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Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study.

BackgroundWe aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk of central line associated bloodstream infections (CLABSI) in haematology patients.MethodsMulticentre retrospective cohort study among haematology patients receiving PICCs between 2013 and 2015. Occurrence of CLABSI based on CDC definitions was assessed. We calculated incidence rates, determined risk factors for CLABSI and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time. We compared diagnoses and treatment character

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… In January 2014, chlorhexidine replaced iodine tincture as disinfectant for PICC placements. Throughout the study period, StatLock® was used for fixation which was routinely replaced every 3 weeks. A chlorhexidine coated dressing (Tegaderm HCG®) was used to seal the insertion site. …

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study.

INTRODUCTION: The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. METHODS: We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. RESULTS: We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patie

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… The use of antiseptic (chlorhexidine 0,2% mouthwashes 30 ml swished up to 60 seconds, 3x daily 7 days pre-operatively and 15 days post-operatively) and sodium-hyaluronate (local application 3x daily 10 days post-operatively) was also prescribed ( Table 2 ); autologous PRP (Plateltex ACT System, Biomed … Photodynamic Inactivation of Actinomyces naeslundii in Comparison with Chlorhexidine and Polyhexanide - A New Approach for Antiseptic Treatment of Medication-Related Osteonecrosis of the Jaw? …

Consensus Statement on Full-Arch Implant Rehabilitations: Evidence-Based Recommendations from the Italian Consensus Conference.

Full-arch implant-supported rehabilitations are widely recognized as an effective treatment option for edentulous patients. Nevertheless, clinical decision-making regarding patient selection, surgical planning, prosthetic material choice, and long-term maintenance protocols remains heterogeneous and requires structured evidence-based guidance. A modified Delphi consensus process was conducted involving 29 experts during the Italian Consensus Conference. A systematic literature review covering the period 2015-2024 was performed, and the certainty of evidence was assessed using the Grading of Re

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… Post-operative chlorhexidine 0.20% mouthwash twice daily for 14 days is recommended in all cases. … Apply perioperative antibiotic prophylaxis based on the IAO 2021 framework [ 49 ]: chlorhexidine rinse before and after surgery, single pre-operative dose of amoxicillin 2 to 3 g (or clindamycin 600 mg in penicillin allergy). …

Proceedings of the CIMAGO Meeting - Challenges in Oncobiology Coimbra, 31st january 2020.

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Уровни гингивальной креветочной жидкости пролактина у пациентов, страдающих периодонтитом, с контролируемым или неконтролируемым типом 2 диабет. Контролируемое клиническое испытание.

В ходе этого исследования были исследованы уровни гингивальной кревикулярной жидкости (ГХФ) гормона пролактина (ПРЛ) на этапе III периодонтит (П) пациентов с типом 2 сахарный диабет (T2DM) до и 3 через несколько месяцев после нехирургической периодической терапии (НППТ). В этом деле под контролем суда, 80 Темы были разделены на 4 группы: группа I: здоровый контроль; группа II: системно здоровый этап III P пациентов; группа III: этап III P пациентов с контролируемым Т2ДМ; группа IV: этап III P пациентов с неконтролируемым Т2ДМ. Все пациенты П получили NSPT. Three Спустя несколько месяцев после

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… Treated pockets were then thoroughly rinsed with 0.2% chlorhexidine digluconate solution. … Patients were instructed to rinse twice daily for 2 min with a 0.2% chlorhexidine digluconate solution for 1 week to enhance plaque control and reduce microbial recolonization during the early healing phase following NSPT 21 . …

Clinical characteristics and prognostic impact of Burkholderia cepacia complex colonization and infection in patients with hematologic malignancies.

