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Update in the management of chronic lymphocytic leukemia.

Advances in the treatment of chronic lymphocytic leukemia (CLL) have improved initial overall response (OR) rates, complete response (CR) rates and progression free survival (PFS). Despite these advances, CLL remains incurable with standard therapies. Thus, there remains a need for more effective therapies in both the upfront and relapsed setting, particularly for patients with high-risk cytogenetic abnormalities such as del(11q22) and del(17p13). The 2008 American Society of Hematology (ASH) Annual Meeting featured several presentations which highlighted the ongoing clinical advances in CLL.

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… The Mayo Clinic and Ohio State retrospectively compared results of a phase II study of pentostatin and rituximab (PR) to previously published results using pentostatin, cyclophosphamide and rituximab (PCR) [ 8 ]. … Lin et al. presented combined phase I/II results of flavopiridol (alvocidib) in 116 relapsed patients treated at Ohio State, 70% of whom were fludarabine-refractory [ 27 ]. OR in this high-risk population was 47%. …

The burden of diseases, injuries, and risk factors by state in the USA, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides a comprehensive assessment of health and ris … D rates than any country in the world: West Virginia, Kentucky, Oklahoma, Pennsylvania, New Mexico, Ohio, Tennessee, and Arizona. Low back pain was the leading cause of YLDs in the USA in 1990 and 2021, although the age-standardised rate declined by 7·9% (1·8-13·0) from 1990. Depressive disorders (56·0% increase [48·2-64·3]) and drug use disorders (287 …

Surveillance for Violent Deaths - National Violent Death Reporting System, 42 States, the District of Columbia, and Puerto Rico, 2019.

PROBLEM/CONDITION: In 2019, approximately 67,000 persons died of violence-related injuries in the United States. This report summarizes data … ri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming), three states with data from counties representing a subset of their population (30 California counties, representing 57% of …

Integration of a Geriatric Assessment With Intervention in the Care of Older Adults With Hematologic Malignancies.

The incidence of hematologic malignancies (HMs) is highest in the seventh decade of life and coincides with increasing occult, age-related vulnerabilities. Identification of frailty is useful in prognostication and treatment decision-making for older adults with HMs. This real-world analysis describes 311 older adults with HMs evaluated in a multidisciplinary oncogeriatric clinic. The accumulation of geriatric conditions [1-unit increase, hazards ratio (HR) = 1.13, 95% CI 1.00-1.27, p = 0.04] and frailty assessed by the Rockwood Clinical Frailty Scale (CFS, mild/moderate/severe frailty vs. ver

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… Methods This real-world analysis includes all patients seen consecutively from February 1, 2016 to October 1, 2019 in the outpatient multidisciplinary oncogeriatric clinic, named Cancer and Aging Resiliency (CARE) clinic, at The Ohio State University Comprehensive Cancer Center/James Cancer Hospital … Ethics Statement The studies involving human participants were reviewed and approved by Ohio University Cancer Institutional Review Board. The patients/participants provided their written informed consent to participate in this program study. …

Surveillance for Violent Deaths - National Violent Death Reporting System, 39 States, the District of Columbia, and Puerto Rico, 2018.

PROBLEM/CONDITION: In 2018, approximately 68,000 persons died of violence-related injuries in the United States. This report summarizes data … esota, Missouri, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin), three states with data from counties representing a subset of their population (21 California counties, 28 Illinois counties, and 39 …

Calpastatin phosphorylation regulates radiation-induced calpain activity in glioblastoma.

