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Повышение роли пациентов в научном написании: понимание на основе глобального подхода с участием людей с множественным склерозом.

ВВЕДЕНИЕ: Цель настоящего исследования заключается в том, чтобы охарактеризовать процесс участия путем изучения представлений и ожиданий людей с множественным склерозом (СМЖП) в отношении процесса научного написания (ЗП) и роли участия и качества жизни пациентов в оказании на них влияния. МЕТОДЫ: На основе модели MULTI-ACT было проведено двухэтапное многометодическое исследование. Было организовано четыре семинара-практикума по совместному созданию, и их результаты были использованы для подготовки обследования, которое было переведено на восемь языков и распространено на международном уровне с

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… Furthermore, scientists should engage in reflexivity—critically examining their own biases and the traditional hierarchies in academia—to consciously create space for experiential knowledge within scientific discourse [ 41 ]. …

Leveraging patient experience data to guide medicines development, regulation, access decisions and clinical care in the EU.

Patient experience data (PED), provided by patients/their carers without interpretation by clinicians, directly capture what matters more to patients on their medical condition, treatment and impact of healthcare. PED can be collected through different methodologies and these need to be robust and validated for its intended use. Medicine regulators are increasingly encouraging stakeholders to generate, collect and submit PED to support both scientific advice in development programs and regulatory decisions on the approval and use of these medicines. This article reviews the existing definition

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… In 2015, the Innovative Medicines Initiative (IMI) launched the Patient Preferences in Benefit–Risk Assessments during the Drug Life Cycle project (Project PREFER), a collaborative effort between public and private entities such as the industry, academia, patient organizations, and a HTA organization …

[Narrative Ethicsfrom the Three Attributes of Life: Conceptual Analysis and Principle Construction].

The emergence of narrative medicine offers new possibilities for the research of bioethics.This paper proposes the concept of "life narrative ethics" and uses the three life attributes-natural life,spiritual life,and social life-as an analytical framework to reveal the ethical demands of life narratives in the finiteness of the physical body,the rupture of self-identity,and the transformation of social roles.On this basis,this paper distills four core principles:centering on life stories,dignity integration,interpretive humility,and reciprocal narrative relationships.These principles respectiv

[Patient Narrative Flattening in Digital Health:A Discussion].

Digital health has improved the efficiency of information processing while also changing how patients' illness narratives enter healthcare systems.Patient narrative flattening refers to the excessive compression of patient narratives during digital processing,whereby temporal trajectories,life contexts,value preferences,and other dimensions of illness experience are diminished.It is mainly manifested in the compression of narrative content during expression,the fragmentation of information in clinical documentation,and the fixation of information in subsequent use.Such flattening may constrain

Research Progress in the Relationship Between Porphyromonas Gingivalis Lipopolysaccharide and Atherosclerosis.

Atherosclerosis (AS) is characterized by lipid deposition and the formation of arterial intimal plaques,which can lead to serious cardiovascular events such as acute coronary syndrome,myocardial infarction,or stroke.It is one of the leading causes of mortality among Chinese residents.Recent studies have demonstrated that porphyromonas gingivalis lipopolysaccharide activates the inflammatory pathway through binding to Toll-like receptors,thereby stimulating the expression of inflammatory mediators.This process induces functional impairments in macrophages and endothelial cells,promotes foam cel

Laser-Assisted Pulp Revascularization Therapy for Periapical Periodontitis in an Adult With an Immature Root:Report of One Case.

The conventional treatment for periapical periodontitis faces challenges,especially in the cases with immature roots.This article reports a case of periapical periodontitis in an adult permanent tooth with an immature root,where erbium-doped yttrium aluminum garnet(Er:YAG)laser-activated root canal disinfection was employed to induce apical bleeding and pulp revascularization.A 22-month postoperative follow-up showed healing of the periapical lesion,narrowing of the apical foramen,and positive pulp vitality test results.

Longitudinal Trajectories of Frailty in Middle-Aged and Elderly Patients Undergoing Radiotherapy for Lung Cancer and Their Influencing Factors.

Objective To explore the change trajectories of frailty in middle-aged and elderly patients undergoing radiotherapy for lung cancer and their influencing factors,thus providing a theoretical basis for targeted frailty management. Methods A prospective longitudinal study was conducted.Middle-aged and elderly patients with lung cancer who received radiotherapy in Yunnan Cancer Hospital were recruited by convenience sampling from January 2023 to December 2024.The general information questionnaire was used to investigate the baseline and disease-related data of patients at three time points:1 day

Standards and Guidance for Transparent Disclosure of Human-Artificial Intelligence Collaboration Content in Medical Research (2026).