ObjectiveIn recent years, there has been an increasing number of reports on infections caused by the Burkholderia cepacia complex (Bcc). However, the clinical characteristics and prognosis of Bcc infections in patients with hematological malignancies remain unreported. This study aimed to delineate the clinical trajectory from colonization to active infection and to identify prognostic factors influencing outcomes in hematologic malignancy patients with Bcc colonization.MethodsWe conducted a retrospective analysis of 185 hematological malignancy patients with Bcc colonization at the Department

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… Sterile covers were used for the ultrasound probes to prevent the gel touching the patient’s skin. (3) At least once a week surveillance with throat swabs in HSCT recipients and patients with profound neutropenia ( Jia et al., 2022 ). (4)Enhanced source control including mupirocin nasal drop and chlorhexidine … Comparison of global decolonization efficacy with mupirocin nasal drop and chlorhexidine mouthwash in acute leukemia patients: randomized clinical trial . Support. Care Cancer . 32 , 42 . doi: 10.1007/s00520-023-08232-1 , PMID: 38110726 Ho M. Kang E. Y. Yeh L. Ma D. H. K. Lin H. Tan H. . ( 2021 ). …

Association between Hyperglycemia and Medication-Related Osteonecrosis of the Jaw (MRONJ).

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a type of jawbone necrosis caused by the use of drugs for some types of cancer and osteoporosis. The current study aimed to evaluate the associations between hyperglycemia and the development of medication-related osteonecrosis of the jaw. METHODS: Our research group investigated data collected between 1 January 2019 and 31 December 2020. A total of 260 patients were selected from the Inpatient Care Unit, Department of Oromaxillofacial Surgery and Stomatology, Semmelweis University. Fasting glucose data were used and included

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… Chlorhexidine mouthwash: Chlorhexidine mouthwash is used to manage oral infections and prevent the progression of MRONJ. Local debridement: Local debridement is the removal of necrotic bone tissue in the affected area. …

Тенденции и < < горячие точки > > в глобальных исследованиях галитоса: библиометрический анализ 2010 в адрес 2025.

Цель настоящего исследования заключается в использовании библиометрических методов для изучения глобальной англоязычной литературы по галитозу с целью выявления горячих точек для исследований и определения возможных направлений будущих исследований в этой области. 2010 по июль 2025. Библиометрический анализ проводился с использованием базы данных Medpulse и пакета программного обеспечения R, включая статистический анализ литературных данных, а также тематических и совместных анализов. 1634 статьи, представляющие вклад соответствующих авторов 19 - страны, в которых ведущую роль в выпуске публик

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… As shown in Figure 10 A, terms such as “chlorhexidine,” “malodor,” “probiotics,” “dental,” “caries,” “periodontal diseases,” “halitosis,” “bad breath,” and “periodontitis” are between Q1 and Q4, indicating that these topics have been sufficiently developed and can be used to build research areas. … In terms of theme evolution, the topic word trend changed at the time point in 2019, and the key themes have shifted from “diagnosis,” “probiotics,” “quality of life,” “dentistry” and “chlorhexidine” between 2010 to 2018 into “dental caries,” “tonsillectomy,” “children,” “tongue coating” and “periodontal …

A systematic review of the management of short-term indwelling urethral catheters to prevent urinary tract infections.

BACKGROUND: Indwelling urinary catheterisation is a relatively common procedure in hospital settings, associated with potential risk of infe … ed systems or sealed systems with the addition of silver releasing devices. Neither the addition of chlorhexidine nor hydrogen peroxide to the drainage bag was found to be effective at reducing UTI rates. The findings indicated there was a higher incidence of bacteriuria associated with Foley catheters compared with intermittent catheterisation (P < 0.025). A s …

Vascular Access Devices for Stem Cell Transplantation: A Review of Catheter Types-A Crucial Step Towards the Enhancement of Patient Care.

Central venous access devices (CVADs) play a pivotal role in managing stem cell recipients, providing reliable access for the administration of chemotherapy, blood products, progenitor infusion, parenteral nutrition, and other crucial treatments. This review critically evaluates the various types of CVADs commonly employed in transplant settings, examining their indications, complications, and best practices to enhance patient outcomes. Moreover, it emphasizes the significance of broadening the selection algorithm for vascular devices and incorporating patient expectations and comfort into rou

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… Adjunct technologies: Antimicrobial or silver coatings and chlorhexidine-impregnated dressings significantly reduce CLABSI by inhibiting biofilm formation [ 25 , 26 , 27 ]. HSCT context: No randomized HSCT-specific trials compare PU vs. … ESMO, ASCO, and the most recent clinical practice guidelines underscore the significance of implementing clinical bundles, encompassing aspects such as hand hygiene, maximal barrier precautions, chlorhexidine skin antisepsis during catheter insertion, optimal catheter site selection, and assessment of …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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Pharmacological Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ) with Pentoxifylline and Tocopherol.

