичных (для биологики) или последующих версий небиологических сложных лекарственных средств (НБЦД) может способствовать снижению стоимости ухода за НР и улучшению доступа пациентов. В настоящем обзоре описываются европейские процессы регулирования этих "копий" DMT и им

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… Instead, they comprise high‐molecular weight molecules and nanoparticular elements, such as liposomes or copolymer micelles. …

A review of immunotherapy for bone tumors.

This article reviews the latest research progress in immunotherapy for bone tumors. Bone tumors are a serious threat to human health, and traditional treatments have limitations. Recently, immunotherapy, as an emerging treatment method, has shown great potential in the treatment of bone tumors. This article systematically introduces the pathological features, traditional treatment methods and limitations of bone tumors, and focuses on the principles, application status and challenges of immune checkpoint inhibitors, CAR-T cell therapy, tumor vaccines and other immunotherapies. At the same time

Synthesis and biological evaluation of a new polymeric conjugate and nanocarrier with osteotropic properties.

Bone-seeking (osteotropic) drug delivery systems (ODDS) represent an interesting solution for targeting different types of drugs to the bones. In particular, anticancer and antibacterial agents could take advantage of such therapeutic strategy. We have recently developed an innovative approach to this aim: a new osteotropic biomaterial was prepared, based on the conjugation of a poly(lactide-co-glycolide) (PLGA) with the bisphosphonate drug alendronate (PLGA-ALE); its hemo- and cytocompatibility were verified. Starting with this copolymer, an osteotropic nanoparticle system (NP) was produced f

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… Figure 1 The possible strategies for selective delivering bioactive compounds to the bone: ( A ) a drug or diagnostic agent D is encapsulated/loaded into a conventional nanocarrier (e.g., polymeric or lipid nanoparticles, liposomes, micelles, etc .) and passive targeting is expected (EPR effect); ( B …

A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications.

Bone damage is a complex orthopedic problem primarily caused by trauma, cancer, or bacterial infection of bone tissue. Clinical care management for bone damage remains a significant clinical challenge and there is a growing need for more advanced bone therapy options. Nanotechnology has been widely explored in the field of orthopedic therapy for the treatment of a severe bone disease. Among nanomaterials, gold nanoparticles (GNPs) along with other biomaterials are emerging as a new paradigm for treatment with excellent potential for bone tissue engineering and regenerative medicine application

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… Preparation of rodlike gold particles by UV irradiation using cationic micelles as a template Langmuir 11 9 1995 3285 3287 91 Shao Y. Jin Y. Dong S. Synthesis of gold nanoplates by aspartate reduction of gold chloride Chem. Commun. 9 2004 1104 1105 10.1039/b315732f 15116206 92 Lin G. Lu W. Cui W. …

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies.

Current drugs against multiple human malignancies are limited, and developing new treatment strategies is improbable within a short time. So, considering the current situation, phytochemicals could be a viable option for developing chemotherapeutic agents for managing numerous types of malignancies. Therefore, we aimed to locate all phytochemicals of Eclipta prostrata and unravel their chemotherapeutic mechanisms and strategies individually. We defined 25 active compounds based on their anticancer activities after filtering through IMPPAT and literature search, and these compounds have chemoth

Therapeutic outcome of early-phase clinical trials in multiple myeloma: a meta-analysis.

Great progress in the treatment of patients with multiple myeloma (MM) has been made due to the development of novel drugs. Patients with relapsed/refractory MM (RRMM) can be enrolled in early-phase clinical trials, but their performance across the last decade is unknown. We conducted a meta-analysis on the overall response rate (ORR) and toxicity. PubMed, Embase, and Cochrane Library were systematically searched for phase I and phase II trials investigating an experimental compound as a single agent or in combination with dexamethasone, published from January 1, 2010 to July 1, 2020. Eighty-e

The investigation of oncolytic viruses in the field of cancer therapy.

