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Evaluation of Preventive Role of Systemically Applied Erythropoietin after Tooth Extraction in a Bisphosphonate-Induced MRONJ Model.

Background and Objectives: In this experimental study, the prophylactic effect of systemically administered erythropoietin (EPO) in medication-related osteonecrosis of the jaw (MRONJ) was evaluated. Materials and Methods: The osteonecrosis model was established using 36 Sprague Dawley rats. EPO was systemically applied before and/or after tooth extraction. Groups were formed based on the application time. All samples were evaluated histologically, histomorphometrically, and immunohistochemically. A statistically significant difference in new bone formation was observed between the groups (p <

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… Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model J. Periodontal Res. 2021 56 735 745 10.1111/jre.12870 33682929 41. Kim T.Y. Park J.K. Prasad Aryal Y. Lee E.S. Neupane S. Sung S. Pokharel E. Yeon C.Y. Kim J.Y. Jung J.K. …

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.

Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disease arising from mutations in the dystrophin gene. Upregulation of utrophin to compensate for the missing dystrophin offers a potential therapy independent of patient genotype. The first-in-class utrophin modulator ezutromid/SMT C1100 was developed from a phenotypic screen through to a Phase 2 clinical trial. Promising efficacy and evidence of target engagement was observed in DMD patients after 24 weeks of treatment, however trial endpoints were not met after 48 weeks. The objective of this study was to understand the mechanism o

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… For example, resveratrol, which while exerting pleiotropic effects, has documented AhR antagonist activity 52 and has been shown to increase utrophin expression and decrease inflammation in mdx mice. 53 Furthermore, AhR agonist PCB‐126 has been shown to decrease utrophin mRNA expression in rat liver …

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

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… fiber, 2.4% proteins, 3.2% volatile oil containing aromatic turmerone, dihydroturmerone, turmeronol, curdione, bisacurone | ( 135 ) Infla-Kine | Proprietary blend of Lactobacillus fermentum extract, burdock seed, zinc, lipoic acid, papaya enzyme, BCM-95 | ( 144 ) Killox | 190 mg curcuminoids, 20 mg resveratrol … total curcuminoids), zeaxanthin (4 mg) from marigold flower extract, algal source vitamin D3 (600 IU), medium chain triglyceride oil, linseed oil, olive oil, sunflower lecithin, tocopherol and thyme oil | ( 147 ) natural product capsule by Vitacost | Each 500 mg capsule contain 150 mg curcumin, 75 mg resveratrol …

Exploring the Contribution of Curcumin to Cancer Therapy: A Systematic Review of Randomized Controlled Trials.

Although the anticancer role of curcumin has been extensively addressed in preclinical research, only a few studies were carried out in humans, with conflicting results. The aim of this systematic review is to collate together the results of the therapeutic effect of curcumin in cancer patients. A literature search was carried out in Pubmed, Scopus, and the Cochrane Central Register of Controlled Trials up to 29 January 2023. Only randomized controlled trials (RCTs) designed to evaluate the effects of curcumin on cancer progression, patient survival, or surgical/histological response were incl

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… pharmacokinetics of curcumin; RCTs whose outcomes were assessed through soft endpoints or related to local effects of curcumin on mucositis, radiodermatitis and other skin lesions; RCTs analyzing the effects of curcumin in combination with other nutraceuticals (e.g., piperine to improve bioavailability or resveratrol …

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Osteonecrosis of the femoral head (ONFH) is a debilitating disease that is closely associated with the clinical application of high-dose glucocorticoids. Elevated oxidative stress contributes to the pathophysiological changes observed in ONFH. The lack of effective treatments besides surgical intervention highlights the importance of finding novel therapeutics. Our previous studies demonstrated that D7, a cyclic polypeptide, enhances the adhesion, expansion, and proliferation of bone marrow mesenchymal stem cells (BMSCs). Therefore, in this study, we investigated the therapeutic effects of D7

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… Resveratrol protects against titanium particle-induced aseptic loosening through reduction of oxidative stress and inactivation of NF- κ B Inflammation 2016 39 2 775 785 26878849 10.1007/s10753-016-0306-6 14 Willems P. H. Rossignol R. Dieteren C. E. Murphy M. P. Koopman W. J. …

A Novel Hydroxamic Acid-Based Curcumin Derivative as Potent Histone Deacetylase Inhibitor for the Treatment of Glioblastoma.

