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Страх рецидива рака у онкогематологических пациентов: инструменты оценки и основанные на фактических данных психологические меры - систематический обзор.

ВВЕДЕНИЕ: онкогематологические пациенты проходят сложный процесс эмоциональной адаптации, в рамках которого страх перед раком периодически возникает (ОКП). one из наиболее распространенных проблем. Этот страх не только негативно сказывается на их психологическом благополучии, но и связан со значительным снижением качества жизни. ЦЕЛЬ: Цель настоящего исследования заключается в проведении систематического обзора имеющихся доказательств в отношении: (1) факторы, связанные с FCR у онкогематологических пациентов.2) действительность и надежность инструментов, используемых для его оценки (см.3) тера

"Они не хотят изучать его": доверие, раса и медицинское обслуживание среди пациентов-диадов с множественной миеломой.

БАКГРЕСС: Медицинское недоверие, лежащее в основе неэтичного исследования, является препятствием для лечения лиц из числа чернокожих/африканцев (АА) раком. Решающее значение имеет понимание доверия, недоверия и опыта в области здравоохранения, особенно в случае множественной миэломы (ММ), которая в непропорционально большой степени ложится тяжелым бременем на чернокожих/алкоголиков с точки зрения заболеваемости и выживания. ЦЕЛЬ ИССЛЕДОВАНИЯ: В этом исследовании качественно изучается опыт чернокожих/аАА и белых диад (больных с ММ и взрослых опекунов), с тем чтобы получить представление об этих

Real-world outcomes of diffuse large B-cell lymphoma in the biosimilar era.

BackgroundDiffuse large B-cell lymphoma (DLBCL) is an aggressive and the most common type of non-Hodgkin lymphoma (NHL). The clinical use of rituximab has improved the treatment response and survival of patients with DLBCL. The introduction of rituximab biosimilar into healthcare system has helped in providing a cost-effective treatment to B-cell lymphoid malignancies as standard of care and has improved access to patients worldwide. The aim of this study was to observe the real-world effectiveness and safety of Reditux™ and Ristova® in DLBCL patients.MethodsObservational study in adults with

On CAR-Ts, decentralized in-house models, and the hospital exception. Routes for sustainable access to innovative therapies.

Chimeric Antigen Receptor T cells, or CAR-Ts, are a novel class of gene and cell 'one-shot' therapies based upon collecting, reprogramming, and using patients' own immune cells to treat their cancer. The article discusses the status, prospects, and some relevant legal issues of this frontier of personalized medicine. In particular, it explores the legitimacy of 'in-house' CAR-Ts, ie treatments manufactured and delivered to patients within the same clinical center by relying upon automated cell processing systems, a decentralized model which is very different from the one currently adopted for

An Update on Current Therapeutic Options in IgA Nephropathy.

Immunoglobulin A nephropathy (IgAN) remains the leading cause of primary glomerular disease worldwide. Outcomes are poor with high rates of progressive chronic kidney disease and kidney failure, which contributes to global healthcare costs. Although this disease entity has been described, there were no disease-specific treatments until recently, with the current standard of care focusing on optimal supportive measures including lifestyle modifications and optimization of the renin-angiotensin-aldosterone blockade. However, with significant advances in the understanding of the pathogenesis of I

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… in proteinuria at 9 months Change in eGFR at 9 and 24 months | Awaited IONIS-FB-LRx | Blocks alternative pathway activation by inhibiting Factor B | * NCT04014335 —completed Phase II open-label study | Change in proteinuria at 29 weeks | Eight of 10 patients had a reduction in proteinuria at week 29 IMAGINATION … Based on these results, the phase III Imagination trial has started recruitment (ClinicalTrials.gov Identifier: NCT05797610 ). …

От активности МРТ до эскалации лечения при повторном склерозе: что нам могут сказать новые повреждения Т2?

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Health- related quality of life after surgery for spinal metastases.

