Результаты поиска

The role of the innate immune system in the development and treatment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Most patients present with advanced or metastatic HCC at diagnosis and face a dismal prognosis. Tyrosine kinases are the gold standard treatment for this disease but yield limited survival benefits. Immune checkpoint inhibitors that augment adaptive immunity have been tested in HCC. Complex interactions between tumor cells, lymphocytes and the tumor environment determine the efficacy of such immunotherapies. Innate immune mechanisms - known drivers of liver disease progression in pre-HCC conditions such as fibrosis or cirr

Совпадение в полном тексте источника
… Kessoku T , Imajo K , Honda Y Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis . Sci. Rep. 6 , 22251 ( 2016 ). 26911834 10.1038/srep22251 PMC4766502 70. …

Curcumin: An age-old anti-inflammatory and anti-neoplastic agent.

Curcumin is a natural anti-inflammatory agent that has been used for treating medical conditions for many years. Several experimental and pharmacologic trials have demonstrated its efficacy in the role as an anti-inflammatory agent. Curcumin has been shown to be effective in treating chronic conditions like rheumatoid arthritis, inflammatory bowel disease, Alzheimer's and common malignancies like colon, stomach, lung, breast, and skin cancers. As treatments in medicine become more and more complex, the answer may be something simpler. This is a review article written with the objective to syst

Совпадение в полном тексте источника
… Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma Anticancer Res 24 2004 987 998 15161054 20 Huang M. Lysz T. Ferraro T. Abidi T. Laskin J. Conney A. …

Biological Age, Aging Clocks, and the Interplay with Lymphoid Neoplasms: Mechanisms and Clinical Frontiers.

Lymphoid neoplasms (LN), a diverse group of malignancies arising from lymphocytes, exhibit a striking increase in incidence with chronological age, suggesting a deep connection with the aging process. While chronological age remains a primary risk factor, the concept of biological age, reflecting an individual's physiological state and susceptibility to age-related diseases, offers a more nuanced understanding of this relationship. Aging clocks, particularly epigenetic clocks based on DNA methylation, provide quantitative measures of biological age and have revealed associations between accele

Совпадение в полном тексте источника
… Furthermore, for cancer survivors or patients exhibiting signs of accelerated aging, interventions targeting fundamental aging processes (such as senolytics designed to clear senescent cells, or drugs like metformin and resveratrol) are being explored, although rigorous clinical validation in the context …

Cinobufagin Suppresses Lipid Peroxidation and Inflammation in Osteoporotic Mice by Promoting the Delivery of miR-3102-5p by Macrophage-Derived Exosomes.

BackgroundCinobufagin, the primary active compound in toad venom, is commonly used for anti-tumor, anti-inflammatory, and analgesic purposes. However, its specific bone-protective effects remain uncertain. This research aims to ascertain the bone-protective properties of cinobufagin and investigate underlying mechanisms.MethodsMice were ovariectomized to establish an osteoporosis model, followed by intraperitoneal injections of cinobufagin and cinobufagin-treated RAW.264.7-derived exosomes for therapy. MicroCT, HE staining, and TRAP staining were employed to evaluate bone mass and therapeutic

Совпадение в полном тексте источника
… Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia. J Control Release . 2023;353:675–684. doi: 10.1016/j.jconrel.2022.12.026 28. Wang Y, Lin Q, Zhang H, et al. …

HMMR in human cancers: regulatory mechanism and biological function.

Hyaluronan-mediated motility receptor (HMMR), also referred to as RHAMM or CD168, has gained recognition as a multifunctional protein that mediates the transmission of extracellular matrix-derived hyaluronan (HA) signals to intracellular pathways regulating tumor growth, migration, and mitosis. Overexpression of HMMR is observed in various cancers, including head and neck squamous cell carcinoma, breast cancer, lung cancer, and prostate cancer, as well as several hematologic malignancies. This elevated expression correlates with poor prognosis, rendering it a valuable marker for survival predi

Совпадение в полном тексте источника
… Additionally, resveratrol suppresses HMMR expression, enhances CD8 + T cell cytotoxicity, remodels the immune microenvironment, and activates ferroptosis pathways, all of which contribute to a more robust antitumor immune response [ 139 ]. …

Окисляющий/нетрозирующий стресс, апоптоз и сигнализация " Redox " : основные игроки в нейродегенеративных заболеваниях.

