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Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium.

IMPORTANCE: The COVID-19 pandemic continues to affect millions of people globally, with increasing reports of neurological manifestations bu … ndrome). The most common self-reported symptoms included headache (1385 of 3732 patients [37%]) and anosmia or ageusia (977 of 3700 patients [26%]). The most prevalent neurological signs and/or syndromes were acute encephalopathy (1845 of 3740 patients [49%]), coma (649 of 3737 patients [17%]), and stroke (222 of 3737 patients [6%]), while meningitis and/ …

Automatic Segmentation of the Olfactory Bulb.

The olfactory bulb (OB) has an essential role in the human olfactory pathway. A change in olfactory function is associated with a change of … nformation of the subject's smelling ability. One dataset contained data of patients suffering from anosmia or hyposmia (N = 79), and the other three datasets contained data of healthy controls (N = 91). First, the manual segmentation labels of the OBs were created by two experienced raters, independently and blinded. The algorithm consisted of the follow …

Comparison of Three Surgical Approaches for Frontobasal Meningiomas: Purely Endoscopic Endonasal, Purely Microscopic Bifrontal Transcranial, and Combined Endoscopic and Microscopic Supraorbital Transciliary Approaches.

Surgical removal of frontobasal meningiomas (FBMs) can be achieved using different techniques, including endoscopic, transcranial, and combi … ch, whereas the other patient underwent the microscopic bifrontal approach. Post-operative hyposmia/anosmia or decreased olfactory function was the most common complication observed in 5 patients, 2 patients each in the EEA and MTA groups and one in the STA group. The second most common complication was wound infection in one patient in the MTA group and …

Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study.

BACKGROUND: Spain is one of the European countries most affected by the COVID-19 pandemic. Serological surveys are a valuable tool to assess … 1·1-92·1; both tests positive) to 91·8% (86·3-95·3; either test positive). In 7273 individuals with anosmia or at least three symptoms, seroprevalence ranged from 15·3% (13·8-16·8) to 19·3% (17·7-21·0). Around a third of seropositive participants were asymptomatic, ranging from 21·9% (19·1-24·9) to 35·8% (33·1-38·5). Only 19·5% (16·3-23·2) of symptomatic …

Antimicrobial mouthwashes (gargling) and nasal sprays to protect healthcare workers when undertaking aerosol-generating procedures (AGPs) on patients without suspected or confirmed COVID-19 infection.

BACKGROUND: COVID-19 infection poses a serious risk to patients and - due to its contagious nature - to those healthcare workers (HCWs) trea … symptomatic or test-positive COVID-19 infection in HCWs or patients; 2) significant adverse event: anosmia (or disturbance in sense of smell). Our secondary outcomes were: 3) COVID-19 viral content of aerosol (when present); 4) change in COVID-19 viral load at site(s) of irrigation; 5) other adverse events: changes in microbiome in oral cavity, nasal cav …

Classes and predictors of reversal in male patients with congenital hypogonadotropic hypogonadism: a cross-sectional study of six international referral centres.

BACKGROUND: Although some male patients with congenital hypogonadotropic hypogonadism (CHH) undergo spontaneous reversal following treatment … ni syndrome (fertile eunuch) subtype of CHH. Patients without CHH reversal were more likely to have anosmia (p=0·016), cryptorchidism (p=0·0012), complete absence of puberty (testicular volume <4 cm³; p=0·0016), and two or more rare genetic variants (ie, oligogenicity; p=0·0001). Among patients who underwent genetic testing, no patients (of 75) with CHH r …

Платеже-Rich Plasma-Derived Exosom Olficy Инъекции для лечения травматического обесценения

Фон: В последнее время для лечения травматической обонятельной дисфункции, связанной с болезнью коронавируса, использовались носовые инъекции плазмы с высоким содержанием тромбоцитов (РРП). 2019. Однако в настоящее время экзосомы, получаемые из плазмы, богатой тромбоцитами, становятся ключевыми факторами, влияющими на активность ПРП, и, по сравнению с ПРП, характеризуются высокой устойчивостью и минимальной иммуногенностью. Представление дела: Мы описали случай 27-year-old женщина, которая потеряла свою обонятельную функцию после того, как ударилась головой 8 июль 2022. Анализ запаха показал п

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… Although approximately one third of patients may recover spontaneously, recovery is often incomplete and usually occurs within the first year after trauma; therefore, persistent anosmia beyond 1 to 2 years generally indicates a poorer prognosis [ 5 , 6 ]. … The effect of olfactory training on odor identification in patients with traumatic anosmia. Int. Forum Allergy Rhinol. 2019;9:1244–1251. doi: 10.1002/alr.22409. 15. …

Neurological Manifestations in Hospitalized Geriatric Patients With COVID-19 at King Abdulaziz Medical City in Jeddah, Western Region, Saudi Arabia From 2020 to 2021: A Cross-Sectional Study.

