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Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects.

The need for bone substitutes is a major challenge as the incidence of serious bone disorders is massively increasing, mainly attributed to modern world problems, such as obesity, aging of the global population, and cancer incidence. Bone cancer represents one of the most significant causes of bone defects, with reserved prognosis regarding the effectiveness of treatments and survival rate. Modern therapies, such as hyperthermia, immunotherapy, targeted therapy, and magnetic therapy, seem to bring hope for cancer treatment in general, and bone cancer in particular. Mimicking the composition of

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… Among advanced techniques, stereolithography was the first developed, as it was based on the use of a photopolymer and ultraviolet radiation. … In another study, fused deposition modeling and stereolithography were combined in order to obtain magnetic nanocomposite scaffolds based on PCL and poly(ethylene glycol)—PEG—with adequate morphology and remarkable mechanical properties [ 192 ]. …

Artificial intelligence assisted preoperative planning and 3D-printing guiding frame for percutaneous screw reconstruction in periacetabular metastatic cancer patients.

BACKGROUND: The percutaneous screw reconstruction technique, known as the "Tripod Technique," has demonstrated favorable clinical outcomes in the management of metastatic periacetabular lesions, as evidenced by our prior investigations and corroborated by independent studies. Nevertheless, there is a steep learning curve in handling this technique, with possible complications such as intraarticular screw placement. METHODS: Preoperative pelvic CT scans were acquired before surgery and utilized for the guiding frame design. A convolutional neural network model was trained with annotated data t

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… The stereolithography file of the guiding frame was imported into the 3D printer (FORMIGA P110, EOS GmbH, Germany) for polylactic acid-based frame printing. …

Modeling the Bone Marrow Niche in Multiple Myeloma: From 2D Cultures to 3D Systems.

Multiple myeloma is a hematologic malignancy characterized by the clonal proliferation of plasma cells within the bone marrow. The tumor microenvironment plays a crucial role in multiple myeloma pathogenesis, progression, and drug resistance. Traditional two-dimensional cell culture models have been instrumental in multiple myeloma research. However, they fail to recapitulate the complex in vivo bone marrow microenvironment, leading to limited predictive value for clinical outcomes. Three-dimensional cell culture models emerged as more physiologically relevant systems, offering enhanced insigh

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… A variety of 3D printing techniques are available, including fused deposition modeling (FDM), stereolithography (SLA), direct ink writing (DIW), and laser-guided direct writing (LGDW). … SLA Stereolithography. DIW Direct ink writing. LGDW Laser-guided direct writing. PCL Polycaprolactone. PLA Poly(lactic acid). MGUS Monoclonal gammopathy of undetermined significance. TNF-α Tumor necrosis factor alpha. IL-1 Interleukin 1. TEM Effector memory T. …

Musculoskeletal Organs-on-Chips: An Emerging Platform for Studying the Nanotechnology-Biology Interface.

Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their clinical translation requires a deep understanding of the complex interplay between nanotechnology and MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative and versatile microphysiological platform to replicate the dynamics of tissue microenvironment for studying nanotechnology-biology interactions. This review first covers recent advances and applications of MSK OoCs and their ability to mimic the biophysic

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… steps of OoC fabrication by soft lithography, including pattern design, mask and master fabrication, replica molding, and generation of OoCs. [ 133 ] B) Schematic representation of 3D bioprinting strategies for engineering OoCs, including nozzle‐based inkjet and extrusion technologies and light‐based stereolithography … types, enabling the creation of customized, reproducible, and intricate patient‐specific 3D biomimetic tissue constructs with precise cell placement. [ 142 , 144 ] 3D bioprinting can be categorized into nozzle‐based bioprinting, including inkjet and extrusion bioprinting, and photobioprinting, such as stereolithography …

Улучшить долгосрочные механические свойства термопластических короткокалорийных соединений с использованием альтернативных матриц.

Древесные пластиковые композитные материалы (ВКН) обеспечивают средства для уменьшения углеродного следа за счет использования натуральных волокон для повышения механических свойств. Однако имеется ограниченная информация о механических свойствах этих материалов во враждебных условиях. В этом исследовании была проведена оценка составов полипропилена (PP), полистирола (PS) и полилактической кислоты (PLA), обработанных путем экструдирования и инъекции. Были проведены испытания на прочность и модулю прочности на растяжение и флексур, температуру смещения тепла (HDT) и на анализ ползучести при раз

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… Photopolymer Resins with Biobased Methacrylates Based on Soybean Oil for Stereolithography. ACS Appl. Polym. Mater. 2020;2:949–957. doi: 10.1021/acsapm.9b01143. 3. Åkesson D., Skrifvars M., Walkenström P. …

Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies.

Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment str

MSC-EV therapy for bone/cartilage diseases.

Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of bioactive molecules such as proteins, messenger RNAs (mRNAs), and micro RNAs (miRNAs) and modify the function of the recipient cells by transferring these molecules. Despite the promising potential of EV therapy as a substitute for MSC therapy, there are challenges that need to be addressed for the clinical success of EV therapy. EV quality ha

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… Desktop-stereolithography 3D printing of a radially oriented extracellular matrix/mesenchymal stem cell exosome bioink for osteochondral defect regeneration Theranostics 9 2019 2439 2459 10.7150/thno.31017 31131046 PMC6525998 Chen X. Shi Y. Xue P. Ma X. Li J. Zhang J. …

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