Результаты поиска

Biomarkers of postmenopausal osteoporosis and interventive mechanism of catgut embedding in acupoints.

INTRODUCTION: Postmenopausal osteoporosis (PMOP), which is a common and frequently occurring age-related metabolic bone disease in perimenopausal women, severely affects patients living quality. Modern medicine therapies for PMOP have several problems such as side reactions, low compliance, and high costs. Thus, nonpharmacological modality is urgently needed. Although acupoint thread embedding treatment is widely used in clinical practice, there is no persuasive evidence of its effect on increasing bone mass for PMOP. This experiment aims to investigate the efficacy and safety of acupoint thre

Совпадение в полном тексте источника
… This study is based on syndrome differentiation of viscera (kidney syndrome differentiation) to determine the acupoints used in thread embedding therapy. … The researchers searched papers for nearly 10 years and found that the treatment of osteoporosis based on viscera syndrome differentiation (kidney syndrome differentiation) is effective. …

VP3.15, двойной ингибитор GSK-3β/PDE7, уменьшает рост опухоли глиобластомы, изменяя микроопухоль в контексте PTEN дикой природы.

Глиобластома (ГБ) — неизлечимый рак мозга, и необходимо срочно определить эффективные методы лечения. Это может быть достигнуто либо путем идентификации новых молекул, либо путем переочистки наркотиков. Для определения терапевтического потенциала известных ингибиторов GSK-3β и/или PDE7 в GB был проведен анализ наркотиков с использованием модели глиомы Дрософила меланогастера. VP3.15, двойной ингибитор с противовоспалительными и нейрозащитными функциями при множественном склерозе, был выбран для дальнейшего изучения. VP3.15 продемонстрировал высокую антиопухоль против панели клеток человека и м

Совпадение в полном тексте источника
… Next, we pushed until the internal wall and viscera were exposed to the exterior. Finally, the viscera of the larva were removed, and the brain was located and separated from the rest of the body. We fixed Drosophila tissues with 4 ​% formaldehyde (PFA) for 20 ​min at room temperature (RT). …

Time to Next Treatment as a Meaningful Endpoint for Trials of Primary Cutaneous Lymphoma.

Time to next treatment (TTNT) is an emerging endpoint in clinical studies of primary cutaneous T-cell lymphomas (CTCL), with utility as a surrogate marker for the "duration of clinical benefit". TTNT provides a highly clinically meaningful endpoint that uniquely reflects not only the duration of treatment efficacy on disease and symptom control, but also incorporates the patient experience by accounting for patient compliance and tolerance to the studied therapy(s). Given the distinct challenges of pin-pointing the exact date of progression in patients with multi-compartmental CTCL, TTNT overc

Совпадение в полном тексте источника
… Thirdly, discordant disease responses in skin, nodes, viscera, or blood, can confuse the overall impression of DOR, triggering a disease progression event despite sustained response elsewhere. … Additionally, disease progression in one compartment (for example, the skin) may be addressed with localised therapy(s) without necessitating changes in systemic therapy if disease control is sustained in other compartment(s) (blood, nodes, and viscera). …

The Liver in Systemic Illness

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Encephalopathy and fatty degeneration of the viscera: a disease entity in childhood. Lancet. 1963;2:749. doi: 10.1016/s0140-6736(63)90554-3. 95. Hurwitz ES, Nelson DB, Davis C. National surveillance for Reye's syndrome: a five year review. Pediatrics. 1982;70:895. 96. … Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera) N Engl J Med. 1971;285:1339. doi: 10.1056/NEJM197112092852402. 107. Teem WR. Inherited and acquired syndromes of hyperammonemia and encephalopathy in children. …

EXPERIMENTS ON THE EFFECTS OF INJECTION OF EGG-ALBUMEN AND SOME OTHER PROTEIDS.

THE CONCLUSIONS WHICH WE DERIVE FROM OUR OBSERVATIONS ARE AS FOLLOWS: 1. The excretion of injected, egg-albumen as such is in no case comple … s change. Chloretone did not cause the degeneration, but is followed by congestion of the abdominal viscera. 18. Native egg-albumen, injected into the femoral vein of a dog, was followed in one case by a fatal ending with convulsions and coma, after several intervening cases of good health. Further experiments demonstrated that there is no toxicity inhere …

Polyphyllin I Inhibits the Metastasis of Cervical Cancer Through the Regulation of the β-Catenin Signaling Pathway.