Introduction COVID-19 involvement in the nervous system has been reported in many cases. Viral neuroinvasion has multiple routes of entry. Neurological manifestations of COVID-19 can be divided into ones of the central nervous system (CNS), such as headache, dizziness, altered mental status, ataxia, and seizure, and of the peripheral nervous system (PNS), including ageusia, anosmia, acute illness demyelinating polyneuropathy, and neuralgia. Aim and objectives This study aims to observe and report the neurological manifestations in geriatric patients who were diagnosed with COVID-19 at KAMC-J a…

Post-COVID-19 Symptoms 2 Years After SARS-CoV-2 Infection Among Hospitalized vs Nonhospitalized Patients.

IMPORTANCE: Identification of long-term post-COVID-19 symptoms among hospitalized and nonhospitalized patients is needed. OBJECTIVE: To com … ong hospitalized than among nonhospitalized patients (112 [31.1%] vs 36 [11.7%]; P < .001), whereas anosmia was more prevalent among nonhospitalized than among hospitalized patients (66 [21.4%] vs 36 [10.0%]; P = .003). Hospitalized patients were assessed at a mean (SD) of 23.8 (0.6) months after hospital discharge, and nonhospitalized patients were asses …

Clinical Characteristics and Factors Associated with Poor Outcomes in Hospitalized Patients with Novel Coronavirus Infection COVID-19.

Aim      To evaluate the clinical picture and factors associated with unfavorable outcomes in admitted patients with COVID-19.Material and m … had shortage of breath and chest pain/compression, 40.3% had headache, 31.1% had myalgia, 28.8% had anosmia, and 25.5% had ageusia. Arterial oxygen saturation was &lt;93.0 % in 55.7 % of cases. According to laboratory blood tests the patients had anemia (58.2 %), lymphopenia (34.8 %), neutropenia (19.2 %), thrombocytopenia (11.9 %), and increased levels o …

Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross-Sectional Study.

OBJECTIVE: To describe the semiology of pain and its associated features in patients with coronavirus disease 2019 (COVID-19) and headache p … al comorbidities and laboratory data. Patients with confirmed COVID-19 showed a higher incidence of anosmia (21/54 [38.9%] vs 28/45 [62.2%], P = .021) and pneumonia (10/54 [18.5%] vs 18/45 [40%], P = .018), headache at onset (32/54 [59.3%] vs 39/45 [86.7%], P = .002), and hospital admission (0/54 [0%] vs 2/45 [11.1%], P = .017). In most cases, the headach …

Высокоагрессивный множественный склероз релапсируется во время беременности после инфекции SARS-COV-2: Case Report and Licture Review.

Мы сообщаем о сложном случае с 32-летней ранее здоровой беременной женщиной при 17+2-недельной беременности с новым диагнозом исключительно высокоактивного релапсирующего множественного склероза (RRMS), спровоцированного интенсивным острым респираторным синдромом коронавируса 2 (SARS-COV-2). Замечательными клиническими характеристиками были быстрое ухудшение клинического состояния, серьезность и характер симптомов, включая спастическую тетраплегию, диспнею, дисфагию, анартхрию и синдром сильной боли, что привело к необходимости интенсивной терапии и механической вентиляции в течение 24 часов.

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… Authors, year Sex Major manifestation  First symptoms after COVID-19 infection  Therapy  Outcome  Moore et al., 2021 [ 18 ] Male Blurry vision, vertigo Two weeks  Methylprednisolone  Improvement vision and nystagmus Palao et al., 2020 [ 19 ] Female Optic neuritis, anosmia Three weeks Methylprednisolone … weeks  Remdesivir, dexamethasone Improvement of vision and other neurological symptoms  Karsidag et al., 2021 [ 23 ] Male/female Numbness, weakness legs/jaw and facial pain/truncal ataxia, dysmetria  Four months/four weeks/two weeks  Methylprednisolone Improvement  Pignolo et al., 2021 [ 24 ] Male  Anosmia …

Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials.

BACKGROUND: Long COVID, characterized by persistent multi-organ symptoms post-SARS-CoV-2 infection, poses a substantial global health burden … dence. Respiratory muscle training and PEA-LUT offer targeted benefits for respiratory strength and anosmia, while tDCS may address fatigue. Telerehabilitation, as a form of supervision, also improved the effectiveness of the intervention. In contrast, steroid sprays and olfactory training lack efficacy, highlighting the need for personalized, symptom-spe …

Clinical course and biomarkers in patients with type 1 Gaucher disease and Parkinson's disease: A retrospective cohort study.

