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One stage full- versus partial-mouth disinfection in the treatment of chronic adult or generalized early-onset periodontitis. II. Long-term impact on microbial load.

BACKGROUND: Recent studies showed the clinical benefits of a one stage full-mouth disinfection, when compared to the worldwide standard treatment strategy of consecutive root planings per quadrant without proper disinfection of the remaining intraoral niches. The purpose of this study was to investigate the microbiological benefits of such a one stage full-mouth disinfection with special attention to all intraoral niches for periodontopathogens and to evaluate the perception by the patients of the new treatment strategy. METHODS: Sixteen patients with early-onset periodontitis and 24 patients

Treatment-induced mucositis: an old problem with new remedies.

Mucositis may be a painful, debilitating, dose-limiting side-effect of both chemotherapy and radiotherapy for which there is no widely accepted prophylaxis or effective treatment. The basis of management is pain relief, prevention of dehydration and adequate nutrition. When tested vigorously, most antiseptic mouthwashes and anti-ulcer agents are ineffective. Simple mechanical cleansing by saline is the most effective traditional measure. A variety of new agents are effective. Granulocyte macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) act outwith

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… Effect of nystatin and chlorhexidine digluconate on Candida albicans. 67 3 3 1989 279 281 Oral Surg Oral Med Oral Pathol 2648241 10.1016/0030-4220(89)90354-x Berger A. Henderson M. Nadoolman W. Duffy V. Cooper D. Saberski L. Bartoshuk L. … Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation. 73 6 6 1992 682 689 Oral Surg Oral Med Oral Pathol 1437036 10.1016/0030-4220(92)90009-f Epstein J. B. Wong F. L. …

Treatment of oral mucositis in hematologic patients undergoing autologous or allogeneic transplantation of peripheral blood stem cells: a prospective, randomized study with a mouthwash containing camelia sinensis leaf extract.

Oral mucositis is an important side effect of hematopoietic stem cell transplantation (HCST), mainly due to toxicity of conditioning regimens. It produces significant pain and morbidity. The present study reports a prospective, randomized, non-blinded study testing the efficacy of a new mouthwash, called Baxidil Onco(®) (Sanitas Farmaceutici Srl, Tortona, Italy) in 60 hematologic patients undergoing HCST (28 autologous, 32 allogeneic). Baxidil Onco(®), used three times a day from Day -1 to Day +30, in addition to standard prophylactic schedules, was administered to 14 patients undergoing autol

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… The following agents were not found to be effective: benzy-damine, HCl, sucralfate, tetrachlorodecaoxide, chlorhexidine. … Ferretti GA Ash RC Brown AT Control of oral mucositis and candidiasis in marrow transplant patients: a prospective double-blind trial of chlorhexidine gluconate oral rinse . Bone Marrow Transplant . 1988 ; 3 : 483 - 93 3056555 17. Vesole DH Fuchs HJ IB-367 Phase II Investigators. …

Association of HSV-1 and Reduced Oral Bacteriota Diversity with Chemotherapy-Induced Oral Mucositis in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation.

Oral mucositis (OM) is a common complication of chemotherapy and remains a significant unmet need. The aim of this study was to investigate the role of oral bacteriota and HSV-1 in OM. Forty-six patients admitted for autologous hematopoietic stem cell transplantation were longitudinally evaluated for OM, Candida, HSV-1, and leukocyte count, and buccal mucosal bacterial samples were obtained during their admission period. The bacterial communities collected at the baseline and post-chemotherapy, chosen from the time with the highest severity, were analyzed by sequencing the 16S rRNA gene. Twent

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… All patients were also under prophylactic ciprofloxacin and used chlorhexidine gargle during the study period. … First, ciprofloxacin, chlorhexidine, micafungin, and nystatin were uniformly used, and their role in the chemotherapy-accompanied dysbiosis of buccal mucosal bacteriota cannot be clarified. …

Связанный с лекарствами остеонекроз челюсти у нескольких пациентов миэломы: серия случаев.

Остеонекроз челюсти (MRONJ), связанный с лекарственными препаратами, является осложнением антирепрессивной и антиангиогенной терапии, используемой при лечении злокачественных заболеваний, и может вызывать значительную функциональную и эстетичную заболеваемость у пациентов. Множественная миелома (ММ) — гематологическая порча плазмы и клеток, часто связанная с остеолитической болезнью костей. Антирезорптивная терапия (АРТ) уменьшает связанные со скелетом явления в MM и других магнатах с участием скелета, но связана с повышенным риском заболевания MRONJ. В настоящем документе представлены клиниче

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… Exposed bone was irrigated with 0.2% chlorhexidine. The patient was prescribed metronidazole 400 mg and amoxicillin 500 mg three times daily (TDS) for five days, followed by doxycycline 100 mg once daily (OD) for 14 days, along with 0.2% chlorhexidine mouthwash twice daily (BD). … Initial treatment included metronidazole 400 mg and amoxicillin 500 mg TDS for five days, followed by doxycycline 100 mg OD for 14 days, with 0.2% chlorhexidine mouthwash BD. …

Oral mucositis induced by anticancer treatments: physiopathology and treatments.

