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Helically Chiral Aromatics: The Synthesis of Helicenes by [2 + 2 + 2] Cycloisomerization of π-Electron Systems.

Advanced molecular nanocarbons are now in the spotlight reflecting the basic discoveries of fullerenes, carbon nanotubes, and graphene. This research area includes also the chemistry, physics, and nanoscience of nonplanar polycyclic hydrocarbons, many of which exhibit helical chirality, such as iconic helicenes and their congeners. The combination of unique π-electron systems with the chirality phenomenon makes them highly attractive in various fields of science. Helicenes are polyaromatic compounds that are composed of all-angularly annulated benzene units, but other (hetero)cycles can also b…

Advanced Precision Dual Photothermal and Photodynamic Therapy for Prostate Cancer Using PSMA-ICG-Conjugated Gold Nanorods.

Prostate cancer is the second most common cancer among men globally. In this study, we developed a prostate-cancer-targeted gold nanoparticle-based photothermal and photodynamic complex (GNR-ICG-FA@PSMA) to enhance the targeting efficiency of prostate cancer cells and simultaneously deliver photothermal therapy (PTT) and photodynamic therapy (PDT). For the in vitro tests, ROS assays, annexin V/PI staining, and MTT assays were conducted. In the in vivo tests, fluorescence and photoacoustic imaging systems were used to track the distribution of nanoparticles in animal models. Tumor tissues were

The use of gold nanorods as a new vaccine platform against schistosomiasis.

Schistosomiasis is an important parasitic disease affecting >207 million people in 76 countries around the world and causing approximately 250,000 deaths per year. At present, the main strategy adopted for the control of schistosomiasis is the use of safe chemotherapy, such as praziquantel. However, the high rates of reinfection after treatment restrict the use of this treatment approach and assume the need for other forms of control such as vaccination. Sm29 is a protein that is localized in the Schistosoma mansoni tegument of adult worms and schistosomula and is considered a powerful vaccine

Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy.

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.

Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem.

OBJECTIVE: Seizure-induced bradycardia and asystole have been documented by video-EEG monitoring periods in patients with epilepsy. This cardiac dysfunction during or after seizures may contribute to sudden unexpected death in epilepsy (SUDEP). Abnormal neurocardiac function during seizures could potentially be caused by seizures propagating to the brainstem, passing through the parasympathetic nerve and disrupting cardiac control networks. METHODS: We simultaneously recorded activity from the brain and vagus nerve as well as heart rate and respiration in adult Sprague-Dawley rats under ureth

Dataset from analytical pyrolysis assays for converting waste tires into valuable chemicals in the presence of noble-metal catalysts.

About 25.7 million tons of waste tires (WT) are discarded each year worldwide causing important environmental, and health problems. This was … benzene, toluene, and xylenes (BTX) and p-cymene on noble metals (Pd, Pt, Au) supported on titanate nanotubes (NT-Ti). The comprehensive analysis of this data was recently published, thus, the analytical techniques, experimental conditions and dataset are given in the present paper as a complement to that publication [1]. The reaction was evaluated in an an …

Organic/inorganic hybrid materials: challenges for ab initio methodology.

CONSPECTUS: Organic/inorganic hybrid structures are most exciting since one can expect new properties that are absent in either of their bui … and inorganic semiconductors. Poly(para-phenylene) adsorbed on graphene and encapsulated in carbon nanotubes represent case studies to demonstrate the impact of polarization effects and exciton delocalization in optoelectronic excitations, respectively. Polaron-induced band narrowing and its consequences for charge transport in organic crystals is exemplif …

Митохондриальная передача метаболических перепрограмм и лекарственная устойчивость в метастазе костей: механизмы и терапевтические стратегии.

