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P2X7 Receptor Function in Bone-Related Cancer.

Modulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host interactions, and metastatization. This paper summarizes recent findings on expression and function of P2X7 receptor for extracellular ATP in primary and metastatic bone cancers. Search of mRNA expression microchip databases and literature analysis demonstrate a high expression of P2X7 in primary bone tumors as well as in other malignancies such

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… s2.0-0042047374 12874700 10.1007/s00223-002-2098-y 53 Pellegatti P Falzoni S Donvito G Lemaire I Di Virgilio F P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration FASEB Journal 2011 25 4 1264 1274 2-s2.0-79954583662 21233486 10.1096/fj.10-169854 54 Ke HZ Qi …

Gene regulation by non-Coding RNAs in infertility: a mechanistic review.

Infertility is a significant global health issue affecting millions of couples, with noncoding RNAs (ncRNAs) emerging as pivotal regulators in reproductive biology. This review explores the roles of various ncRNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs), long noncoding RNAs (lncRNAs), PIWI-interacting RNAs (piRNAs), and circular RNAs (circRNAs) in male and female infertility. These ncRNAs modulate critical processes such as spermatogenesis, oogenesis, follicular development, and embryo implantation through mechanisms like post-transcriptional regulation, chromatin remode

Targeting erythroid progenitor cell metabolism to enhance cancer immunotherapy.

While cancer immunotherapy has transformed clinical management for cancer patients, its low response rates remain a critical challenge to be addressed. Tumor immune evasion now extends beyond the tumor microenvironment (TME), as advanced tumors induce extramedullary hematopoiesis (EMH) in the spleen, leading to a substantial expansion of erythroid progenitor cells (EPCs) with potent immunosuppressive capacity. EPCs are typically transient populations in erythroid maturation and differentiation; however, under tumor burden, they undergo profound metabolic reprogramming that exacerbates their im

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… . & Qi, C. Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy. Mol. Cancer 24 , 5 (2025). 17. Raskov, H., Orhan, A., Gaggar, S. & Gogenur, I. …

The double-edged sword of tumor-targeted treatment: the influence of targeted therapy on the heart.

As an important means of modern cancer treatment, targeted therapy has significant efficacy, but cardiac toxicity cannot be ignored. From subclinical myocardial injury to severe heart failure (HF), it poses significant challenges to the long-term survival and quality of life of patients. This article summarizes the impact of targeted therapy drugs on cardiac function and their mechanisms, including cardiomyocyte damage, myocardial hypertrophy, and HF, and conducts in-depth research into potential molecular mechanisms. These include direct cardiomyocyte damage through targeted pathway inhibitio

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… Qi WX, Shen Z, Lin F, et al. Incidence and risk of hypertension with vandetanib in cancer patients: a systematic review and meta-analysis of clinical trials. Br J Clin Pharmacol 2013;75:919-30. 10.1111/j.1365-2125.2012.04417.x 21. Schneeweiss A, Chia S, Hickish T, et al. …

Повышение эффективности лечения нескольких миелом: интеграция четырехкратной и двойной антигенной терапии CAR-T.

Множественная миелома (ММ), своего рода гематологическая порча, характеризуется бесконтрольным распространением плазменных клеток в костном мозге. При лечении MM возникли серьезные проблемы, связанные с такими факторами, как рецидив, сопротивление и побег антигенов. За последнее десятилетие алгоритм лечения сместился с традиционной химиотерапии на иммунную терапию и четырехкратные индукционные режимы. Насколько нам известно, ни один опубликованный обзор пока не содержит комплексного анализа применяемых в настоящее время УЛХ методов лечения CAR-T и четырёхкратного лечения для MM. В настоящем об

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… Shi M., Wang J., Huang H., Liu D., Cheng H., Wang X., Chen W., Yan Z., Sang W., Qi K., et al. Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial. Nat. Commun. 2024;15:3371. doi: 10.1038/s41467-024-47801-8. 49. …

Снимки нервной системы в системной нейропатии: мини-обзор экспериментальных и точных методов лечения.

