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Treatment preferences of patients with relapsed and refractory multiple myeloma: a qualitative study.

BACKGROUND: Multiple myeloma is a haematological malignancy characterized by significant morbidity and mortality. This study sought to develop an in-depth understanding of patients' lived experiences of relapsed or refractory multiple myeloma (RRMM) and its treatment, and to identify which features of treatment were most important to them. METHODS: Qualitative interviews and focus groups (FGs) were conducted with 32 people living with RRMM across Canada. In Phase 1, interviews focused on participants' accounts of their experiences with the disease and its treatment and laid the groundwork for

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… Grounded theory methodology. In: Denzin NK, Lincoln YS, editors. Handbook of Qualitative Research. Thousand Oaks: Sage Publications; 1994. pp. 273–285. 31. Charmaz KC. Qualitative interviewing and grounded theory analysis. In: Holstein JA, Gubrium JF, editors. … Basics of qualitative research: techniques and procedures for developing grounded theory. Thousand Oaks: Sage Publications; 1998. 36. Gilchrist VJ, Williams RC. Key informant interviews. In: Crabtree BF, Miller WL, editors. Doing Qualitative Research. 2. …

Understanding Medication Adherence in Patients With Primary Osteoporosis in China: A Qualitative Study Guided by the Integrated Theory of Health Behavior Change.

AIM: To qualitatively analyse determinants of medication adherence in Chinese patients with PO using the Integrated Theory of Health Behavior Change (ITHBC). DESIGN: The study was conducted as a qualitative study using. The data is systematically analysed using thematic analysis method. We followed the COREQ Checklist to ensure rigour in our study. METHODS: This qualitative descriptive study, guided by the ITHBC, was conducted at a national medical center in China (November 2023-June 2024). Sixteen patients with PO were purposively sampled until data saturation. Semi-structured interviews we

How do Internal Medicine Residents from Different Backgrounds Make Subspecialty Career Choices? A Qualitative Analysis.

PurposeMedical career decisions are complex. Gender and racial disparities remain among internal medicine (IM) subspecialty fellows, particularly in procedural subspecialties. This qualitative study aims to thematically explore factors that influence IM resident subspecialty career choice, with a focus on factors specific to women and UIM trainees to better understand existing disparities. This is the first study to explore IM residents own stated reasons to subspecialize into various fields.MethodsWe conducted virtual focus groups with 37 IM residents from multiple institutions, organized by

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… Data Analysis Based on grounded theory, we used inductive coding to analyze the transcribed focus groups. 25 , 26 Two investigators (E.T., A.I.V.) reviewed two transcripts selected at random and created an initial codebook to inductively create data-driven themes and codes. 27 – 29 The study team (E.T … Constructing Grounded Theory . Second edition. Thousand Oaks, CA: SAGE Publications; 2014. 26. Corbin JM. Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory . Fourth edition. Thousand Oaks, CA: SAGE; 2015. 27. Boyatzis RE. …

Приоритеты пациентов, врачей и исследователей в отношении важных результатов в множестве миеломы: исследование смешанных методов.

Исследования в области миеломы во все большей степени основываются на суррогатных конечных точках для ускорения утверждения, однако они могут не отражать приоритеты пациентов. Мы провели исследование по смешанным методам для определения результатов, оцениваемых пациентами и врачами, и их сопоставления с конечными точками, используемыми в выборочных контролируемых испытаниях (РСТ). Собеседования с 10 пациентов и пациентов 6 Клиники определили приоритеты в области лечения, которые вместе с конечными точками на основе систематического обзора миэломных РСТ, информированных специализированных обсле

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… The qualitative component was guided by a grounded theory 29 approach within the constructivist research paradigm. 30 FIGURE 1 Schematic representation of mixed‐methods study. … What is grounded theory? Evid Based Nurs . 2016 ; 19 ( 2 ): 34 – 35 . 26872777 10.1136/eb-2016-102306 30 Creswell JW , Plano Clark VL . Designing and conducting mixed methods research . 3rd ed. Los Angeles : SAGE ; 2018 . 31 O'Cathain A , Murphy E , Nicholl J . …

The Persistence of Stigma and Other Challenges Experienced by Medical Cannabis Users: A Thematic Synthesis of Qualitative Studies.

