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Publisher Correction: Investigation of the relationship between COVID-19 disease and semen parameters in idiopathic male infertility patients.

Eur Rev Med Pharmacol Sci 2023; 27 (1): 378-383-DOI: 10.26355/eurrev_202301_30891-PMID: 36647886, published online on January 13, 2023. This erratum addresses errors in the reference list of the published PDF version. Due to an internal error during layout finalization, incorrect references from another article were inadvertently inserted into the final PDF. The error was not detected by the authors prior to publication, and the PDF file was approved for publication. The corrected list of references is provided below: 1.         Chen J, Jiang Q, Xia X, Liu K, Yu Z, Tao W, Gong W, Han JJ. Indiv

Medical Ozone Treatment Attenuates Male Reproductive Toxicity Induced by Bleomycin, Etoposide, and Cisplatin Regimen in an Experimental Animal Model.

The chemotherapeutic combination of bleomycin, etoposide, and cisplatin (BEP) is well-documented to exert gonadotoxic effects, ultimately leading to impaired fertility. This experimental rat study investigated the potential protective role of repeated medical ozone therapy in mitigating the deleterious effects of BEP treatment in male rats. Thirty-two adult male Sprague Dawley rats were randomly assigned to four groups: (i) a healthy control group, (ii) a group receiving injections of the BEP regimen over nine weeks, (iii) a group receiving the same BEP regimen plus medical ozone (1 mg/kg IP)

Bortezomib treatment causes long-term testicular dysfunction in young male mice.

BackgroundWith increased long-term survivors of childhood cancer patients, therapy-associated infertility has become one of the most common late side-effects and significantly affects their life-quality. Therefore, evaluation of anti-cancer agents on male reproduction and infertility prevention are urgently demanding. The proteasome inhibitor bortezomib has been launched in clinical trials for childhood cancers, however, its potential side effects on reproduction have so far been neither investigated experimentally nor reported in treated children. Thus the present study is designed to explore

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… Altogether 15% of tubules showed a Sertoli cell only phenotype (SCO, Figure 1 C and D, arrows), no morphological abnormalities of Sertoli and Leydig cells (LCs) were observed. The length of the seminiferous tubules was comparable to control (Table 1 ). … Germ cells were positively stained ( D , arrows) suggesting DNA fragmentation while Sertoli, peritubular and Leydig cells were all TUNEL negative (open triangle, arrowheads, and solid triangle). …

New understanding of the damage of SARS-CoV-2 infection outside the respiratory system.

Since early December 2019, a number of pneumonia cases associated with unknown coronavirus infection were identified in Wuhan, China, and many additional cases were identified in other regions of China and in other countries within 3 months. Currently, more than 80,000 cases have been diagnosed in China, including more than 3000 deaths. The epidemic is spreading to the rest of the world, posing a grave challenge to prevention and control. On February 12, 2020, the International Committee on Taxonomy of Viruses and the World Health Organization officially named the novel coronavirus and associa

Exosomes in oncofertility: emerging roles in chemotherapy-induced reproductive damage and fertility preservation.

ABSTRACT: Oncofertility has emerged as a critical interdisciplinary field addressing the reproductive challenges faced by cancer patients, particularly those undergoing chemotherapy. While chemotherapeutic agents remain indispensable in cancer therapy, their gonadotoxic effects frequently result in diminished ovarian reserve, impaired spermatogenesis, and long-term infertility. Exosomes - small extracellular vesicles enriched with nucleic acids, proteins, and lipids - are increasingly recognized as key mediators of intercellular communication in both pathological and regenerative contexts. Rec

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… In addition, exosome-mediated communication between Sertoli and Leydig cells influences testosterone synthesis and testicular recovery after systemic chemotherapy exposure ( Liang et al. 2021 ). … A2t the same time, exosome-mediated communication between Sertoli and Leydig cells contributes to the regulation of steroidogenesis and maintenance of testicular homeostasis, thereby supporting recovery of endocrine function ( Ma et al. 2021 ). …

GPER1 Активация Антитуморной активности в Множестве миелом.