Cervical cancer ranks as the fourth most prevalent cancer and cause of cancer-related mortality among women globally. It exhibits a recurrence/metastasis rate of approximately 30% and a dismal 5-year survival of only 17% in metastatic cases. Despite significant advancements in surgical techniques, chemoradiotherapy, and targeted therapies, effective treatment options for metastatic cervical cancer remain limited. This study explored Polyphyllin I (PPI), which is a monomeric compound derived from the Rhizoma of Paris Polyphyllin, as a potential inhibitor of cervical cancer metastasis. Mechanist

Совпадение в полном тексте источника
… The fluorescence quantitative analysis of the total viscera from each group of six mice revealed a marked diminution in the total fluorescence intensity in the viscera of mice treated with 8 mg/kg PPI ( Figure 7 B). … Subsequently, the viscera sections were prepared and stained with hematoxylin–eosin (HE). …

Neck swelling in a patient with gout - What is the cause?

We describe the case of a 55-year-old man with underlying tophaceous gout who presented with a 6-month history of multiple joint pains and associated constitutional symptoms. Physical examination revealed firm and non-tender swelling measuring 3x4 cm adjacent to the left clavicular head. This swelling did not move with deglutition. Neck imaging showed bilateral heterogeneous soft tissue lesions at the sternoclavicular, first costochondral and acromioclavicular joints. Multiple lytic lesions with cortical destruction involving the upper manubrium and distal ends of both clavicles were seen. Fin

Совпадение в полном тексте источника
… Nevertheless, atypical deposition has been reported in less common sites such as the head, neck, axial skeleton, viscera and even middle ear. 3 , 4 When gout deposits occur at unusual sites, they often pose a diagnostic challenge, leading to delays in establishing the diagnosis and initiating appropriate …

Lysosomal storage diseases.

Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the accumulation of the material meant for lysosomal degradation. Examples include glycogen in the case of Pompe disease, glycosaminoglycans in the case of the mucopolysaccharidoses, glycoproteins in the cases of the oligosaccharidoses, and sphingolipids in the cases of Niemann-Pick disease types A and B, Gaucher disease, Tay-Sachs disease, Krabbe disease, and metachromatic leukodystrophy. Sometimes, the lysosomal storage ca

Совпадение в полном тексте источника
… In the viscera, lipid inclusions are frequently membrane-bound and contain stacked membranes, concentrically laminated membranes, and pleomorphic profiles with both electron-dense and electron-lucent cores ( Fig. 10 ) [ 40–43 ]. … Viscera are usually not significantly enlarged and only subtle bone changes may be present. Deficiency of β-galactosidase results in excessive accumulation of GM 1 ganglioside and its asialo derivative in the CNS and of a keratan sulfate-like galactose-containing proteoglycan in viscera. …

Successful treatment of an adult with Kasabach-Merritt syndrome using thalidomide, vincristine, and prednisone.

ObjectiveKasabach-Merritt syndrome is a rare disease that mainly occurs in infants and adolescents. It usually manifests as disseminated intravascular coagulation and severe bleeding, and is associated with high mortality. However, its low incidence and clinical rarity in adults mean that there is currently no well-verified treatment regimen for this disease. We report on an effective novel therapeutic regimen in a patient with Kasabach-Merritt syndrome.MethodsA woman with Kasabach-Merritt syndrome presented with a recurrent subcutaneous mass and disseminated intravascular coagulation, and was

Совпадение в полном тексте источника
… The initial manifestation is usually a vascular lesion on the skin, frequently located on the limbs or trunk, but occasionally in the viscera and retroperitoneal space. Lesions involving the limbs and retroperitoneal space tend to have an earlier presentation. …

A rare case of multi-segmental lumbar intradural ependymoma: clinical presentation and surgical management: a case report.

BACKGROUND: Intradural extramedullary(IDEM)-type Ependymoma is a rare clinicalentity belonging to the broader category of uncommon glial neo … ensely populated by motor neurons and autonomic nerve fibers innervating the lower limbs and pelvic viscera. Consequently, the tumor posed a heightened risk of infiltration into adjacent nerve roots or spinal cord parenchyma. Differential diagnosis:(1) Schwannoma. On MRI, schwannomas are typically iso- to hypointense on T1-weighted images and hyperintense …

Imiglucerase in the treatment of Gaucher disease: a history and perspective.