Glioblastoma (GBM) is an aggressive, malignant brain tumor that inevitably develops resistance to conventional chemotherapy and radiation treatments. In order to identify signaling pathways involved in the development of radiation resistance, we performed mass spectrometry-based phospho-proteomic profiling of GBM cell lines and normal human astrocytes before and after radiation treatment. We found radiation induced phosphorylation of a number of proteins including calpastatin, specifically in GBM stem cells (GSCs). Herein, we focused on calpastatin, an endogenous inhibitor of calpain proteases

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… The 4 primary glioblastoma stem cell lines (OSU-2, −11, −20, and −53) were isolated from glioblastoma patient tissues and authenticated by a neuropathologist at The Ohio State University. … FUNDING R01CA108633, R01CA169368, RC2CA148190, U10CA180850-01 (NCI), Brain Tumor Funders Collaborative Grant, and Ohio State University Comprehensive Cancer Center (all to AC). …

Mesenchymal Stromal Cell Therapy in Solid Organ Transplantation.

Transplantation is the gold-standard treatment for the failure of several solid organs, including the kidneys, liver, heart, lung and small bowel. The use of tailored immunosuppressive agents has improved graft and patient survival remarkably in early post-transplant stages, but long-term outcomes are frequently unsatisfactory due to the development of chronic graft rejection, which ultimately leads to transplant failure. Moreover, prolonged immunosuppression entails severe side effects that severely impact patient survival and quality of life. The achievement of tolerance, i.e., stable graft

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… Stem Cells (Dayton Ohio) (2020) 38:596–605. 10.1002/stem.3151 42. Chen Q-H, Wu F, Liu L, Chen H-B, Zheng R-Q, Wang H-L, et al. Mesenchymal stem cells regulate the Th17/Treg cell balance partly through hepatocyte growth factor in vitro. … Stem Cells (Dayton Ohio) (2020) 38:797–807. 10.1002/stem.3165 102. Wang H, Qi F, Dai X, Tian W, Liu T, Han H, et al. Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin. …

Antifibrotic therapy for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia.

BACKGROUND: Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) are a ubiquitous condition estimated to affect over 50% of men over the age of 50 years. Various treatment options exist for men presenting with LUTS/BPH, including lifestyle and behavioral modification and medical or surgical treatment. Although multiple medical treatments exist, innovation for the medical treatment of BPH has not significantly progressed. METHODS: A comprehensive narrative review was performed to evaluate prostate fibrosis as a contributor to LUTS/BPH and to identify potential anti

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… ACKNOWLEDGEMENTS Matthew Lee was supported by the Ohio State University College of Medicine Research Innovation Career Development Award 2024. Ajinkya R. Limkar is supported by the NIH F30 grant: F30DK143709. FUNDING Open Access funding enabled and organized by Projekt DEAL. … He was funded by the Ohio State University College of Medicine Research Innovation Career Development Award in 2024. Kevin T. McVary:Prodeon, Inc: PI, grant, consultant. Rivermark, Inc: Co-I, grant, equity. Uronext, Inc: Leadership position, equity. NIDDK: PI, consultant. …

Disparities in survival of hematologic malignancies in the context of social determinants of health: a systematic review.

Social determinants of health (SDHs) have been reported as relevant factors responsible for health inequity. We sought to assess clinical data from observational studies conducted in the United States evaluating the impact of SDHs on the outcomes of patients with hematologic malignancies. Thus, we performed a systematic review in 6 databases on 1 September 2021, in which paired reviewers independently screened studies and included data from 41 studies. We assessed the risk of bias using the Joanna Briggs Institute appraisal tools and analyzed the data using a descriptive synthesis. The most co

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… myeloma; multi, multivariate analysis; N, sample size; NC, North Carolina; NC CCR, North Carolina Central Cancer Registry; NCDB, National Cancer Database; NHL, non-Hodgkin lymphoma; NJ, New Jersey; NOS, not otherwise specified; NS, not specified; NY, New York; NYSCR, New York State Cancer Registry; OH, Ohio … lymphoma; HR, hazard ratio; MDS, myelodysplastic syndromes; MO, Missouri; MM, multiple myeloma; multi, multivariate analysis; N, sample size; NC, North Carolina; NCDB, National Cancer Database; NC CCR, North Carolina Central Cancer Registry; NE, Nebraska; NHL, Nnn-Hodgkin Lymphoma; NS, not specified; OH, Ohio …

Management of an oral ingestion of transdermal fentanyl patches: a case report and literature review.

