Результаты поиска

Summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual's suitability for transpla

Совпадение в полном тексте источника
… of or a family history of subarachnoid hemorrhage SECTION 16: GASTROINTESTINAL AND LIVER DISEASE ✓ Evaluate all candidates for the presence of gastrointestinal disease, including liver disease, with a targeted history and physical examination ✓ Candidates with a history of peptic ulcer disease, diverticulitis …

Posttransplant complications: molecular mechanisms and therapeutic interventions.

Posttransplantation complications pose a major challenge to the long-term survival and quality of life of organ transplant recipients. These complications encompass immune-mediated complications, infectious complications, metabolic complications, and malignancies, with each type influenced by various risk factors and pathological mechanisms. The molecular mechanisms underlying posttransplantation complications involve a complex interplay of immunological, metabolic, and oncogenic processes, including innate and adaptive immune activation, immunosuppressant side effects, and viral reactivation.

Совпадение в полном тексте источника
… nausea, vomiting, and diarrhea, may be associated with factors such as immunosuppressant medications (e.g., mycophenolate mofetil [MMF]) and infections (e.g., CMV enteritis). 78 , 79 Moreover, transplant recipients have an increased risk of developing severe gastrointestinal complications, such as diverticulitis …

Продольная стабильность микробиоты Гут в релапсирующих и излучающих множественных склерозах: перспективное исследование наблюдений.

Микробиота кишечника играет ключевую роль в регулировании иммунной системы в множестве склерозов (MS), однако продольные данные о динамике микробиома и их связи с инвалидностью и биомаркерами остаются ограниченными. Цель этого исследования заключалась в выявлении продольных микробиомных изменений кишечника у пациентов с повторно излучающимся множественным склерозом (RRMS) и их связи с инвалидностью и конкретными биомаркерами сыворотки, включая прогнозируемые метаболические пути. В ходе этого перспективного продольного исследования была проведена оценка 29 пациентов, проходящих курс лечения наи

Совпадение в полном тексте источника
… Patients were excluded if they had inflammatory or gastrointestinal disorders (hepatitis, gastritis, Crohn’s disease, ulcerative colitis, diverticulitis, cholecystitis), were pregnant or breastfeeding, or had received, in the preceding 3 months, treatment with probiotics, antivirals, antibiotics, non-steroidal …

Profile of tocilizumab and its potential in the treatment of giant cell arteritis.

Giant cell arteritis (GCA) remains a medical emergency due to the threat of permanent sight loss. High-dose glucocorticoids (GCs) are effective in inducing remission in the majority of patients, however, relapses are common which lengthen GC therapy. GC toxicity remains a major morbidity in this group of patients, and conventional steroid-sparing therapies have not yet shown enough of a clinical benefit to change the standard of care. As the understanding of the underlying immunopathophysiology of GCA has increased, positive clinical observations have been made with the use of IL-6 receptor in

Совпадение в полном тексте источника
… A past history of diverticulitis is a contraindication for using TCZ, particularly if used in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids of MTX. …

Subcutaneous Sarilumab in hospitalised patients with moderate-severe COVID-19 infection compared to the standard of care (SARCOVID): a structured summary of a study protocol for a randomised controlled trial.

OBJECTIVES: The main aim of the study is to evaluate the efficacy of a single dose of sarilumab, in subcutaneous administration, in hospital … ities that can likely lead to an unfavourable result according to clinical judgment. g. Complicated diverticulitis or intestinal perforation. h. Current skin infection (eg, uncontrolled dermopiodermitis). i. Immunosuppressive anti-rejection therapy. j. Pregnancy or lactation. k. Previous treatment with tocilizumab or sarilumab. l. Patients participating in anoth …

Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial.

BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E-mutated advanced rare cancers: anaplastic thyroid carcinoma (n = 36), biliary tract cancer (n = 43), gastrointestinal stromal tumor (n = 1), adenocarcinoma of the small intestine (n = 3), low-grade glioma (n = 13), high-grade glioma (n = 45), hairy cell leukemia (n = 55) and multiple myeloma (n = 19). The primary endpoint of investigator-assessed o

Совпадение в полном тексте источника
… Nine (4.4%) patients had grade 5 AEs: one patient had sepsis, pneumonia and pleural effusion; one had sepsis and pneumonia; and the other seven had pulmonary embolism, general physical health deterioration, adenocarcinoma of the pancreas, diverticulitis, sepsis, sepsis and hemorrhagic stroke. … Fatal SAEs were seen in three (8.3%) patients in the ATC (sepsis, pneumonia, diverticulitis, pleural effusion and pulmonary embolism) cohort and three (5.5%) patients in the HCL (sepsis, pneumonia, adenocarcinoma of the pancreas and hemorrhagic stroke) cohort. …

Monitoring, prophylaxis, and treatment of infections in patients with MM receiving bispecific antibody therapy: consensus recommendations from an expert panel.