Background: This study aimed to evaluate the efficacy of pentoxifylline and tocopherol therapy in patients with medication-related osteonecrosis of the jaw (MRONJ). Methods: During this study, 43 patients participated, including 21 women and 22 men with a mean age of 66.8 years, who showed 63 areas of osteitis altogether. The diagnosis was made based on X-ray imaging and histopathological findings. All the subjects received pharmacological treatment with pentoxifylline 400 mg and tocopherol 400 IU. The study scheme consisted of initial observation and two follow-up examinations every 5-6 month

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… They included surgical approaches (conservative, extensive with or without fluorescent light, laser) and non-invasive options, like chlorhexidine 0.12% mouth rinse, antibiotic therapy, hyperbaric oxygen (HBO), low-level laser therapy, plasma-rich protein (PRP), teriparatide, and the PENTO protocol [ … The non-surgical protocol included the use of an antiseptic mouth rinse (chlorhexidine), periodic dental checks, systemic antibiotic administration (ceftriaxone 1 g/i.m. daily and metronidazole 500 mg/per os twice a day for 7 days once a month), monthly low-level laser therapy, consisting of the irradiation …

Oral Hygiene Management of Hematologic Patients Undergoing Auto-Transplantation: An Observational Study.

Background/Objectives: The present study evaluated the effectiveness of a prevention protocol involving oral hygiene, instructions, and motivation in patients eligible for hematopoietic stem cell transplantation (HSCT). Methods: Consecutive patients scheduled for HSCT were enrolled. All patients received a complete dental examination aimed at assessing periodontal health status through periodontal charting and registration of the levels of plaque and inflammation. Subsequently, patients received professional oral hygiene care and were instructed on and motivated toward oral prophylaxis prior t

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… The use of antiseptic mouthwashes containing chlorhexidine can help reduce microbial load in the oral cavity, thereby decreasing the risk of infections. However, care must be taken to balance antimicrobial efficacy with the potential for mucosal irritation [ 10 ]. … Maintaining oral hygiene through professional cleanings, chlorhexidine rinses, and soft toothbrushes is essential to prevent periodontal issues. Post-transplantation, ongoing oral care remains important as patients recover and their immune system gradually returns to normal function [ 12 ]. …

Theatrical fire pursuant exploratory laparotomy.

Fire in the operating theater is a rare but potentially fatal complication. We report igniting an intraperitoneal fire while preforming an exploratory laparotomy for perforated viscus. Fortunately, the patient suffered no injuries as a result.

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… Fuels include volatile solutions such as alcohol, ether, chlorhexidine, acetone as well as drapes, sponges, blankets, packing materials and gastrointestinal gasses (methane and hydrogen). …

The role of compounded mouthwash with or without acyclovir in managing chemotherapy-induced oral mucositis in cancer patients: a randomized controlled trial.

BackgroundChemotherapy-induced oral mucositis (CIOM) is a prevalent and debilitating condition observed in cancer patients, especially in those suffering from hematologic malignancies. The present study assessed the efficacy of a compounded mouthwash, both with and without the addition of acyclovir, in the management of CIOM. Although various treatment options exist for this condition, their effectiveness remains limited, underscoring the necessity for innovative approaches to the formulation of compounded mouthwashes for improved management of CIOM.MethodsA prospective, double-blind, randomiz

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… Efcacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: a feasibility randomised triple-blind phase III clinical trial. … Efficacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple-blind phase III clinical trial. …

Biology and Diseases of Dogs

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… Kennels should be disinfected with agents such as bleach, chlorhexidine (Nolvasan) or quaternary ammonium chloride (Roccal-D). …

Comparing the Influence of Surgical and Conservative Therapy on Quality of Life in Patients with Early-Stage Medication-Related Osteonecrosis of the Jaw-A Prospective Longitudinal Study.

