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Secretion of beta-human chorionic gonadotropin by non-small cell lung cancer: a case report.

IntroductionWe describe a case of non-small cell lung cancer that was found to stain positive for beta-human chorionic gonadotropin on immunohistochemistry. Only a few case reports have described lung cancers that secrete beta-human chorionic gonadotropin.Case presentationA 68-year-old Caucasian man presented with symptoms of weakness, fatigue and weight loss for the past two months. On examination, he was found to have generalized lymphadenopathy, and radiologic workup revealed numerous metastases in the lungs, liver and kidneys. Biopsy of the supraclavicular lymph node revealed metastatic la

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… Medications at home included paroxetine, tiotropium, and omeprazole. Blood work revealed a hemoglobin level of 7.4 mg/dl with a hematocrit of 20 mg/dl, and then he was sent to the Emergency Department for transfusion. …

Idiopathic Fibrillary Glomerulonephritis: A Case Report Highlighting Diagnostic and Management Challenges.

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by non-branching fibrils within the glomerular basement membrane, often leading to progressive renal dysfunction. Despite advances in diagnostic methods, including DNA-J heat shock protein family member B9 (DNAJB9) immunostaining, the pathogenesis and optimal treatment strategies remain poorly defined. We present the case of a 55-year-old woman with longstanding microscopic hematuria and subnephrotic proteinuria who was diagnosed with idiopathic fibrillary glomerulonephritis (IFGN) following a renal biopsy. Histopat

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… She was on long-term treatment with statin, verapamil, omeprazole, metformin, lisinopril, and allopurinol. Notably, her father had a history of kidney failure requiring nephrectomy at a young age due to a presumed kidney infection. …

Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches.

The high morbidity and mortality of cancer make it one of the leading causes of global death, thus it is an urgent need to develop effective drugs for cancer therapy. Vascular endothelial growth factor receptor-2 (VEGFR2) acts as a central modulator of angiogenesis, and is therefore an important pharmaceutical target for developing anti-angiogenic agents. In this study, ligand-based naïve Bayesian (NB) models and structure-based molecular docking were combined to develop a virtual screening (VS) pipeline for identifying potential VEGFR2 inhibitors from FDA-approved drugs. The best validated na

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… Other compounds including etofenamate, rabeprazole, rilpivirine, lansoprazole, dex-lansoprazole, omeprazole, pranlukast and papaverine were purchased from Target Molecule Corp. (Boston, MA, USA). All compounds were dissolved in dimethyl sulfoxide (DMSO) and stored at −20 °C. … Anthelmintic | 126.236 | 0.875 | True DB01129 | Rabeprazole | | Anti-ulcer | 140.515 | 0.869 | True DB08864 | Rilpivirine | | Anti-HIV | 121.471 | 0.841 | True DB00448 | Lansoprazole | | Anti-ulcer | 139.411 | 0.812 | True DB05351 | Dex-lansoprazole | | Anti-ulcer | 139.411 | 0.791 | True DB00338 | Omeprazole …

Association between bile area in the duodenal bulb and abdominal symptoms: Quantitative analysis using blue laser imaging.

Bile acids are strongly associated with the pathogenesis of functional gastrointestinal diseases. In recent years, blue laser imaging (BLI) endoscopy has emerged as a novel image-enhanced endoscopic method, which illustrates bile as a reddish hue. The present study investigated the factors that affect the area of bile in duodenal bulbs using BLI. For this purpose, patients (356 cases) who underwent upper endoscopy with BLI between April, 2017 and December, 2019, and completed patient background and symptom questionnaires [Constipation Scoring System (CSS), Bristol Stool Form Scale (BSFS) and F

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… Daily use of any of the five types of PPIs/PCABs (rabeprazole, lansoprazole, omeprazole, esomeprazole or vonoprazan) for >8 weeks was regarded as indicating a PPI/PCAB user. Patients taking a normal dose of aspirin or a PPI/PCAB were regarded as users of such therapies. …