Glioblastoma (GBM) is one of the most common primary and deadliest malignant brain tumor with chemoresistance and poor prognosis. There is a lack of effective chemotherapeutic drug for the treatment of GBM. In this work, we reported the preparation of a histone deacetylase (HDAC) inhibitor, DMC-HA, from the structural modification of natural product curcumin. DMC-HAs were tested in an HDAC inhibition assay and an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for cytotoxicity. It showed potent inhibition of HDAC1-2 and HDAC6 with IC50 values in the submicromolar conce

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… Indeed, several natural products have been found to exhibit anticancer activities by affecting HDACs, like resveratrol, heliomycin chalcones, and curcumin ( 20 ). Curcumin is a polyphenol extracted from turmeric, which exhibits diverse and broad pharmacological activities ( 21 ). …

Anti-Inflammatory Drugs as Anticancer Agents.

Inflammation is strictly associated with cancer and plays a key role in tumor development and progression. Several epidemiological studies have demonstrated that inflammation can predispose to tumors, therefore targeting inflammation and the molecules involved in the inflammatory process could represent a good strategy for cancer prevention and therapy. In the past, several clinical studies have demonstrated that many anti-inflammatory agents, including non-steroidal anti-inflammatory drugs (NSAIDs), are able to interfere with the tumor microenvironment by reducing cell migration and increasin

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… Natural Products Different foods or natural products have shown anti-inflammatory effects such as grapes/red wine (resveratrol), garlic (various compounds), curry powder (curcumin) [ 153 , 154 , 155 , 156 , 157 ]. …

Targeting the NLRP3 inflammasome in kidney disease: molecular mechanisms, pathogenic roles, and emerging small-molecule therapeutics.

Inflammatory responses represent a core pathological process driving the progression of both acute and chronic kidney diseases. As a key effector of the innate immune system, the NLRP3 inflammasome is widely activated in renal resident cellsand infiltrating immune cells, positioning it as a critical nexus linking metabolic dysregulation, cellular stress, and tissue injury. Accumulating preclinical and clinical evidence in recent years demonstrates that aberrant activation of the NLRP3 inflammasome directly promotes glomerular damage, tubulointerstitial inflammation, fibrosis, and vascular dysf

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… The potential renal protective effect of resveratrol in a rat model of gouty nephropathy may involve inhibiting the NF-κB signaling pathway, subsequently suppressing NLRP3 activation to block the recruitment of Caspase-1 for IL-1β and IL-18, reducing their secretion, inhibiting the occurrence of pyroptosis … Research suggests that the potential renal protective effect of resveratrol in a rat model of gouty nephropathy may involve inhibiting the NF-κB signaling pathway, subsequently suppressing NLRP3 activation to block the recruitment of caspase-1 for IL-1β and IL-18, reducing their secretion, inhibiting …

Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.

Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation of redox signaling-driven by genetic mutations, epigenetic alterations, and posttranscriptional or posttranslational modifications-plays a central role in malignant transformation and cancer progression. Cancer cells typically exhibit elevated basal ROS levels due to increased metabolic activity, mitochondrial dysfunction, and oncogene activation. This mode

Роль ИЛ-17А в предотвращении воспламенительных реакций и прогрессии нейродегенеративных заболеваний.

IL-17A был замешан в качестве критического провоспалительного цитокина в патогенезе аутоиммунных и нейродегенеративных расстройств. Появляющиеся данные свидетельствуют о его способности активировать микроглиальные клетки и астроциты, что впоследствии приводит к созданию подстрекательских посредников, усугубляющих нейронные травмы и функциональные нарушения. Клинические наблюдения выявили продемонстрированную связь между концентрациями ИЛ-17А и дисфункцией мозгового барьера (ББД), создав патологический цикл обратной связи, усиливающий нейровоспалительные реакции. Последние достижения свидетельс

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… Dou et al. demonstrated that resveratrol ameliorates intestinal epithelial and vascular permeability caused by transient middle cerebral artery occlusion (tMCAO). This protective effect was achieved by modulating the intestinal microbiota. …

От ожирения до митохондриальной дисфункции в периферальных тканях и в центральной нервной системе.