Purpose. Fentanyl is available as a transdermal system for the treatment of chronic pain in opioid-tolerant patients; however, it carries a black box warning due to both the potency of the product and the potential for abuse. In this report, we describe a case of transbuccal and gastrointestinal ingestion of fentanyl patches and the management of such ingestion. Summary. A 32-year-old man was brought to the emergency department (ED) via emergency medical services for toxic ingestion and suicide attempt. The patient chewed and ingested two illegally purchased transdermal fentanyl patches. In th

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… Lexi-Drugs Online TM 2010 Hudson, Ohio, USA Lexi-Comp 12 Moeller KE Lee KC Kissack JC Urine drug screening: practical guide for clinicians Mayo Clinic Proceedings 2008 83 1 66 76 18174009 10.4065/83.1.66 13 Zimmerman JL Poisonings and overdoses in the intensive care unit: general and specific management …

Аккумуляция железа в множестве склерозов и последствия для когнитивной и клинической прогрессии: систематический обзор передовых исследований в области нейронизации.

ИЗМЕНЕНИЯ, связанные с железом, часто связаны с многократным склерозом (MS) нейродегенерацией, однако их связь с клиническими симптомами и когнитивными нарушениями остается неясной. Мы систематически анализировали данные, связывающие метрики магнитного резонанса (MRI) на основе железочувствительности с когнитивными результатами, с тем чтобы оценить их потенциальную роль в качестве диагностических и прогнозирующих биомаркеров когнитивного упадка в MS. МАТЕРИАЛЫ И МЕТОДЫ: Был проведен систематический обзор с использованием руководящих принципов ПРИСМА. 600 исследования были выявлены путем поиска

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… of New York (New York) | Cross-sectional | 85 | 57 RRMS 28 SPMS | 27 HC | 10.9 ± 7.6 | 3.6 ± 1.9 Pinter et al., 2015 [ 33 ] | Department of Neurology, Medical University of Graz (Austria) | Cross-sectional | 69 | 17 CIS 47 RRMS 5 SPMS | – | 7.1 (8.3) | 2.0 (0–8) Schmalbrock et al., 2016 [ 35 ] | The Ohio … State University, Columbus (Ohio) | Cross-sectional | 29 | RRMS | – | 6.55 (5.5) | 3.0 (1.5) Fujiwara E. et al., 2017 [ 22 ] | Northern Alberta Multiple Sclerosis Clinic in Edmonton (Canada) | Cross-sectional | 40 | 16 RRMS 24 PPMS 9 SPMS | 27 HC | 14.90 ± 8.91 | 5.25 (2.0–9.0) Lommers et al., 2019 …

Secondary Impact of the Coronavirus Disease 19 Pandemic on Patients and the Cellular Therapy Healthcare Ecosystem.

The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has significantly impacted global health and healthcare delivery systems. To characterize the secondary effects of the COVID-19 pandemic and mitigation strategies used in the delivery of hematopoietic stem cell transplantation (HSCT) care, we performed a comprehensive literature search encompassing changes in specific donor collection, processing practices, patient outcomes, and patient-related concerns specific to HSCT and HSCT-related healthcare delivery. In this review,

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… Email: Mark.Mueller@cchmc.org Sagar Patel, MD; Huntsman Cancer Institute, University of Utah; Salt Lake City, Utah; Email: Sagar.Patel@hci.utah.edu Veronika Polishchuk, MD; Division of Hematology, Oncology, and Bone and Marrow Transplant, Nationwide Children's Hospital, Department of Pediatrics, Ohio … Email: Veronika.Polishchuk@nationwidechildrens.org Audrey Sigmund, Divisions of Hematology and Medical Oncology, The Ohio State University, Columbus, OH; Email: Audrey.Sigmund@OSUMC.edu Sarah Tarquini Ph.D.; Dana-Farber Boston Children's Cancer and Blood Disorders Center; Email: Sarah_Tarquini@dfci.harvard.edu …

Ожог среди врачей, которые лечат пациентов с множественным склерозом в США: подкаст.

