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Repurposing Anti-Cancer Drugs for COVID-19 Treatment.

The novel coronavirus disease 2019 (COVID-19) pandemic has caused catastrophic damage to human life across the globe along with social and financial hardships. According to the Johns Hopkins University Coronavirus Resource Center, more than 41.3 million people worldwide have been infected, and more than 1,133,000 people have died as of October 22, 2020. At present, there is no available vaccine and a scarcity of efficacious therapies. However, there is tremendous ongoing effort towards identifying effective drugs and developing novel vaccines. Early data from Adaptive COVID-19 Treatment Trials

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… Chen C , Qi F , Shi K , et al. Thalidomide combined with low-dose glucocorticoid in the treatment of COVID-19 . pneumonia . 2020 . 10.1002/ctm2.35 PMC7403664 32508009 75. Treon SP , Castillo J , Skarbnik AP , et al. …

MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance.

MicroRNAs (miRNAs, or miRs) are single-strand short non-coding RNAs with a pivotal role in the regulation of physiological- or disease-associated cellular processes. They bind to target miRs modulating gene expression at post-transcriptional levels. Here, we present an overview of miRs deregulation in the pathogenesis of multiple myeloma (MM), and discuss the potential use of miRs/nanocarriers association in clinic. Since miRs can act as oncogenes or tumor suppressors, strategies based on their inhibition and/or replacement represent the new opportunities in cancer therapy. The miRs delivery s

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… Qi Y. Loong F. Lam W.L. Wong L.G. Jin D.Y. Costello J.F. Liang R. Epigenetic inactivation of the miR-34a in hematological malignancies Carcinogenesis 2010 31 745 750 10.1093/carcin/bgq033 20118199 39. Misso G. Di Martino M.T. De Rosa G. Farooqi A.A. Lombardi A. Campani V. Zarone M.R. Gullà A. …

Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer.

Tissue homeostasis is the result of a complex intercellular network controlling the behavior of every cell for the survival of the whole organism. In mammalian tissues, cells do communicate via diverse long- and short-range communication mechanisms. While long-range communication involves hormones through blood circulation and neural transmission, short-range communication mechanisms include either paracrine diffusible factors or direct interactions (e.g., gap junctions, intercellular bridges and tunneling nanotubes) or a mixture of both (e.g., exosomes). Tumor growth represents an alteration

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… Lu Z., Qi L., Li G.X., Bo X.J., Liu G.D., Wang J.M. Se-methylselenocysteine suppresses the growth of prostate cancer cell DU145 through connexin 43-induced apoptosis. J. Cancer Res. 2015;11:840–845. doi: 10.4103/0973-1482.139265. 97. Fukushima M., Hattori Y., Yoshizawa T., Maitani Y. …

Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.

Colon cancer is the second most common cause of cancer mortality in the Western world with metastasis commonly present at the time of diagnosis. Screening for propagation and metastatic behavior in a novel chimeric-mouse colon cancer model, driven by mutant p53 and β-Catenin, led to the identification of a unique, invasive adenocarcinoma. Comparison of the genome of this tumor, CB42, with genomes from non-propagating tumors by array CGH and sequencing revealed an amplicon on chromosome five containing CDK6 and CDK14, and a KRAS mutation, respectively. Single agent small molecule inhibition of

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… Dev Cell 17 : 788 – 799 . 20059949 10.1016/j.devcel.2009.11.006 38 Li C, Qi L, Bellail AC, Hao C, Liu T PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis . …

Circadian clock and cancer.

Circadian rhythms play a critical role in regulating physiological and behavioral processes, such as the sleep-wake cycle, hormone secretion, and metabolism. These rhythms are controlled by endogenous biological clocks, which are synchronized with environmental cues, primarily the light-dark cycle. Notably, disruption or reprogramming of circadian rhythms is closely associated with cancer initiation, progression, and treatment response. At the molecular level, the dysregulation of core clock genes can disturb normal cellular rhythms, leading to aberrant cell proliferation, impaired DNA repair,

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.

The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstre

Targeting HDACs with dacinostat amplifies radiation-induced DNA damage via sustained phosphorylated p53 and repair inhibition in aggressive meningioma.

