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Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models.

Dysregulation of the Hepatocyte growth factor (HGF)/c-Met signaling axis upregulates diverse tumor cell functions, including cell proliferation, survival, scattering and motility, epithelial-to-mesenchymal transition (EMT), angiogenesis, invasion, and metastasis. (-)-Oleocanthal is a naturally occurring secoiridoid from extra-virgin olive oil, which showed antiproliferative and antimigratory activity against different cancer cell lines. The aim of this study was to characterize the intracellular mechanisms involved in mediating the anticancer effects of (-)-oleocanthal treatment and the potent

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… Western Blot Analysis To study treatment effects of (-)-oleocanthal on MDA-MB-231 cell cycle progression, cells in the various treatment groups were synchronized in G1 phase [23] . … Cells must pass through a restriction point in the G1 phase before progression into S phase and subsequently undergoing mitosis [34] . Early in G1 phase progression, mitogenic factors enhance the expression of cyclin D1. …

AVN944 Elicits Apoptotic Responses and Impedes Tumorigenic Potential in Ewing's Sarcoma Cells.

Inosine monophosphate dehydrogenase 2 (IMPDH2) is implicated in survival and proliferation of cancer cells because of its role in guanine nucleotide biosynthesis. This study evaluates the efficacy of AVN944, an IMPDH2 inhibitor, as a treatment for Ewing's sarcoma, a challenging malignancy in pediatric and young adult patients. Gene expression data, as well as clinical outcomes for sarcoma patients, from The Cancer Genome Atlas (TCGA) were analyzed to determine the association between IMPDH2 expression and survival. Human Ewing's sarcoma cell lines and xenograft models were used to evaluate the

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… Flow cytometry analysis revealed progressive accumulation of cells in the sub-G1 phase, as well as an increase in the Annexin V-positive population of both cell lines. … Our data align with these findings; AVN944 treatment resulted in significant accumulation of cells in the sub-G1 phase, indicative of DNA fragmentation and apoptosis. …

Доказательства потенциала гуанидов против Leishmania (Viannia) braziliensis: исследование витро эффективности, токсичности и влияния на ответ иммунной системы.

Лейшманиаз — это сложная группа инфекционных и паразитарных заболеваний, которая поражает десятки тысяч людей на пяти континентах. Лечение лейшманиаза остается сложной задачей, так как оно зависит от лекарств, известных своей высокой токсичностью и ограниченной эффективностью, что делает необходимым поиск новых молекул, которые обеспечивали бы большую эффективность и безопасность. Настоящее исследование посвящено изучению влияния семи синтетических гуанидиновых производных (LQOF-G1, LQOF-G2, LQOF-G6, LQOF-G7, LQOF-G32, LQOF-G35 и LQOF-G36) на паразита Leishmania (Viannia) braziliensis и витроп

Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.

Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing lo

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… However, a slight decrease in the G0/G1 phase was caused by MCP, leading to substantial cell arrest in G2. In addition, MCP was found to increase the production of the pro-apoptotic protein Bax and cleavage of the CASP3 precursor. … The rate of sub-G1 phase cells increased in S phase cells, indicating apoptosis, which may be mediated by a decrease in signal transduction, as indicated by the downregulation of AKT, IκB, p65 NF-κB, and IκB kinase (IKK) after 24 h [ 59 ]. …

The Polyphenols α-Mangostin and Nordihydroguaiaretic Acid Induce Oxidative Stress, Cell Cycle Arrest, and Apoptosis in a Cellular Model of Medulloblastoma.

Medulloblastoma is a common malignant brain tumor in the pediatric age. The current therapeutics present serious collateral effects. Polyphenols α-mangostin and nordihydroguaiaretic acid (NDGA) exert potent antitumoral activity in different cancer models, although their antitumoral effects have not been described in medulloblastoma cells yet. This study aimed to examine the proapoptotic effects of these polyphenols on human medulloblastoma cells. Medulloblastoma cell line Daoy was incubated with increasing concentrations of α-mangostin or NDGA for 24 h. The cell viability was analyzed using cr

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… For instance, Gao et al. [ 27 ] reported that NDGA induced cell cycle arrest at the G1 phase in cervical cancer SiHa cells by upregulating the expression of p21, a key mediator of G1/S transition. … Furthermore, a novel derivative NDGA-based compound, NDGA-P21, could inhibit glioma cell proliferation and arrest the cell cycle in the G1 phase but with poor apoptosis induction [ 45 ]. …

Investigation of the cytotoxicity induced by cannabinoids on human ovarian carcinoma cells.