Oral mucositis is a frequent and devastating side effect of anticancer treatments. It impairs the patient's quality of life and also can be life threatening because severe infections and delayed or incomplete anticancer treatments may result. This problem has been largely overlooked and underestimated in the past. However, recently studies have been performed to precisely identify the epidemiology, cost, consequences, physiopathology, and treatments of oral mucositis. Clinical guidelines have recently been published to help the daily management of this frequent complication. In addition, some

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… Chlorhexidine Chlorhexidine reduces mucosal colonization by microorganisms, but this effect has never been translated into clinical benefits for patients receiving either chemotherapy or conventional or high-dose radiotherapy ( Saadeh 2005 ). … In a randomized trial, chlorhexidine was found to be less effective and more toxic than a placebo rinse in patients with head-and-neck tumors receiving radiotherapy ( Foote et al 1994 ). Chlorhexidine is not recommended in the clinical guidelines ( Rubenstein et al 2004 ). …

Curcumin as a complementary treatment in oncological therapy: a systematic review.

PurposeCurcumin, the active ingredient in turmeric, is employed by numerous cancer patients to support conventional cancer therapy. This systematic review aims to summarize the existing clinical evidence and to provide an overview of the potential benefits and risks associated with curcumin supplementation.MethodsIn January 2024, we conducted a systematic search of five electronic databases (Embase, Cochrane, PsycInfo, CINAHL, and Medline) using a complex search strategy. We included randomized controlled trials on the use, effectiveness, and potential harm of additional curcumin therapy in ad

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… on day 5 compared to Mucosamin® and chlorhexidine ( p ’s < 0.040; [ 13 ]). … Curcumin was found to be more advantageous than chlorhexidine gluconate after 2 weeks ( p < 0.001; [ 11 ]), at day 3 compared to Mucosamin® and chlorhexidine ( p = 0.020; [ 13 ]), and after 20 days compared to chlorhexidine mouthwash ( p < 0.001; [ 25 ]). …

Debridement Technique for Single-Stage Revision Shoulder Arthroplasty.

BACKGROUND: The incidence of revision shoulder arthroplasty continues to rise, and infection is a common indication for revision surgery. Tr … d tomographyWBC = white blood cellCRP = C-reactive proteinESR = erythrocyte sedimentation rateCHG = chlorhexidine gluconateAC = acromioclavicularGT = greater tuberositySGHL = superior glenohumeral ligament.

Interventions for preventing oral mucositis for patients with cancer receiving treatment.

BACKGROUND: Treatment of cancer is increasingly more effective but is associated with short and long-term side effects. Oral side effects re … amifostine, antibiotic pastille or paste, benzydamine, beta carotene, calcium phosphate, camomile, chlorhexidine, clarithromycin, folinic acid, glutamine, GM-CSF, honey, hydrolytic enzymes, ice chips, iseganan, keratinocyte GF, misonidazole, oral care, pentoxifylline, povidone, prednisone, propantheline, prostaglandin, sucralfate, traumeel and zinc sulphate. O …

Osteonecrosis of the jaws in patients treated with bisphosphonates.

The literature describes an increasing presence of bisphosphonate-induced osteonecrosis of the jaws (ONJ), characterized by the exposure for over 8 weeks of necrotic bone in the maxillofacial region, after bisphosphonate therapy, in the absence of prior maxillary radiotherapy. The present literature review examines the etiopathogenesis, risk factors, clinical forms, diagnosis, treatment and prevention of bisphosphonate-induced ONJ. In addition, a review is made of all the series involving over 15 patients diagnosed with this disorder between 1 January 2011 and 15 May 2011. A PubMed-Medline sea

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… bone exposure but with fistulas or deep periodontal pockets causing symptoms and treated only with chlorhexidine rinses and systemic antibiotics. … Bocanegra-Pérez et al. ( 36 ) recommend treating these patients on a conservative basis, administering oral antibiotics such as amoxicillin – clavulanic acid 1000/62.5 mg two tablets/day/30 days, or metronidazole 250 mg two tablets/8 hours/10-20 days, and 0.12% chlorhexidine rinses 3-4 times a day. …

Navigating Stomatologic Complications Secondary to Antineoplastic Agents-A Comprehensive Review.