G белковый рецептор эстрогена. 1 Активация (GPER1) становится перспективной терапевтической стратегией борьбы с различными видами рака. Несмотря на то, что в контексте твердых опухолей широко изучался вопрос о адресации GPER, его воздействие на гематологию еще предстоит понять в полной мере. Здесь мы показываем, что GPER1 mRNA понижается в плазменных клетках от открытой множественной миэломы (MM) и лейкемии от плазмы по сравнению с нормальными спонсорами или преднасыщенными условиями (моноклональная гаммопатия неопределённого значения и удушающая MM); кроме того, более низкое выражение GPER1 а

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… Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells. Cell Death Dis. 2013;4:e747. doi: 10.1038/cddis.2013.275. 17. Ambrosini G., Natale C.A., Musi E., Garyantes T., Schwartz G.K. …

Special Issue "Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases, 2nd Edition".

The dynamic transcriptomic landscape of the human genome, comprising both coding and non-coding RNA (ncRNA) transcripts, serves as a molecular fingerprint of cellular and tissue-specific physiological states [...].

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… The authors discuss how these ncRNAs influence germ cell development, meiosis, and sperm maturation, as well as their roles in testicular somatic cells such as Sertoli and Leydig cells. …

Molecular and Clinical Insights in Malignant Brenner Tumor of the Testis With Liver Metastases:A Case Report.

Malignant Brenner Tumor (mBT) is extremely rare. Although BT are almost exclusive ovarian neoplasms, they may constitute a highly unusual tumor of the testis; in fact, only seven fully documented cases have been reported to date. Because of their rarity, the pathogenesis of these tumors has not been clarified and there is no standard therapeutic approach. We report the first case of epididymal mBT with synchronous, multiple, liver metastases and a very dramatic clinical course. Both primary tumor and metastasis were subjected to mutational analysis of 20 cancer associated genes. Primary tumor

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… (D) Testis showing tubular atrophy and Leydig cells hyperplasia (x10 magnification). Histological Diagnosis On gross pathological examination, the resected specimen was composed by testis sized cm 2 × 1.5 × 1.5 with hemorrhagic features of tunica vaginalis and cm 5 of spermatic cord. …

Advanced Diagnostic Techniques

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Phosphodiesterase type 5 and cancers: progress and challenges.

Cancers are an extraordinarily heterogeneous collection of diseases with distinct genetic profiles and biological features that directly influence response patterns to various treatment strategies as well as clinical outcomes. Nevertheless, our growing understanding of cancer cell biology and tumor progression is gradually leading towards rational, tailored medical treatments designed to destroy cancer cells by exploiting the unique cellular pathways that distinguish them from normal healthy counterparts. Recently, inhibition of the activity of phosphodiesterase type 5 (PDE5) is emerging as a

Clinical and Therapeutic Implications of Male Obesity.

The prevalence of obesity, a disorder linked to numerous comorbidities and metabolic complications, has recently increased dramatically worldwide and is highly prevalent in men, even at a young age. Compared to female patients, men with obesity more frequently have delayed diagnosis, higher severity of obesity, increased mortality rate, and only a minority of obese male patients are successfully treated, including with bariatric surgery. The aim of this review was to present the current state of knowledge about the clinical and therapeutic implications of obesity diagnosed in males.

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… It has been reported that high leptin concentration in obesity inhibits Leydig cells function and, thus, testosterone synthesis [ 71 ]. … Experimental studies have also shown that a decrease in BMI (body mass index) leads to the increase in the levels of osteocalcin; osteocalcin directly stimulates Leydig cells in the testes to synthesize testosterone [ 80 ]. …

Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects.

Resveratrol (RES), a naturally occurring polyphenolic compound, has garnered significant attention due to its diverse biological activities, which include anti-inflammatory, antioxidant, and antiaging properties. This review synthesizes current evidence concerning the molecular mechanisms, therapeutic efficacy, and safety profile of RES across a variety of pathologies, with an emphasis on the latest research conducted in recent years. Mechanistically, RES is known to modulate critical signaling pathways such as the activation of sirtuin 1. These actions collectively contribute to the attenuati

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… In mouse Leydig cells, RES reverses cAMP‐mediated progesterone synthesis in a dose‐dependent manner, with effective concentrations ranging from 10 to 50 µM. …

A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice.

BACKGROUND: Dietary supplementation with leucine and fish oil rich in omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has previously been shown to reduce cachexia-related outcomes in C26 tumour-bearing mice. To further explore associated processes and mechanisms we investigated changes in plasma Ca2+ levels, the involvement of parathyroid hormone related protein (PTHrP), and its possible interactions with cyclooxygenase 2 (COX-2). METHODS: CD2F1 mice were subcutaneously inoculated with C26 adenocarcinoma cells or sham treated and divided in: (1) controls, (2) tu

Physical activity and testicular cancer survivorship health-related quality of life: a scoping review.