BACKGROUND: Surgery for spinal metastases is almost always palliative and part of a multidisciplinary approach that has determined a significant increase of life expectancy in the last decade; thus, an improvement in health-related quality of life (HRQOL) is the main goal of the treatment of spinal metastases. We report here the results of a prospective study conducted with the aim of evaluating the impact of spinal surgery on HRQOL, measured by Patient-Reported Outcomes Measures (PROMs). We analyzed clinical outcomes (ambulatory status, performance status, pain, neurological status) and HRQOL

General population norms for the EQ-5D-3 L in Norway: comparison of postal and web surveys.

BackgroundThe EQ-5D-3 L instrument is a standardized questionnaire which was developed as a simple, generic measure of health for clinical and economic appraisal. To aid in the interpretation, scores are often compared with a normative group. The objectives of this study were 1) to provide population norms for the EQ-5D-3 L for Norway, and 2) to compare scores from postal and web surveys.MethodsWe conducted two surveys in samples that were aimed to be representative of the Norwegian general population: 1) a postal survey (n = 5000) and 2) a panel study with electronic data collection (n = 1936

Protocol for a randomised controlled feasibility trial of an integrated psychosexual intervention for sexual difficulties in people with Multiple Sclerosis: the PIMS trial.

BACKGROUND: Multiple Sclerosis (MS) is a long-term condition that significantly diminishes quality of life (QoL). Sexual difficulties (SDs) are common, but often overlooked symptom, affecting 50-80% of people with MS (PwMS). The emergence of SDs in MS results from the intricate interplay of disease processes, treatments, and psychosocial factors, contributing to a further decline in QoL and adverse effects on body image, relationships, and psychological well-being. Despite the limited treatment options, which mainly include medications and physiotherapy, there is promise in psychological inter

Incidence and Factors Influencing Locomotive Syndrome in Cancer Patients Living in the Community.

Background Investigating locomotive syndrome (LS) of cancer survivors in the community will help clarify the importance of rehabilitation for cancer survivors in the community and provide a basis for exploring effective interventions. The primary purpose of this study was to conduct a comparison of LS, fatigue, psychological problems, and physical activity in cancer survivors and those without cancer in the community. The secondary purpose was to analyze factors influencing LS in cancer patients. Methods The study involved 59 cancer patients undergoing chemotherapy at home and 59 people withou

Cutting edge developments in bone oncology - Highlights from the Cancer and Bone Society 2024 annual meeting.

The 2024 Annual Conference of the Cancer and Bone Society (CABS), held jointly with the Bone Research Society at the University of Sheffield, highlighted the Society's enduring mission to advance understanding of cancer-bone interactions through collaboration, mentorship, and scientific excellence. Established from the early Cancer Induced Bone Disease meetings and re-emerging as an independent body in 2016, CABS continues to serve as a global community bridging basic, translational, and clinical research. This year's meeting featured a comprehensive scientific program spanning tumor-bone biol

Effect of Acupuncture in Pain Management of Head and Neck Cancer Radiotherapy: Prospective Randomized Unicentric Study.

This prospective randomized open-label trial aimed to evaluate the role of acupuncture in the treatment of pain related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. Patients in two arms (30 patients in each arm) underwent standard oncology therapy and standard supportive care with or without acupuncture. The stratification factors were the type of treatment and chemotherapy indication. The toxicity assessed was represented by pain rated on a 10-point pain scale and analgesic use. Average pain (AP) and the worst pain during the day (WP) were significantly lower in the a

Use of complementary and alternative medicine by patients with hematological diseases experience at a university hospital in northeast Mexico.

BackgroundComplementary and alternative medicine includes a diverse group of medical and healthcare systems, practices and products not considered part of conventional medicine. Although there is information on unconventional practices in oncological diseases, specific data regarding the use of complementary and alternative medicine by hematology patients is scarce.ObjectiveThe aim of this study is to document the prevalence of this modality of unconventional therapy in patients with malignant and benign hematological diseases, particularly children with acute lymphoblastic leukemia.MethodsAn

Налтрексон для острого управления навязчивыми сексуальными и одержимыми симптомами у пациента с неевроразвитым расстройством.

