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[Determination of 42 antimicrobials in disinfection products by dispersive solid phase extraction-high performance liquid chromatography-tandem mass spectrometry].

Antimicrobials inhibit the growth and reproduction of microorganisms thereby alleviating skin and other problems caused by microorganisms. Antimicrobials are classified into different categories, including antibacterials, antifungals, and antivirals, among others, and include azoles, sulfonamides, tetracyclines, quinolones, and many other classes of synthetic and natural compound. The inappropriate or excessive use of antimicrobials can damage skin and other human organs and increase antimicrobial resistance. Relevant regulations and standards clearly state that antimicrobials are prohibited f

[Current status of the female condom in Africa].

The female condom was developed in the 1980s. It is a contraceptive device used by women that protects against both pregnancy and sexually-transmitted diseases (STDs) including HIV infection. Two studies have investigated the contraceptive effectiveness of the female condom, and it was found to be as effective as other barrier methods. It has been shown to be effective against STD and HIV transmission in vitro but there is only limited evidence of its efficacy in vivo. No serious local side effects or allergies have been reported and the female condom can be used with any type of lubricant, sp

Attachment Styles and Sexual Function Among Survivors of Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study.

Background and Objectives: Autologous hematopoietic stem cell transplantation (AHSCT) offers life-saving treatment for hematologic malignancies but can result in persistent sexual dysfunction and relationship challenges. Attachment theory provides a valuable framework for understanding how enduring relational patterns influence sexual well-being. This study aimed to assess sexual function and attachment styles in AHSCT survivors and examine correlations between attachment and sexual health outcomes. Materials and Methods: A multicenter, cross-sectional study was conducted from December 2019 to

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… “Avoidance” presented a moderate positive statistically significant correlation with “lubrication” of the FSFI. … An unexpected finding was the moderate positive correlation between attachment avoidance and lubrication in women. …

Effects of trying to conceive using an every-other-day strategy versus fertile window monitoring on stress: a 12-month randomized controlled trial.

STUDY QUESTION: Can animation videos on how to optimize the chances of pregnancy influence stress, anxiety, depression and sexual functionin … reases in all female sexual functioning dimensions (desire, satisfaction, arousal, pain, orgasm and lubrication). In men, there were significant variations in orgasm, intercourse satisfaction and erectile function, but not desire and sexual satisfaction. Revealed pregnancy rates were 16% for participants in the EOD group, 30% for the FWM group and 20% for the …

Autologous serum eye drops for dry eye.

BACKGROUND: =Theoretically, autologous serum eye drops (AS) have a potential advantage over traditional therapies based on the assumption that ASserve not only as a lacrimal substitute to provide lubrication, but also contain other biochemical components mimicking natural tears more closely. The application of AS in dry eye treatment has gained popularity as a second-line therapy in the treatment of dry eye.Published studies on the subject indicate that autologous serum could be an effective treatment for dry eye. OBJECTIVES: To evaluate the efficacy and safety of AS compared to artificial te…

Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial.

Head and neck radiotherapy quantitatively and qualitatively compromises salivary flow, and salivary substitutes have the potential to alleviate the symptoms. This study aims to assess the effectiveness of two salivary substitutes in relieving symptoms of radiotherapy-induced xerostomia through a double-blind randomized controlled trial. Twenty-four patients were selected from a dental oncology clinic and randomly assigned to the over-the-counter or compounded mouthwash group. Each patient was instructed to rinse their oral cavity with the assigned solution three times a day for 30 days. Both p

[Effect of compound chamomile and lidocaine hydrochloride gel on oropharyngeal complications after the use of laryngeal mask airway with positive pressure ventilation].

Objective: To evaluate the effect of compound chamomile and lidocaine hydrochloride gel on oropharyngeal complications after the use of laryngeal mask airway with positive pressure ventilation. Methods: A total of 64 patients undergoing elective surgery under general anesthesia using laryngeal mask airway (LMA) with positive pressure ventilation in Beijing Tongren Hospital Affiliated to Capital Medical University From January to March 2023 were prospectively selected and divided into two groups by the random number table method: normal saline group (n=32), with 18 males and 14 females, aged 28

Vaginal Dilators: Issues and Answers.

INTRODUCTION: Vaginal dilators are often prescribed to facilitate an adaptive brain-body connection to decrease anxiety and pain that can be experienced in anticipation of sexual intercourse among populations of women with sexual pain syndromes. Postmenopausal women, cancer survivors, and women with a wide variety of pelvic floor disorders who experience genito-pelvic pain/penetration disorder (GPPPD) are often advised to incorporate vaginal dilators into their pelvic floor rehabilitation program and treatment regimens to enable penetrative intercourse with less pain. However, little is known

Sexual health in older adults with hematologic malignancies - a sub-analysis of a Danish cross-sectional study.