Нейродегенеративные заболевания представляют собой серьезную проблему для здоровья, которая оказывает глубокое воздействие на качество и продолжительность жизни миллионов людей. Эти заболевания характеризуются патологическими изменениями в различных областях мозга, конкретными генетическими мутациями, связанными с болезнью, залежами аномальных белков и дегенерацией неврологических клеток. Поскольку нейродегенеративные расстройства различаются по своим эпидемиологическим характеристикам и степени уязвимости нейронов, лечение этих заболеваний обычно направлено на замедление развития заболеваний.

Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, shows a dismal and grim overall prognosis and survival rate, which have remained virtually unchanged for over half a century. PDAC is the most lethal of all cancers, with the highest mortality-to-incidence ratio. PDAC responds poorly to current therapies and remains an incurable malignancy. Therefore, novel therapeutic targets and drugs are urgently needed for pancreatic cancer treatment. Selective induction of apoptosis in cancer cells is an appealing approach in cancer therapy. Apoptotic cell death is highly

Совпадение в полном тексте источника
… Drugs A number of antitumor drugs have been reported to act through an ER stress response in different human cancers, including bortezomib (also known as Velcade or PS-341) [ 117 , 118 ], cisplatin [ 119 ], cannabinoids [ 120 ], and a wide number of plant-derived natural compounds, such as curcumin, resveratrol …

Viral warfare: unleashing engineered oncolytic viruses to outsmart cancer's defenses.

Oncolytic virotherapy (OVT) has emerged as a promising and innovative cancer treatment strategy that harnesses engineered viruses to selectively infect, replicate within, and destroys malignant cells while sparing healthy tissues. Beyond direct oncolysis, oncolytic viruses (OVs) exploit tumor-specific metabolic, antiviral, and immunological vulnerabilities to reshape the tumor microenvironment (TME) and initiate systemic antitumor immunity. Despite promising results from preclinical and clinical studies, several barriers, including inefficient intratumoral virus delivery, immune clearance, and

Cardiac Cachexia: Unaddressed Aspect in Cancer Patients.

Tumor-derived cachectic factors such as proinflammatory cytokines and neuromodulators not only affect skeletal muscle but also affect other organs, including the heart, in the form of cardiac muscle atrophy, fibrosis, and eventual cardiac dysfunction, resulting in poor quality of life and reduced survival. This article reviews the holistic approaches of existing diagnostic, pathophysiological, and multimodal therapeutic interventions targeting the molecular mechanisms that are responsible for cancer-induced cardiac cachexia. The major drivers of cardiac muscle wasting in cancer patients are au

Совпадение в полном тексте источника
… The prevention of cardiac atrophy via the administration of potent antioxidant resveratrol in C26 tumor-bearing mice indicates the crucial role of reactive oxygen species (ROS) in the development of cancer-induced cardiac atrophy [ 34 ]. … Resveratrol does not ameliorate muscle wasting in different types of cancer cachexia models. Clin. Nutr. 2007;26:239–244. doi: 10.1016/j.clnu.2006.12.001. 35. Springer J., Tschirner A., Hartman K., Von Haehling S., Anker S.D., Doehner W. …

Перенос Митохондрии для ремонта миелина.

Обезвоживание является общей характеристикой нейро-воспалительных и дегенеративных заболеваний центральной нервной системы (КНС), таких, как множественный склероз (МС). Часто это связано с нарушениями межклеточной связи, биоэнергетики и метаболического баланса в сочетании с митохондриальной дисфункцией в таких клетках, как олигодендроциты, нейроны, астроциты и микроглиа. Несмотря на то, что нынешние методы лечения MS сосредоточены на иммуномодуляции, они не могут остановить или обратить вспять прогресс демиэлизации. Последние достижения подчеркивают межклеточный митохондриальный обмен в качест

Совпадение в полном тексте источника
… fractions could have therapeutic effect. 73 Moreover, EVs can be engineered to optimize their cargo loading, 129 target-specific delivery, endosomal escape mechanisms, and therapeutic efficacy. 130 Treatment of NIH/3T3, a fibroblast cell line and hCMEC/D3, a human BEC line with PGC-1α (resveratrol …

Astragaloside II, природный садонин, облегчает ремимиэлирование в демиэлинговых неврологических заболеваниях с помощью рецептора P75NTR, опосредованного осью сигнала β-катенина/Id2/MBP в клетках-прекурсорах олигодендроцитов.