Bispecific antibodies (BsAbs) are emerging as an important novel class of immunotherapeutic agents for the treatment of multiple myeloma (MM), and are set to be more widely used in clinical practice. However, this new class of therapies is associated with a distinct adverse event (AE) profile that includes cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, as well as AEs leading to increased infection risk such as cytopenias and hypogammaglobulinemia, and infections themselves. As preliminary data with this class of agents shows an increased risk of infection

Совпадение в полном тексте источника
… Test choice depends on infection site (level III) • Imaging to provide greater insight and confirm extent of infection (level III) • For further confirmation: imaging such as CT or PET-CT scans for pneumonia evaluation, suspected colitis, diverticulitis or abdominal abscesses, or procedural biopsy based … If further confirmation is required, use imaging, such as CT or PET-CT scans for pneumonia evaluation, suspected colitis, diverticulitis or abdominal abscesses, or procedural biopsy based on the infection site. …

Targeting Amyloid Fibrils by Passive Immunotherapy in Systemic Amyloidosis.

Systemic amyloidoses are characterized by the unrelenting deposition of autologous proteins as highly ordered fibrils in target organs. The ensuing, potentially fatal organ dysfunction is the result of the combined damage caused by the proteotoxic effect of prefibrillar species and by the cytotoxicity and the structural alterations produced by the amyloid fibrils. Current therapy is focused on eliminating the amyloid protein, thus extinguishing the amyloid cascade at its origin. While this approach may end the cell damage caused by prefibrillar aggregates and prevent further amyloid accumulati

Совпадение в полном тексте источника
… 16, 24 mg/kg IV every 28 days ≤1 year MTD not achieved; no DLTs, anti-drug Ab or hypersensitivity reactions; all patients escalated to 24 mg/kg; cardiac and renal responses in 57% and 60% of evaluable patients, respectively; half-life of NEOD001: 13–16 days AE grade 3 or higher: Hyponatremia (7%); diverticulitis … 24 mg/kg IV every 28 days | ≤1 year | MTD not achieved; no DLTs, anti-drug Ab or hypersensitivity reactions; all patients escalated to 24 mg/kg; cardiac and renal responses in 57% and 60% of evaluable patients, respectively; half-life of NEOD001: 13–16 days | AE grade 3 or higher: Hyponatremia (7%); diverticulitis …

A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for denosumab.

BACKGROUND: Denosumab is authorized to treat several diseases, including cancer and bone disorders. Nevertheless, its use in clinical practice has been affected by safety concerns. The work retrospectively investigated adverse events (AEs) of denosumab to better understand toxicities. METHODS: The FAERS data base data from Q1 of 2010 to Q3 of 2023 was chosen. The definition of Medical Dictionary for Regulatory Activities (MedDRA) was dependent on preferred terms (PTs) and system organ class (SOCs). Following the removal of duplicate reports, a disproportionality analysis was conducted to iden

Совпадение в полном тексте источника
… 8.555116776 | 7.682400362 | 9.526973291 | 2213.818882 Upper limb fracture | 347 | 3.22188823 | 2.896531467 | 3.583791127 | 519.421664 Blood calcium increased | 340 | 8.228284299 | 7.375895089 | 9.179179162 | 2039.548062 Multiple fractures | 335 | 3.428973067 | 3.07665532 | 3.821635858 | 562.3246446 Diverticulitis …

Stereotactic radiotherapy for patients with bone metastases: a selected group with low rate of radiation treatment during the last month of life?

BackgroundComplex high-precision radiotherapy, such as stereotactic body radiotherapy (SBRT), should only be offered to patients with sufficiently long survival. In the context of bone metastases radiotherapy, low rates of treatment close to the end of life, e.g. last 30 days (RT30), may serve as a quality of care indicator. While traditional, pain-relieving short-course regimens have been studied comprehensively, real-world SBRT results are still limited.MethodsRetrospective analysis (2010-2023, n = 1117 episodes) of patients with bone metastases treated with traditional single-fraction (8 Gy

Совпадение в полном тексте источника
… He was hospitalized for bowel perforation from diverticulitis, i.e. not treatment-related, and died in the early post-operative phase from COVID-19. It is of course impossible to predict this type of acute health deterioration with fatal outcome. …

Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database).

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospitalization for PCI between January-November in each of the years 2010-2014 were included from the United States Nationwide Readmissions Database. Of 2 723 455 included patients, the 30-day unplanned readmission rate was 7.2% (n = 196 581, 42.3% female). This included 9.8% (n = 19 183) with angina and 11.1% (n = 21 714) with non-specific chest pain.