Ожирение - это состояние хронического низкосортного воспаления, затрагивающего периферийные органы тела, а также центральную нервную систему. Дефункция жировой ткани, возникающая в условиях ожирения, является ключевым фактором возникновения и развития различных заболеваний, включая нейродегенеративные расстройства. Митохондрия, ключевые органеллы в производстве клеточной энергии, играет важную роль в этой дисфункции тканей. В многочисленных исследованиях подчеркивается тесная связь между ожирением и дисфункцией митохондриалов адипоцита, что приводит к чрезмерному производству ROS и воспалению

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… Resveratrol (RES, 3, 5, 4′-trihydroxystilbene) and curcumin (CM) have been proven to have cytoprotective effects, preventing and/or minimizing cellular and mitochondrial damage. …

Advances and development of prostate cancer, treatment, and strategies: A systemic review.

The most common type of cancer in the present-day world affecting modern-day men after lung cancer is prostate cancer. Prostate cancer remains on the list of top three cancer types claiming the highest number of male lives. An estimated 1.4 million new cases were reported worldwide in 2020. The incidence of prostate cancer is found predominantly in the regions having a high human development index. Despite the fact that considerable success has been achieved in the treatment and management of prostate cancer, it remains a challenge for scientists and clinicians to curve the speedy advancement

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… Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int. J. Cancer 125 (1), 1–8. 10.1002/ijc.24336 Omabe K., Paris C., Lannes F., Taïeb D., Rocchi P. (2021). …

Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials.

Curcuminoids are bioactive polyphenols, mainly extracted from Curcuma longa (turmeric), and have received much attention due to their pleiotropic anticancer properties. Recent evidence suggests that curcumin and analogs prevent the activation of a variety of signaling pathways, including the MAPK, PI3K/Akt, and NF-kB pathways, resulting in the induction of apoptosis, prevention of proliferation, and suppression. In addition to these processes, curcumin has been shown to enhance the efficacy of the conventional anti-cancer modalities such as radiation and chemotherapy. By suppressing the expres

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… Natural compounds like curcumin and resveratrol can reduce oxidative stress by suppressing these pathways and restoring redox balance (Abdollahi et al. 2021 ). …

Sphingolipid metabolism and hematologic disorders: current understanding and future directions.

Sphingolipids are not only key structural components of cell membranes but also serve as important signaling molecules, and their metabolic homeostasis is essential for the maintenance of cellular functions. In recent years, with the advancement of technologies such as metabolomics, studies have revealed that sphingolipid metabolic abnormalities are extensively involved in the occurrence and development of various hematological disorders, including immune thrombocytopenia, myeloproliferative neoplasms, graft-versus-host disease, hereditary hematological diseases, and hematologic malignancies.

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… Furthermore, resveratrol exerts antiproliferative and pro-apoptotic effects in FLT3-ITD-positive AML cells by downregulating the expression of sphingosine kinase-1 (SK-1) and glucosylceramide synthase (GCS) ( Ersöz and Adan, 2022 ). …

Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets.

The onerous health and economic burden associated with head and neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of novel surgical techniques and therapeutic protocols, there is an incessant need for efficacious diagnostic and therapeutic targets to monitor the invasion, metastasis and recurrence of HNSCC due to its substantial morbidity and mortality. The differential expression patterns of histone deacetylases (HDACs), a group of enzymes responsible for modifying histones and regulating gene expression, have been demonstrated in neoplastic tissues. However, th

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… Among these, the most extensively studied class of sirtuin agonists is known as SIRT1-activating compounds (STACs), with resveratrol being a prominent example [ 205 ]. … Resveratrol has demonstrated its ability to significantly and specifically increase the affinity of SIRT1 for its substrate small peptides and to effectively promote the deacetylase activity of SIRT1 [ 206 ]. …

Chemotherapy-induced acute kidney injury: epidemiology, pathophysiology, and therapeutic approaches.

