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Cost-effectiveness of an experimental caries-control regimen in a 3.4-yr randomized clinical trial among 11-12-yr-old Finnish schoolchildren.

The aim of this study was to assess the cost-effectiveness of an experimental caries-control regimen in a randomized clinical trial (RCT) conducted in Pori, Finland, in 2001-2005. Children (n = 497) who were 11-12 yr of age and had at least one active initial caries lesion at baseline were studied. The children in the experimental group (n = 250) were offered an individually designed patient-centered regimen for caries control. The children in the control group (n = 247) received standard dental care. Furthermore, the whole population was exposed to continuous community-level oral health promo

[Necrotizing folliculitis in Behçet's disease].

We report a 24-year-old man with a known Behcet's disease who was lost to follow-up for a year. The patient was admitted for the association of scrotal ulceration and inguinal folliculitis, suggesting a Behcet's disease flare-up. Necrotizing course of the folliculitis led to the diagnosis of skin infection caused by a community-acquired methicillin-resistant Staphylococcus aureus strain, carrying Panton-Valentine leukocidin genes. Bacteriological analysis should be mandatory in the absence of specific criteria for the diagnosis of Behcet's disease.

Molecular identification and quantification of bacteria from endodontic infections using real-time polymerase chain reaction.

INTRODUCTION: It was the aim of the present study to evaluate root canal samples for the presence and numbers of specific species as well as for total bacterial load in teeth with chronic apical periodontitis using quantitative real-time polymerase chain reaction (PCR). METHODS: Forty adult patients with one radiographically documented periapical lesion were included. Twenty teeth presented with primary infections and 20 with secondary infections, requiring retreatment. After removal of necrotic pulp tissue or root canal filling, a first bacterial sample was obtained. Following chemo-mechanic

Treatment of bisphosphonate-related osteonecrosis of the jaws - a report of seven cases.

AIM OF THE STUDY: The aim of the study was to report on seven cases of BRONJ treated with surgical debridement, oral antibiotics and gentamicin-collagen sponge (Collatamp EG) placed in the bone wound. MATERIAL AND METHODS: Seven patients with 9 sites of BRONJ stage 2 were included in the study. Perioperative oral antibiotics, surgical debridement and/or sequestrotomy and gentamicin-collagen sponge (Collatamp EG) were used. Postoperative monitoring was carried out for the next 3 months. RESULTS: Three weeks after the surgery, six sites of BRONJ in five patients were treated successfully. In t

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… The patients used chlorhexidine mouth rinse, chlorhexidine topical gel and Solcoseryl. Two months after surgery the exposed areas were completely covered with oral epithelium. … Among the protocols applied in BRONJ treatment, chlorhexidine seems to be the main tool against fungal agents [ 4 ]. …

Conservative Management of Medication-Related Osteonecrosis of the Jaws (MRONJ): A Retrospective Cohort Study.

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of bisphosphonates and anti-resorptive drugs prescribed for treatment of severe osteoporosis, Paget's disease, and bone malignancies. The aim of this study was to evaluate the clinical outcome of a combined pharmacological and surgical management strategy on patients affected by MRONJ. MATERIALS AND METHODS: Medical records of patients with MRONJ were retrospectively examined to collect clinical history data. Conservative management included an initial pharmacological phase with antibiotics and antiseptic

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… Topical antiseptic therapy with 0.2% chlorhexidine mouthwash and 1% chlorhexidine gel, applied onto exposed necrotic bone, was also prescribed [ 17 ]. … This conservative approach of MRONJ management was based on previous study outcomes [ 1 , 9 , 21 , 22 ] and included systemic antibiotics as well as antiseptic therapy with 0.2% chlorhexidine mouthwash and 1% chlorhexidine gel applied onto exposed necrotic bone [ 17 ]. …

Eficacy of Cryotherapy in the Prevention of Oral Mucosistis in Adult Patients with Chemotherapy.

Oral mucositis (OM) is a common side effect of cancer therapies. It causes ulcerative, painful lesions in the oral cavity that can provoke malnutrition, increased risk of infection, longer hospital stays, and seriously affect the quality of life. Cooling the mucosa with oral cryotherapy (OC) during and/or after chemotherapy is the most accessible and tolerable intervention available. The aim of this study is to define the efficacy of OC for preventing OM induced by chemotherapy/radiotherapy in adult patients with cancer. Secondary endpoints include associated problems as pain. A systematic sea

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… EG1 data were collected from patients in the study groups who had oral care with chlorhexidine twice a day; EG2 had cryotherapy once a day. … Only one of them proposed the use of chlorhexidine rinses instead of OC to decrease the incidence of OM and to facilitate an oral diet [ 22 ]. …

Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings.