The lack of standard systemic treatments in meningioma presents a therapeutic challenge, making radiotherapy a crucial intervention for recurrent, high-grade, or inoperable tumours. Nonetheless, the efficacy of radiotherapy is constrained by the inherent radioresistance of meningiomas, attributed to their proficient DNA damage repair and robust cell cycle checkpoint regulation. These biological barriers, along with anatomical constraints of avoiding damage to adjacent neural tissues, restrict dose escalation and therapeutic gains. Histone deacetylases (HDACs) are mediators of radioresistance i

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… Zhang H, Qi L, Du Y, Huang LF, Braun FK, Kogiso M. Patient-Derived Orthotopic Xenograft (PDOX) mouse models of primary and recurrent meningioma. Cancers. 2020;12:1478 46. Mathews Griner LA, Zhang X, Guha R, McKnight C, Goldlust IS, Lal-Nag M, et al. …

Oral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures.

Background: Osteoporotic vertebral compression fractures (OVCFs) are the most prevalent manifestation of osteoporotic skeletal disease, associated with severe pain, functional decline, and elevated risk of subsequent fractures. Conservative management remains the first-line approach for stable fractures, yet pain control is often suboptimal, and vertebral collapse progresses in up to 37% of patients. Bio-activated orthosilicic acid combined with vitamins D3 and K2 (BioSi-DK) may support fracture healing through complementary mechanisms acting on osteoblast differentiation, collagen synthesis,

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… Qi H. Zhang Y. Wang J. Xue J. Vertebral bone marrow edema in magnetic resonance imaging correlates with bone healing histomorphometry in (sub)acute osteoporotic vertebral compression fracture Eur. Spine J. 2021 30 2708 2717 10.1007/s00586-021-06814-3 33743056 47. Delrue C. Speeckaert M.M. …

Exploring the applicability, combined strategies, and challenges of ablation in hematology based on its characteristics and immunomodulatory mechanisms.

Malignant hematological diseases, such as lymphoma, leukemia, and multiple myeloma, are frequently accompanied by clinical challenges including local progressive lesions, relapsed/refractory conditions, and poor tolerance to standard treatments in special populations. Systemic therapies represented by chemotherapy and targeted therapy have inherent limitations in addressing local tumor burden, relieving organ compression, and being suitable for frail patients. As a minimally invasive local treatment technology, ablation has been widely used in solid tumor therapy due to its advantages of preci

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… Li J, Zhao X, Qi M, Chen X, Chen W, Zhang S, et al. Cryoablation combined with programmed cell death protein 1 (PD-1) inhibitors regulates myeloid-derived suppressor cells (MDSCs) through the JAK2-STAT3-S100A8/A9 axis in mice with Lewis lung carcinoma. …

Естественные модули вкуса и микробиомеозная поддержка в области питания для иммунотерапии-ассоциированной дисгеусии: перевод для оказания помощи в лечении рака.

Дисгейсия является клинической, но по-прежнему недостаточно стандартизированной токсичностью для лечения рака. В эпоху иммунотерапии расстройства вкуса становятся все более актуальными для пациентов, получающих ингибиторы на иммунных контрольно-пропускных пунктах, химерик антигенные рецепторы (CAR) T-клеток и T-перенаправленные антитела, с группой G-белковых рецепторов C 5 - лечение в множестве миэлома, осуществляемое под руководством члена D (GPRC5D), представляет собой особенно поучительную модель с высокой нагрузкой. Мы провели структурированный критический обзор с картированием доказательс

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… Deng L.J., Qi M., Li N., Lei Y.H., Zhang D.M., Chen J.X. Natural products and their derivatives: Promising modulators of tumor immunotherapy. J. Leukoc. Biol. 2020;108:493–508. doi: 10.1002/jlb.3mr0320-444r. 24. Huo J.-L., Fu W.-J., Liu Z.-H., Lu N., Jia X.-Q., Liu Z.-S. …

Нейрологическая токсичность, не связанная с ИКАНС, после терапии BCMA CAR-T: систематический обзор и метаанализ 4630 Пациенты с множественной миеломой.