The scientific and therapeutic development of imiglucerase (Cerezyme(®)) by the Genzyme Corporation is a paradigm case for a critical examination of current trends in biotechnology. In this article the authors argue that contemporary interest in treatments for rare diseases by major pharmaceutical companies stems in large part from an exception among rarities: the astonishing commercial success of Cerezyme. The fortunes of the Genzyme Corporation, latterly acquired by global giant Sanofi SA, were founded on the evolution of a blockbuster therapy for a single but, as it turns out, propitious ul

Совпадение в полном тексте источника
… Most children with severe growth deficiency have severe disease in the viscera. 51 Interstitial lung disease is a less common manifestation of Gaucher disease. 47 It occurs when Gaucher cells infiltrate the alveolar spaces and interstitium. … and bone marrow. 126 In effect the plasma disappearance of the isotope and its uptake in the affected viscera and bone marrow was rapid, but the remodeled enzymes appeared to dwell within affected visceral organs over several days. …

A 65-Year-Old Woman with an Enlarged Tongue Due to Amyloidosis.

BACKGROUND Amyloidosis is a clinical condition characterized by the extracellular deposition of insoluble, abnormal amyloid fibrils in various body tissues. It is generally categorized into 2 forms - localized and systemic - with a wide range of signs and symptoms. This case report discusses the localized amyloidosis involvement of the oral cavity and its treatment. CASE REPORT A 65-year-old woman presented to the oral medicine clinic reporting painless tongue enlargement, which has been slowly progressing over several years, leading to difficulty in tongue movement, eating, and swallowing. Ex

Совпадение в полном тексте источника
… In general, amyloidosis can be localized, where it affects a particular organ such as the skin or oral cavity, whereas it is considered systemic when involving several body tissues such as viscera, blood vessel walls, and connective tissues [ 2 ]. …

Diagnosis and treatment of multisystem amyloidosis associated with SGPL1 mutation: A case report and review of the literature.

RATIONALE: Amyloidosis is a rare, clinically heterogeneous disease, which makes its diagnosis difficult. The relationship between amyloidosis and gene mutations is insufficiently understood. We report a case of sphingosine-1-phosphate lyase 1 (SGPL1) mutation-related amyloidosis, and review the related literature. PATIENT CONCERNS: A 53-year-old man was admitted to our hospital with a 5-month history of renal dysfunction and abdominal distension, aggravated since 2 days. Five months ago, the patient was diagnosed with nephrotic syndrome, with liver dysfunction and abdominal distension. His sy

Совпадение в полном тексте источника
… electrophoresis results, but different clinical manifestations: multiple myeloma is clinically characterized by osteodynia, anemia, hypercalcemia, and renal abnormalities, and on diagnostic work-up, abnormalities are often revealed on bone marrow aspiration and flow cytometry, whereas AL primarily affects the viscera … Therefore, we hypothesized that SGPL1 gene mutation can lead to the visceral deposition of S1P and subsequent amyloid deposits, leading to viscera-related amyloidosis. …

How many diseases is triple negative breast cancer: the protagonism of the immune microenvironment.

Triple negative breast cancer (TNBC) is a type of breast cancer (BC) that does not express the oestrogen and the progesterone receptors and the human epidermal growth factor receptor type 2 (HER2). Since there are no positive markers to reliably classify TNBC, these tumours are not yet treated with targeted therapies. Perhaps for this reason they are the most aggressive form of breast carcinomas. However, the clinical observation that these patients do not carry a uniformly dismal prognosis, coupled with data coming from pathology and epidemiology, suggests that this negative definition is not

Совпадение в полном тексте источника
… genomic heterogeneity has been observed in TNBC using deep sequencing. 12 25 TNBC has an aggressive behaviour with presentation of de novo metastatic BC, large locally advanced breast lesion or metastatic disease developing shortly after adjuvant chemotherapy. 26–28 TNBC frequently metastasises to the viscera … Metastasis develop preferentially in the viscera in patients that relapse more rapidly, leading to a bad prognosis. On the other hand, patients with later relapse present TNBC with a tendency to develop bone metastasis, leading to a better prognosis. …

Solitary Plasmacytoma of the Breast: A Case of an Uncommon Breast Neoplasm.