Background and Objectives: The purpose of this study was to evaluate the impact of surgical and conservative, non-surgical treatment on general health-related (QoL) and oral health-related quality of life (OHRQoL) in patients suffering from AAOMS stage I MRONJ. Materials and Methods: In the course of this prospective clinical study, QoL and OHRQoL using QLQ-C30 and QHIP G14 questionnaire were longitudinally assessed in N = 174 prospectively enrolled patients with indication of treatment of MRONJ stage I over a period of 12 months. Patients received conservative or surgical treatment. The measu

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… In short, treatment consisted of antimicrobial mouth rinsing by applying 0.2% chlorhexidine solution (GlaxoSmithKline Consumer Healthcare GmbH& Co. KG, Munich, Germany) three times a day and the daily topical application of 1% chlorhexidine gel (GlaxoSmithKline Consumer Healthcare GmbH & Co. …

How does the clinical and tomographic appearance of MRONJ influences its treatment prognosis?

OBJECTIVES: To identify clinical and tomographic prognostic factors for conservative and surgical treatment of medication-related osteonecrosis of the jaws (MRONJ). METHODS: A retrospective search identified patients treated with antiresorptive drugs (ARDs), diagnosed with Stage 1, 2 or 3 MRONJ, and having CBCT scans previous to conservative or surgical treatment. Following data collection, imaging assessment of the following parameters on each MRONJ site was performed: involvement of teeth and/or implants, presence of osteosclerosis, osteolysis, sequestrum formation, periosteal reaction, and

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… Conservative treatment Conservative treatment involved the prescription of antiseptic mouthwashes, such as 0.12% chlorhexidine or 0.5% sodium hypochlorite during the first 2 weeks of treatment. Subsequently, 0.05% chlorhexidine was used for maintenance throughout the follow-up period. …

Survival Rates and Clinical Outcomes of Implant Overdentures in Old and Medically Compromised Patients.

Studies on the survival rate of implant overdentures in medically compromised patients are limited because most studies exclude patients with systemic diseases affecting implant prognosis. This retrospective study aimed to evaluate the survival rate and clinical outcomes of dental implants used for overdentures in medically compromised patients. A total of 20 patients (9 men, 11 women; mean age: 67.55 ± 6.84 years, range: 53-81 years) were included. Fourteen patients had more than two systemic diseases, and nine patients had more than three systemic diseases. The mean follow-up period was 39.0

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… To minimize the risk of implant failure, systemic reviews and clinical studies recommend strict metabolic control before, during, and after implantation; antibiotic prophylaxis; chlorhexidine digluconate rinsing; experienced surgeons; and short recall intervals [ 17 , 18 ]. … They suggested that an antiplaque agent (chlorhexidine 0.12%) and regular maintenance were efficient in decreasing the implant failure rate in patients with diabetes [ 18 ]. Thirteen (65%) of the 20 patients in this study had DM, including two patients with uncontrolled DM (HbA1c ≥ 8.5). …

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).

Patients with haematological malignancies (HM) are at high risk of developing invasive fungal disease (IFD) with high morbidity and attributable mortality. We reviewed data published until September 2021 to update the 2017 antifungal prophylaxis recommendations of the German Society of Haematology and Medical Oncology (DGHO). The strong recommendation to administer antifungal prophylaxis in patients with HM with long-lasting neutropenia, i.e. 7 days remains unchanged. Posaconazole remains the drug of choice for mould-active prophylaxis in these patients. Novel treatment options in HM, such as

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… | Intervention | SoR | QoE | Reference To prevent IFD | Neutropenic diet | D | IIr,u | 84–86 To prevent invasive aspergillosis | Wearing well-fitting (FFP2) masks | C | IIt | 87 To prevent IFD | HEPA filters LAF systems | A B | IIu IIu | 88–91 To prevent CVC-related fungal bloodstream infections | Chlorhexidine-coated … A randomized trial on chlorhexidine dressings for the prevention of catheter-related bloodstream infections in neutropenic patients. Ann Oncol 2016; 27: 1916–22. 10.1093/annonc/mdw275 93. Estcourt LJ, Stanworth S, Doree C et al. …