Регулируемая химериком антигена рецептора Т-клектора (CAR-T) абстрагированная клеточная антигенная терапия (BCMA) позволила резко улучшить результаты лечения пациентов с повторной или рефрактной множественной миеломой. Хотя синдром цитокина, связанный с КАР-Т, и синдром нейротоксичности, связанный с иммунным эффектом клеток (ИКАНС), хорошо описаны, нейрологическая токсичность (NINTs), не связанная с КАР-Т, по-прежнему недостаточно определена, при этом данные о частотности и факторах риска являются ограниченными. Мы провели систематический обзор и метаанализ возможных клинических испытаний и ре

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… Zhang X, Ouyang C, Sun G, Liu H, Qi J, Suo X. Anti-BCMA CAR-T cell immunotherapy for relapsed or refractory multiple myeloma. Exp Ther Med. 2023;26(4):471–477. doi: 10.3892/etm.2023.12170. 90. Zhang X, Wang L, Yang J, et al. …

The Impact of Monoclonal Antibody Usage on Hearing Outcomes: A Systematic Review.

ObjectiveTo ascertain trends in ototoxicity observed with monoclonal antibodies (mABs) and understand the impact they may have on hearing function.Data sourcesPubMed, Embase, Scopus.Review methodsA systematic review was performed following PRISMA guidelines. Data were reviewed for demographics, utilized mABs with respective indication and dosing, audiometric outcomes, and treatment for otologic effects.ResultsOf 757 studies reviewed, a total of 44 were included, encompassing 18,046 patients treated with mABs. Mean age of the sample was 57.8 years old. The search yielded 18 agents of ototoxicit

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… Zhang S, Wang Y, Qi Z, Tong S, Zhu D. Data mining and analysis of adverse event signals associated with teprotumumab using the Food and Drug Administration adverse event reporting system database. Int J Clin Pharmacol. 2024;46(2):471‐479. 10.1007/s11096-023-01676-9. 53. …

Opportunities and Challenges in Antibody-Drug Conjugates for Cancer Therapy: A New Era for Cancer Treatment.

The antibody, linker, and payload moieties all play a significant role in giving the ADC its unique therapeutic potential. The antibody subclass employed in ADCs is determined based on relative individual receptor affinities and pharmacokinetics. Meanwhile, the linker used in an ADC can either be cleavable or non-cleavable. ADC therapy comprises antibody-dependent mechanisms in addition to the direct cytotoxic effects of the payload. These include antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and antibody-dependent cellular phagocytosis, as well as the "bystander

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… Zhao Y., Ting K.K., Coleman P., Qi Y., Chen J., Vadas M., Gamble J. The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking. Cancers. 2021;13:1724. doi: 10.3390/cancers13071724. 58. Jin Y., Schladetsch M.A., Huang X., Balunas M.J., Wiemer A.J. …

Research trends of acupuncture therapy for painful peripheral nervous system diseases from 2004 to 2023: a bibliometric and meta-analysis.

BackgroundPeripheral nervous system diseases (PNSD) have represented a major global health burden, leading to significant economic impacts a … most productive country and institution were China and Kyung Hee University, respectively. Fang Jianqiao, was the most prolific author with the highest publications. Among journals, "Pain," was the most frequently cited, while the top-cited reference was a randomized controlled pilot trial by Lu Weidong in 2020. "Acupuncture" emerged as the keyword w …

How does medication-related osteonecrosis of the jaw (MRONJ) influence the health-related quality of life after surgery?

BACKGROUND: Medication-Related Osteonecrosis of the Jaw (MRONJ), an established side effect of antiresorptive and antiangiogenic medication, could sometimes require surgical intervention, such as decortication. The objectives of this retrospective patient survey study were to evaluate the effect of surgical treated MRONJ on health-related quality of life (QoL) and to assess the awareness of the risk of MRONJ. METHODS: The MRONJ-related QoL in both cancer and osteoporosis patients was determined in four different time periods after surgery applying the European Organisation for Research and Tr

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… Qi WX, Tang LN, He AN, Yao Y, Shen Z. Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: a meta-analysis of seven randomized controlled trials. Int J Clin Oncol. 2014;19(2):403–10. 10.1007/s10147-013-0561-6. 9. Jadu F, Lee L, Pharoah M, Reece D, Wang L. …

Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy?