Cannabinoids have been shown to induce anti-tumor activity in a variety of carcinoma cells such as breast, prostate, and brain. The aim of the present study is to investigate the anti-tumor activity of cannabinoids, CBD (cannbidiol), and CBG (cannabigerol) in ovarian carcinoma cells sensitive and resistant to chemotherapeutic drugs. Sensitive A2780 cells and resistant A2780/CP70 carcinoma cells and non-carcinoma cells were exposed to varying concentrations of CBD, CBG, carboplatin or CB1 and CB2 receptor antagonists, AM251 and AM630, respectively, alone or in combination, at different exposure

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… Similar to CBD, when A2780 cells were treated with CBG, there was an increase in G0/G1 phase from control values of 71.3 ± 0.5% to 79.1 ± 0.4%, at 10 μM and 80.2 ± 1.3% at 30 μM. The increase in G0/G1 phase was correlated with a decrease in S phase compared to control values. … In the present study the cell cycle arrest was induced by cannabinoids at G0–G1 phase. …

Sensitivity of Cutaneous T-Cell Lymphoma Cells to the Mcl-1 Inhibitor S63845 Correlates with the Lack of Bcl-w Expression.

Long-term, curative treatment of cutaneous T-cell lymphomas (CTCL) remains a major challenge. Therapy resistance is often based on apoptosis deficiency, and may depend on antiapoptotic Bcl-2 proteins, such as Bcl-2, Bcl-xL, Bcl-w and Mcl-1. For their targeting, several antagonists have been generated, which mimic the Bcl-2 homology domain 3 (BH3 mimetics). As dysregulation and overexpression of Mcl-1 has been reported in CTCL, the use of Mcl-1 inhibitors appears as an attractive strategy. Here, we investigated the effects of the selective Mcl-1 inhibitor S63845 in a series of four CTCL cell li

Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use.

In the current chapter, a new strategic compilation of phytochemicals with potent antitumor properties has been addressed, most importantly focusing on cell cycle arrest and apoptotic signaling mechanism. A promising approach in tumor prevention is to eliminate cancer cells preferably via cell cycle arrest and programmed cell death with lesser harm to neighboring normal cells. Cancer cells have a survival advantage to escape apoptosis and relentlessly divide to proliferate, gearing up the cell cycle process. Recently, the use of phytochemical-derived conjugated chemotherapeutic agents has incr

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… phase. … It lowers tumor proliferation by restricting its growth at the G0/G1 phase of the cell cycle, inducing apoptotic cancer cell death. …

Recent Progress in CDK4/6 Inhibitors and PROTACs.

Cell division in eukaryotes is a highly regulated process that is critical to the life of a cell. Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase (CDK) activation, is a key pathological mechanism in cancer. Recently, selective CDK4/6 inhibitors have shown clinical success, particularly in treating advanced-stage estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer. This review provides an in-depth analysis of the action mechanism and recent advancements in CDK4/6 inhibitors, categorizing them based

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… For instance, RB1 is monophosphorylated during the G1 phase and becomes inactivated in the late G1 phase by cyclin E-CDK2, which hyperphosphorylates RB1 on multiple residues. … It arrests cells in the G1 phase and is supposed to bind to CDK4 [ 92 ]. …

Cohort study of consistency between the compliance with guidelines for chemotherapy-induced nausea and vomiting and patient outcome.

BackgroundChemotherapy-induced nausea and vomiting is one of the most influential factors that affect patient quality of life; thus, preventing this adverse event could lead to better patient outcome. Standard preventive guidelines for antiemetic treatment have already been established based on the emetogenicity of chemotherapeutic agents. It is important that compliance with in-house guidelines and their effect on patient outcome is monitored.MethodsIn 3 years since the Akita university hospital antiemetic guidelines were outlined, we assessed the incidence of chemotherapy-induced nausea and

Radioligand Therapy in Cancer Management: A Global Perspective.