Oncolytic viruses (OVs) have emerged as a potential strategy for tumor treatment due to their ability to selectively replicate in tumor cells, induce apoptosis, and stimulate immune responses. However, the therapeutic efficacy of single OVs is limited by the complexity and immunosuppressive nature of the tumor microenvironment (TME). To overcome these challenges, engineering OVs has become an important research direction. This review focuses on engineering methods and multi-modal combination therapies for OVs aimed at addressing delivery barriers, viral phagocytosis, and antiviral immunity in

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… Various targeting ligands incorporated into acoustically active materials, such as nanoparticles ( 170 , 177 ), polymeric micelles, and liposomes ( 178 ), contribute to this effect. …

Обобщение и оценка воздействия нанопчастей аторвастатина и аторвастатина на вызванную ими демиелинацию Cuprizone: модуляция прохода с сигналами Nrf2/NF-kB.

Множественный склероз (MS) является хроническим воспалительным заболеванием центральной нервной системы (CNS), характеризующимся повреждением миелинской оболочки и, со временем, постепенным неврологическим расстройством. Статины привлекли внимание к исследованиям в области MS из-за их антивоспалительных и нейрозащитных эффектов. ЦЕЛИ: В этом исследовании оценивалось, может ли аторвастатин улучшить поведение и гистопатологические изменения мозга мужчины C57BL/6 Мыши. Все группы мышей, за исключением контрольной группы, которая получила нормальное питание, были накормлены 0.2% (КПЗ) в их ежеднев

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… Andalib S, Molhemazar P, Danafar H. in vitro and in vivo delivery of atorvastatin: a comparative study of anti-inflammatory activity of atorvastatin loaded copolymeric micelles. Journal of biomaterials applications. 2018;32(8):1127–38. doi: 10.1177/0885328217750821. 48. …

Linoleate-pazopanib conjugation as active pharmacological ingredient to abolish hepatocellular carcinoma growth.

Small molecule compounds targeting multiple kinases involved in neoangiogenesis have shown survival benefits in patients with unresectable hepatocellular carcinoma (HCC). Nonetheless, despite the beneficial effects of multikinase inhibitors (MKIs), a lack of boosting adjuvant limits their objective response rate. Lipid conjugates have been used to improve delivery efficacy or pharmaceutical benefits for decades. However, the feasibility of utilizing lipid-drug conjugates (LDCs) in HCC regimens remains untested. In this study, oral feeding of linoleate-fluorescein isothiocyanate conjugates show

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… In vivo fate of biomimetic mixed micelles as nanocarriers for bioavailability enhancement of lipid–drug conjugates. ACS Biomaterials Sci. Eng. 3 (10), 2399–2409. 10.1021/acsbiomaterials.7b00380 Mahmud N., Fricker Z., Hubbard R. A., Ioannou G. N., Lewis J. D., Taddei T. H., et al. (2021). …

Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy.

In cancer treatments, many natural and synthetic products have been examined; among them, protease inhibitors are promising candidates for anti-cancer agents. Since dysregulated proteolytic activities can contribute to tumor development and metastasis, antagonization of proteases with tailored inhibitors is an encouraging approach. Although adverse effects of early designs of these inhibitors disappeared after the introduction of next-generation agents, most of the proposed inhibitors did not pass the early stages of clinical trials due to their nonspecific toxicity and lack of pharmacological

Curcumin: An age-old anti-inflammatory and anti-neoplastic agent.

Curcumin is a natural anti-inflammatory agent that has been used for treating medical conditions for many years. Several experimental and pharmacologic trials have demonstrated its efficacy in the role as an anti-inflammatory agent. Curcumin has been shown to be effective in treating chronic conditions like rheumatoid arthritis, inflammatory bowel disease, Alzheimer's and common malignancies like colon, stomach, lung, breast, and skin cancers. As treatments in medicine become more and more complex, the answer may be something simpler. This is a review article written with the objective to syst

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… Curcumin acts to modulate several pathways as enlisted in Table 1 . 7 The wide range of action of curcumin can be demonstrated by its activity in inhibiting lipoxygenase by binding lipoxygenase itself or binding to phosphatidylcholine micelles. 8 Curcumin also inhibits tumor invasion and angiogenesis …

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment.

Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complica

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… technology has progressed to the point that a number of nanomedicines for cancer treatment are already on the market, with many more in advanced phases of development and clinical testing employing various nanosystems, i.e., metallic nanoparticles, liposomes, quantum dots, carbon nanotubes, polymeric micelles … Clinical application of polymeric micelles for the treatment of cancer Mater. Chem. Front. 2017 1 1485 1501 10.1039/C6QM00289G 28. Mukerjee A. Vishwanatha J.K. …

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, h

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… Different curcumin formulations have been designed to enhance its bioavailability, including synthetic curcuminoids, nanoparticles, liposomes, micelles, and phospholipid complexes. … Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo . Nanoscale 3 , 1558 – 1567 . 10.1039/c0nr00758g 21283869 Granados-Castro L. F. Rodriguez-Rangel D. S. Fernandez-Rojas B. Leon-Contreras J. C. Hernandez-Pando R. Medina-Campos O. N. ( 2016 ). …

Immune-based cancer therapies: mechanistic insights, clinical progress, and future directions.

The field of cancer immunotherapy has evolved rapidly, offering new treatment paradigms by harnessing the body's own immune system to target and destroy malignancies. Various immunotherapeutic approaches, including immune checkpoint inhibitors, CAR-T cell therapy, cancer vaccines, cytokine therapies, and oncolytic viruses, have shown significant promise in treating different cancer types. This review provides a comprehensive examination of the historical development and recent advances in cancer immunotherapy. We discuss the mechanisms of action of key immunotherapeutic modalities, along with

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… Copolymer micelles have demonstrated enhanced permeability and retention (EPR) effects when employed for tumor targeting. … The chemical doxorubicin was specifically released at the tumor location, and the modified drug-loaded micelles exhibited anticancer properties in both laboratory and live circumstances [ 171 ]. …

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors.

The ubiquitin-proteasome system (UPS) is a critical regulator of cellular protein levels and activity. It is, therefore, not surprising that its dysregulation is implicated in numerous human diseases, including many types of cancer. Moreover, since cancer cells exhibit increased rates of protein turnover, their heightened dependence on the UPS makes it an attractive target for inhibition via targeted therapeutics. Indeed, the clinical application of proteasome inhibitors in treatment of multiple myeloma has been very successful, stimulating the development of small-molecule inhibitors targetin

Marizomib in the therapy of brain tumors-how far did we go and where do we stand?

Out of several types of tumors of the central nervous system (CNS), glioblastoma (GBM) represents one of the most frequent and malignant forms of brain neoplasms. To date, GBM holds very limited therapeutic options leaving patients with poor prognosis of survival. As such, novel treatment approaches are constantly quested. One of these strategies is based on the utilization of proteasome inhibitors (PIs). However, although several PIs have been approved as therapy for patients with hematological malignancies, these treatment benefits cannot not be easily extrapolated to brain tumors. This is m

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… Liu J Xu X Li Y Xu J Zhao R Liu S Bortezomib-loaded mixed micelles realize a three-in-one effect for enhanced breast cancer treatment Biomater Sci 2023 11 4890 906 10.1039/d3bm00254c 37306225 Liu J, Xu X, Li Y, Xu J, Zhao R, Liu S, et al. … Bortezomib-loaded mixed micelles realize a three-in-one effect for enhanced breast cancer treatment. Biomater Sci. 2023;11:4890–906. 10.1039/d3bm00254c. 37306225 10.1039/d3bm00254c 26. …

Theranostics - a sure cure for cancer after 100 years?

Cancer has remained a formidable challenge in medicine and has claimed an enormous number of lives worldwide. Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer. This review aims to provide an overview of theranostics in oncology: exploring its history, current advances, challenges, and prospects. We present the fundamental evolution of theranostics from radiotherapeutics, cellular therapeutics, and nanotherapeutics, showcasing critical milestones in the last decade. From the early concept of targeted d

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… Tang BZ A Feasible Strategy of Fabricating Type I Photosensitizer for Photodynamic Therapy in Cancer Cells and Pathogens ACS Nano 2021 15 7735 43 33856778 10.1021/acsnano.1c01577 106 Ding H Yu H Dong Y Tian R Huang G Boothman DA Photoactivation switch from type II to type I reactions by electron-rich micelles …