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Belantamab Mafodotin-blmf: A Novel Antibody-Drug Conjugate for Treatment of Patients With Relapsed/Refractory Multiple Myeloma.

Multiple myeloma (MM) is a hematologic malignancy characterized by proliferation of plasma cells with or without production of monoclonal immunoglobulins. Management of patients with MM begins with induction therapy, typically a proteasome inhibitor (PI) with dexamethasone and an immunomodulator (IMID), followed by autologous hematopoietic stem cell transplantation in eligible patients. Although various treatments are available, MM is considered incurable, and patients with progression after multiple treatment lines, including CD38 monoclonal antibodies, have a median overall survival of 8.6 m

Evaluation of salivary flow in patients following hematopoietic stem cell transplantation: a retrospective study.

INTRODUCTION: Hematopoietic stem cell transplantation is an effective treatment for hematological diseases but it is frequently associated with oral complications such as hyposalivation and xerostomia, particularly in cases of chronic Graft-versus-Host Disease. The objective of this study was to evaluate unstimulated salivary flow in patients who underwent transplantations at least five years previously and to investigate possible associations between hyposalivation and systemic and oral chronic Graft-versus-Host Disease. METHODS: This retrospective cross-sectional study included 27 patients

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… In cases of marked glandular hypofunction resulting from parenchymal destruction, the use of gel lubricants and specific rinses for oral mucosa lubrication is recommended [ 13. , 14. , 15. ]. … Changes in salivary proteins, antimicrobial constituents, and antioxidant capacity after HSCT may compromise lubrication and salivary defense mechanisms, potentially contributing to dryness symptoms even when flow rates remain within normal limits. …

Beyond the Cutoff: Outcomes After Sigmoid Colon Vaginoplasty in Patients With BMI ≥35.

BACKGROUND: Sigmoid colon vaginoplasty is a gender-affirming procedure offering a self-lubricating neovagina with adequate depth. However, the impact of BMI on outcomes of sigmoid colon vaginoplasty remains unclear. OBJECTIVE: To evaluate the effect of elevated BMI on short- and medium-term postoperative outcomes in patients undergoing sigmoid colon vaginoplasty. DESIGN: Retrospective cohort study. SETTING: Single-institution study conducted at a tertiary academic medical center. PATIENTS: Transgender and nonbinary patients who underwent sigmoid colon vaginoplasty between December 2020 and

[The cornea: stasis and dynamics].

The physiological roles of the cornea are to conduct external light into the eye, focus it, together with the lens, onto the retina, and to provide rigidity to the entire eyeball. Good vision thus requires maintenance of the transparency and proper refractive shape of the cornea. Although the cornea appears to be a relatively static structure, dynamic processes operate within and around the cornea at the tissue, cell, and molecular level. In this article, I review the mechanisms responsible for maintenance of corneal homeostasis as well as the development of new modes of treatment for various

Pharmacological treatment for antipsychotic-related constipation.

BACKGROUND: Antipsychotic-related constipation is a common and serious adverse effect, especially for people taking clozapine. Clozapine has been shown to impede gastrointestinal motility, leading to constipation, and has been reported in up to 60% of patients receiving clozapine. In rare cases, complications can be fatal. Appropriate laxatives should be prescribed to treat constipation in people taking antipsychotics, but there is a lack of guidance on the comparative effectiveness and harms of different agents in this population. An understanding of the effectiveness and safety of treatment

Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient.

OBJECTIVE: To update the 2002 version of "Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient." DESIGN: A Task Force comprising 17 members of the Society of Critical Medicine with particular expertise in the use of neuromuscular-blocking agents; a Grading of Recommendations Assessment, Development, and Evaluation expert; and a medical writer met via teleconference and three face-to-face meetings and communicated via e-mail to examine the evidence and develop these practice guidelines. Annually, all members completed conflict of interest statem

Osteoarthritis of the knee - biochemical aspect of applied therapies: a review.

The most prevalent form of arthritis is osteoarthritis (OA) of the knee, which is characterized by a degeneration of articular cartilage resulting in the development of osteophytes, or bone spurs. Main goals of OA treatment are to reduce pain, slow the disease progression, and improve joint function and the quality of life. The purpose of this study was to verify all the therapies recommended by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) from the biochemical point of view. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesi

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… The number of lubricant molecules in the synovial membrane including hyaluronic acid secreted by fibroblast-like cells, and lubricin (proteoglycan 4; PRG4) secreted by the surface chondrocytes of the articular cartilage is decreased [ 7 , 8 ]. … The synovial fluid is a viscous fluid that has lubrication, metabolic, and regulatory functions [ 58 ]. HA supplements decrease OA pain by lubricating knee joints and provide an opportunity to treat symptomatic OA and improve its function. …

Окулярная токсичность целевой терапии и иммунотерапии гематологов.