Кость это one из наиболее распространенных участков удаленного метастаза в твердых опухолях, в частности рак груди, рак простаты и рак легких. Метатические повреждения костей часто свидетельствуют о стойком сопротивлении многосистемной терапии, включая химиотерапию, целевую терапию, эндокринную терапию и ингибиторы иммунных контрольно-пропускных пунктов (ИПК). Накопляющиеся данные свидетельствуют о том, что метаболическая перепрограммирование в пределах костной микроокружающей среды способствует этому сопротивлению, однако механизмы в верхнем течении по-прежнему недостаточно понятны. В качеств

Совпадение в аннотации оригинала
Bone is one of the most common sites of distant metastasis in solid tumors, particularly breast cancer, prostate cancer, and lung cancer. Bo … ells (BMSCs) have been reported to deliver functional mitochondria to tumor cells through tunneling nanotubes (TNTs), extracellular vesicles (EVs), and gap junctions, a process proposed to be regulated by metabolic stress, chemokine signaling (CXCL12/CXCR4), and inflammatory cues. The bone marrow microenvironment-characterized by hypoxia, high cell density, …

Multifunctional palygorskite@ZnO nanorods enhance simultaneously mechanical strength and antibacterial properties of chitosan-based film.

A general and effective strategy was developed for improving simultaneously the mechanical strength and antibacterial performance of biopolymer-based films. The well-dispersed zinc oxide (ZnO) nanoparticles were in-situ loaded on non-toxic natural palygorskite (PAL) nanorod to form an antibacterial PAL@ZnO composite nanorod, which can be embedded into chitosan/gelatin (CS/GL) film to produce the composite films with noticeably enhanced mechanical properties and antibacterial activity against S. aureus and E. coli bacteria (inhibition zones are 21.82 ± 0.95 mm and 16.36 ± 1.64 mm, respectively)

Stable Liposome in Cosmetic Platforms for Transdermal Folic acid delivery for fortification and treatment of micronutrient deficiencies.

Oral folate fortification has been successful in many developed nations, however, developing countries still face low compliance and high incidence of folate deficiency associated with low birth weight infants and preterm deliveries. We report safe and efficient approach for transdermal systemic folate delivery using fluidising liposomes (120 ± 4 nm) stabilised within 3D matrix of naturally occurring cosmetic bases: Fuller's earth and henna with room temperature stability. The proof of stratum corneum fluidisation was established ex-vivo by Langmuir-Blodgett film, FTIR and confocal imaging in

Electrochemical immunosensor for antibody recognition against SARS-CoV-2 B-cell epitope: impact of RBD mutations on antigen-antibody binding.

During the SARS-CoV-2 pandemic, the receptor-binding domain (RBD) of the spike protein emerged as a critical target for neutralizing antibodies. While immunoinformatics predicts binding sites, in vitro confirmation of epitope-antibody interactions remains a challenge. Here, we present a modular and highly sensitive square wave voltammetry immunosensor platform based on zinc oxide nanorods (ZnONRs) for detecting antibody responses to SARS-CoV-2 variant epitopes. The device leverages three distinct B-cell peptides (P44; spike415-429) corresponding to the wild-type (WT), gamma, and omicron varian

Золотые нанороды, покрытые силикой, в качестве фототермальной терапевтической платформы для лечения опухолей мозга.

Золотые нанороды, покрытые вирусом Рабиза, сфабрикованы путем имитации размера, формы, поверхностного гликпротеина и в vivo поведения вируса бешенства. Эти нанороды не только напоминают внешний вид вируса бешенства, но и проникают в мозг через нейронный путь, проходящий через барьер кровеносного мозга, и, кроме того, реагируют на почти инфракрасное лазерное облучение (808 нм), испускают тепло и эффективно подавляют опухоли мозга.

Application of Carbon Nanoparticles in Endoscopic Thyroidectomy via Bilateral Areola Approach: Total Thyroidectomy Plus Central Lymph Node Dissection.

Background: The aim of this report was dual: (a) to describe the step-by-step standardized intraoperative percutaneous injection of carbon nanoparticles (CNPs) procedure for CNP-stained central compartment lymph nodes (CLNs) and passive display of parathyroid gland by CNP-stained thyroid in endoscopic thyroidectomy via bilateral areola approach (ETBAA) and (b) evaluation and outcomes of percutaneous injection of CNPs in total thyroidectomy plus CLN dissection through ETBAA. Materials and Methods: Video describes the technique of intraoperative percutaneous injection of CNPs for central compart

Graphene-modified CePO4 nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability.