This review systematically examines the oral complications associated with conventional and novel anti-cancer therapies. It highlights that while molecularly targeted agents including monoclonal antibodies targeting the vascular endothelial growth factor and its receptor, the epidermal growth factor receptor, tyrosine kinase inhibitors, and immune checkpoint inhibitors tend to exhibit a lower overall toxicity profile compared to traditional cytotoxic chemotherapeutics, they are nonetheless linked to significant oral adverse events. These complications encompass inflammatory mucosal reactions k

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… Prophylactic measures such as tartar removal, fluoride application, and chlorhexidine mouth rinses are highly recommended. Chlorhexidine exhibits bactericidal properties against both Gram-positive and Gram-negative bacteria by disrupting the cell membrane and enzymatic activity. … Despite these recommendations, Cardona et al., evaluated the effect of chlorhexidine on oral mucositis in cancer patients undergoing chemoradiation. …

Oral hygiene care for adults with dementia in residential aged care facilities.

OBJECTIVE: The objective of this systematic review was to report on the best available evidence relating to oral hygiene for adults with dem … shing with fluoride toothpaste, use of therapeutic fluoride products and application of therapeutic chlorhexidine gluconate products are validated by research as effective for the general population and some populations with special needs.

Oral Side Effects in Patients with Metastatic Renal Cell Carcinoma Receiving the Antiangiogenic Agent Pazopanib-Report of Three Cases.

Pazopanib is a potent multi-kinase inhibitor that hinders angiogenesis and blocks tumor growth. It has been approved for the treatment of metastatic renal cell carcinoma (mRCC) and advanced soft tissue sarcoma. There is emerging evidence that bleeding is a common adverse effect of pazopanib and other targeted therapies in patients with mRCC. In addition, jaw osteonecrosis related to pazopanib was recently described in the literature. We report three cases of patients with mRCC who developed adverse oral events related to pazopanib. The first patient, treated with pazopanib as monotherapy, pres

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… Oral hygiene instructions were delivered, including the use of soft toothbrush, interdental cleaning with suitable interdental brushes, and rinses with chlorhexidine 0.2% two times daily and warm chamomile mouthwash. … Antibiotics, chlorhexidine and chamomile mouth rinses were used, the latter traditionally used as a treatment for many inflammatory diseases. …

Mineral trioxide aggregate apical plugs in teeth with open apical foramina: a retrospective analysis of treatment outcome.

INTRODUCTION: Teeth with open apical foramina present a challenge during root canal treatment, and little is known about the clinical outcome of treatment in such teeth. This retrospective study assessed healing of teeth with open apices managed by the placement of mineral trioxide aggregate apical plugs. METHODS: Seventy-two patients with 78 teeth with apical resorption or excessive apical enlargement, treated between 2000 and 2006, were contacted for follow-up examination 12 to 68 months after treatment (median 30.9 months). Treatments were provided by supervised undergraduate students (27%

Mucositis and Infection in Hematology Patients.

Survival in patients with hematological malignancies has improved over the years, both due to major developments in anticancer treatment, as well as in supportive care. Nevertheless, important and debilitating complications of intensive treatment regimens still frequently occur, including mucositis, fever and bloodstream infections. Exploring potential interacting mechanisms and directed therapies to counteract mucosal barrier injury is of the utmost importance if we are to continue to improve care for this increasingly growing patient population. In this perspective, I highlight recent advanc

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… Two small studies of Cheng et al. and one large study of Sorensen [ 22 , 23 , 24 ] reported statistically significant differences favoring the chlorhexidine group, but none of the studies actually attempted to recover the microorganisms by culture to determine or evaluate the effect of chlorhexidine … Besides azithromycin, patients in both groups received sodium chloride 0.9% and chlorhexidine mouthwash 5 mL three times daily to reduce the risk of oral infections [ 26 ]. …

Impact of bisphosphonate drugs on dental implant healing and peri-implant hard and soft tissues: a systematic review.

OBJECTIVE: Implantology represents the gold standard for oral rehabilitation, unfortunately, often, despite there are no local contraindications to this type of rehabilitation, there are uncertainties regarding the general health of our patients. Many patients nowadays take bisphosphonate drugs, often without first seeking advice from an oral surgeon or a dentist. The purpose of this review is precisely to highlight any contraindications to this type of treatment reported in the literature, in patients who take or have taken bisphosphonate drugs. METHODS: For this study the scientific informa

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… gluconate 0.2% (oral rinse) Day surgery Oral rinse with chlorhexidine gluconate 0.2% for 1 min Flapless or mini-flap approach Copious irrigation during implants sites preparation Two-stage implants placement Post-surgical Ibuprofen 600 mg every 8 h for 2 days (later on if needed) Periodic (3–6 months … If osteonecrosis of the jaw is present, management should be conservative: oral chlorhexidine and antibiotics. Surgical treatment should be reserved for those patients who are symptomatic. …

Nursing Procedures for the Prevention and Treatment of Mucositis Induced by Cancer Therapies: Clinical Practice Guideline Based on an Interdisciplinary Consensus Process and a Systematic Literature Search.