BackgroundThe legislation, practices, and guidance shaping patient and professional access to medical cannabis (MC) for managing chronic pain and other conditions vary widely across jurisdictions. Despite promising evidence of effectiveness, challenges persist for those trying to access or prescribe MC. Little is known about how patients navigate these complex environments. We aimed to understand the evidence related to personal lived experiences associated with using MC for chronic pain and other conditions in negotiating these challenges.SummaryWe used a framework by Thomas and Harden for co

Healing Environments for Cancer Care: Toward a Patient-Centered Design Guideline for Inpatient Settings.

ObjectivesThis study proposes an evidence-based design guideline for oncology inpatient rooms that addresses the physical, emotional, and psychosocial needs of cancer patients.BackgroundCancer inpatients frequently experience long hospital stays with emotional vulnerability and clinical stress. Growing evidence suggests environmental design can shape patient experience, comfort, and recovery. Yet, current literature lacks an integrated framework for the spatial and sensory needs of this population.MethodA systematic literature review was conducted across Web of Science, Scopus, and PubMed. Fro

Антибиотическое управление в случае предполагаемой нейтральной лихорадки (испытание ASTERIC): мультицентр, тип 1 гибридный протокол проведения экспериментальных исследований по вопросам эффективности, ступенчатый, выборочный и контролируемый.

ВВЕДЕНИЕ: Нейтропеническая лихорадка (НФ) имеет общий коэффициент смертности: 3-18%. Международные руководящие принципы рекомендуют всем пациентам, имеющим NF, получать антибиотики сверхширокого спектра (UBSA) в пределах 1 час регистрации аварийного отделения (ЭД). Тем не менее, 70% пациентов, поступающих в больницу с подозрением в наличии NF (SNF), не могут получить доступ к абсолютному числу нейтрофильов (ANC) в пределах 1 час, не имеет NF и не требует UBSA. В скорой и госпитализированных пациентах, имеющих SNF, мы предполагаем, что протокол ASTERIC эффективно и безопасно сокращает использов

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… Qualitative analysis Qualitative data related to the barriers to and facilitators of the implementation of the ASTERIC protocol in routine care services will be analysed using grounded theory methodology with thematic analysis of responses to open-ended questions. … The Discovery of Grounded Theory: Strategies for Qualitative Research. New York: Aldine de Gruyter; 1967. 31. Strauss A, Corbin J. Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory. Thousand Oaks (CA): Sage; 1998. 32. …

A hierarchical and configurational analysis of Health Technology Assessment outcomes for cell and gene therapies.

BackgroundCell and gene therapies (CGTs) challenge traditional Health Technology Assessment (HTA), creating a fragmented global access landscape. This study identifies the determinants of CGT reimbursement outcomes by quantifying the influence of key variables and identifying the configurations leading to a positive recommendation.MethodsA dual-methodology approach was employed. We constructed a comprehensive dataset of all HTA decisions for CGTs across seven major jurisdictions between January 2017 and July 2025. Hierarchical Linear Modeling (HLM) was used to identify independent predictors o

Depoliticisation, Resilience and the Herceptin Post-Code Lottery Crisis: Holding Back the Tide.

Research Highlights and Abstract This article: Covers new empirical terrain in the study of depoliticisation, with an in-depth case study of health technology regulation;Analyses depoliticisation from a novel analytical perspective, examining how depoliticised institutions are resilient to external pressure for politicisation;Posits a distinctive framework for analysing resilience, drawing on cognate literatures on policy networks and agencification;Raises interesting and distinctive questions about the nature of depoliticisation in advanced liberal democracies, arguing it is more contested th

Контекстуальная модель поведения в химсексе: структурное уравнение моделирования психологических предикторов гиперсексуальности и использования веществ

Фон и цель. Chemsex, определенный как намеренное использование психоактивных веществ в сексуальных контекстах, становится все более распространенным среди геев и бисексуалов и связан с широким спектром психических, физических и социальных последствий. Целью этого исследования было проверить контекстуальную модель поведения, изучающую, как психическая негибкость, одиночество, трудности в интимных отношениях и внутреннее гомофобное чувство вносят вклад в гиперсексуальность и сексуальное использование веществ. Методы. Проведено поперечное исследование с участием 252 испытуемых, говорящих на испан

Psychobiographical Reflections on Marilyn Yalom's Experience of Death and Dying.