BACKGROUND: Breast cancer bone metastasis has become one of the most common complications; however, it may cause cancer recurrence and bone nonunion, as well as local bone defects. METHODS: Herein, In vitro, we verified the effect of bioscaffold materials on cell proliferation and apoptosis through a CCK8 trial, staining of live/dead cells, and flow cytometry. We used immunofluorescence technology and flow cytometry to verify whether bioscaffold materials regulate macrophage polarization, and we used ALP staining, alizarin red staining and PCR to verify whether bioscaffold material promotes b

Comparison of LNS-AmB, a novel low-dose formulation of amphotericin B with lipid nano-sphere (LNS), with commercial lipid-based formulations.

Three lipid-based delivery systems (AmBisome, Amphocil, and Abelcet) for amphotericin B (AmB) have been marketed to overcome the disadvantages associated with the clinical use of AmB. However, to show their efficacy, they need to be administered at higher doses than the conventional dosage form, Fungizone. In this study, we compared LNS-AmB, our new low-dose therapeutic system for AmB using lipid nano-sphere (LNS), with these commercial formulations in terms of their pharmacokinetics and efficacy. The plasma AmB levels yielded by LNS-AmB after intravenous administration to rats were much highe

Controlled-temperature photothermal and oxidative bacteria killing and acceleration of wound healing by polydopamine-assisted Au-hydroxyapatite nanorods.

UNLABELLED: Since skin wounds are subject to bacterial infection and tissue regeneration may be impeded, there is demand for biomaterials that possess rapid bactericidal and tissue repair capability. Herein we report in situ promotion of wound healing by a photothermal therapy (PTT) assisted nanocatalytic antibacterial system utilizing a polydopamine (PDA) coating on hydroxyapatite (HAp) incorporated with gold nanoparticles (Au-HAp). The PDA@Au-HAp NPs produce hydroxyl radicals (OH) via catalysis of a small concentration of H2O2 to render bacteria more vulnerable to the temperature change. The

Combination of drug-conjugated SWCNT nanocarriers for efficient therapy of cancer stem cells in a breast cancer animal model.

Targeting breast cancer and more specifically cancer stem cell (CSC) subpopulation, responsible for tumor growth, resistance and self-renewal, using combination of therapeutic drugs selectively delivered via biocompatible nanocarriers, provides a novel approach for effective therapy. Here, we propose to evaluate the potential therapeutic efficacy of combining Paclitaxel and Salinomycin drugs actively targeted to both breast cancer and CSCs in xenograft murine model after conjugation with biocompatible CD44 antibody conjugated SWCNTs via hydrazone linker allowing pH-responsive release mechanism

Diffusion Reflection: A Novel Method for Detection of Oral Cancer.

Intraoperative detection of residual disease in oral cancer may reduce the high rate of recurrences. The aim of the present study was to evaluate the detection sensitivity of diffusion reflection (DR) measurements of bioconjugated gold nanorods (GNRs) to cancerous sites in a rat model of oral squamous cell carcinoma. We used hyperspectral spectroscopy and DR measurements of GNRs bioconjugated to slide specimens of rat tongues where squamous carcinoma was induced by 4NQO (4-nitroquinoline-N-oxide). Wistar-derived male rats were used: 6 were sacrificed at wk 32 to 37 following 4NQO administratio

Activity-Based Sensing Methods for Monitoring the Reactive Carbon Species Carbon Monoxide and Formaldehyde in Living Systems.

Carbon is central to the chemistry of life, and in addition to its fundamental roles as a static component of all major biomolecules spannin … s, such as metal-complex-based time-gated luminescence and materials-based imaging scaffolds (e.g., nanotubes, nanoparticles, and carbon dots), with modalities extending to Raman and Rayleigh scattering readouts. This pursuit of leveraging selective chemical reactivity to develop highly specific ABS probes for imaging of RCS provides not only practical tool …

Contorted polycyclic aromatics.

CONSPECTUS: This Account describes a body of research in the design, synthesis, and assembly of molecular materials made from strained polyc … cs such as silicon oxide. We use ultrathin point contacts made from individual single-walled carbon nanotubes that are separated by a few nanometers to probe the electronic properties of short stacks of a few contorted discs. We find that these materials have high mobility and can sense electron-deficient aromatic molecules. The concave surfaces of these di …