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Research on metabolic characteristics of multiple sclerosis.

By comparing the fecal metabolite profiles of multiple sclerosis patients with those of healthy controls, to screen for significantly differ … enosine, 9,10-DiHOME, palmitic acid, succinate, lithocholic acid, pentadecanoic acid, L-isoleucine, androsterone sulfate, L-leucine, 3-(3-hydroxyphenyl)propionic acid, nicotinic acid, L-arginine, isomaltose, thymidine, 4-aminobutyric acid, uracil, choline, hydroxyarachidonic acid, trehalose, 4-oxoretinol, 3-methylhistidine, DL-norvaline, creatinine, and capsai …

From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis.

BACKGROUND: Growing evidence suggests that gut microbiota (GM) plays a role in diabetic retinopathy (DR), but the causal microbial drivers a … five metabolites (asparagine, cystine, gamma-glutamylglycine, ximenoylcarnitine (C26:1) levels, and androsterone glucuronide to etiocholanolone glucuronide ratio) as key mediators bridging causal GM-DR links, with considerable mediating proportions of 6.75%, 14.90%, 3.03%, 7.25%, and 11.97%, respectively. CONCLUSION: This study pioneers causal longitudinal ma …

Metabolomic profiling of human feces and plasma from extrauterine growth restriction infants.

BACKGROUND: Extrauterine growth restriction (EUGR) affects a substantial proportion of preterm infants and may influence both short-term com … rm infants, while 1-palmitoyl-2-palmitoleoyl-GPC displayed the opposite pattern. In plasma samples, androsterone glucuronide displayed a significant positive correlation with the growth characteristics of preterm infants, whereas 2-methoxyhydroquinone sulfate generated an opposite pattern. Moreover, 2-oleoylglycerol and sphinganine-1-phosphate exhibited the hi …

Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung.

We describe a new member of the 17beta-hydroxysteroid dehydrogenase group of enzymes. Human Pan1b displays greatest activity with 5alpha-androstan-3alpha,17beta-diol (3alpha-Diol) as substrate, suggesting that it may be important in androgen metabolism. Enzymic activity was non-saturable with 3alpha-Diol but saturable with retinoids, although retinoids were not metabolized. Immunohistochemical studies on 10% formalin fixed and paraffin embedded sections of human tissues showed that Pan1b was present in acini and ciliated epithelia of the lung. In the fetus immuno reactivity was present in cili

Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids.

1. The modulation of the gamma-aminobutyric acidA (GABAA) receptor by reduced metabolites of progesterone and deoxycorticosterone has been c … he principle action of the active steroid isomers. 4. GABA-evoked currents were also potentiated by androsterone (1 microM) and the deoxycorticosterone metabolite 5 alpha-pregnane-3 alpha,21-diol-20-one (100 nM). 5. Secobarbitone (10-100 microM), pentobarbitone (10-300 microM) and phenobarbitone (100-500 microM) reversibly and dose-dependently potentiated the …

Effect of risk-reducing salpingo-oophorectomy on sex steroid hormone serum levels among postmenopausal women: an NRG Oncology/Gynecologic Oncology Group study.

BACKGROUND: Risk-reducing salpingo-oophorectomy is an effective ovarian cancer risk reduction strategy. However, bilateral oophorectomy has … cases. Serum hormone levels of testosterone, androstenedione, androstenediol, dihydrotestosterone, androsterone, dehydroepiandrosterone, estrone, estradiol, and sex hormone-binding globulin were measured at baseline and follow-up. Spearman correlation coefficients were used to compare ovarian volumes as measured on transvaginal ultrasound and pathology examin …

16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs.

16alpha-Bromoepiandrosterone (HE2000) is a synthetic steroid that limits non-productive inflammation, enhances protective immunity and improves survival in clinical studies of patients with human immunodeficiency virus (HIV), malaria and tuberculosis infections. We now show that HE2000 decreased nitric oxide production by lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Treatment with HE2000 also reduced non-productive inflammation associated with carrageenan-induced pleurisy and LPS-induced lung injury in mice. In the hapten-carrier reporter antigen popliteal lymph node assay, HE2000 incre…

[Clinical aspects of the anti-androgens].

The ongoing development and gradual availability of the new anti-androgens hold exciting clinical implications for the future. The biosynthesis and interchangeability of the sex steroids, the roles of the ovaries and adrenals and the value and interpretation of biochemical assays in clinical practice are briefly discussed. Because the anti-androgens are used primarily for seborrhoea/acne/hirsutism/oligomenorrhoea, the pathophysiological basis of this socially debilitating syndrome is discussed. The classification of the anti-androgens, their indications, side-effects, dosage schemes and result

Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase.

UDP-glucuronosyltransferase (UGT) enzymes belonging to the UGT2B subfamily catalyze the transfer of glucuronic acid to a large number of endogenous compounds, particularly steroids, to facilitate their elimination from target cells. A novel human UGT2B cDNA of 1666 bp was isolated and encodes a 529-amino acid protein named UGT2B28 type I. Glucuronidation assays demonstrated that UGT2B28 type I catalyzes the conjugation of endogenous and exogenous compounds. The tissue distribution of UGT2B28 revealed the expression of the type I transcript in the liver, breast, and LNCaP cells. Two other UGT2B

Comparative limitations and benefits of liquid chromatography - mass spectrometry techniques for analysis of sex steroids in tears.

Sex steroids impact regulation of the ocular surface tissues and thus influence dry eye. Most tissues in the human body synthesise and metab … rospray ionisation (ESI) methods for detection of fourteen target sex steroids, including dehydroepiandrosterone-sulphate (DHEAS), testosterone, oestradiol and their metabolites, using standards and pooled tears. The MS was programmed to switch between positive and negative polarity ionization modes at designated times through the UPLC run, in order to detect …

Цереброспинная жидкость и сывороточные биомаркеры в идиопатической внутричерепной гипертонии: систематический обзор.

ЦЕЛЬ: Это исследование было направлено на систематический анализ литературы по растворимым биомаркерам у взрослых с идиопатической внутричерепной гипертонией (МИГ). КОЛИЧЕСТВО: Идиопатическая внутричерепная гипертония представляет собой многофакторное расстройство, характеризующееся повышенным внутричерепным давлением без какой-либо явной причины. Хотя она в первую очередь затрагивает женщин репродуктивного возраста с избыточным весом, ее патогенез по-прежнему не до конца изучен. Симптомы включают головную боль и визуальные нарушения, вызванные папилледомой. Все большее внимание уделяется раст

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… activity: ↑ Androstenedione, 11‐OH‐androstenedione, 11‐ketoandrostenedione: ↓ | | Mass spectrometry Sinclair et al. 2010 (prospective cohort) | 22 | CSF and S: cortisol, cortisone, tetrahydrocortisol, 5α‐tetrahydrocortisol, tetrahydrocortisone, total cortisol metabolites, total cortisone metabolites, androsterone … , etiocholanolone | CSF glucocorticoids: no change after therapeutic weight loss | Cortisol, cortisone, cortisol/cortisone ratio: no change Tetrahydrocortisol +5α‐tetrahydrocortisol/tetrahydrocortisone, total cortisol/cortisone metabolites, androsterone, androsterone/etiocholanolone ratio: ↓ | Weight …