Физический извержение, усиливающийся кризис в системе здравоохранения Соединенных Штатов Америки (США), характеризуется долгосрочным стрессом, связанным с работой, который проявляется в истощении энергии, чувстве повышенной умственной дистанции или цинизме к работе и снижении профессиональной эффективности. В частности, неврологи относятся к числу тех, у кого наиболее высокие показатели вымирания и наименьший уровень удовлетворенности сбалансированностью между работой и личной жизнью. В то же время данные об истощении среди врачей, которые лечат пациентов с множественным склерозом (МС), остают

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… Mary Rensel, Director of Wellness at the Department of Neurology at the Mellen Center for Multiple Sclerosis Treatment and Research at the Cleveland Clinic in Ohio, United States of America (USA). Thank you, Dr. Amy Sullivan, for joining me today for this important discussion. …

Idiopathic multicentric Castleman disease treated with siltuximab for 15 years: a case report.

UNLABELLED: Human herpes virus-8 (HHV8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder sustained by pro-inflammatory cytokines, including interleukin-6 (IL-6). According to the international evidence-based criteria developed by the Castleman Disease Collaborative Network (CDCN), siltuximab, which works by inhibiting IL-6, is the recommended choice for iMCD treatment. We report a case of a 63-year-old white male with iMCD who has been on maintenance therapy with siltuximab for 15 years - representing one of the longest treatment periods of any

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… Pathology was consistent with Castleman disease, plasma cell type, as described by the angiofollicular hyperplasia on the pathology report from the local hospital in Ohio in 2005. …

A Rare Case of Aggressive Systemic Mastocytosis With Skeletal Osteosclerotic Lesions on Presentation: A Diagnostic Conundrum.

Systemic mastocytosis (SM) is a heterogeneous group of disorders caused by mast cell proliferation. SM often presents with non-specific symptoms making it a diagnostic challenge. Moreover, presentation with bone involvement is highly uncommon. Here, we report a rare case of SM in a 68-year-old female who initially presented with gastrointestinal symptoms and was later found to have sclerotic bone lesions on imaging. This case highlights an unusual presentation of SM, informing clinicians of the importance of keeping this disease process on the differential list of diagnostic conundrums.

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… Acknowledgments We would like to thank Ayza Taimur DO, Department of Radiology, Aultman Hospital, Canton, Ohio, for his contribution to radiological images. The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. …

Role of microRNAs in hematological malignancies research: A bibliometric analysis.

ObjectivesMicroRNAs (miRNAs) are pivotal regulators of cancer biology, including hematological malignancies. Their roles include tumor suppression, oncogenic activities, modulation of immune responses, and treatment resistance. This study aimed to provide a quantitative analysis of research trends, thematic evolution, and key contributions to the field of miRNAs and hematological malignancies.MethodsUsing BIBLIO-Checklist and advanced visualization tools (VOSviewer and bibliometrix), data from key databases were analyzed for publication trends, author co-citations, thematic clusters, and emerg

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… The most productive affiliations in the research field of miRNAs in hematological malignancies were led by Ohio State University, USA, with 201 articles. Huazhong University of Science and Technology, China, followed by 87 articles, and Harvard Medical School, USA, had 85 articles. … Other notable contributors include Ohio State University (62 articles, USA), The University of Texas MD Anderson Cancer Center (55 articles, USA), the University of Ferrara (54 articles, Italy), Central South University (52 articles, China), and the University of Chicago (45 articles, USA). …

Острый инфекционный мононуклеоз порождает стойкие, функциональные антитела EBNA-1 с высокой поперечной реактивностью до альфа-кристаллической бета.

