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Postoperative Natural Killer Cell Dysfunction: The Prime Suspect in the Case of Metastasis Following Curative Cancer Surgery.

Surgical resection is the foundation for the curative treatment of solid tumors. However, metastatic recurrence due to the difficulty in eradicating micrometastases remain a feared outcome. Paradoxically, despite the beneficial effects of surgical removal of the primary tumor, the physiological stress resulting from surgical trauma serves to promote cancer recurrence and metastasis. The postoperative environment suppresses critical anti-tumor immune effector cells, including Natural Killer (NK) cells. The literature suggests that NK cells are critical mediators in the formation of metastases i

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… nor-NOHA, sildenafil, tadalafil, anti-PD-1 with entinostat siRNA or decoy oligonucleotides | Systemic inflammation/autoimmunity Increased risk of heart failure | MDSC TME migration | Small molecule inhibitors or chemotherapeutic drugs (reparixin, MK7123) | | MDSCs (depletion) | Dimethyl amiloride, omeprazole … The MDSC population can be depleted by inhibiting the conversion of immature myeloid cells into MDSCs using dimethyl amiloride or omeprazole to reduce extracellular vesicles in serum. …

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.

BACKGROUND: Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-repositioning approach which exploits old drugs approved for non-cachexia disease. Amiloride, a diuretic drug, is clinically used for treatments of hypertension and edema due to heart failure. Here, we explored the effects of the amiloride treatment for ameliorating muscle wasting in murine models of cancer cachexia. METHODS: The CT26 and LLC tumor cells were subcutaneously in

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… Similar to amiloride, some other drugs or chemical inhibitors, such as GW4869 [ 49 – 51 ], omeprazole [ 12 ], chlorpromazine [ 52 ], and statins [ 53 – 55 ], also possess the effects of inhibiting cellular exosome release, and could be exploited as potential drugs against cancer cachexia too. …

Кислотная терапия и риск излечения в случае воспламенительной болезни лопатки: сравнительное исследование в целях информирования о личностном лечении в мире.

Предыстория/цели: Известно, что ингибиторы протонных насосов (ИПЦ) изменяют состав кишечника микробиота; однако их связь с курсами заболеваний и результатами у пациентов с воспалительным кишечным заболеванием (ИБД) остается неопределенной. Наши цели заключались в оценке связи между использованием ИЦП и эскалацией лечения, диффицией Клостридиодов и использованием медицинских услуг в ИБД. Методы: Мы провели ретроспективное когортное исследование на платформе TriNetX. Пациенты IBD с ИЦП или histamine-2 Совпадали антагонисты рецептора (H2RA) one- чтобы...one с помощью баллов склонности. Итогом это

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… Patients were required to have a documented diagnosis of IBD, including ulcerative colitis (UC, ICD-10 code K51) or Crohn’s disease (CD, ICD-10 code K50), and subsequent exposure to either PPI (omeprazole, pantoprazole, esomeprazole, lansoprazole, or rabeprazole) or H2RAs (cimetidine, famotidine, nizatidine …

Endocrine paraneoplastic syndromes in lung cancer: A call for clinical vigilance (Review).

Endocrine paraneoplastic syndromes (PNS) are uncommon but clinically impactful manifestations associated with malignancies, particularly lung cancer, most notably small-cell lung cancer. These syndromes arise from ectopic hormone production by malignant cells, causing systemic effects that are independent of direct tumor invasion or metastasis. Their presentation often precedes or signals recurrence of the primary cancer, underscoring the importance of early recognition and targeted intervention. Common endocrine PNS in lung cancer include syndrome of inappropriate antidiuretic hormone secreti

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… Management usually begins with high-dose proton pump inhibitors, such as omeprazole or esomeprazole, to control the severe acid hypersecretion, often at doses higher than those used for standard peptic ulcer disease ( 53 , 54 ). …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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… Sulfasalazine Labeled 19 1.85 Esomeprazole Labeled 8 0.78 Strontium ranelate Not approved 8 0.78 Acetaminophen Labeled 1 0.10 Acetylcysteine Not labeled 1 0.10 Carbocysteine Not approved 1 0.10 Dimercaptopropane Not approved 1 0.10 Erlotinib hydrochloride Labeled 1 0.10 Hydroxychloroquine Labeled 1 0.10 Omeprazole … | 8 | 0.78 Strontium ranelate | Not approved | 8 | 0.78 Acetaminophen | Labeled | 1 | 0.10 Acetylcysteine | Not labeled | 1 | 0.10 Carbocysteine | Not approved | 1 | 0.10 Dimercaptopropane | Not approved | 1 | 0.10 Erlotinib hydrochloride | Labeled | 1 | 0.10 Hydroxychloroquine | Labeled | 1 | 0.10 Omeprazole …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

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… | Conditional risk of TdP (n=4) | Furosemide (C03CA01) | 3 (0.2) Torsemide (C03CA04) | 1 (0.1) Possible risk of TdP (n=3) | Hydrochlorothiazide (C03AA03) | 3 (0.2) Proton pump inhibitor (n=632) | Conditional risk of TdP (n=632) | Pantoprazole (A02BC02) | 616 (46.2) Lansoprazole (A02BC03) | 12 (0.9) Omeprazole …

Treatment of acute kidney injury in cancer patients.