The rapid iteration of artificial intelligence (AI) tools is propelling medical research into a new phase characterized by human-AI collaboration.In the course of this process,AI has evolved from an external instrument into a functional component embedded within research workflows.As the collaborative boundary between human researchers and AI becomes increasingly ambiguous,governance challenges have grown increasingly salient.Concurrently,there remains a lack of internationally harmonized standards for the declaration of AI-assisted content,giving rise to notable disclosure gaps and implementa

Application Value of Super-Resolution Ultrasound Imaging in the Diagnosis of American College of Radiology Thyroid Imaging Reporting and Data System Category 4 and 5 Thyroid Nodules.

Objective To investigate the value of super-resolution ultrasound (SRUS) imaging in the diagnosis of American College of Radiology Thyroid Imaging Reporting and Data System category 4 and 5 thyroid nodules diagnosed by routine ultrasound examination. Methods This study prospectively included the patients who were scheduled for ultrasound-guided aspiration biopsy due to suspicious thyroid nodules found on routine ultrasound.Contrast-enhanced ultrasound (CEUS) examination and SRUS analysis were performed to observe the enhancement characteristics of the nodules and conduct quantitative analysis.

Comparison of the Consistency and Application Value of Transabdominal Intestinal Ultrasound and Computed Tomography Enterography in the Diagnosis of Inflammatory Bowel Disease Complicated With Intestinal Stenosis.

Objective To explore the consistency and clinical application value of transabdominal intestinal ultrasound (IUS) and computed tomography enterography (CTE) in the diagnosis of inflammatory bowel disease (IBD) complicated with intestinal stenosis. Methods A retrospective study was conducted on 115 patients diagnosed with IBD in Beijing Friendship Hospital,Capital Medical University from 2015 to 2024 and who underwent both IUS and CTE examinations during the same period.Clinical and imaging data were collected.Endoscopy was used as the gold standard to compare the detection,localization,and dia

Conceptual Evolution and Research Focus of Narrative Competence in Healthcare Professionals:CiteSpace-Based Knowledge Mapping.

Objective To systematically review the conceptual evolution and research focus of narrative competence among healthcare professionals and to reveal the differences and complementary relationships between Chinese and English articles. Methods CiteSpace-based knowledge mapping was conducted on the articles related to narrative competence published between 2001 and 2025,including 103 articles from four major English databases (PubMed,Web of Science Core Collection,APA PsycINFO,and CINAHL) and 186 articles from three major Chinese databases (CNKI,Wanfang Data,and VIP).Keyword co-occurrence analysi

Conception of the Discipline Construction of Palliative Medicine(Continued).

By comprehensively utilizing literature analysis to trace the disciplinary evolution and theoretical foundations of palliative medicine globally and domestically,and employing comparative research to examine the discipline accreditation standards and implementation practices from internationally recognized bodies,including the Royal College of Physicians and Surgeons of Canada and the American Board of Medical Specialties,we clearly define the conceptual definitions and logical relationship between palliative care(as clinical practice)and palliative medicine(as an academic discipline).On this

Responding to Suffering:Development Course and Social Dimensions of Palliative Care.

A review of the development course of palliative care reveals that its goal of alleviating suffering determines the indispensability of the social dimension in this field.As palliative care emerges in response to the general trends such as aging and disease spectrum changes of social development,it naturally becomes one of the key solutions to social issues including the difficulties in caregiving and hospitalization for end-of-life patients.Beyond its social value,the comprehensiveness and localization of care emphasized by palliative care also require the support and intervention of theoreti

Exploring the Practice of Palliative Medicine Through Lens of Body Philosophy.

Palliative medicine is a newly emerging branch of clinical medicine,with palliative care forming the core of its clinical practice.It is experiencing dynamic progress in China.This paper analyzes the similarities and differences among four definitions of palliative care to reveal the theoretical breakthroughs emerging from its localization process.From the perspective of body philosophy,it elucidates the shift in clinical reasoning from symptom management to holistic care.Palliative care,grounded in the integrity of the human body,implements the holistic care that approaches patients' pain,suf

Roles,Effects,and Elements of Palliative Care Development in General Hospitals Based on the Consolidated Framework for Implementation Research.

Objective To analyze the roles,effects,and key elements of palliative care development in Peking Union Medical College Hospital based on the Consolidated Framework for Implementation Research(CFIR),thus providing a reference for the development of palliative care in other general hospitals. Methods Semi-structured interviews and observation were employed to collect data,which were analyzed and coded in accordance with the CFIR. Results More than 35 000 words were written in the observation diary and 11 subjects were interviewed.A total of 64 codes were extracted,which were categorized into 26

Current Situation of Construction and Implementation of Hospice Care System in Beijing.

Objective To examine the progress in incorporating hospice care as a key component to improve the quality of life for the elderly within Beijing's city-wide elderly health support system. Methods Relevant policy documents and literature,as well as the progress in system construction and service model development of hospice care in Beijing,were reviewed to comprehensively evaluate the effects and challenges of policy implementation. Results Guided by national policies,Beijing has advanced hospice care through innovative service models that integrate hospital,community,and home-based care,suppor