INTRODUCTION: Pathogenic variants in GBA1, the gene encoding beta-glucocerebrosidase, are significant genetic risk factors for Parkinson's disease (PD). Patients with type 1 Gaucher disease (GD1), caused by biallelic GBA1 variants, have approximately six-fold higher lifetime risk for PD compared to the general population. However, few studies have described the clinical presentation of GD-associated PD (GD-PD) in GD1 patients. We describe the variable presentation of PD and evaluate clinical characteristics and biomarkers in a cohort of patients with concurrent diagnoses of GD-PD. METHODS: Re

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… For GD-PD, all patients at this site were screened yearly using a standardized review of symptoms related to PD (including bradykinesia, gait difficulties, hyposmia/anosmia, REM sleep behavior disorder, constipation) as well as an exam assessing rigidity, tremor, movement speed, and gait. … Seven patients had non-motor symptoms including cognitive deficits, hallucinations, hyposmia/anosmia, and orthostatic hypotension ( Table 3 ). …

COVID-19: A 2020 update

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… Frequent | Common | Uncommon Fever | Headache | Anorexia Cough | Myalgias | Diarrhea Dyspnea | Pharyngitis | Nausea/vomiting | Fatigue | Abdominal pain | Sinus and nasal congestion | Rash | | Anosmia/ageusia Viral pneumonia is the most prevalent presentation in hospitalized patients and is often … Anosmia and ageusia: Common findings in COVID-19 patients. Laryngoscope. 2020;130:1787. doi: 10.1002/lary.28692. 15. Recalcati S. Cutaneous manifestations in COVID-19: A first perspective. J Eur Acad Dermatol Venereol. 2020;34:e212–3. doi: 10.1111/jdv.16387. 16. Gu J, Han B, Wang J. …

Clinical Features and Outcomes of Pediatric and Adult Patients Hospitalized for Coronavirus Disease 2019: A Comparison Across Age Strata.

BackgroundCoronavirus disease 2019 (COVID-19) continues to cause hospitalizations and severe disease in children and adults.MethodsThis study compared the risk factors, symptoms, and outcomes of children and adults hospitalized for COVID-19 from March 2020 to May 2023 across age strata at 5 US sites participating in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence consortium. Eligible patients had an upper respiratory swab that tested positive for severe acute respiratory syndrome coronavirus 2 by nucleic acid amp

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… Clinical variables collected at presentation included COVID-19 symptoms such as fever, chills, headache, fatigue, cough, shortness of breath/dyspnea, nasal congestion/rhinorrhea, sore throat, myalgias, nausea/vomiting, diarrhea, conjunctivitis, and anosmia/dysgeusia. … Regarding symptoms, children more commonly had fever, nasal congestion/rhinorrhea, conjunctivitis, and nausea/vomiting but less commonly had chills, headache, fatigue, cough, shortness of breath, and anosmia/dysgeusia ( P < .05 for all comparisons). …

Acute gastrointestinal and post-acute COVID-19 gastrointestinal syndrome assessment on the Gastrointestinal Symptom Rating Scale scoring system: A questionnaire-based survey.

BACKGROUND: Post-acute coronavirus disease 2019 (COVID-19) syndrome (PACS) is the persistence of sequel of acute SARS-COV-2 infection. Persi … ± 0.93076), and diarrhea syndrome (mean score 1.8122 ± 0.90899). Overall, fever (95.1%, P = 0.007), anosmia (45.0%, P = 0.042), cough (80.1%, P = 0.032), and hospitalization (30.0%, P = 0.003) had a more significant association with one of the major four GI symptoms during the acute phase of SARS-COV-2 illness. Home-isolated patients having loss of appeti …

Long-Term Effects of COVID-19 on Taste and Olfactory Functions in Individuals with a History of Substance Abuse: A Retrospective Cohort Study from the TriNetX US Collaborative Networks

Background: Substance use disorders not only subject individuals to increased suffering from chronic pain, poisonings, and economic hardship … ulation, such as disturbances of taste (HR [95% CI] = 1·258 [1·072–1·477]), smell related disorder, anosmia (HR [95% CI] = 1·292 [1·065–1·566]). The risk of two composite endpoints, disturbances of taste event (HR [95% CI] = 1.258 [1·072–1·477]) and any disturbances of small (HR [95% CI] = 1·218 [1·013–1·464]), were both higher in the substance abuser tha …

A Multi-Center Study Investigating Long COVID-19 in Healthcare Workers from North-Eastern Italy: Prevalence, Risk Factors and the Impact of Pre-Existing Humoral Immunity-ORCHESTRA Project.

Introduction: The impact of long-COVID-19 syndrome is rather variable, since it is influenced by several residual confounders. This study ai … myalgia (13.7%), cough (12.4%), dyspnea (10.2%), concentration deficit (8.1%), headache (7.3%), and anosmia (6.5%), in decreasing order of prevalence. The risk of long COVID-19 at 30-60 days was significantly higher in HCWs hospitalized for COVID-19 (aOR = 3.34; 95%CI: 1.62; 6.89), those infected with SARS-CoV-2 during the early pandemic waves-namely the …

[Clinical and epidemiological characteristics of pediatric COVID-19 patients in a community-based study].

UNLABELLED: Összefoglaló. Bevezetés: A COVID-19-pandémia kapcsán számos tanulmány vizsgálta a tünetek gyakoriságát és a járványterjedés jell … tients of >10 years, where high frequency of general symptoms was found (30-40% headache, weakness, anosmia). In the third wave, the ratio of the age group 11-18 years declined from 68% to 47%, the frequency of respiratory symptoms increased significantly, while the ratio of general symptoms decreased. Household exposition was more frequent in the third w …