BackgroundWhile the benefits of physical activity (PA) for cancer survivors are well-documented, there is limited research specifically exploring its effects on health-related quality of life (HRQoL) among testicular cancer (TC) survivors. This review aims to examine the available literature on the relationship between PA and HRQoL in TC survivors post-treatment.ObjectiveTo identify and synthesize existing studies on the effects of PA on HRQoL outcomes in TC survivors.Eligibility criteriaStudies that examined the relationship between PA, TC survivorship, and HRQoL across various phases of surv

Advanced Diagnostic Techniques

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Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.

Alcohol Denat. is the generic term used by the cosmetics industry to describe denatured alcohol. Alcohol Denat. and various specially denatu … ml of Quassin did not possess any cytotoxic or antiplasmodial activity. Quassin administered to rat Leydig cells in vitro at concentrations of 5-25 ng/ml inhibited both the basal and luteinizing hormone (LH)-stimulated testosterone secretion in a dose-related fashion. Quassin at doses up to 2.0 g/kg in drinking water using rats produced no significant effect o …

PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases.

Metastatic breast cancer (BrCa) is currently incurable despite great improvements in treatment of primary BrCa. The incidence of skeletal metastases in advanced BrCa occurs up to 70%. Recent findings have established that the distribution of BrCa metastases to the skeleton is not a random process but due to the favorable microenvironment for tumor invasion and growth. The complex interplay among BrCa cells, stromal/osteoblastic cells, and osteoclasts in the osseous microenvironment creates a bone-tumor vicious cycle (a feed-forward loop) that results in excessive bone destruction and progressi

Influence of anticancer agents on sexual function: An in vivo study based on the US FDA Adverse Event Reporting System.

BackgroundPatients with cancer are treated with chemotherapeutics that cause adverse effects, including erectile dysfunction (ED).ObjectivesWe investigated erectile function in rats after the administration of anticancer agents based on data retrieved through mining of the US Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database.Materials and methodsThe statistical signal strength for the association between anticancer drugs and ED was calculated using the reporting odds ratio (ROR). A drug-event combination was detected when the lower limit of the 95% confidence in

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… Following administration of L‐PAM and MTX to rats on day 1, high doses of both temporarily decreased erectile function and testosterone levels. 27 , 28 However, L‐PAM also injures Leydig cells and decreases testosterone level, which are essential for erectile function. 29 Therefore, it may be necessary …

Optimal Delivery of Follow-Up Care After Allogeneic Hematopoietic Stem-Cell Transplant: Improving Patient Outcomes with a Multidisciplinary Approach.

The increasing indications for allogeneic stem-cell transplant in patients with hematologic malignancies and non-malignant diseases combined with improved clinical outcomes have contributed to increase the number of long-term survivors. However, survivors are at increased risk of developing a unique set of complications and late effects, besides graft-versus-host disease and disease relapse. In this setting, the management capacity of a single health-care provider can easily be overwhelmed. Thus, to provide appropriate survivorship care, a multidisciplinary approach for the long-term follow-up

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… The interstitial compartment of the testis, containing Leydig cells that produce and secrete testosterone, is much more resistant than seminiferous tubules to the damage induced by RT 93 and/or chemotherapy. 94 As a consequence, after anticancer treatments, patients often show impairment in fertility … Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol . 1989;120(1):161–165. doi: 10.1677/joe.0.1200161 94. Wallace WH, Shalet SM, Lendon M, Morris-Jones PH. Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia. …

Higher Incidence of Diabetes in Cancer Patients Compared to Cancer-Free Population Controls: A Systematic Review and Meta-Analysis.

Background: Diabetes increases the risk of certain types of cancer. However, the literature regarding the incidence of diabetes after cancer diagnosis is inconsistent. We aimed to assess whether there was a higher incidence of diabetes among cancer patients by performing a systematic review and meta-analysis of results from cohort studies. Methods: A systematic electronic literature search was carried out from cohort studies regarding the incidence of diabetes in cancer patients, using the databases PubMed (MEDLINE), Embase, Web of Science, and the Cochrane Library. Random-effects meta-analyse