Мы исследуем масштаб, специфичность и функциональные свойства ядерного антигена 1 (EBNA-1) вируса Эпштейн-Барр (EBV) у молодых людей в ходе первичной инфекции. Обнаружены специфические связующие антитела EBNA-1, а также антитела, способные к осаждению клеточного фагоцитоза (ADCP) и дополняющего антитела (ADCD). Эти антитела в первую очередь направлены против региона EBNA-1, который, как известно, вызывает перекрестные антитела для нескольких самопептидов. У лиц, имеющих по крайней мере один аллеле HLA-DRB1*15:01, отмечаются высшие связующие и ADCD антитела EBNA-1. Альфакристалллин бета (КРИАБ)

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… SinoBiological Custom Synthesis Recombinant Epstein-Barr virus EBNA-1 1–56 B95-8 SinoBiological Custom Synthesis Recombinant Epstein-Barr virus EBNA-1 421–476 AG876 SinoBiological Custom Synthesis Recombinant Epstein-Barr virus EBNA-1 449–504n B95-8 SinoBiological Custom Synthesis Influenza AH1N1(A/Ohio … SinoBiological Custom Synthesis Recombinant Epstein-Barr virus EBNA-1 1–56 B95-8 SinoBiological Custom Synthesis Recombinant Epstein-Barr virus EBNA-1 421–476 AG876 SinoBiological Custom Synthesis Recombinant Epstein-Barr virus EBNA-1 449–504n B95-8 SinoBiological Custom Synthesis Influenza AH1N1(A/Ohio …

Воспаление у людей с множественным склерозом, обработанных ингибиторами иммунных контрольно-пропускных пунктов.

В ходе этого исследования была проведена оценка заболеваемости у людей с множественным склерозом (PwMS), которые получили ингибиторы на иммунных контрольно-пропускных пунктах (ИКИ), по сравнению с PwMS, которые не лечились с ICI. Существует 108 PwMS, в том числе (27 PwMS+ICIS и 81 PwMS-контроль), совместимые с возрастом, полом, продолжительностью болезни, DMT и курсами по заболеваниям MS. Из 27 PwMS+ICIs один (4%) имел рецидив, а четыре (15%) - новые МРТ-вреды без клинических симптомов. Время рецидива и активность МРТ сравнивались с использованием кривых Каплан-Мейер и моделей регрессии Кокса.

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… Methods In this retrospective multicenter cohort study, we identified adult PwMS from the Cleveland Clinic Mellen Center registry ( n = 9158) and cases exposed to ICIs (CTLA4, PD1 or PDL1 inhibitors) at Cleveland Clinic (Ohio, Florida, Nevada) between 2017 and 2023. …

Hypercalcemia-Associated Hodgkin's Lymphoma Presenting as Normal Pressure Hydrocephalus: A Case Report.

Hodgkin's lymphoma is a malignancy of the lymphatic system that can rarely present with advanced-stage features such as spinal cord involvement and hypercalcemia. We present the case of a 63-year-old Caucasian male with advanced Hodgkin's lymphoma, presenting with hypercalcemia and symptoms resembling normal pressure hydrocephalus. The patient exhibited gait impairment, altered mental status, and urinary incontinence, forming the classic triad seen in normal pressure hydrocephalus. Laboratory findings revealed leukocytosis, anemia, hypercalcemia, and acute kidney injury. Imaging showed extensi

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… He had recently moved to Mississippi from Ohio approximately six months ago, and his daughter observed a decline in his health since the move. The patient is a current cigarette smoker with a history of intermittent smoking throughout his adult life. …

2020 ACVIM Forum On Demand Research Abstract Program.

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… Kochie 1 ; Karsten Schober 1 ; Jaylyn Rhinehart 1 ; Randolph Winter 1 ; John Bonagura 2 ; Annie Showers 1 ; Vedat Yildiz 1 1 The Ohio State University; 2 North Carolina State University Arterial thromboembolism (ATE) is a sequelae of hypertrophic cardiomyopathy (HCM) in cats related to left atrial …