BackgroundPatients with cancer receiving tumor therapy often suffer from oral mucositis.ObjectivesThe aim of this project was to summarize experiences with nursing procedures by experts in integrative oncology and to establish recommendations for nursing interventions that can prevent or cure mucositis.MethodsThe study design was an interdisciplinary consensus process based on a systematic literature search.ResultsThe panel discussed and agreed on 19 nursing procedures, which included mouthwashes, such as teas, supplements, oil applications, and different kinds of ice cubes to suck, as well as

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… OraLife gel and mouthwash | Stearic acid, azelaic acid, palmidrol, Aloe vera leaves extract, sodium fluoride, olaflur, chlorhexidine digluconate, oleic acid, xylitol, 9,11-linoleic acid, palmitic acid Saliva Natura oral spray for treating xerostomia | Natural extract of the plant yerba santa ( Eriodictyon … Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracil-based chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer. 2008;112:1600-1606. 21. …

Nitrogen containing bisphosphonates associated osteonecrosis of the jaws: A review for past 10 year literature.

Nitrogen containing bisphosphonate (N-BP) therapy is used extensively to treat osteoporosis and osteolytic bone lesions. Recently, a special form of osteonecrosis limited to the maxillofacial skeleton has been discovered especially within those patients who are receiving either long-term N-BP therapy alone and/or associated with invasive dental procedure. Bisphosphonates accumulate almost exclusively in maxillofacial skeleton owing to high bone turn over remodeling to maintain the mechanical competence. The pathogenesis and why it commonly appears in maxillofacial skeleton and the fixed treatm

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… If the exposed bone is pain less, treatment started with 0.12% chlorhexidine mouth rinse, but if patient complaints pain and/or clinical evidence of infection, antibiotic therapy should be provided in addition to the 0.12% chlorhexidine.[ 4 21 ] However, invasive dental procedure is indicated only when … Stage 1-These patients benefit from the use of antiseptic mouth washes (chlorhexidine gluconate 0.12%) and/or analgesia is proposed for patients with clinical evidence of BRONJ, but in the absence of any evidence of infection. …

Scheduled removal of central venous catheters (CVC) to prevent CVC-related bloodstream infections in patients with hematological disease or autologous stem cell transplantation: a registry-based randomized simulation-study.

Although not generally recommended, scheduled central venous catheter (CVC) removal is sometimes carried out in order to reduce the CVC-related bloodstream infection (CRBSI) incidence. We conducted a simulation for scheduled CVC removal within the multicenter CRBSI registry (SECRECY). Non-tunneled jugular and subclavian CVC in patients with hematological disease or with germ cell tumors (including patients receiving autologous stem cell transplantation [SCT]) were included. Cases were randomized in a 1:1:1:1 ratio to either a simulated, scheduled CVC removal after 7, 14, and 21 days, or to non

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… Jugular veins were the predominant insertion site (93.2%), about 10% of the CVCs were antimicrobial-coated CVC, and in approximately one-third of the cases, chlorhexidine-coated CVC dressings were used. About every sixth patient (17.6%) was neutropenic at the time of CVC insertion. … A randomized trial on chlorhexidine dressings for the prevention of catheter-related bloodstream infections in neutropenic patients. Ann Oncol. 2016;27:1916–1922. doi: 10.1093/annonc/mdw275. 10. …

Platelet rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw: personal experience and review of the literature.

Bisphosphonates (BPs) are a class of synthetic drugs commonly used to treat bone metastasis and various bone diseases that cause osseous fragility (such as osteoporosis). Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a common complication in patients who received BPs, especially intravenously. Recently, osteonecrosis of the jaw (ONJ) caused by chemotherapeutic not belonging to BPs drug class has been reported. For this reason, it has been proposed recently to rename BRONJ in antiresorptive agents related osteonecrosis of the jaw (ARONJ), to include a wider spectrum of drugs that m

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… All patients with every grade (0, 1, 2, or 3) of lesions underwent a two-week nonsurgical treatment (per os 500 mg ciprofloxacin and chlorhexidine 0,20% mouth rinse, twice a day); thus, the status of the lesion(s) was updated. … Some authors recommend that exposed bone should be irrigated with 0.12% chlorhexidine every 72 h for 4 weeks rather than the use of chlorhexidine mouthwash only. …