PurposeThis study aims to emphasize the importance of sexual health in older adults with hematologic malignancy (HM) in Denmark by exploring the prevalence of sexual symptoms and factors that influence sexual activity and function.MethodsA sub-analysis of a Danish cross-sectional study including older adults (≥ 65 years) diagnosed with a HM from 20/1-2013 to 20/8-2022. Eligible participants received electronic validated questionnaires about quality of life, sexuality, and sexual health in their officially assigned digital mailbox.ResultsDecreased libido, impaired sexual activity, diminished co

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… In menopausal women, changes in hormone levels can lead to vaginal wall atrophy, reduced lubrication, and vaginal dryness, which often result in dyspareunia [ 7 ]. … Further, women can experience age related sexual problems, including vaginal atrophy, reduced vaginal lubrication, and decreased sensitivity in erogenous zones affecting libido [ 7 , 32 ]. …

Sexual health in patients with malignant hematological disease: a Danish cross-sectional study.

BackgroundPatients who undergo treatment for hematologic malignancies may experience a decline in sexual health, alterations in sexual functioning, and reproductive capacity during survivorship.AimThis study investigated the prevalence of sexual dysfunction and factors influencing sexual activity and functioning in patients with hematologic malignancies, to identify potential targets for interventions in clinical practice.MethodsThis nationwide cross-sectional study included adult patients diagnosed with a hematologic malignant disease in Denmark in the period from January 20, 2013, to August

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… of life (QOL), and distress, all of which pose a threat to overall sexual well-being. 5 , 6 Sexual dysfunction is prevalent in cancer patients and can result in diminished sexual desire and arousal, and difficulty achieving orgasm. 7 In women, it comprises dyspareunia, vaginal dryness, insufficient lubrication … Yet, women with AL reported better levels of lubrication ( P = .037) and arousal ( P = .045) across all diagnoses. Specifically, women with AL reported a higher level of sexual desire compared with patients with MM ( P = .009) and lower levels of pain compared with patients with MDS ( P = .008). …

Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?

BACKGROUND: Hyaluronan, or hyaluronic acid (HA), is the major hydrodynamic nonprotein component of joint synovial fluid (SF). Its unique viscoelastic properties confer remarkable shock absorbing and lubricating abilities to SF, while its enormous macromolecular size and hydrophilicity serve to retain fluid in the joint cavity during articulation. HA restricts the entry of large plasma proteins and cells into SF but facilitates solute exchange between the synovial capillaries and cartilage and other joint tissues. In addition, HA can form a pericellular coat around cells, interact with proinfla

Разработка и осуществление мер по улучшению сексуального здоровья женщин, страдающих эндометриозом: протокол исследования смешанных методов и план мероприятий.

Ээндометриоз может оказать негативное воздействие на фертильность, психическое и сексуальное здоровье женщин. Поскольку в ходе проведенных исследований не были всесторонне рассмотрены потребности и стратегии по улучшению сексуального здоровья и разработке необходимых программ и мероприятий для этой группы женщин, цель настоящего исследования заключается в разработке и осуществлении мер по улучшению сексуального здоровья женщин, страдающих эндометриозом. 4 Этапы. фазы 1 - качественное исследование с использованием полуструктурированных бесед для изучения потребностей и стратегий с точки зрения

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… Common treatments include surgical procedures to excise lesions and alleviate pain (19, 20), pharmacological options such as sedatives and progestins (21), couples therapy (22), use of vaginal lubricants, sexual counseling, and positional adjustments (16). … The questionnaire measures 6 domains: sexual desire (2 items), arousal (4 items), lubrication (4 items), orgasm (3 items), satisfaction (3 items), and pain (3 items). …

Stevens Johnson Syndrome: Past, Present, and Future Directions Gynecologic Manifestations and Management in SJS/TEN.

UNLABELLED: Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe mucocutaneous hypersensitivity disorders characterized by sudden onset epidermal necrosis. Acute manifestations of SJS/TEN often include vulvovaginal erosions, ulcerations, vaginal discharge, bleeding, vaginal pain, dysuria, and urinary retention. If not treated, this can lead to complications such as vulvovaginal adhesions, vaginal stenosis or dryness, pain, dyspareunia, bleeding, and adenosis. Even with adequate treatment, there are lasting impacts including difficulty with vaginal exams and psychologi

Topical treatments for blepharokeratoconjunctivitis in children.

BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and

Pain in infants who are younger than 2 months during suprapubic aspiration and transurethral bladder catheterization: a randomized, controlled study.

OBJECTIVE: Proper diagnosis of urinary tract infections depends on obtaining an uncontaminated urine sample for culture. Suprapubic aspiration and transurethral catheterization are the 2 recommended procedures for obtaining specimens for urine culture from young infants. The objective of the current study was to compare the pain that is experienced during these 2 procedures when performed in young infants. METHODS: A prospective, single-blind, randomized, controlled study was conducted at a university-affiliated hospital in Israel. Institutional Research Ethics Board approved the study. Infan

:: распространенность сексуальной дисфункции среди женщин, страдающих множественным склерозом.

Сексуальная дисфункция является одной из основных жалоб у женщин с множественным склерозом (МС) и затрагивает различные аспекты их жизни. Мы стремились определить распространенность сексуальной дисфункции среди пациентов с НР и устранить основные факторы, способствующие этому. МЕТОДЫ: Это перекрестное исследование было проведено для 100 женщин с РС, которые были направлены в больницу Бу-Али Сина в 2020 - 2021 годах. Мы заполнили для каждого участника вопросник по индексу сексуальной функции женщин (ИФОЖ) из 19 пунктов. Мы также собирали демографические данные. Специалист по неврологии распреде

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… The observed inverse correlation in four subdomains including desire, lubrication, Orgasm, and pain was also significant. … Additionally, higher EDSS scores often reflect more severe neurological damage, which can disrupt the neural pathways involved in sexual response, including arousal, lubrication, and orgasm. …

Нейрогенная желудочно-кишечная, мочевая и сексуальная дисфункция при множественном склерозе: многодисциплинарная основа для клинической практики.

Нейрогенные желудочно-кишечные, мочевые и сексуальные симптомы широко распространены у людей с множественным склерозом и существенно ухудшают качество жизни, повседневное функционирование и психосоциальное благополучие. Несмотря на их частотность и клиническую актуальность, управление по-прежнему носит разрозненный характер по различным специальностям, тесная взаимосвязь между этими симптомами зачастую игнорируется, а у клинических работников отсутствует прагматическая основа, адаптированная к различным условиям здравоохранения. Этот обзор преобразует нынешние данные в прагматичную модель уход

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… Erectile dysfunction (ED) and premature ejaculation (PE) are common sexual complaints in male pwMS, while female pwMS frequently experience decreased vaginal lubrication and difficulties in reaching orgasm. … For women with dyspareunia and/or vaginal dryness, anesthetic and water-soluble lubricants can be used. In case of postmenopausal vaginal atrophy, topical estrogen therapy is indicated. Vibrators can be useful when decreased genital sensation limits intimacy. …

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… or estrogen | Moderate discomfort or pain associated with vaginal penetration; discomfort or pain partially relieved with use of vaginal lubricants or estrogen | Severe discomfort or pain associated with vaginal penetration; discomfort or pain unrelieved by vaginal lubricants or estrogen | | Table … For vaginal lubrication, the first-line therapies are nonhormonal agents, including short-acting lubricants for sexual activity and longer-acting moisturizers for replacement of normal vaginal secretions ( Falk and Bober, 2016 , Sinha and Ewies, 2013 ). …

Erratum: Rat Model of Normothermic Ex-Situ Perfused Heterotopic Heart Transplantation.

An erratum was issued for: Rat Model of Normothermic Ex-Situ Perfused Heterotopic Heart Transplantation. The Protocol section was updated. Section 4 of the Protocol was updated from: 4. Implantation Preparation of recipient Begin the recipient preparation 30 min before the cessation of ex situ perfusion. Anesthetize the recipient animal using the same method as mentioned in step 2.2. Place the rat in a supine position on the heating pad and insert the temperature probe into the rectum to maintain the body temperature at 37 °C. Apply eye lubricant, shave the pubic to the epigastric area, and cl

[Determination of seven perfluoroalkyl and polyfluoroalkyl substances in serum of pregnant women and evaluation of neonatal neurobehavior based on high performance liquid chromatography-tandem mass spectrometry].

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been extensively used as synthetic fluorine-containing compounds in various consumer products, including surfactants, cookware, lubricants, clothing, and food packaging, since the 1950s. Evidence has shown that PFASs cross the placental barrier and interfere with fetal thyroid hormone homeostasis, which is crucial for fetal growth and neurobehavioral development in children aged 2-9 years. However, no epidemiological data on the association between prenatal PFAS exposure and neonatal neurobehavioral development are available. In this s