Ocrelizumab-Induced Hemophagocytic Lymphohistiocytosis: A Case Report.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon disorder marked by severe immune system dysfunction and excessive inflammation. Its clinical features often mimic those of severe sepsis, including persistent high fevers, multiorgan failure, cytopenia, and coagulation abnormalities. HLH can be triggered by infections, malignancies, rheumatological disorders, genetic factors, and medications, particularly those that cause immunosuppression. Ocrelizumab, an anti-CD20 monoclonal antibody used in the treatment of multiple sclerosis, has been associated with rare immune-mediated complications

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… Her regular medications included fluoxetine 20 mg OD, carbamazepine 100 mg PO OD, pregabalin 300 mg BD, folic acid 5 mg OD, omeprazole 20 mg OD, senna 15 mg OD, co-codamol 30/500 PRN QD, and Evorel Sequi topical (fortnightly). She had no known allergies except for Stemetil. …

Pharmacological treatment of children with gastro-oesophageal reflux.

BACKGROUND: Gastro-oesophageal reflux (GOR) is a common disorder, characterised by regurgitation of gastric contents into the oesophagus. GO … of Gaviscon Infant(®) , but further studies with longer follow-up times are recommended. Studies of omeprazole and lansoprazole in infants with functional GOR have demonstrated variable benefit, probably because of differences in inclusion criteria.No robust RCT evidence has been found regarding treatment of preterm babies with GOR/GORD or children with neur …

Ocular complications with the use of radium-223: a case series.

BackgroundRadium-223 is used for the treatment of osseous metastases in castrate-resistant prostate cancer, and has been shown to increase time to the first skeletal-related event, reduce the rate of hospitalization, and improve quality of life. It is well tolerated, with hematologic toxicity as the main adverse event. Thus far, no ocular complication has been reported in the literature after initial administration of radium-223 with a single case reported of ocular complications after a patient's second course of radium-223.Case presentationsWe present three cases of ocular complications afte

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… At that time, he was taking tadalafil 5 mg daily, amlodipine 10 mg daily, ibuprofen 600 mg daily, omeprazole 40 mg daily, mirabegron 50 mg daily, darolutamide 300 mg daily and alfuzosin 10 mg daily. There were no recent changes in medications or dosing. …

Evaluation of Proteasome Inhibitors in the Treatment of Idiopathic Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia, and it has a worse prognosis than non-small cell lung cancer. The pathomechanism of IPF is not fully understood, but it has been suggested that repeated microinjuries of epithelial cells induce a wound healing response, during which fibroblasts differentiate into myofibroblasts. These activated myofibroblasts express α smooth muscle actin and release extracellular matrix to promote matrix deposition and tissue remodeling. Under physiological conditions, the remodeling process stops once wound heal

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… However, omeprazole may modulate pirfenidone level, so omeprazole treatment should be avoided in patients taking pirfenidone. … Because pirfenidone is mainly metabolized by cytochrome P450 1A2 (CYP1A2) enzymes, patients should avoid the concomitant use of other CYP1A2 inhibitors (e.g., fluvoxamine and ciprofloxacin) or inducers (e.g., tobacco, omeprazole, and rifampicin) [ 93 ]. …

Primary or secondary antifungal prophylaxis in patients with hematological maligancies: efficacy and damage.

BackgroundPatients with hematological malignancies often develop febrile neutropenia (FN) as a complication of cancer chemotherapy. Primary or secondary antifungal prophylaxis is recommended for patients with hematological malignancies to reduce the risk of invasive fungal infection (IFI). This study retrospectively evaluated the efficacy and potential harm of administration of primary and secondary antifungal prophylaxis to patients with hematological malignancies at one hospital.MethodsAll patients with hematological malignancies older than 14 years of age who had experienced at least one FN

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… The incidence of poor metabolism, which may lead the VOR level to be four times higher in those affected compared to those not affected, has been reported to be 20% in non-Indian Asians and 5% in Caucasians and African–Americans. 21 Use of CYP2C19 isoenzyme inhibitors, such as omeprazole, and inducers …

A case of tumor lysis syndrome and acute renal failure associated with elotuzumab treatment in multiple myeloma.