BACKGROUND AND OBJECTIVES: Gingivitis and periodontitis are common periodontal diseases that can significantly harm overall oral health, aff … of application were the intervention whereas placebo or the rest of the tested mouthwashes such as, chlorhexidine, sodium fluoride with cetylpyridinium chloride, sterile distilled water, hydrogen peroxide, were the ones to which propolis mouthwashes were compared. Treatment duration extended from 14 days to 3 months and the follow-up period differed from 14 day …

Indian Society of Critical Care Medicine Position Statement for Central Venous Catheterization and Management 2020.

BACKGROUND AND PURPOSE: Short-term central venous catheterization (CVC) is one of the commonly used invasive interventions in ICU and other … (Cardiac Cath Lab); CDC: Centers for Disease Control and Prevention; CFU: Colony forming unit; CHG: Chlorhexidine gluconate; CL: Central line; COMBUX: Comparison of Bedside Ultrasound with Chest X-ray (COMBUX study); CQI: Continuous quality improvement; CRBSI: Catheter-related blood stream infection; CUS: Chest ultrasonography; CVC: Central Venous Catheter; CXR …

Interventions for replacing missing teeth: treatment of perimplantitis.

BACKGROUND: One of the key factors for the long-term success of oral implants is the maintenance of healthy tissues around them. Bacterial p … ement; (3) different techniques of subgingival debridement; (4) laser versus manual debridement and chlorhexidine irrigation/gel; (5) systemic antibiotics plus resective surgery plus two different local antibiotics with and without implant surface smoothening; and (6) nanocrystalline hydroxyapatite versus Bio-Oss and resorbable barriers. Follow-up ranged from 3 …

Management of short-term indwelling urethral catheters to prevent urinary tract infections.

BACKGROUND: This systematic review updates a previous review published in 2000. The objective of this review was to present the best availab … ed systems or sealed systems with the addition of silver releasing devices. Neither the addition of chlorhexidine nor hydrogen peroxide to the drainage bag was found to be effective at reducing UTI rates. The findings indicated there was a higher incidence of bacteriuria associated with Foley catheters compared with intermittent catheterisation (P < 0.025). A s …

Prevention of oral mucositis or oral candidiasis for patients with cancer receiving chemotherapy (excluding head and neck cancer).

BACKGROUND: Treatment of cancer is increasingly more effective but is associated with short and long term side effects. Oral side effects re … acyclovir, allopurinol mouthrinse, amifostine, antibiotic pastille or paste, benzydamine, camomile, chlorhexidine, clarithromycin, folinic acid, glutamine, GM-CSF, hydrolytic enzymes, ice chips, oral care, pentoxifyline, povidone, prednisone, propantheline, prostaglandin, sucralfate and traumeel. Of the 21 interventions included in trials, nine showed some evid …

Late-onset medication-related osteonecrosis of the jaw 11 years after IV bisphosphonates following implant placement.

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a recognized complication of intravenous (IV) bisphosphonate therapy, par … n confirmed MRONJ. The lesion was treated with conservative surgical debridement, followed by 0.12% chlorhexidine gluconate rinses twice daily for 2 weeks. Healing was allowed by secondary intention without sutures, and postoperative systemic antibiotic therapy was prescribed. Follow-up examinations at 2 and 4 weeks demonstrated complete clinical healing, with …

[A study of using dexmedetomidine in ventilator bundle treatment in an ICU].

OBJECTIVE: To compare the sedative effect and safety of dexmedetomidine and midazolam in the intensive care unit (ICU) patients undergoing v … se of proton pump inhibitors for peptic ulcer prevention, prevention of deep vein thrombosis (DVT), chlorhexidine mouth nursing, and removal of sputum by suction from subglottic area. When the patients in both groups obtained satisfactory target sedation, daily awakening was conducted, and spontaneous breathing test (SBT) was carried out to determine optional w …

Interventions for preventing oral mucositis for patients with cancer receiving treatment.

BACKGROUND: Treatment of cancer is increasingly more effective but is associated with short and long term side effects. Oral side effects re … iotic pastille or paste, benzydamine, beta carotene, calcium phosphate, camomile, Chinese medicine, chlorhexidine, etoposide, folinic acid, glutamine, granulocyte/macrophage colony-stimulating factor (GM-CSF), histamine gel, honey, hydrolytic enzymes, ice chips, iseganan, keratinocyte GF, misonidazole, pilocarpine, pentoxifylline, povidone, prednisone, propanth …

Medication-Related Osteonecrosis of the Jaw: Successful Medical Management of Complex Maxillary Alveolus with Sinus Involvement.

