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Impact of Age on Mortality and Decompensation Events in Patients With Liver Cirrhosis: A Multicenter, Propensity Score Matched Study.

BACKGROUND: The incidence of cirrhosis is increasing in the older population. Limited data are available on the disease progression and mortality in the older population with cirrhosis. This study is aimed at evaluating the impact of age at diagnosis on all-cause mortality and decompensation events in patients with liver cirrhosis. METHODS: This is a retrospective cohort study utilizing TriNetX. ICD codes were used to identify individuals with the diagnosis of liver cirrhosis between the ages of 20 and 80. Patients with the diagnosis of congestive heart failure (CHF), end-stage renal disease

Characterization of health indices and socio-demographic correlates of HIV infection recency among newly diagnosed patients in Lagos, Nigeria: a cross-sectional study.

BACKGROUND: Achieving human immunodeficiency virus (HIV) epidemic control by 2030 requires identifying recent HIV infections to enhance surveillance and enable prompt, targeted interventions. Understanding the pattern of recent versus long-term infections provides critical insight into the dynamics of HIV transmission in specific populations and geographic areas. OBJECTIVES: This study aimed to characterize health indices among newly diagnosed HIV-positive patients at the Lagos University Teaching Hospital HIV Clinic based on their recency test classification as either “recent” or “long-term”

Low blood CD8+ T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children.

OBJECTIVE: Human immunodeficiency virus type 1 (HIV-1)-associated progressive encephalopathy (PE) is a common and devastating complication of HIV-1 infection in children, whose risk factors have not yet been clearly defined. Regardless of the age of presentation, PE shortens life expectancy. Paradoxically, as survival of patients has been prolonged as a result of the use of antiretroviral therapy, the prevalence of PE has increased. Therefore, a predictive marker of PE emergence is critical. The objective of this study was to determine in an observational study whether any immunologic (CD4(+)

Unusual Manifestations of Secondary Syphilis: Case Presentations.

Dear Editor, Syphilis is an infection caused by Treponema pallidum. Without treatment, it goes through the following stages: primary, secondary, latent, and tertiary (1). The clinical picture of secondary syphilis is very variable (2,3). We present two rare cases of secondary syphilis, one with nodular lesions initially considered to be lymphoma and second with periostitis, which was initially interpreted as an osteoma. To date, only 15 cases with nodular lesions and 10 cases with periostitis in secondary syphilis have been reported in the literature. The first patient was a 59 year old man wh

Extracorporeal photophoresis: an evidence-based analysis.

OBJECTIVE: To assess the effectiveness, safety and cost-effectiveness of extracorporeal photophoresis (ECP) for the treatment of refractory erythrodermic cutaneous T cell lymphoma (CTCL) and refractory chronic graft versus host disease (cGvHD). BACKGROUND: CUTANEOUS T CELL LYMPHOMA: Cutaneous T cell lymphoma (CTCL) is a general name for a group of skin affecting disorders caused by malignant white blood cells (T lymphocytes). Cutaneous T cell lymphoma is relatively uncommon and represents slightly more than 2% of all lymphomas in the United States. The most frequently diagnosed form of CTCL i

Spinal Epidural Abscess.

AUDIENCE: The aim of this simulation case is to educate senior medical students, resident physicians, and advanced practice providers on the recognition, diagnosis, and management of spinal epidural abscesses. This scenario is most applicable to the emergency medicine setting but can be applied to the outpatient office or urgent care settings. INTRODUCTION: Spinal epidural abscess is an infection leading to an epidural collection of purulent material. This uncommon condition is estimated to occur less than 12 times per 100,000 hospital admissions.1,2 However, this infection can lead to devast

Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients.