Renal dysfunction is a common comorbidity of multiple myeloma. However, tumor lysis syndrome is a rare cause of renal dysfunction in multiple myeloma. Elotuzumab is a newly US FDA-approved monoclonal antibody used in the treatment of refractory multiple myeloma. To our knowledge, elotuzumab has not been associated with a case of tumor lysis syndrome. We present the case of a patient who developed clinical tumor lysis syndrome 1 week after treatment with elotuzumab accompanied by renal failure with hyperphosphatemia, hyperkalemia, and profound hyperuricemia. His course was further complicated b

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… 2017), albuterol 90 µg p.r.n., biotin 500 mg daily, calcium carbonate and vitamin D3 1,500 – 400 units b.i.d., codeine-guaifenesin 20 – 200 mg q.i.d. p.r.n., ferrous sulfate 325 mg daily, hydrocodone-acetaminophen 5 – 325 mg p.r.n., melatonin 3 mg QHS, multivitamins and vitamin B12 (doses unknown), omeprazole …

Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance.

We report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity. The identification of macro-ALP is important to rule out pathological causes of increased ALP activity and to avoid unnecessary diagnostic investigation. The patient was subsequently diagnosed with vitamin D deficiency, gallstone pancreatitis, and monoclonal gammopathy of undefined significance (MGUS). Macro-ALP can coexist with disease that can increase serum ALP activity. We report, for the first time, a case of macro-ALP in a pa

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… His treatment included amlodipine, vitamin D, clopidogrel, omeprazole, pravastatin, and lisinopril. Following cholecystectomy, his ALP remained raised, and alanine aminotransaminase, bilirubin, gamma-GT, serum calcium, and renal function were within the reference limit. …

Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma.

Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM. To our knowledge, this is the first biopsy-proven case. In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA. This supports a possible causal role of bortezomib. The exact mechanisms remain to be elucidated.

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… Other medications at that time included (total daily doses) nifedipine 120 mg, levothyroxine 75 μ g, omeprazole 40 mg, duloxetine 20 mg, amitriptyline 20 mg, calcium carbonate 1000 mg, cholecalciferol 880 E, and acetaminophen 4000 mg. Blood pressure was well controlled. …

Преодоление разрыва в знаниях о беременности: реальный всемирный анализ потребления лекарств и риска взаимодействия наркотиков в болезни Крона и множественном склерозе.

Исключение беременных людей из клинических испытаний привело к значительному разрыву в уровне медицинских знаний для этого населения. Использование реальных данных (РВД) является важнейшим звеном в распространении и использовании лекарственных средств во время беременности. С помощью базы данных планов медицинского страхования " IQVIA Pharmetrics(R) Plus " мы провели оценку использования методов лечения заболеваний и сопутствующих лекарств у беременных. Мы сосредоточились на two примеры: болезнь Крона (CD) и множественный склероз (MS)-анализирующие пациенты с историей использования D

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… Ketoconazole | 37 (0.8%) | 27 (1.1%) | Strong | Moderate Sensitive | | Yes | Methylprednisolone | 62 (1.4%) | 33 (1.4%) | | Moderate Sensitive | Weak | | Nifedipine | 79 (1.8%) | 39 (1.6%) | | Moderate Sensitive | | Yes | Nirmatrelvir‐ritonavir | 49 (1.1%) | 28 (1.1%) | Strong | | | | Omeprazole …

Ferret coronavirus-associated diseases.

A novel coronavirus of ferrets was first described in 1993. This coronavirus caused an enteric disease called epizootic catarrhal enteritis (ECE). Recently, a ferret systemic coronavirus (FRSCV)-associated disease was discovered. This new systemic disease resembles the dry form of feline infectious peritonitis (FIP) and has been reported in the United States and Europe. This article addresses the clinical signs, pathology, pathogenesis, diagnosis, treatment, and prevention of this ferret FIP-like disease.

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… Sucralfate (Carafate oral suspension) can be administered orally at a dose of 75 to 100 mg/kg, 10 to 15 minutes before each feeding and before prednisolone administration. 56 , 57 Antacids such as cimetidine hydrochloride (Tagamet), famotidine (Pepcid AC), ranitidine (Zantac), and omeprazole (Prilosec … Omeprazole and famotidine have the advantage of only once-a-day administration; however, cimetidine also has some beneficial effects on the immune system. 57 , 58 , 59 , 60 , 61 , 62 Cimetidine is a type 2 histamine receptor blocker, and can have antiviral activity, stimulate the CMI, and increase T-lymphocyte …

Non-Chinese herbal medicines for functional dyspepsia.