The universal awareness of death is central to the framework of existential psychology. However, its subjective confrontation remains deeply personal. Marilyn Yalom (1938-2019), distinguished feminist scholar and cultural historian, documented her intimate reflections on dying in a book co-authored with her husband, Irvin Yalom, renowned existential psychotherapist and author. This single-case psychobiography sought to examine her experience, focusing on her diarised reflections on living with and dying from a terminal illness in this book as the primary data source. Data analysis examined Mar

Deciding to Enrol in a Cancer Trial: A Systematic Review of Qualitative Studies.

BackgroundClinical trials are essential for the advancement of cancer treatments; however, participation by patients is suboptimal. Currently, there is a lack of synthesized qualitative review evidence on the patient experience of trial entry from which to further develop decision support. The aim of this review is to synthesise literature reporting experiences of participants when deciding to enrol in a cancer clinical trial in order to inform practice.MethodsA systematic review and meta-synthesis of qualitative studies were conducted to describe the experiences of adult cancer patients who d

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… The balancing of options in the loneliness of autonomy: a grounded theory interview study. Acta Oncol . 2007;46(1):49–59. doi: 10.1080/02841860600911164 37. Moynihan C, Lewis R, Hall E, et al. … Attitudes towards clinical research among cancer trial participants and non-participants: an interview study using a grounded theory approach. J Med Ethics . 2007;33(4):234–240. doi: 10.1136/jme.2005.015255 55. Schutta KM, Burnett CB. …

Романтические отношения, сексуальность и близость между молодыми людьми и подростками с тяжелыми психическими заболеваниями: обзор литературы.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Лица с тяжелыми психическими заболеваниями (СМИ), включая шизофрение и психотические расстройства, часто сталкиваются с серьезными проблемами в развитии и поддержании романтических и интимных отношений. Несмотря на сильное стремление к общению и сексуальному выражению, эти люди часто сталкиваются с такими препятствиями, как общественное осуждение, когнитивные проблемы и психические симптомы, влияющие на социальное функционирование. В рамках существующих исследований основное внимание уделяется прежде всего общей социальной вовлеченности, а не специфическим сложностям ром

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… Aged 22 to 62 years (mean = 42 years) Twenty-eight semi-structured interviews analyzed using the Grounded Theory method. Almost all participants experienced unfulfilled needs in sexual expression. … Aged 22 to 62 years (mean = 42 years) Twenty-eight semi-structured interviews analyzed using the Grounded Theory method. Almost all participants experienced unfulfilled needs in sexual expression. …

Validation of a data-driven multicomponent T2 analysis for quantifying myelin content in the cuprizone mouse model of multiple sclerosis.

BACKGROUND: Myelin quantification is essential for understanding a wide range of neurodegenerative pathologies. Voxel-wise multicomponent T2 (mcT2) analysis is the common approach for this purpose, yet no gold standard technique exist that can overcome the ambiguity of fitting several T2 components to a single-voxel signal. This challenge is further exacerbated in preclinical scan settings due to the addition of spurious diffusion encoding, resulting from the use of imaging gradients that are at least an order of magnitude larger than on typical clinical scanners. PURPOSE: Assess the utility

What Can Patient Narratives Reveal to Us About the Experience of a Diagnosis of Myeloma? A Qualitative Scoping Review.

In recent years, there have been major advances in treatment options for myeloma and an improved prognosis as a result. There is a wealth of literature that explores the experience of specific treatments from a clinical perspective but there is comparatively little known about the reality of living with myeloma. This research aims to explore the experience of a myeloma diagnosis, to map out key patient experience literature, and examine common themes to support both medical practice and the planning of further research. Following a scoping review methodology, PubMed, StarPlus (the University o

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… Analyzed on the principles of grounded theory. Used qualitative and quantitative methods - Difficult to cope with the sudden label of being “ill” - Big impact on daily life due to fatigue and back pain. … Analyzed on the principles of grounded theory. Used qualitative and quantitative methods | - Difficult to cope with the sudden label of being “ill” - Big impact on daily life due to fatigue and back pain. …