Целенаправленная терапия и иммунная терапия изменили методы борьбы с гематологическими заболеваниями. Однако эти агенты могут также иметь непреднамеренные окулярные неблагоприятные последствия. Эти токсичные вещества часто недооцениваются, но могут существенно повлиять на качество жизни пациентов и на процесс принятия терапевтических решений. Всеобъемлющее понимание этих последствий имеет важное значение для междисциплинарного управления. В этом обзоре обобщаются имеющиеся в настоящее время данные об окулярной токсичности, связанной с современными целенаправленными и иммунными терапиями, испол

Hormone therapy use and cancer survivorship.

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… Hypoestrogenism due to menopause is associated with a constellation of genitourinary signs and symptoms, referred to as GSM. 7 Hallmark symptoms include vaginal dryness and decreased lubrication, which may lead to dyspareunia and postcoital bleeding. …

Физиотерапия половых дисфункций у пациентов с множественным склерозом: обзор клинических испытаний.

Множественный склероз (MS) представляет собой провокационное аутоиммунное расстройство, которое в первую очередь затрагивает центральную нервную систему, приводящее к значительной инвалидности у молодых людей, причем среди женщин отмечается более высокий уровень заболеваемости. Разнородное клиническое представление MS создает значительные проблемы с диагностикой и лечением. В последние годы значительное внимание уделяется повышению качества жизни пациентов, страдающих НР, при этом одним из ключевых компонентов этой оценки является сексуальное здоровье. В литературе говорится, что сексуальные д

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… Sexual arousal disorders Female Difficulties in achieving or maintaining an adequate level of sexual arousal, such as problems with vaginal lubrication [ 7 ]. 3. … Sexual dysfunctions in patients with multiple sclerosis can be divided into the following types: Primary—resulting from direct damage to the nervous system, which impairs a specific phase of the sexual response to stimulation (sensory disturbances, lubrication issues, erectile dysfunction, pain, orgasm …

Множественный склероз, инфекция мочевого тракта и бесплодие: всеобъемлющий обзор аналитического исследования.

Множественный склероз (MS) — аутоиммунное заболевание, связанное с центральной нервной системой. ПМС широко распространены среди взрослых молодых людей и постепенно уничтожают аксоны и миелин. Лица, страдающие НР, часто сталкиваются с такими осложнениями, как дефункция мочевого тракта, инфекция мочевого тракта и сексуальная дисфункция. У молодых людей РС может вызывать сексуальную дисфункцию и бесплодие, которое ухудшается по мере развития болезни. Были рассмотрены имеющиеся данные из различных исследований (микробиологические и клинические исследования, полученные из баз данных PubMed и Scopu

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… In contrast, women may experience decreased lubrication and genital hyper/hypo-sensitivity, which may even include complete anesthesia or hypoesthesia, and various types of pain ( 61 ). … Among female patients with MS, the most common instances of sexual dysfunction are decreased libido (31-64%), decreased vaginal lubrication and sensation (33-52%), and anorgasmia (37-38%) ( 66 ). …

Novel Treatments for Patients With Relapsed/Refractory Multiple Myeloma.

Therapeutic options for patients with multiple myeloma have multiplied in the past decade. However, multiple myeloma remains an incurable disease, and relapsed/refractory myeloma is characterized by genetic and cytogenetic alterations that drive resistance and result in progressively shorter durations of remission to each subsequent therapy. At JADPRO Live 2022, presenters discussed the multifactorial process for choosing the right therapy for a particular patient and strategies to manage unique treatment complications associated with novel treatment modalities used for patients with relapsed/

Нефармакологические мероприятия по охране сексуального здоровья при множественном склерозе: систематический обзор и метаанализ.

Множественный склероз (MS), нейродегенеративное заболевание, часто вызывает сексуальную дисфункцию (SD), помимо хорошо известного повреждения двигателя, что значительно снижает качество жизни пациентов (QOL). АИМ: Этот метаанализ позволяет оценить эффективность нефармакологических мероприятий в области УР, связанных с НР. МЕТОДЫ: Следуя предпочтенным принципам отчетности для системных обзоров и мета-анализов, систематический поиск баз данных PubMed, ScienceDirect, CINAHL и Cochrane выявляет случайные и клинические испытания; были извлечены данные, оценивался риск отклонения и проводились метаа

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… In short, the pooled analysis indicated a significant improvement in the sexual functioning and satisfaction of women in six different domains: desire, arousal, lubrication, orgasm, satisfaction, and pain in terms of FSFI, and female and male patients in terms of MSQOL-54 (sexual function domain) after … Nevertheless, the narrative evaluation of both reviews found that the majority of interventions improved SD, including lubrication, arousal, desire, and orgasm. However, several relevant RCT studies that met the inclusion criteria in both reviews were overlooked and not included. …

Roadmap for new practitioners to navigate the multiple myeloma landscape.