BACKGROUND: One-third of people with gastrointestinal disorders, including functional dyspepsia, use some form of complementary and alternat … ompared to other interventions, essential oils may improve global symptoms of dyspepsia compared to omeprazole. Peppermint oil/caraway oil, STW5, Nigella sativa and Curcuma longa may provide little to no benefit compared to other treatments. AUTHORS' CONCLUSIONS: Based on moderate to very low-certainty evidence, we identified some herbal medicines that may …

Bisphosphonate-loaded bone cement: Background, clinical indications and future perspectives.

Bisphosphonates represent an established treatment against bone resorption and osseous loss. Local application could help increase bone mineral density while minimizing their systemic use side-effects. Bone cement, used on a large scale in orthopedic surgery and a historically successful drug carrier, could represent an effective scaffold. The aim of this review was to investigate the alterations produced on the cement's structure and properties by this mixture, as well as its antiosteoporotic and antitumor effect. After a thorough research of articles, title screening and duplicate removal we

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… Zenios M Bisphosphonate-laden acrylic bone cement:Mechanical properties, elution performance, and in vivo activity J Biomed Mater Res - Part B Appl Biomater 2008 87 2 482 491 10.1002/jbm.b.31130 18506825 13 Bodde EWH Kowalski RSZ Spauwen PHM Jansen JA No increased bone formation around alendronate or omeprazole …

Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream and Lapacho Tea Wraps: A Case Report.

IntroductionDevelopment of singular keratoacanthoma (KA) is generally considered a benign condition as it has a tendency to regress spontaneously in spite of histological similarity to squamous cell carcinoma. Most KAs undergo excision to rule out differential diagnoses. Several alternative treatment modalities (keratinolytic, ablative, immunomodulating, antiproliferative, or targeted therapy) have been described in the past with varying success, underlining the therapeutic challenges associated with large or multiple lesions. Isomorphic response (Koebner phenomenon) may limit the efficacy of

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… The permanent medication consisted of felodipine, bisoprolol, clonidine, ramipril, urapidil, cholecalciferol, acetylsalicylic acid, allopurinol, phenprocoumon, thyroxine, iodine, fluvastatin, calcium acetate, omeprazole, and sevelamer carbonate. …

Evaluation of toceranib for treatment of apocrine gland anal sac adenocarcinoma in dogs.

BackgroundThere is no widely accepted standard medical treatment for apocrine gland anal sac adenocarcinoma (AGASACA) in dogs. Targeted agents such as toceranib may be effective in treatment of AGASACA, but the number of clinical reports investigating its efficacy is limited.Hypothesis/aimTo evaluate the efficacy of toceranib treatment of AGASACA in dogs, and to assess prognostic factors in the study population. Our hypothesis was that toceranib would provide a clinical benefit in the treatment of dogs with AGASACA.AnimalsThirty-six client-owned dogs with either a cytologic or histologic diagn

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… terminology criteria for AEs (VCOG‐CTCAE v1.1). 27 For gastrointestinal AEs, supportive care included, but was not limited to, a 7‐day toceranib treatment holiday, antidiarrheal agents (eg, metronidazole, tylosin), antiemetics (eg, maropitant, metoclopramide, ondansetron) and gastric protectants (eg, omeprazole …

Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis.

BACKGROUND: Osteoporosis-associated fractures are of increasing importance in trauma surgery. Systematic diagnostics and treatment of osteoporosis during a hospital stay, however, remain inadequate. Therefore, a specific algorithm for diagnosing and treating osteoporosis in trauma surgery patients was developed based on the DVO (German Osteology Society) guideline for osteoporosis from 2014. METHODS: In a first step, the individuals' age and risk profile for osteoporosis is identified considering specific fractures indicating osteoporosis and risk factors assessed by a specific questionnaire.

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… If it is decided to initiate anti-resorptive treatment with an oral bisphosphonate during a hospital stay, the combination with a proton pump inhibitor (PPI) such as omeprazole is problematic. …

Disorders of the Gastrointestinal System

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