Acute kidney injury (AKI), either of pre-renal, renal or post-renal origin, is an important complication in cancer patients, resulting in worse prognosis, withdrawal from effective oncological treatments, longer hospitalizations and increased costs. The aim of this article is to provide a literature review of general and cause-specific treatment strategies for AKI, providing a helpful guide for clinical practice. We propose to classify AKI as patient-related, cancer-related and treatment-related in order to optimize therapeutic interventions. In the setting of patient-related causes, proper as

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… Molecular pathways driving omeprazole nephrotoxicity. Redox Biol 2020; 32: 101464. 67. Eijgelsheim M, Sprangers B.. Kidney biopsy should be performed to document the cause of checkpoint inhibitor–associated acute kidney injury: PRO. Kidney360 2020; 1: 158–161 68. Brudno JN, Kochenderfer JN. …

Global first-in-class drugs approved in 2023-2024: Breakthroughs and insights.

First-in-class (FIC) drugs are considered the main drivers of new drug discovery and have novel targets and mechanisms. The proportion of FIC drugs among new drugs provides fundamental guidance for both academic and pharmaceutical research. From a global perspective, 81 FIC drugs were approved in 2023 and 2024. Among them, small-molecule drugs account for a greater percentage (51.9%), illustrating the discovery of new chemical entities. Macromolecule drugs (48.1%), which mainly consist of antibody analogs, represent a growing trend as new biotechnology techniques have emerged. In terms of FIC

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… A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole Nat. Rev. Drug Discov. 2 2003 132 139 12563304 10.1038/nrd1010 5 Keam S.J. Zolbetuximab: First Approval Drugs 84 2024 977 983 38967717 10.1007/s40265-024-02056-x 6 Nakayama I. Qi C. Chen Y. …

Curcumin as a promising therapeutic agent for diabetic neuropathy: from molecular mechanisms to functional recovery.

Diabetes mellitus is an endocrine disorder characterized by prolonged hyperglycemia. It results from either insulin deficiency (type 1 diabetes mellitus, T1DM) or insulin resistance (type 2 diabetes mellitus, T2DM). This condition has emerged as a significant health concern in recent years. Hyperglycemia induces the overproduction of reactive oxygen species (ROS), which can modulate multiple pathways, including AGEs-RAGE, PKC stimulation, NF-κB and PI3K/AKT. These pathways contribute to diabetes-related complications such as inflammation, oxidative stress, insulin resistance, and reduced gluco

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… Comparative evaluation of the anti-ulcer activity of curcumin and omeprazole during the acute phase of gastric ulcer—efficacy of curcumin in gastric ulcer prevention against omeprazole. Food and Nutrition Sciences. 2011;2011. 19. …

Multidrug-Resistant Gram-Negative Bacteria Decolonization in Immunocompromised Patients: A Focus on Fecal Microbiota Transplantation.

Antimicrobial resistance is an important issue for global health; in immunocompromised patients, such as solid organ and hematological transplant recipients, it poses an even bigger threat. Colonization by multidrug-resistant (MDR) bacteria was acknowledged as a strong risk factor to subsequent infections, especially in individuals with a compromised immune system. A growing pile of studies has linked the imbalance caused by the dominance of certain taxa populating the gut, also known as intestinal microbiota dysbiosis, to an increased risk of MDR bacteria colonization. Several attempts were p

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… The patient underwent FMT by NDT, following a 48-h bowel cleanse with polyethylene glycol and pre-medication with proton pump inhibitor (PPI) omeprazole. …

PROCEEDINGS 32nd Symposium ESVN-ECVN WROCLAW, POLAND 12th-14th September 2019. Selected research communications of the 32nd Symposium of the ESVN-ECVN Wroclaw, Poland 12th to 14th September 2019.

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ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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Кровавая добавка и болезни человека: обзор клинических испытаний.

Медицинальные свойства турмеров (Curcuma longa L.) — растения, использовавшегося на протяжении веков в качестве противовоспалительного средства, объясняются его полифеноловыми каркуминоидами, где преобладает кёркумин. Хотя «куркуминовые» добавки являются топ-продаваемыми ботаническими с перспективными доклиническими эффектами, остаются вопросы о биологической активности у человека. Для решения этой проблемы был проведен обзор аналитического исследования с целью оценки клинических испытаний человека, в ходе которых сообщалось о пероральном воздействии каркумина на результаты лечения. Eight :: п

Oxidized Lipids in Persistent Pain States.