Medication-related osteonecrosis of the jaw (MRONJ) in cancer patients presents a considerable challenge in management. Current management is primarily based on interventions in a limited number of cases assessing a single approach. Medical management typically is reported to include antimicrobial therapy with or without surgery. Advances in the understanding of pathogenesis have led to the investigation of additional medical interventions for early-stage necrosis. We present 3 patients with advanced-stage MRONJ of the maxilla using combined medical modalities including antimicrobial therapy,

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… We present three stage IV breast cancer (BC) patients (1 patient also had multiple myeloma [MM]) with complex clinical presentation of MRONJ managed at our institute using: (1) a combination of Pent-E, chlorhexidine, and PBM; (2) Augmentin, chlorhexidine, Pent-E, red/infrared light therapy, and teriparatide … ; and (3) ciprofloxacin, chlorhexidine rinse, Pent-E, and PBM therapy. …

Radiation-Induced Oral Mucositis.

Radiation-induced oral mucositis (RIOM) is a major dose-limiting toxicity in head and neck cancer patients. It is a normal tissue injury caused by radiation/radiotherapy (RT), which has marked adverse effects on patient quality of life and cancer therapy continuity. It is a challenge for radiation oncologists since it leads to cancer therapy interruption, poor local tumor control, and changes in dose fractionation. RIOM occurs in 100% of altered fractionation radiotherapy head and neck cancer patients. In the United Sates, its economic cost was estimated to reach 17,000.00 USD per patient with

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… Chlorhexidine is a bisguanidine exhibiting broad-spectrum antibacterial and antimycotic activities. The clinical trials done with chlorhexidine concluded that it cannot be recommended for the prophylaxis or the treatment of RIOM ( 117 – 120 ). … Alcohol-containing chlorhexidine mouth rinse should be avoided during clinical oral ulceration. Therefore, the MASCC/ISOO guidelines recommend against the use of chlorhexidine mouth rinse for prevention or treatment OM ( 33 ). …

Updates in penile prosthesis infections.

Inflatable penile prostheses are an important tool in the treatment of medically refractory erectile dysfunction. One of the major complications associated with these prostheses is infections, which ultimately require device explanation and placement of a new device. Over the past several decades, significant work has been done to reduce infection rates and optimize treatment strategies to reduce patient morbidity. This article reviews the current state of knowledge surrounding penile prosthesis infections, with attention to the evidence for methods to prevent infection and best practices for

Воздействие моделей перорального ухода на профилактику перорального слизистого слизняка, вызванного высокими дозами мельфалана у пациентов, страдающих АЦТ.

Высокодозированные мелфаланы (МЭЛ) в сочетании с аутологической трансплантацией стволовых клеток (ASCT) эффективно лечат множественные миеломы (MM), но часто вызывают оральный слизистой мукосит (OM), влияющий на исход пациента. Цель этого исследования заключается в оценке эффективности усовершенствованной модели орального ухода в деле предотвращения ОМ, вызванного МЭЛ. В этом ретроспективном исследовании были рассмотрены медицинские записи 87 больные с MM, которые прошли ACCT в первой родственной больнице Сокхоуского университета в декабре 2019 и февраль 2022. В соответствии с протоколами о пе

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… Care plan | Control group | Observation group Wake up in the morning before going to bed | Use chlorhexidine acetate mouthwash with a sponge stick to brush your teeth. | Use chlorhexidine acetate mouthwash with a sponge stick to brush your teeth. … Oral care interventions Both groups adhered to standard oral hygiene practices, which involved washing the mouth with chlorhexidine acetate mouthwash rinsed with warm water before meals and brushing teeth with a sponge stick containing chlorhexidine acetate mouthwash upon awakening and before bed, as …

Comparison of the Effectiveness of Conservative and Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: a Systematic Review.

OBJECTIVES: The objective of this systematic review is to evaluate the current knowledge on the effectiveness of conservative and surgical treatment of medication-related osteonecrosis of the jaw. MATERIAL AND METHODS: MEDLINE (PubMed), ScienceDirect and Cochrane Library search in combination with hand-search of relevant journals was conducted including human studies published in English between January 2017 and February 2023. Studies assessing treatment strategies for medication-related osteonecrosis of the jaw (MRONJ) were included. Quality and risk-of-bias assessment were evaluated by Joan

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… Conservative treatment includes oral hygiene, chlorhexidine mouth rinses, teriparatide medications, and systemic antibiotics to control infection. … Seventy-five patients with 92 lesions were treated with antimicrobial mouth rinse three times a day with 0.2% chlorhexidine solution and daily topical application of 1% chlorhexidine gel, no antibiotics were used. …

Retrospective analysis of open apex teeth obturated with mineral trioxide aggregate.

This study is a retrospective analysis of the outcome of initial nonsurgical root canal treatment of teeth with open apices, obturated with mineral trioxide aggregate when no apical barrier existed. One hundred sixteen patients from a single private endodontic office were treated between 1999 and 2006. Treatments on 144 teeth were completed either in one (92/144) or two visits with an interim calcium hydroxide interappointment medication (52/144). Fifty-four percent (78/144) of the teeth were available for recall (60.3% one visit and 39.7% two visits). The maximum time to recall was 4.87 years