КОЛИЧЕСТВО: Демиелинация является отличительной чертой неврологических расстройств, таких, как множественный склероз и оптика нейромиелита, что приводит к неврологическим расстройствам. Существующая терапия в первую очередь модифицирует иммунную реакцию, но не позволяет напрямую содействовать ремонту миелина. Расширение дифференциации олигодендроцитов и производства олигодендроцитов (ООП) имеет решающее значение для восстановления целостности миелина.ЦЕЛИ: В рамках этого исследования изучался терапевтический потенциал астрагалосида II (AS-II), биоактивного садонина с нейрозащитными и продиффер

Совпадение в полном тексте источника
… While small-molecule therapeutics have emerged as promising remyelination enhancers [ 24 , 25 , 44 ], such as curcumin [ 45 ], ginsenosides [ 10 , 46 ], and resveratrol [ 47 ], their clinical translation has been hampered by insufficient targeting specificity. …

Drug Delivery Approaches for the Treatment of Cervical Cancer.

Cervical cancer is a highly prevalent cancer that affects women around the world. With the availability of new technologies, researchers have increased their efforts to develop new drug delivery systems in cervical cancer chemotherapy. In this review, we summarized some of the recent research in systematic and localized drug delivery systems and compared the advantages and disadvantages of these methods.

Совпадение в полном тексте источника
… Effects of doxorubicin mediated by gold nanoparticles and resveratrol in two human cervical tumor cell lines Colloids Surf. B 2015 135 726 734 10.1016/j.colsurfb.2015.08.036 26340362 50. Firer M.A. Gellerman G. Targeted drug delivery for cancer therapy: The other side of antibodies J. Hematol. …

Chromatin modifiers in human disease: from functional roles to regulatory mechanisms.

The field of transcriptional regulation has revealed the vital role of chromatin modifiers in human diseases from the beginning of functional exploration to the process of participating in many types of disease regulatory mechanisms. Chromatin modifiers are a class of enzymes that can catalyze the chemical conversion of pyrimidine residues or amino acid residues, including histone modifiers, DNA methyltransferases, and chromatin remodeling complexes. Chromatin modifiers assist in the formation of transcriptional regulatory circuits between transcription factors, enhancers, and promoters by reg

Совпадение в полном тексте источника
… In this regard, Gallic acid, Resveratrol, Clinacanthus nutan, Andrographolide, ligistin, Wogonin, and Triptolide have been identified as potential candidates for inhibiting their target chromatin modifiers [ 206 – 212 ]. …

Blockage of Autophagy for Cancer Therapy: A Comprehensive Review.

The incidence and mortality of cancer are increasing, making it a leading cause of death worldwide. Conventional treatments such as surgery, radiotherapy, and chemotherapy face significant limitations due to therapeutic resistance. Autophagy, a cellular self-degradation mechanism, plays a crucial role in cancer development, drug resistance, and treatment. This review investigates the potential of autophagy inhibition as a therapeutic strategy for cancer. A systematic search was conducted on Embase, PubMed, and Google Scholar databases from 1967 to 2024 to identify studies on autophagy inhibito

Совпадение в полном тексте источника
… Additionally, the combined effect of another natural product called resveratrol with HCQ was investigated on an osteosarcoma cell line (MG-63). … The Synergistic Effect of Resveratrol and Hydroxychloroquine on Osteosarcoma Cell Line (MG-63) by Autophagy Modulating Available online: https://www.researchgate.net/publication/349641481_The_Synergistic_Effect_of_Resveratrol_and_Hydroxychloroquine_on_Osteosarcoma_Cell_Line_MG-63_by_Autophagy_Modulating …

От профилактики к управлению: изучение воздействия рациона питания на множественный склероз.

Множественный склероз (MS) — хроническое имунное заболевание центральной нервной системы, характеризующееся нейроинфламмацией и прогрессивным нейродегенерацией. Растущие данные свидетельствуют о том, что диетическое вмешательство может влиять на прогресс и управление симптомами MS, изменяя воспаление, окислительный стресс и кишечный микробиотический состав. В настоящем описательном обзоре рассматриваются последствия средиземноморского, растительного, кетогенного, вальса, сванка, периодического постирования и без глютена наряду с такими ключевыми питательными веществами, как жирные кислоты омег

Совпадение в полном тексте источника
… dietary supplements, egg, gluten-free diet, gut-brain axis, inflammation, immune system modulation, intermittent fasting (IF), ketogenic diet, low-fat diet, Mediterranean diet, microbiome, MS, neuroprotection, omega-3 fatty acids, oxidative stress, plant-based diet, polyphenols, pro- and prebiotics, resveratrol …

AMMI и GПЭ анализ биплетов генотипа на основе взаимодействия с окружающей средой для определения урожайности и составных характеристик кондитерского арбуза.