Despite significant advancements in oncology, conventional chemotherapy remains the primary treatment for diverse malignancies. Acute kidney injury (AKI) stands out as one of the most prevalent and severe adverse effects associated with these cytotoxic agents. While platinum compounds are well-known for their nephrotoxic potential, other drugs including antimetabolites, alkylating agents, and antitumor antibiotics are also associated. The onset of AKI poses substantial risks, including heightened morbidity and mortality rates, prolonged hospital stays, treatment interruptions, and the need for

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… Various animal and human studies have demonstrated that several natural products and antioxidants, including Resveratrol, Quercetin, Lycopene, Melatonin, Capsaicin, vitamins C and E, Selenium, Glutamine, and N-acetylcysteine (NAC) are potentially effective in reducing CIA due to their anti-inflammatory … Resveratrol attenuates cisplatin-induced nephrotoxicity in rats. Arch Toxicol. (2008) 82:363–70. doi: 10.1007/s00204-007-0262-x 90. Tan R, Wang C, Deng C, Zhong X, Yan Y, Luo Y, et al. …

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies.

The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor progn

Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.

Patients with multiple myeloma, an incurable malignancy of plasma cells, frequently develop osteolytic bone lesions that severely impact quality of life and clinical outcomes. Eliglustat, a U.S. Food and Drug Administration-approved glucosylceramide synthase inhibitor, reduced osteoclast-driven bone loss in preclinical in vivo models of myeloma. In combination with zoledronic acid, a bisphosphonate that treats myeloma bone disease, eliglustat provided further protection from bone loss. Autophagic degradation of TRAF3, a key step for osteoclast differentiation, was inhibited by eliglustat as ev

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… Khusbu FY Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration Int. J. Biochem. Cell Biol. 2020 118 105644 31712163 10.1016/j.biocel.2019.105644 Khusbu, F. Y. et al. … Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration. Int. J. Biochem. Cell Biol. 118 , 105644 (2020). 31712163 10.1016/j.biocel.2019.105644 43. …

Воздействие расширительного энергетического субстрата на козлятину, хранящуюся в 17 °С.

Искусственное оплодотворение у коз, как правило, зависит от охлажденных доз спермы, однако оптимальный энергетический субстрат для поддержания метаболизма спермы остается неясным. Цель этого исследования состояла в том, чтобы оценить воздействие различных энергетических субстратов на метаболизм спермы козла и спермы козлятины и их моторность при охлаждении 17 °С. Семя от six Козлы мужского пола Мурциано-Гранадина были собраны и разбавлены в ПБД, дополненных 35 mM глюкозы, фруктозы, пируваты или лактата в ходе первого эксперимента. В ходе второго эксперимента оценивалось воздействие различных к

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… Improving the quality of cryopreserved goat semen with a commercial bull extender supplemented with resveratrol Anim. Reprod. Sci. 2019 208 106127 31405456 10.1016/j.anireprosci.2019.106127 12. Mocé E. Lozano-Palazón S.A. Martínez-Granell M.D.M. Mocé M.L. Gómez E.A. …

Роль полиморфизмов гена SIRT1 и его уровня в сыворотке у пациентов с множественной скlerозом

Цель: Цель данной работы заключалась в исследовании распространенности генетических вариантов SIRT1 rs3818292, rs3758391 и rs7895833, а также уровней SIRT1 в сыворотке крови, связанных с множественной скlerозой (МС) в литовской популяции. Методы: В исследовании участвовали 250 пациентов с МС и 250 здоровых контрольных лиц. Генотипирование проводилось с использованием метода RT-PCR. Статистический анализ был выполнен с использованием «IBM SPSS version 29.0». Уровень SIRT1 в сыворотке крови определялся методом ELISA. Результаты: Мы обнаружили, что rs3818292 ассоциирован с увеличением шансов разв

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… Alzheimer’s Disease Cooperative Study A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015;85:1383–1391. doi: 10.1212/WNL.0000000000002035. 18. Ntetsika T., Papathoma P.E., Markaki I. Novel targeted therapies for Parkinson’s disease. Mol. …