E-selectin, a cytoadhesive glycoprotein, is expressed on venular endothelial cells and mediates leukocyte localization to inflamed endothelium, the first step in inflammatory cell extravasation into tissue. Constitutive marrow endothelial E-selectin expression also supports bone marrow hematopoiesis via NF-κB-mediated signaling. Correspondingly, E-selectin interaction with E-selectin ligand (sialyl Lewisx) on acute myeloid leukemia (AML) cells leads to chemotherapy resistance in vivo. Uproleselan (GMI-1271) is a carbohydrate analog of sialyl Lewisx that blocks E-selectin binding. A Phase 2 tri

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… Hum Mol Genet 1994 ; 3 ( 11 ): 1935 – 7 . 7533025 10.1093/hmg/3.11.1935 [49] Qi L , Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes . …

Electroretinographic dysfunction, insulin resistance, and childhood trauma in early-course psychosis: A case-control exploratory study.

BACKGROUND: Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) and its ability to promote brain plasticity, taVNS has emerged as a promising therapeutic option for SAH patients. However, the effects of taVNS on cardiovascular dynamics in critically ill patients, like those with SAH, have not yet been investigated. Given the association between cardiac complications and e

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… This is particularly notable as cardiovascular abnormalities following SAH, such as prolonged elevated heart rate and QT prolongation, are associated with an increased risk of poor outcomes ( Norberg et al., 2018 ; Schmidt et al., 2014 ; Zhang and Qi, 2016 ; van der Bilt et al., 2009 ). …

NK92 Разоблачение антиBCMA CAR и Secreted TRAIL для лечения множественной миеломы: предварительная оценка in Vitro.

Множественная миелома (ММ) стала свидетелем улучшения качества жизни пациентов благодаря совершенствованию терапевтических подходов. В частности, аллогенная трансплантация стволовых клеток, протеаозные ингибиторы, иммуномодулятивные препараты и моноклонные антитела способствовали повышению качества жизни. Недавно появилась многообещающая авеню с клетками химерика антигенного рецептора (CAR) Т, направленными против антигена созревания клеток B-клеток (BCMA), широко выраженная на клетках MM. Чтобы уменьшить риски, связанные с аллогенными Т-клетками, мы изучили потенциал выражения BCMA CAR в нату

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… Yimer H., Melear J., Faber E., Bensinger W.I., Burke J.M., Narang M., Stevens D., Gunawardena S., Lutska Y., Qi K., et al. Daratumumab, bortezomib, cyclophosphamide and dexamethasone in newly diagnosed and relapsed multiple myeloma: LYRA study. Br. J. …

Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration.

Low-magnitude (≤1 g) high-frequency (≥30 Hz) (LMHF) vibration has been shown to enhance bone mineral density. However, its regulation in breast cancer bone metastasis remains controversial for breast cancer patients and elder populations. Yoda1, an activator of the mechanosensitive Piezo1 channel, could potentially intensify the effect of LMHF vibration by enhancing the mechanoresponse of osteocytes, the major mechanosensory bone cells with high expression of Piezo1. In this study, we treated osteocytes with mono- (Yoda1 only or vibration only) or combined treatment (Yoda1 and LMHF vibration)

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… -W., Qi H.-Y., Shi H., Fan Y.-B. The Bio-Response of Osteocytes and Its Regulation on Osteoblasts under Vibration. Cell Biol. Int. 2016;40:397–406. doi: 10.1002/cbin.10575. 44. Zarka M., Etienne F., Bourmaud M., Szondi D., Schwartz J.-M., Kampmann K., Helary C., Rannou F., Haÿ E., Cohen-Solal M. …

Repurposing FDA approved drugs as possible anti-SARS-CoV-2 medications using ligand-based computational approaches: sum of ranking difference-based model selection.

The worldwide burden of coronavirus disease 2019 (COVID-19) is still unremittingly prevailing, with more than 440 million infections and over 5.9 million deaths documented so far since the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic. The non-availability of treatment further aggravates the scenario, thereby demanding the exploration of pre-existing FDA-approved drugs for their effectiveness against COVID-19. The current research aims to identify potential anti-SARS-CoV-2 drugs using a computational approach and repurpose them if possible. In the present study, we have

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… Hu S, Jiang S, Qi X, Bai R, Ye XY, Xie T (2022) Races of small molecule clinical trials for the treatment of COVID‐19: an up‐to‐date comprehensive review. Drug Dev Res 83(1):16–54 10.1002/ddr.21895 PMC8653368 34762760 34. …