Multiple myeloma (MM) is a blood cancer in which monoclonal plasma cells cause end organ damage resulting in hypercalcemia, renal failure, anemia, and bone lesions. MM is considered incurable, however, recent advances in treatment have improved survival. Historically, MM has been treated with immunomodulatory drugs (IMiDs), proteosome inhibitors (PIs), and corticosteroids. While newer therapeutic approaches such as monoclonal antibodies and cellular therapies have broadened the treatment horizon, the selection and sequencing of these therapies has become more complex. This review aims to help

NTP technical report on the toxicity studies of 1,6-Hexanediamine Dihydrochloride (CAS No. 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice.

1,6-Hexanediamine (HDA) is an aliphatic amine that is produced in large volumes in the United States. HDA is widely used as a corrosion inhibitor in lubricants and as an intermediate in the industrial synthesis of paints, resins, inks, and textiles. Toxicity studies of the dihydrochloride salt of HDA (HDDC) were conducted in male and female Fischer 344/N rats and B6C3F1 mice by the drinking water (2-week studies only) and whole-body inhalation routes (2-week and 13-week studies). Animals were evaluated for histopathology, clinical chemistry, hematology, and reproductive toxicity. In addition,

< < Холистическое управление множественной миеломой > > : доклад по делу < < Терапия Сидды > > как дополнение к режиму Бортезомиба-Леналидомида-Дексаметасона (БЛД).

Множественная миелома (ММ) — сложная гематология, характеризующаяся клональным распространением плазменных клеток в костном мозге. Это вторая по распространенности гематологическая халатность, которая проявляется у пожилых пациентов. Инкорпорирование дополнительной медицины в обычные методы лечения рака все чаще наблюдается среди пациентов, что обусловлено такими факторами, как управление симптомами, целостное благосостояние и культурная увязка. В настоящем докладе представлена информация о комплексном управлении деятельностью 65-year-old Пациент мужского пола диагностировал ММ, который получа

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… It is based on the theory of three fundamental bio-energies or doshas: Vatham (movement and neurological function), Pitham (metabolism and energy), and Kapham (structure and lubrication), whose imbalance is believed to cause disease. …

Vaginal lasers for treating stress urinary incontinence in women.

BACKGROUND: Stress urinary incontinence (SUI) in women is common and can have a profound impact on an individual's quality of life. Vaginal lasers, designed for treating vulvovaginal atrophy, have been explored as a clinic-based option for treating SUI. However, the effect of vaginal lasers on SUI remains unclear. OBJECTIVES: To assess the effects of vaginal lasers for treating SUI in women and to summarise the principal findings of relevant economic evaluations. SEARCH METHODS: We performed a comprehensive search using the Cochrane Incontinence Specialised Register (searched 29 April 2024).

Intermittent self-dilatation for urethral stricture disease in males.

BACKGROUND: Intermittent urethral self-dilatation is sometimes recommended to reduce the risk of recurrent urethral stricture. There is no consensus as to whether it is a clinically effective or cost-effective intervention in the management of this disease. OBJECTIVES: The purpose of this review is to evaluate the clinical effectiveness and cost-effectiveness of intermittent self-dilatation after urethral stricture surgery in males compared to no intervention. We also compared different programmes of, and devices for, intermittent self-dilatation. . SEARCH METHODS: We searched the Cochrane I

Adverse events of antibody-drug conjugates on the ocular surface in cancer therapy.

Antibody-drug conjugates consist of a monoclonal antibody attached to a cytotoxic therapeutic molecule by a connector. This association allows a highly specific therapy, which increases their effectiveness and decreases their potential toxicity. This new therapy emerged approximately 20 years ago; since then, numerous combinations have appeared in the field of treatment-related neoplasms as an alternative for patients who do not achieve good results with conventional treatment options. Adverse effects of these drugs on the ocular surface are frequent and varied. Their prevalence ranges from 20

Oral manifestations and dental management in patients undergoing CAR-T cell therapy: a retrospective observational study.

Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a highly effective treatment for refractory and relapsed hematologic malignancies. Despite its clinical benefits, CAR-T therapy is associated with a unique toxicity profile, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and prolonged immunosuppression. Oral complications in this population remain underreported. This retrospective case series was aimed at describing oral manifestations and dental management in patients undergoing CAR-T therapy at a tertiary referral cente

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… Reduced salivary flow not only causes discomfort but also compromises oral mucosal lubrication and protection, increasing the risk of infections, dental caries, and difficulties with food intake. …