Навязчивое сексуальное расстройство (CSBD) характеризуется постоянной сложностью контроля за сексуальными желаниями и поведением, связанным с явными расстройствами или расстройствами. Данные, основанные на населении, свидетельствуют о том, что ~8.6% , взрослых американцев испытывают трудности, связанные с борьбой с сексуальными желаниями, чувствами и поведением, в то время как крупные международные исследования в области скрининга показывают, что ~5% ОСББ может подвергаться высокому риску, однако лишь меньшинство обращается за лечением. Диагностическая классификация по-прежнему сопряжена с тру

Response-The Road Less Travelled: Why did Miles Little Turn to Qualitative Research and Where Did This Lead?

Miles Little is an Australian surgeon, poet, and philosopher whose published work spans diverse topics in surgery, medicine, philosophy, and bioethics. In 1974 he co-authored a survey that included an analysis of interviews conducted with amputees. This was his first foray into qualitative research. Twenty years later he established a research centre at the University of Sydney that initiated a programme of qualitative research in cancer medicine. For twenty years after that, the centre acted as a hub for research that applied qualitative methods from the social sciences to study the experienc

THE FATE OF THE GIANT CELLS IN HEALING TUBERCULOUS TISSUE, AS OBSERVED IN A CASE OF HEALING TUBERCULOUS MENINGITIS.

From the foregoing description of the histological changes in the leptomeninx it is quite evident that we are dealing with a chronic, stationary, healing form of tuberculous inflammation. This statement is substantiated, in the first place, by the clinical history. The only reasonable interpretation of the symptoms would establish the duration of the process as four months. The imaginable contingency that there existed first a meningeal syphilitic lesion that was dispersed by the iodide of potassium only to be followed by a tuberculous infection is so remote and unlikely that it need not be di

Symptom tracking made simple? Observational data on the clinical use of the PERS2ON score in cancer patients receiving palliative care.

ContextA standardized assessment of symptoms is essential for individualized palliative care (PC). While numerous tools exist, many are too complex for daily clinical use.ObjectiveThe PERS2ON score was developed as a brief and practical tool to assess symptom burden in PC. This study aimed to evaluate its feasibility in a rural hospital setting, although it did not include formal feasibility metrics such as recruitment or adherence rates.MethodsPatients admitted to the palliative care unit of a rural hospital were assessed using the PERS2ON score, which includes seven items: pain, eating, reha

Isolated compression of the ulnar motor branch due to carpal joint ganglia: clinical series, surgical technique and postoperative outcomes.

The entrapment of the ulnar nerve in Guyon's canal (GC) is a well-known wrist canalicular syndrome which is usually followed by a gradual combination of both sensitive and motor symptomatology. However, GC nerve compression could also cause a pure hand motor dysfunction. This condition, less frequent than the classic Guyon's syndrome, can be difficult to diagnose. Authors report a case series of eight patients affected by isolated compression of the ulnar nerve motor branch, due to piso-triquetrum or triquetro-hamate joint ganglia. Surgical technique and postoperative outcomes are discussed in

Sagittal and Frontal Plane Evaluation of the Whole Spine and Clinical Outcomes after Vertebral Fractures.

Although it is known that a change in any level of the spine alters biomechanics, there are not many studies to evaluate the spine as a whole in both sagittal and frontal planes. This prospective cohort study evaluates the morphology and mobility of the entire spine in patients with vertebral fractures. The Treatment Group consisted of 43 patients who underwent percutaneous balloon kyphoplasty or percutaneous balloon kyphoplasty plus fixation. The Control Group consisted of 39 healthy subjects. Spinal Mouse was used for the assessment of the curvatures and the mobility of the spine. Clinical o

Новый биомаркер оптической совместимости для диагностики острого оптического неврата в множестве склерозов.

ЦЕЛЬ: Ценна ли съемка ретроламинарного оптического нерва во время атаки острого оптического неврата в множественных склерозах? МЕТОДЫ: Это перспективное исследование серии наблюдений. Twenty two Пациенты, набранные в клиниках Университета Аль-Азхар и благотворительном центре < < Глазный центр > > Эль-Мустафа, Каир; с октября 2022 по февраль 2024. Пациенты были названы, так как у них развился приступ острого оптического неврита. Полные офтальмологические и неврологические обследования были проведены для всех пациентов внутри 2 недель острого оптического неврата. Изображение перипапо