BACKGROUND: The reported prevalence of immunodeficiencies in bronchiectasis patients is variable depending on the frequency and extent of immunological tests performed. European Respiratory Society guidelines recommend a minimum bundle of tests. Broadening the spectrum of immunological tests could increase the number of patients diagnosed with an immunodeficiency and those who could receive specific therapy. The primary objective of the present study was to assess the performance of different sets of immunological tests in diagnosing any, primary, secondary or treatable immunodeficiencies in a

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… On one hand, bronchiectasis is a very common pulmonary complication of common variable immunodeficiency (CVID) [ 6 ]. … CVID: common variable immunodeficiency. # : including 26 post-infective, eight primary ciliary dyskinesia and five allergic bronchopulmonary aspergillosis. …

Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future.

B cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an indelible mark on the field of clinical pathology, and recently has also dramatically reshaped the therapeutic landscape of diseases that were once considered incurable. Evaluating patients with primary immunodeficiency diseases (PID)/inborn errors of immunity (IEI) that primarily affect B cells, offers us an opportunity to further our understanding of how B cells develop, mature, function and, in certain instances, cause further disease. In t

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… Common Variable Immunodeficiency (CVID) and CVID-like Disorders 3.4.1. CVID Among the defects beyond the class-switching phase of B cell development and differentiation, CVID is the most common disorder. … Genetic Diagnosis Using Whole Exome Sequencing in Common Variable Immunodeficiency Front. Immunol. 2016 7 220 10.3389/fimmu.2016.00220 27379089 PMC4903998 81. Abolhassani H. Hammarström L. Cunningham-Rundles C. …

Immunodeficiencies and CFTR dysfunction: results from a systematic screening in a cohort of adults with cystic fibrosis and CFTR-related disorders.

BackgroundImmunodeficiencies (IDs) are conditions caused by immune system dysfunctions which predispose to chronic infections. Cystic fibrosis (CF) patients are characterized by the presence of bronchiectasis filled with hyper-viscous secretions that constitute the ideal environment for infections. Although CF and IDs might share similarities in the pathophysiological mechanism of bronchiectasis development, they each offer different treatment options. We hypothesize that the introduction of a bundle of tests would increase the number of ID diagnoses among adults with Cystic Fibrosis Transmemb

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… Immunoglobulin replacement therapy is critical and cost-effective in increasing life expectancy and quality of life in patients suffering from Common Variable Immunodeficiency Disorders (CVID): a health-economic assessment . … Immun Inflamm Dis 2021 ; 9 : 608 – 614 . 33783131 10.1002/iid3.426 PMC8127551 23 Sikora MM Bansal R El-Dahr JM . 43 Cystic fibrosis and associated common variable immunodeficiency . J Invest Med 2007 ; 55 : S254. 24 Khalili B Montanaro A . Cough and weight loss in a patient with cystic fibrosis . …

Selected Abstracts from the 12th Annual Meeting of the Clinical Immunology Society: 2021 Virtual Annual Meeting: Immune Deficiency and Dysregulation North American Conference.

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… (6) Common Variable Immunodeficiency in a young male uncovers Nuclear Factor 훋B-1 (NFKB1) haploinsufficiency with variable phenotype in several relatives: the importance of pursuing a genetic diagnosis Maria Chitty Lopez , MD 1 , Farnaz Tabatabaian, MD 2 , Hana Niebur, MD 3 , Erinn Kellner, MD 4 , … Table 2: Immunophenotype of Proband at Presentation Keywords: Common Variable Immunodeficiency, NFKB1 loss of function, Monogenic CVID Disclosures: Hana Niebur was a member of Horizon Therapeutics Advisory Board. …

Adequate IVIG dosing is associated with an improved long-term outcome in secondary immunodeficiency: A prospective, non-interventional study.

OBJECTIVE: To assess the safety, tolerability, and effectiveness of the intravenous immunoglobulin (IVIG) Intratect 50 g/L in immunoglobulin replacement therapy (IgRT) in a prospective, large-scale non-interventional study (NIS). The analysis focused upon patients with secondary immunodeficiency (SID), the most frequent indication for IgRT in this NIS. MATERIALS AND METHODS: Patients were enrolled at 123 centers in Germany. Each patient received IVIG as prescribed by the physician, guided by the Summary of Product Characteristics. Data were acquired from medical records and patients' question

Personalized Management of Chronic Rhinosinusitis in the Context of Immune Deficiency.