Radioligand therapy (RLT) is a targeted treatment modality that combines a tumour-specific ligand with a therapeutic radionuclide. Once administered, the radiopharmaceutical binds selectively to cancer-associated targets, delivering cytotoxic radiation directly to tumour cells while sparing surrounding tissues. Two RLT agents, [177Lu]Lu-DOTA-TATE (Lutathera®) and [177Lu]Lu-PSMA-617 (Pluvicto®), have received regulatory approval for the treatment of advanced gastroenteropancreatic neuroendocrine tumours and metastatic castration-resistant prostate cancer, respectively. As of July 2025, more tha

The anti-tumor potential of sinomenine: a narrative review.

BACKGROUND AND OBJECTIVE: Currently, chemotherapy is the main treatment for most tumors. However, drug resistance and many adverse reactions associated with chemotherapy greatly limit its use. Therefore, an increasing number of researchers have shifted the research focus the anti-tumor activity of traditional Chinese medicine. The objective of this article is to review the anti-tumor mechanism of sinomenine and its derivatives to provide a reference for further study and clinical transformation. METHODS: In this study, we searched for relevant articles on the anti-tumor mechanism of Sinomeniu

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… In addition, Xu et al. have shown that sinomenine hydrochloride inhibited ovarian cancer cell growth by reducing the expression of long non-coding RNA-HOST 2, thus downregulating Cyclin D1, CDK 4 and CDK 6 to induce cell G0/G1 phase arrest ( 19 ). … Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation. Technol Cancer Res Treat 2018;17:1533034618770305. 10.1177/1533034618770305 36. Chen SY, Zou Y, Huang YQ. …

Impact of cryotherapy on incidence and severity of oral mucositis in hematopoietic stem cell transplantation: retrospective observational study.

Oral mucositis (OM) is a common and significant complication of chemotherapy and radiotherapy, particularly in patients undergoing hematopoietic stem cell transplantation (HSCT). This retrospective observational study assessed the effectiveness of oral cryotherapy in reducing the incidence and severity of OM in 258 HSCT recipients treated at a single transplant center in Poland between 2018 and 2024. Patients were divided into two groups: 199 received cryotherapy as part of their conditioning regimen, while 59 did not. Cryotherapy was administered using ice chips from 10 min before chemotherap

Talquetamab in Multiple Myeloma: Efficacy, Safety, and Future Directions.

Relapsed and refractory multiple myeloma (RRMM) remains a challenging condition despite advances in immunotherapies. Novel bispecific antibodies (BsAbs), including talquetamab, have shown promising efficacy in heavily pretreated patients, even those with triple- and penta-refractory disease. Talquetamab, recently approved by the FDA and EMA, is indicated for patients who have progressed after at least three or four prior lines of therapy (LOTs). Administered following a step-up dosing phase to manage cytokine release syndrome (CRS), talquetamab demonstrated a high overall response rate (ORR) o

A Natural Organic Compound "Decursin" Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma.

Osteosarcoma is a rare malignant tumor that commonly occurs in children. Anticancer drugs, for example, cisplatin, aid in postsurgery recovery but induce side effects such as renal damage, affecting the life prognosis of patients. Decursin which is one of the bioactive components has been reported for its anti-inflammatory, antioxidant, and antitumor effects, but the effect on osteosarcoma is unexplained. In this study, the research theme was to examine the sensitizing effect of decursin and its influence on cisplatin-induced nephrotoxicity. The cell viability and half maximal inhibitory conce

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… Decursin Acts on the G0/G1 Phase The cell cycle was evaluated by deep red cell cycle assay for 143B and EdU assay for Mg63. … In this study, decursin increased the number of cells in the G0/G1 phase and decreased in the S-phase on human osteosarcoma cell lines at 24 h. Decursin also acted on cyclin D1 and CDK6 that arrests the cell cycle in G0/G1 phase. We believe that decursin affects the cell cycle. …

Abemaciclib, A Selective CDK4/6 Inhibitor, Restricts the Growth of Pediatric Ependymomas.