Нейропатия маленького жира - это обычное осложнение метаболических, нейродегенеративных и связанных с лечением расстройств. Раннее обнаружение может быть проблематичным, поскольку установленные диагностические подходы могут быть инвазивными, ресурсоемкими или относительно нечувствительными к ранам, наносимым на ранних этапах малоразмерных частиц. Конфокальная микроскопия (CCM) представляет собой быструю и неинвазивную технологию визуализации, позволяющую количественно оценить подбассейный нервный слиз и предложенную в качестве биомаркера повреждённого периферийным малым фюзеляжем. Этот мини-об

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… Chen X Graham J Dabbah MA Petropoulos IN Tavakoli M Malik RA An Automatic Tool for Quantification of Nerve Fibers in Corneal Confocal Microscopy Images IEEE Trans Biomed Eng 2017 64 786 794 10.1109/TBME.2016.2573642 PMC5512547 27295646 16 Williams BM Borroni D Liu R Zhao Y Zhang J Lim J Ma B Romano V Qi …

Computational Drug Repurposing Across the Multiple Myeloma Spectrum: From MGUS to MM.

Background/objectivesMultiple myeloma (MM) is a challenging, B cell malignancy characterised by the uncontrolled proliferation of plasma cells within the bone marrow. Despite significant advances in treatment options nowadays, MM remains an incurable malignancy, with the majority of patients succumbing to the disease. MM develops from a pre-malignant state known as monoclonal gammopathy of unknown significance (MGUS), which then has the potential to evolve either into smouldering (asymptomatic) multiple myeloma (SMM) or into MM. Since novel drug discovery takes years to reach the clinic, drug

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… Nooka A.K., Rodriguez C., Mateos M.V., Manier S., Chastain K., Banerjee A., Kobos R., Qi K., Verona R., Doyle M., et al. Incidence, timing, and management of infections in patients receiving teclistamab for the treatment of relapsed/refractory multiple myeloma in the MajesTEC-1 study. …

Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting.

BackgroundThe clinical translation of positron emission tomography (PET) radiotracers for cancer management presents complex challenges. We have developed consensus-based recommendations for preclinical and clinical assessment of novel and established radiotracers, applied to image different cancer types, to improve the standardisation of translational methodologies and accelerate clinical implementation.MethodsA consensus process was developed using the RAND/UCLA Appropriateness Method (RAM) to gather insights from a multidisciplinary panel of 38 key stakeholders on the appropriateness of pre

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… Cherry SR, Jones T, Karp JS, Qi J, Moses WW, Badawi RD. Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care. J Nucl Med. 2018;59(1):3–12. 55. Garrow AA, Andrews JPM, Gonzalez ZN, Corral CA, Portal C, Morgan TEF, et al. …

Прогресс и перспективы на будущее в химерикском антигенном рецепторе Т-клетке и биконкретной антителной терапии для множественных миелом.

Начавшаяся терапия перенаправления Т-клеток значительно изменила условия лечения повторной/изъятий множественной миеломы (RRMM), особенно у пациентов с тремя классами обнаженных или рефрактных заболеваний. Лечение химерных антигенных рецепторов (CAR) Т-клеток и биконкретные антитела (BSAbs), которые в первую очередь нацелены на антигены созревания клеток B (BCMA), показали замечательную эффективность в ключевых испытаниях и реальных условиях мира. В последнее время группа рецепторов G с протеиновым сцеплением C 5 В качестве многообещающих вариантов были выбраны агенты D, особенно для пациентов

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… Ma S, Wang Y, Qi K, et al. Associations of granulocyte colony-stimulating factor with toxicities and efficacy of chimeric antigen receptor T-cell therapy in relapsed or refractory B-cell acute lymphoblastic leukemia. Cancer Immunol Immunother. 2024; 73: 104. 57. …

Combined spatial metabolomics and 4D-DIA quantitative proteomics approaches to explore the relationship between lung cancer and the heart.

Lung cancer and cardiovascular disease pose persistent threats to human health, despite advancements in targeted therapy, percutaneous coronary intervention, and drug treatments. Challenges such as side effects, drug resistance, hospitalization rates, and mortality remain high. These diseases are closely linked, sharing common risk factors and intricately influencing each other. This study aims to investigate the interplay between lung disease and cardiovascular disease by examining changes in cardiac metabolites and protein expression using spatial metabolomics and 4D-DIA quantitative proteom

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… Qi, X. H., Wang, F., Sun, H., Wang, S. Y. & Liu, N. Progress on the relationship between tumors and cardiovascular disease. J. Clin. Cardiol. 38 (07), 585–592 (2022). 49. Hou SH. Effects and Mechanism of Melittin on the Proliferation of Human Non-small Cell Lung Cancer A549 Cells.Youjiang Med. …

Dawn of CAR-T cell therapy in autoimmune diseases.

AbstractChimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in the treatment of hematological malignancies. Based on the immunomodulatory capability of CAR-T cells, efforts have turned toward exploring their potential in treating autoimmune diseases. Bibliometric analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases, covering a range of subtypes such as systemic lupus erythematosus, multiple sclerosis, among others. CAR-T therapy hold

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… Qi Y Zhao M Hu Y Wang Y Li P Cao J, et al. Efficacy and safety of CD19-specific CAR T cell-based therapy in B-cell acute lymphoblastic leukemia patients. Blood 2022;139:3376–3386. doi: 10.1182/blood.2021013733. 60. Quintas-Cardama A. GPRC5D-targeted CAR T cells for myeloma. …

The prevalence of obstructive sleep apnea-hypopnea syndrome in patients with multiple sclerosis: a systematic review and meta-analysis.

OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome is the most common respiratory disorder in patients with multiple sclerosis. The purpose of this meta-analysis was to evaluate the prevalence of OSAHS in MS patients and to analyze their sleep monitoring indicators of patients. METHODS: Online databases such as PubMed, EMBASE, Web of Science, CNKI, and WanFang were used to review the Chinese and English literature about OSAHS in MS patients in detail. Two researchers analyzed the Quality of included studies based on the Quality Assessment of Diagnostic Accuracy Studies. The prevalence and s

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… Ma S, Rui X, Qi P, Liu G, Yang J. Sleep disorders in patients with multiple sclerosis in China. Sleep Breath. (2017) 21:149–54. doi: 10.1007/s11325-016-1416-y, PMID: 32. González-Platas M, González-Platas J, Bermúdez-Hernández M, Pérez-Martín MY, Croissier-Elías C, Pérez-Lorensu PJ. …

Education, Employment, and Financial Outcomes in Adolescent and Young Adult Cancer Survivors-A Systematic Review.

Adolescents and young adults (AYAs) with cancer face unique challenges. We aimed to describe (i) education, employment, and financial outcomes and (ii) determinants for adverse outcomes in AYA cancer survivors. We performed a systematic literature search. We included original research articles on AYA (15-39 years of age) cancer survivors (≥2 years after diagnosis) and our outcomes of interest. We narratively synthesized the results of the included articles. We included 35 articles (24 quantitative and 11 qualitative studies). Patients in education had to interrupt their education during cancer

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… Qi R. Zhao J. Yabroff K.R. Nathan P.C. Medical Financial Hardship in Survivors of Adolescent and Young Adult Cancer in the United States J. Natl. Cancer Inst. 2021 113 997 1004 10.1093/jnci/djab013 33839786 PMC8328985 39. Nord C. Olofsson S.-E. Glimelius I. Cedermark G.C. Ekberg S. …

CAR-T State of the Art and Future Challenges, A Regulatory Perspective.

This review is an outlook on CAR-T development up to the beginning of 2023, with a special focus on the European landscape and its regulatory field, highlighting the main features and limitations affecting this innovative therapy in cancer treatment. We analysed the current state of the art in the EU and set out a showcase of the field's potential advancements in the coming years. For this analysis, the data used came from the available scientific literature as well as from the European Medicines Agency and from clinical trial databases. The latter were investigated to query the studies on CAR

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… Qi C., Gong J., Li J., Liu D., Qin Y., Ge S., Zhang M., Peng Z., Zhou J., Cao Y., et al. Claudin18.2-specific CAR T cells in gastrointestinal cancers: Phase 1 trial interim results. Nat. Med. 2022;28:1189–1198. doi: 10.1038/s41591-022-01800-8. 18. …

Chinese expert consensus on the diagnosis and treatment of bone metastasis in lung cancer (2022 edition).

Lung cancer is the leading cause of cancer-related deaths worldwide. Bone is a common metastatic site of lung cancer, about 50% of bone metastatic patients will experience skeletal related events (SREs). SREs not only seriously impact the quality of life of patients, but also shorten their survival time. The treatment of bone metastasis requires multi-disciplinary therapy (MDT) and development of individualized treatment plan. In order to standardize the diagnosis and treatment of bone metastasis in lung cancer, the expert group of the MDT Committee of the Chinese Medical Doctor Association ha

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… Radiological imaging for the diagnosis of bone metastases Q J Nucl Med 45 1 2001 53 64 11456376 28 Yu H Qi J Xia T. …

Chimeric antigen receptor T-cell therapy: challenges and opportunities in lung cancer.