Primary and secondary immunodeficiency as a cause of recalcitrant or difficult to treat chronic rhinosinusitis (CRS) and recurrent acute rhinosinusitis (RARS) are under-appreciated etiologies. Patients with persistent symptoms, frequent exacerbations despite appropriate medical therapy, or other sinopulmonary conditions known to be related to an immunodeficient state warrant further testing for immunodeficiency, as up to 20% of this cohort of patients may have underlying immunodeficiency. Testing for immunodeficiency includes CBC with differential, immunoglobulin levels, and pneumococcal vacci

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… Primary immunodeficiencies, such as common variable immunodeficiency, selective IgA deficiency, and specific antibody deficiency, are frequently associated with recurrent sinopulmonary infections. 1 , 7–9 Similarly, secondary immunodeficiencies, including those related to hematologic malignancy, immunosuppressive … Table 2 Summary of the Personalized Management of CRS in the Context of Immunodeficiency Abbreviations : CVID, common variable immunodeficiency; SAD, specific antibody deficiency; IRT, immunoglobulin replacement therapy; ESS, endoscopic sinus surgery; ID, immunodeficiency. …

Clinicopathological findings of FeLV- positive cats at a secondary referral center in Florida, USA (2008-2019).

OBJECTIVES: The aim of this study was to describe the seroprevalence, presenting complaint, clinicopathological changes, co-morbidities and outcomes of feline leukemia virus positive cats presented to a specialty referral center in Florida, USA. METHODS: In this retrospective study, medical records of 8050 cats presented to a private referral center from August 2008 to September 2019 were reviewed. Inclusion criteria required was a positive result for feline leukemia virus by point-of-care antigen testing or immunofluorescence assay. RESULTS: Forty-one cases met the inclusion criteria. Of 20

Real-world results with IgPro20 for hypo- or agammaglobulinemia in Japan.

BackgroundSubcutaneous immunoglobulin is one of the standard treatments for hypogammaglobulinemia in primary immunodeficiencies (PID) worldwide. In Japan, IgPro20 (Hizentra® ; l-proline-stabilized 20% human subcutaneous immunoglobulin) is approved for agammaglobulinemia or hypogammaglobulinemia due to PID or secondary immunodeficiency (SID); however, its safety and effectiveness has not previously been assessed in a real-world setting.MethodsThis multicenter, open label post-marketing surveillance study was conducted between January 2014 and March 2019. Patients who received IgPro20 due to PID

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… variable immunodeficiency (CVID) and X‐linked agammaglobulinemia (XLA). 2 , 3 Agammaglobulinemia or hypogammaglobulinemia may also develop in patients with secondary immunodeficiencies (SID), either as a result of drug‐induced adverse effects from various treatments, such as immunosuppressive agents … TABLE 1 Demographic and patient characteristics of the safety analysis set Abbreviations: ADA2, adenosine deaminase 2; ADR, adverse drug reactions; CVID, common variable immunodeficiency; IgG, immunoglobulin G; IVIG, intravenous immunoglobulin; PID, primary immunodeficiency syndrome; PLGE, protein‐losing …

Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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… of Medicine 2 University of Utah 3 University of South Florida We seek to identify the role of the microbiome in immune dysregulation in Common Variable Immunodeficiency (CVID). … Variable Immunodeficiency (CVID), although COVID-19 and other polypeptide vaccine responses appear to be only modestly reduced in some patients. …

Электронная добыча медицинских карт свидетельствует о воздействии иммунного состояния пациента на клинические результаты имплантации биоматериалов после повреждения мышечной ткани скелета.