Pediatric ependymomas are a type of malignant brain tumor that occurs in children. The overall 10-year survival rate has been reported as being 45-75%. Maximal safe surgical resection combined with adjuvant chemoradiation therapy is associated with the highest overall and progression-free survival rates. Despite aggressive treatment, one-third of ependymomas exhibit recurrence within 2 years of initial treatment. Therefore, this study aimed to find new agents to overcome chemoresistance and defer radiotherapy treatment since, in addition, radiation exposure may cause long-term side effects in

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… The data reveal that treatment with a low concentration of abemaciclib increased the accumulation of cells at the G1 phase at 24 and 48 h ( Figure 3 C and Figure S2 ). … However, a fraction of ependymoma cells treated with a high concentration of abemaciclib were arrested at the G2 rather than G1 phase at 24 and 48 h ( Figure 3 C and Figure S2 ). …

Clinically proven natural products against breast cancer, with mechanistic insights.

BackgroundBreast cancer still stands to be the foremost contributor to cancer-related incidence and mortality in women globally accounting for about 14% of all female cancer-related deaths worldwide. This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment.MethodologyRequired data for this review article was retrieved employing several readily obtainable search databases, including Web of Science® (Thomson Reuters, USA), PubMed® (U.S. National Library of Medicine, USA), and SciVerse Scopus® (Elsevier Properties S.A., USA), takin

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… Consequently, DHA induces cell cycle arrest, primarily at the G1 phase, and promotes apoptosis. … Together, these molecular alterations cause either G1/M phase arrest or G1 phase arrest [ 84 ] ( Fig. 8 ). …

Изучение связи между ядерными рецепторами в гематологических галереях.

Гематологические магнации (ГМ) представляют собой подмножество новообразований, затрагивающих кровь, костный мозг и лимфатические системы, которые в основном подразделяются на лейкемию, лимфому и множественную миелому. Их прогнозы значительно отличаются друг от друга, причем, несмотря на текущее лечение, часто возникает опасность рецидива. Несмотря на то, что современные терапевтические стратегии расширили общее выживание пациентов, они не предлагают лечения на продвинутых этапах и часто приводят к таким проблемам, как приобретение лекарственной устойчивости, рецидивы и серьезные побочные эффе

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… phase ↓ Cell growth | [ 72 ] | In vitro | CEM-C1 cells | Rapamycin + Dex A | ↑ Apoptosis, Cell cycle arrest G0/G1 phase, GRα, p-GR, Bim-EL ↓ Cell Growth, p-p70S6K, mTOR | [ 72 ] | In vitro | B-CLL cells | Rolipram, Cilomilast, Roflumilast | ↑ GRα, Apoptosis | [ 73 ] | In vitro | B-CLL cells | Actinomycin-D … An intriguing study demonstrated that the treatment of 4-hydroxy tamoxifen (4-OHTam), a selective estrogen receptor modulator (SERM), decreased proliferation and increased apoptosis in LP1, CAC-2, CAC-6, NCI H929, U266 cells and G1 phase cell cycle arrest in LP1, NCI H929 cells [ 155 ]. …

BCMA-targeted immunotherapy for multiple myeloma.

B cell maturation antigen (BCMA) is a novel treatment target for multiple myeloma (MM) due to its highly selective expression in malignant plasma cells (PCs). Multiple BCMA-targeted therapeutics, including antibody-drug conjugates (ADC), chimeric antigen receptor (CAR)-T cells, and bispecific T cell engagers (BiTE), have achieved remarkable clinical response in patients with relapsed and refractory MM. Belantamab mafodotin-blmf (GSK2857916), a BCMA-targeted ADC, has just been approved for highly refractory MM. In this article, we summarized the molecular and physiological properties of BCMA as

New targets for the treatment of follicular lymphoma.

The last two decades have witnessed striking advances in our understanding of the biological factors underlying the development of Follicular lymphoma (FL). Development of newer treatment approaches have improved the outlook for many individuals with these disorders; however, with these advances come new questions. Given the long-term survival of patients with FL, drugs with favourable side-effect profile and minimal long-term risks are desired. FL is incurable with current treatment modalities. It often runs an indolent course with multiple relapses and progressively shorter intervals of remi

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… BFA-induced cell death is associated with profound ER stress, mitochondrial breach and subsequent caspase cascade activation with clear predominance of apoptosing cells at a G1 phase of the cell-cycle [ 53 , 54 ]. … TQ inhibit G1 phase of cell cycle via increase in the expression of the cyclin-dependent kinase inhibitor p16 and downregulation of cyclin D1 protein expression in papilloma cells [ 110 ]. …