Plasmacytoma is a rare cancer that originates from a single plasma cell and is characterized by the abnormal proliferation of monoclonal plasma cells. It is typically localized in a single area of the body, most commonly in the bone or soft tissue. Solitary plasmacytoma can be further classified as either solitary plasmacytoma of bone (SPB) or solitary extramedullary plasmacytoma (SEP or EMP). Diagnosis may be delayed in symptomatically silent plasmacytomas, but early diagnosis and prompt treatment are crucial for the management of this disease. The mean age for patients with plasmacytoma vari

Совпадение в полном тексте источника
… Soft tissue plasmacytomas can arise from a variety of locations, including muscles, subcutaneous tissue, and viscera, and are often accompanied by nonspecific symptoms such as pain, swelling, or weakness. …

Tagraxofusp for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Brief Report on Emerging Data.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists of human interleukin-3 fused to a truncated diphtheria toxin. It is currently the only novel therapy with a prospective evaluation of efficacy and safety in the treatment of BPDCN and is also the only one to achieve FDA approval. In this short review, the results of tagraxofusp are

Совпадение в полном тексте источника
… Tagraxofusp, administered intravenously at a dose of 12 or 12.5 mg/kg/day for 5 days every 3 weeks, results in promising clinical activity in BPDCN, and in all the sites involved in the disease (skin, bone marrow, spleen, lymph node and viscera). …

The changing therapeutic landscape, burden of disease, and unmet needs in patients with cutaneous T-cell lymphoma.

Cutaneous T-cell lymphomas (CTCLs) have a chronic, relapsing course, and the most common subtypes are mycosis fungoides and Sézary syndrome. The disease causes visible skin alterations and can also cause alopecia, pruritus and pain, all of which can impact patients' health-related quality of life (HRQoL). The goal of treatment is to reduce symptoms and prevent disease progression. However, treatment recommendations are often based on low levels of evidence due to the lack of well-designed randomised clinical trials and treatment guidelines, and approved drugs vary considerably across different

Совпадение в полном тексте источника
… cell transplantation (allo‐HSCT) may be indicated in a small number of eligible patients and is the only curative option. 8 , 14 , 15 , 16 Therefore, the goals of therapy are to improve or clear lesions and to control symptoms across all affected disease compartments (skin, blood, lymph nodes, and viscera … The PFS, based on global composite scores of response in each disease compartment (i.e. skin, blood, lymph nodes, and viscera), was significantly longer with mogamulizumab (7·7 months) compared with vorinostat (3·1 months). 104 The ORR in skin, blood, and lymph node compartments was improved for 42%, …

Feline Coronavirus Infection

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Histopathology revealed severe, multifocal pyogranulomatous meningoencephalitis, choroiditis, and ventriculitis, and pyogranulomatous inflammatory lesions were also found throughout the thoracic and abdominal viscera. … Histopathology revealed severe, multifocal pyogranulomatous meningoencephalitis, choroiditis, and ventriculitis, and pyogranulomatous inflammatory lesions were also found throughout the thoracic and abdominal viscera. …

Р

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… abdominal p. a pad for the absorption of discharges from abdominal wounds, or for packing off abdominal viscera to improve exposure during surgery. communal p. metacarpal pad. fat p. a pad of fat lying within a joint, covered with synovial membrane and thought to assist in the spreading of synovial lubricant … pain occurs in animals but it seems likely on anatomical grounds. p. threshold the lowest level at which a stimulus can be applied and cause perceptible pain. p. tolerance the level of stimulation at which pain becomes intolerable. visceral p. caused by inflammation of serous surfaces, distention of viscera …

Management of cutaneous T cell lymphoma: new and emerging targets and treatment options.

Cutaneous T cell lymphomas (CTCL) clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin), and pralatrexate in CTCL.

Совпадение в полном тексте источника
… Cutaneous Lymphoma Task Force of the EORTC have developed consensus guidelines to facilitate collaboration in clinical trials. 15 These proposed guidelines consist of: recommendations for standardizing general protocol design; a scoring system for assessing tumor burden in skin, lymph nodes, blood, and viscera … ; definition of response in skin, nodes, blood, and viscera; a composite global response score; and a definition of end points. …