Проект для самостоятельной мотивации: Качественное собеседование по вопросам предприимчивости выживших жертв рака к программам изменения цифрового здоровья.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Несмотря на повышенный риск рецидива, связанный с изменением образа жизни, многие лица, пережившие рак, не соблюдают рекомендации по укреплению здоровья. Цифровое медико-санитарное вмешательство открывает перспективы для поддержки изменений в поведении, однако лишь немногие исследования предусматривают участие выживших жертв в разработке мер вмешательства, что потенциально ограничивает эффективность реального мира. Понимание предпочтений и потребностей в поддержке выживших жертв рака имеет решающее значение для разработки эффективных мер по изменению поведения в цифровой

Navigating Hope and Illness Cognition in Advanced Ovarian Cancer Patients: A CSM-Based Phenomenological Study.

BACKGROUND: Advanced ovarian cancer patients face profound psychosocial challenges in maintaining hope amidst terminal illness and treatment uncertainty. Understanding mechanisms supporting adaptive hope could inform psychosocial interventions. METHODS: Phenomenological qualitative study of 16 women with advanced ovarian cancer receiving platinum-based and/or targeted therapies at a tertiary center in southern China. Semi-structured interviews conducted across 11-month observation period; thematic analysis guided by Leventhal's Common-Sense Model (CSM). RESULTS: Participants demonstrated a t

Physical Activity and Quality of Life in Cancer Survivors: A Meta-Synthesis of Qualitative Research.

Qualitative research on the impact of physical activity on quality of life (QoL) in adults diagnosed with cancer is accumulating. However, the field of physical activity and cancer survivorship lack a synthesis of this research to reliably understand the implications for future research and practice. The aim of this meta-synthesis was to identify, appraise, and synthesize qualitative research on cancer survivors' perspectives of the impact of physical activity on their QoL. Seven electronic databases were searched for original studies published in English, and reference lists of relevant studi

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… Other analytical techniques used included: case study analysis ( n = 1), categorical aggregation ( n = 1), constant comparison ( n = 1), framework analysis ( n = 5), grounded theory ( n = 1), mixed data analysis techniques ( n = 1), systematic text condensation ( n = 1), and thematic analysis ( n = 6 … In this way, researchers may want to consider using more diverse qualitative methodologies (e.g., ethnography, narrative discourse, grounded theory). …

The unseen symptom: A longitudinal qualitative interview study exploring mobility loss in people with advanced cancer.

BACKGROUND: Mobility loss is a common symptom in people with advanced cancer and is associated with reduced function and quality of life. While its physical consequences are well documented, less is known about how individuals and their families experience and adapt to these changes over time. AIM: To explore how individuals with advanced cancer and their caregivers experience and respond to mobility loss. DESIGN: A qualitative longitudinal study using Interpretative Phenomenological Analysis. Participants completed two semi-structured interviews, with follow-ups prompted by changes in mobil

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… ‘Living in a shrinking world’—The experience of loneliness among community-dwelling older people with reduced mobility: a qualitative grounded theory approach. BMC Geriatr 2022; 22: 285. 31. Wang C, Qiu X, Yang X, et al. …

Пациентский опыт биопсихосоциального воздействия синдрома Гильен-Барре: обзор.

Синдром фоновой гильии-барре (GBS) — острый аутоиммунный расстройство периферической нервной системы, которое может привести к слабости мышц, дыхательной недостаточности и длительной инвалидности. Хотя клинические аспекты были широко изучены, данные о биопсихосоциально-духовном воздействии на взрослых остаются ограниченными.2005) и был представлен в соответствии с руководящими принципами PRISMA-ScR. Поиски литературы проводились в Пуббмеде, Скопусе и EBCOCOhost для исследований, опубликованных с января 2015 и январь 2025. Используя систему PCC, мы включили проверенные первичные исследования по

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… theory further added an essential perspective on psychological adaptation after GBS, conceptualized as “Loss, Determination, Adjustment”, while emphasizing the significance of support, information, and hope in the coping process. 35 In addition, psychotherapeutic interventions such as Acceptance and … The psychological effects of Guillain-Barré syndrome: a grounded theory study. Qual Health Res . 2024;1–11. 36. Peña L, Moreno CB, Gutierrez-Alvarez AM. Pain management in Guillain-Barre syndrome: a systematic review. Neurologia . 2015;30(7):433–438. doi: 10.1016/j.nrl.2014.04.009 37. …