Совпадение в полном тексте источника
… Gastroduodenal ulcer (except haemorrhage) 140 | Gastritis and duodenitis 141 | Other disorders of stomach and duodenum 142 | Appendicitis and other appendiceal conditions 143 | Abdominal hernia 144 | Regional enteritis and ulcerative colitis 145 | Intestinal obstruction without hernia 146 | Diverticulosis and diverticulitis …

Benefit and danger from immunotherapy in myasthenia gravis.

In the last years, significant advances have improved the knowledge of myasthenia gravis (MG) immunopathogenesis and have enabled to realize new molecules with a selective action targeting compounds of the immunological system. This review discusses emerging treatments for MG, including complement inhibitors, neonatal Fc receptor targeting agents, and B cell interfering drugs, focusing on benefit and danger. In the second section of the review, several related adverse events of immunotherapy, including MGonset, are debated.

Совпадение в полном тексте источника
… No TEAEs were reported; however, perforated diverticulitis occurred in patients with RA receiving the drug [ 53 ]. Tocilizumab has been used in severe cases of COVID-19: one patient with MG, receiving tocilizumab after a myasthenic crisis, was extubated without myasthenic exacerbation [ 54 ]. …

Воздействие кетогенного рациона питания на качество жизни взрослых людей с хроническими заболеваниями: систематический обзор случайных контролируемых испытаний.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Хронические заболевания отрицательно сказываются на качестве жизни (КОЛ). Кетогенное питание (КД) может улучшить КОЛ. ЦЕЛЬ: Цель этого систематического обзора заключалась в обобщении имеющихся данных о выборочных контролируемых испытаниях (РСТ) для определения воздействия KD на QOL у взрослых, страдающих хроническими заболеваниями. МЕТОДЫ: Представление докладов осуществлялось в соответствии с руководящими принципами ПРИСМА. Мы включали в себя выборочные контролируемые испытания (РСТ), проведенные на взрослых с хроническими заболеваниями, включая группу вмешательства, ко

Совпадение в полном тексте источника
… Musculoskeletal ailments: I: n = 8; C: n = 13 [Associated with exercise training: I: n = 6; C: n = 8]; Gastrointestinal disorders (constipation and diverticulitis): I: n = 2; C: n = 1, Esophageal ulcers with Helicobacter pylori infection: C: n = 1; Non-hospitalized hypoglycemia incident …

Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD.

BACKGROUND: COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients. METHOD: Retrospective cohort study based on 2012-2013 electronic health records from 179 Dutch general practices. Comorbidities from patients with physician-diagnosed COPD were categorized according to International Classification of Primary Care (ICPC) codes. Chi-squared tests, uni- and multivariable logistic, and Cox regression analyses were used to study associations with exacerbations, de

Совпадение в полном тексте источника
… months after first ICPC code [ 39 ] Eczema 4.1 Atopic dermatitis S87 ICPC code before 1-1-12 Heart valve disease 3.9 Heart valve disease K83, K83.01, K83.02 ICPC code before 1-1-12 Heart valve disease (rheumatic) K71.02 ICPC code before 1-1-12 Diverticular disease of intestine 3.9 Colonic diverticula, diverticulitis … code [ 39 ] Eczema | 4.1 | Atopic dermatitis | S87 | ICPC code before 1-1-12 Heart valve disease | 3.9 | Heart valve disease | K83, K83.01, K83.02 | ICPC code before 1-1-12 Heart valve disease (rheumatic) | K71.02 | ICPC code before 1-1-12 Diverticular disease of intestine | 3.9 | Colonic diverticula, diverticulitis …

Epidemiology, Risk Factors, and Outcomes of Neutropenic Enterocolitis in Onco-Hematological Patients According to Chemotherapy Regimen.

BackgroundWhile neutropenic enterocolitis (NEC) is a well-known life-threatening complication during intensive chemotherapy, its incidence, impact, and outcome on specific at-risk populations remain ill defined.MethodsWe report 178 NEC episodes during 1963 myeloablative chemotherapy courses among 1259 adult patients with acute myeloid (AML) or lymphoblastic (ALL) leukemia or receiving autologous hematopoietic stem cell transplantation (auto-HCT) for lymphoma or multiple myeloma. Risk factors were assessed by multivariate logistic regression models.ResultsMost NEC cases (93.3%) occurred during

Совпадение в полном тексте источника
… vomiting, and/or bloody stools), with the presence of BWT greater than 4 mm (measured on axial CT images) over more than 30 mm of length (measured on coronal CT images) in any bowel segment, as proposed by Gorschlüter et al [ 5 ], in the absence of other well-recognized entities on CT (appendicitis, diverticulitis …

Advances in the Study of Denosumab Treatment for Osteoporosis and Sarcopenia in the Chinese Middle-Aged and Elderly Population.