На мировом рынке существует высокий спрос на высококачественный съедобный арбуз, особенно для использования столовых орехов. Индия, в частности, обладает значительным потенциалом для экспорта кондитерских орехов с большим семяным орехом. Окружающая среда оказывает значительное влияние на выражение семян, что впоследствии влияет на качество кондитерских генотипов арахисовых орехов. В Индии штаты Гуджарат и Раджастхан являются известными производителями высококачественных арбузов, специально используемых для изготовления кондитерских изделий. Текущее исследование было проведено совместно с 43 Гу

Совпадение в полном тексте источника
… Trace minerals including selenium, manganese, and copper enhance cellular functioning, as can antioxidant polyphenolic substances like flavonoids and resveratrol 3 , 4 . The global market for premium confectionery peanuts is large. …

Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats.

Doxorubicin (DOX) is an effective anticancer drug, but its use is limited by dose-dependent heart toxicity. Quercetin is a natural antioxidant frequently studied for its beneficial properties. Moreover, a wide range of dietary supplements are available for human use. This in vivo study aimed to explore the potential cardioprotective effects of quercetin in chronic DOX treatment. A total of 32 Wistar rats were randomly divided into four groups: control, DOX, DOX/Q-50, and DOX/Q-100, treated with saline, 2.5 mg/kg body-weight DOX, 2.5 mg/kg body-weight DOX + 50 mg quercetin, and 2.5 mg/kg body-w

Совпадение в полном тексте источника
… Combinatorial Resveratrol and Quercetin Polymeric Micelles Mitigate Doxorubicin Induced Cardiotoxicity in Vitro and in Vivo. J. Control. Release. 2015;213:128–133. doi: 10.1016/j.jconrel.2015.06.040. 53. …

Oral cryotherapy for management of chemotherapy-induced oral mucositis in haematopoietic cell transplantation: a systematic review.

BackgroundOral mucositis (OM) is known to be the most common and challenging side effect of conditioning chemotherapy in haematopoietic cell transplant (HCT). This side effect causes significant morbidity and may delay the treatment plan, as well as increase therapeutic expenses. There are few clinical trials in the literature that indicate any kind of treatment or prevention methods are effective. Therefore, the aim of this study is to perform a systematic review of literature and examine the effectiveness of oral cryotherapy (OC) in management of chemotherapy-induced OM in patients with haem

Совпадение в полном тексте источника
… In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues. Bioorg Med Chem. 2018;26(17):4898–906. doi: 10.1016/j.bmc.2018.08.029. 45. Keefe D, Schubert M, Elting L, Sonis S, Epstein J, Raber-Durlacher J, et al. …

An overview of the potential anticancer properties of cardamonin.

Cancer is one of the leading causes of mortality, contributing to 9.6 million deaths globally in 2018 alone. Although several cancer treatments exist, they are often associated with severe side effects and high toxicities, leaving room for significant advancements to be made in the field. In recent years, several phytochemicals from plants and natural bioresources have been extracted and tested against various human malignancies using both in vitro and in vivo preclinical model systems. Cardamonin, a chalcone extracted from the Alpinia species, is an example of a natural therapeutic agent that

Совпадение в полном тексте источника
… Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol. Biosci Rep. 2020;40:BSR20200257. 10.1042/BSR20200257 11. Patra S, Mishra SR, Behera BP, Mahapatra KK, Panigrahi DP, Bhol CS, et al. …

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma.

BackgroundMultiple myeloma (MM) is at present an incurable malignancy, characterized by apoptosis-resistant tumor cells. Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an increased activation of Signal transducer and activator of transcription (Stat)1. The role of Stat1 in MM has not been elucidated, but Stat1 has in several studies been ascribed a pro-apoptotic role. Conversely, IL-6 induction of Stat3 is known to confer resistance to apoptosis in MM.MethodsTo delineate the role of Stat1 in IFN mediated sensitization to apoptosis, sub-lines of t

Совпадение в полном тексте источника
… The drugs used in the assay were etoposide, SAHA, dexamethasone, doxorubicin, As203, bortezomib, irinotecan, amsacrine, parthenolide, fludarabine, IMD 0354, 17-AAG/geldanamycin, TBB, docetaxel, oncovin, and resveratrol. For each drug, five different concentrations were used. …