Имплантация медицинских устройств и биоматериалов может помочь восстановить форму и функцию отсутствующей или поврежденной ткани. Известно, что иммунная система играет важнейшую роль как в позитивном, так и в негативном исходе этих имплантированных материалов. Реакция иностранного организма характеризуется осаждением белка и свертыванием, за которым следуют макрофагенное воспаление, расстройство фагоцитоза, образование гигантских клеток и, в конечном счете, фиброз. Это может препятствовать функционированию имплантированных устройств (например. Инсулиновые насосы), а также космезис (например, к

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… Primary immunodeficiency included congenital or inherited disorders, including severe combined immunodeficiency (SCID), common variable immunodeficiency, DiGeorge syndrome, Bruton's agammaglobulinemia, etc . … B cell immunodeficiencies included Bruton's agammaglobulinemia, selective IgA deficiency, common variable immunodeficiency, etc . ECM- and hydrogel-treated patients demonstrated more variation based on immune compartment (T cell vs. …

Замена иммуноглобулина: Понятия управления несколькими миеломами.

Immunoglobulin (Ig) - заместительная терапия (IGRT) - состоит из применения низкодозированных поликлонных иг человека для лечения первичной и вторичной гипогаммаглобулинемии, которая связана с периодическими инфекциями и иммунной дисфункцией. ИГРТ восстанавливает физиологические уровни антител и вызывает иммуномумудуляторный эффект путем укрепления клеток иммунного эффекта, тем самым уменьшая инфекцию. Здесь мы описываем фармакологию различных составов иг с уделением особого внимания их механизму действий как низкодозированный ИГРТ, включая прямой антимикробный эффект и иммунодуляторную функци

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… These include Common Variable Immunodeficiency (CVID), X-linked agammaglobulinemia (XLA), and Severe Combined Immunodeficiency [ 6 , 7 ]. … Exhaustion of Bacteria-Specific CD4 T Cells and Microbial Translocation in Common Variable Immunodeficiency Disorders. J. Exp. Med. 2014;211:2033–2045. doi: 10.1084/jem.20140039. 56. …

2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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An Overview of the Strategies to Boost SARS-CoV-2-Specific Immunity in People with Inborn Errors of Immunity.

The SARS-CoV-2 pandemic has heightened concerns about immunological protection, especially for individuals with inborn errors of immunity (IEI). While COVID-19 vaccines elicit strong immune responses in healthy individuals, their effectiveness in IEI patients remains unclear, particularly against new viral variants and vaccine formulations. This uncertainty has led to anxiety, prolonged self-isolation, and repeated vaccinations with uncertain benefits among IEI patients. Despite some level of immune response from vaccination, the definition of protective immunity in IEI individuals is still un

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… Of these nine categories, the most prevalent is predominantly antibody deficiency (PAD) [ 17 , 18 ], including patients with Common Variable Immunodeficiency (CVID) and agammaglobulinemia. … Infection outcomes in patients with common variable immunodeficiency disorders: Relationship to immunoglobulin therapy over 22 years. J. Allergy Clin. Immunol. 2010;125:1354–1360.e4. doi: 10.1016/j.jaci.2010.02.040. 23. …

Множественная миелома и вторичный иммунодефицит: Ретроспективный анализ базы данных для оценки бремени, связанного с инфекциями и формами лечения.

Пациенты с множественной миеломой (ММ) и вторичным иммунодефицитом (СИД) подвергаются риску связанной с инфекцией заболеваемости и смертности в связи с процессом заболевания и его токсичностью для лечения. В этом ретроспективном когортном исследовании использовались анонимные данные из базы данных Optum-Humedica (октябрь) 2015-March 2020) для оценки бремени инфекции у пациентов с MM и SID в сравнении с пациентами без SID. Взрослые пациенты ≥ 18 Годы с подтвержденным MM были присвоены SID, и когорты без SID с использованием алгоритма с учетом уровней сыворотки IgG p p p p = 0.446). Что касается