Osteosarcopenia (OS) is a geriatric syndrome characterized by the concurrent presence of osteoporosis and sarcopenia, predominantly affecting the elderly population. Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mass, compromised bone microarchitecture, and heightened bone fragility, substantially elevating fracture risk. Sarcopenia (SP) is defined by decreased muscle mass, strength, and/or functional capacity. Both conditions are age-related degenerative diseases with overlapping pathophysiological mechanisms, commonly co-occurring in elderly individuals an

Совпадение в полном тексте источника
… Common adverse reactions (in ≥1/100 to <1/10 of patients) include urinary tract and upper respiratory infections, while less common reactions (in ≥1/1000 to <1/100 of patients) include diverticulitis, cellulitis, and ear infections. …

Psychological distress, chronic conditions and quality of life in elderly hematologic cancer patients: study protocol of a prospective study.

BackgroundSimilar to most solid tumors, the incidence of hematologic malignancies has been rising. Although the median age at diagnosis is about 70 years, little is known about psychosocial aspects and comorbid conditions in elderly patients with hematologic cancers. The main objectives of our study are to assess the prevalence of psychological distress, chronic conditions, functional disabilities, and quality of life in both elderly hematologic cancer patients aged ≥70 years and an age-matched comparison sample of the general population.MethodsWe conduct a prospective study with three measuri

Совпадение в полном тексте источника
… Hypertension, asthma, chronic Bronchitis/COPD, diabetes, thyroid disorder, back pain, rheumatic disease, rheumatoid arthritis, osteoporosis, colon problems (e.g., diverticulitis, irritable bowel), stomach problems (e.g., gastritis, peptic disease), kidney disease, congestive heart failure, stroke, nerve …

The Impact of a Health Coaching App on the Subjective Well-Being of Individuals With Multimorbidity: Mixed Methods Study.

BackgroundMultimorbidity, the coexistence of 2 or more chronic conditions, is associated with poor well-being. Health coaching apps offer cost-effective and accessible support. However, there is a lack of evidence of the impact of health coaching apps on individuals with multimorbidity.ObjectiveThis study aimed to assess the impact and acceptability of a health coaching app (the Holly Health [HH] app) on the subjective well-being (SWB) of adults with multimorbidity.MethodsThis study used an explanatory-sequential mixed methods design, with quantitative secondary data analysis in the first phas

Совпадение в полном тексте источника
… (27.3) 55‐64 | 10 (45.5) 65+ | 5 (22.7) Ethnicity, n (%) White | 19 (86.4) Other (Asian, Black, or prefer not to say) | 3 (13.6) Chronic conditions, n High blood pressure | 7 Anxiety | 6 Type 2 diabetes | 6 Depression | 4 High cholesterol | 4 Fibromyalgia | 3 Asthma | 2 Chronic fatigue syndrome | 3 Diverticulitis …

Integrated Pleiotropic Gene Set Unveils Comorbidity Insights across Digestive Cancers and Other Diseases.

Comorbidities are prevalent in digestive cancers, intensifying patient discomfort and complicating prognosis. Identifying potential comorbidities and investigating their genetic connections in a systemic manner prove to be instrumental in averting additional health challenges during digestive cancer management. Here, we investigated 150 diseases across 18 categories by collecting and integrating various factors related to disease comorbidity, such as disease-associated SNPs or genes from sources like MalaCards, GWAS Catalog and UK Biobank. Through this extensive analysis, we have established a

Совпадение в полном тексте источника
… Our findings also aligned with known comorbidity patterns reported in the medical community, such as Colorectal Cancer and Diverticulosis Diverticulitis [ 29 ], Esophageal Cancer and Obesity [ 30 ], Hepatobiliary Cancer and HIV [ 31 ], Pancreatic Cancer and Type II Diabetes Mellitus [ 32 ], and Stomach …

The treatment landscape in thyroid cancer: a focus on cabozantinib.

Although patients with thyroid cancer generally fare well, there is a subset for which this is not necessarily true. Progress in understanding the molecular aberrations in thyroid cancer has led to a change in the management of these cases. Since 2011, four multikinase inhibitors (MKIs) have been approved by the US Food and Drug Administration for thyroid cancer - cabozantinib and vandetanib for medullary thyroid cancer and sorafenib and lenvatinib for differentiated thyroid cancer. This change in the treatment landscape has raised challenges for practitioners who may not be familiar with the

Совпадение в полном тексте источника
… perforations and fistulas as well as hemorrhage. 1 As a result, the risk factors for GI bleeding and fistula formation need to be addressed when assessing patients prior to starting targeted therapy. 67 – 69 Important items in the medical history and review of systems include peptic ulcer disease, diverticulitis …