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the paradigm in hematological malignancies treatment, driving an ever-expanding number of basic research and clinical trials of genetically engineering T cells to treat solid tumors. CAR T-cell therapies based on the antibodies targeting Mesothelin, CEA, EGFR, EGFR, MUC1, DLL3, and emerging novel targets provide promising efficacy for lung cancer patients. However, clinical application of CAR T-cell therapy against lung cancer remains limited on account of physical and immune barriers, antigen escape and heterogeneity, on-target

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… Qi, J, Tsuji, K, Hymel, Det al. Chemically programmable and switchable CAR-T therapy. Angew Chem Int Ed Engl 2020; 59: 12178–85. 103. Wiebking, V, Patterson, JO, Martin, Ret al. Metabolic engineering generates a transgene-free safety switch for cell therapy. Nat Biotechnol 2020; 38: 1441–50. 104. …

Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue.

Purpose: In this study we aimed to estimate the effectiveness of pharmacological, nutraceutical, and phytopharmaceutical treatments on CRF. Methods: Ovid MEDLINE, Ovid Embase, Ovid Psych info, CINHAHL and Cochrane Library databases were searched up to 30 September 2021. Randomized controlled trials of pharmacological, nutraceutical and phytopharmaceutical interventions for treatment of CRF for at least one week duration and have used valid tool to assess severity of CRF as a primary or secondary outcome were considered. Results: 32 eligible studies (4896 patients) were reviewed. For the overal

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… Qi E. Chen W. Dong Y. Hou L. Effect of Methylphenidate in Patients with Cancer-Related Fatigue: A Systematic Review and Meta-Analysis PLoS ONE 2014 9 e84391 10.1371/journal.pone.0084391 24416225 PMC3885551 111. Dicato M. Plawny L. Erythropoietin in cancer patients: Pros and cons Curr. Opin. …

Innovative trial approaches in immune-mediated inflammatory diseases: current use and future potential.

BackgroundDespite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest form of evidence on the effectiveness of a potential new treatment regimen, but they are extremely expensive and time consuming to conduct. Consequently, much focus has been given in recent years to innovative design and analysis methods that could improve the efficiency of RCTs. In this article, we review the current use and future potential of these methods within the context

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… Psioda MA, Xu J, Jiang QI, Yang Z, Ibrahim JG. Bayesian adaptive basket trial design using model averaging. Biostatistics. 2019:1–16. 30. Park JJH, Siden E, Zoratti MJ, Dron L, Harari O, Singer J, Lester RT, Thorlund K, Mills EJ. …

Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy.

BackgroundChromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). This adaptation requires DNA and histone epigenetic modifications, which are mediated by several types of enzymes; among them are lysine methyltransferases (KMTs).MethodsKMT inhibitors, chaetocin and tazemetostat (TZM), were used to study their role in the DDR induced by ionizing radiation or doxorubicin in two human sarcoma cells lines. The effect of these KMT inhibitors was tested by the analysis of chromatin epigenetic modifications, H4K16ac and H4K20me2. DDR was monitor

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… Qi Y. Zhang J. Z. H. ( 2020 ). Computational approaches to studying methylated H4K20 recognition by DNA repair factor 53BP1. Phys. Chem. Chem. Phys. 22 6136 – 6144 . 10.1039/c9cp05635a 32124883 Li Z. Huang L. Wei L. Hou Z. Ye W. Huang S. ( 2019 ). …

Chromosome 1q21 abnormalities in multiple myeloma.

Gain of chromosome 1q (+1q) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM), occurring in approximately 40% of newly diagnosed cases. Although it is often considered a poor prognostic marker in MM, +1q has not been uniformly adopted as a high-risk cytogenetic abnormality in guidelines. Controversy exists regarding the importance of copy number, as well as whether +1q is itself a driver of poor outcomes or merely a common passenger genetic abnormality in biologically unstable disease. Although the identification of a clear pathogenic mechanism from +1q rem

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… Chen MH Qi C Reece D Chang H Cyclin kinase subunit 1B nuclear expression predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with bortezomib Hum. Pathol. 2012 43 858 864 10.1016/j.humpath.2011.07.013 22047644 76. …