Chemotherapy, nerve injuries, or diseases like multiple sclerosis can cause pathophysiological processes of persistent and neuropathic pain. Thereby, the activation threshold of ion channels is reduced in peripheral sensory neurons to normally noxious stimuli like heat, cold, acid, or mechanical due to sensitization processes. This leads to enhanced neuronal activity, which can result in mechanical allodynia, cold allodynia, thermal hyperalgesia, spontaneous pain, and may initiate persistent and neuropathic pain. The treatment options for persistent and neuropathic pain patients are limited; f

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… A common approach to increase EET levels is to use either an activator of CYP epoxygenases, like omeprazole, or a sEH inhibitor like, for example, 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU). …

Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.

Experimental data indicate that several pharmacological agents that have long been used for the management of various diseases unrelated to cancer exhibit profound in vitro and in vivo anticancer activity. This is of major clinical importance, since it would possibly aid in reassessing the therapeutic use of currently used agents for which clinicians already have experience. Further, this would obviate the time-consuming process required for the development and the approval of novel antineoplastic drugs. Herein, both pre-clinical and clinical data concerning the antineoplastic function of dist

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… However, in the latter case, these unwanted effects can be satisfactorily managed by drugs protecting the digestive tract mucosa, such as the proton pump inhibitor omeprazole. 72 Another promising option to avoid toxicity is nanoparticle formulation, something that allows successful usage of much lower …

Diagnosis and management of osteoporosis in the older senior.

The older senior is at high risk for osteoporosis. It is important for healthcare providers to be fully aware of the potential risks and benefits of diagnosing and treating osteoporosis in the older senior population. Data indicate that bone mineral density testing is under-utilized and drug therapy is often not initiated when indicated in this population. Bone mineral density testing with central dual energy x-ray absorptiometry is essential and cost-effective in this population. All older seniors should be educated on a bone-healthy lifestyle including age-appropriate weight-bearing exercise

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… One small study found that calcium carbonate absorption was inhibited by co-administration with omeprazole. 71 Since many older seniors may also take a PPI, it may be prudent to recommend supplementation with calcium citrate in those patients. …

ECC-4 Abstracts

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… Methods: Eighty-one patients aged from 9 to 15 years with endoscopically confirmed H. pylori -associated (by urease test and PCR) upper gastrointestinal tract disorders were divided into five comparable groups treated with: roxithromycin, metronidazole, omeprazole—RMO-group (15); clarithromycin, metronidazole … , omeprazole—CMO-group (18); azithromycin, amoxicillin, omeprazole—AAmO3-group (15); azithromycin, furazolidone, omeprazole—AFO-group (16); azitromycin, amoxicillin, omeprazole—AAmO7-group (17). …

2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

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… In studies in dogs and cats, omeprazole has been shown to be more effective at raising gastric pH and it is now recommended for GUE treatment. However, famotidine continues to be widely used by veterinary practitioners especially for conditions in which potent acid suppression is not desired. …

Нейрофармакология каннабиноидов: всеобъемлющий обзор доклинических и клинических данных о экстрактах гемп-деривных веществ и активных соединениях.

Каннабис сатива содержит более 120 фитоканнабиноидов, причем наиболее характерными из них являются Δ9-тетрагидроканнабинол (THC) и каннабидиол (CBD). В настоящем обзоре обобщаются доклинические и клинические данные об экстрактах гематома, каннабиноидах и активных соединениях. THC действует главным образом как частичный агонист каннабиноидного рецептора типа 1 (CB1) и типа 2 (CB2), приводящий к психоактивным, аппетитным, антиэметическим и анальгетическим эффектам. КБР не является опьяняющим и имеет мультимодальный профиль, включающий негативную аллостерическую модуляцию CB1, обратное агонизм CB

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… Mechanism/Enzyme | Affected Drugs | Clinical Consequence and Management CBD inhibits CYP2C19 | Clobazam (→N-desmethylclobazam), diazepam, omeprazole | ↑Active metabolite > 200%; increased sedation—monitor and reduce clobazam dose CBD/THC via CYP3A4 | Ketoconazole, clarithromycin (inhibitors); rifampin …

Medication-Related Osteonecrosis of the Jaws in Patients on Antiresorptive Medication With Dental Implants. A Scoping Review.

OBJECTIVES: Patients receiving antiresorptive medication (AR) for osteoporosis or cancer are at risk of medication-related osteonecrosis of the jaws (MRONJ), especially after surgical procedures. Dental implant (DI) placement in high-dose AR (HDAR) patients is widely discouraged, and thorough counseling is recommended for low-dose AR (LDAR) patients. However, data on the role of AR type, dose, and duration remain limited. This review evaluates MRONJ associated with DIs, focusing on AR type and accumulated dose, and identifies local and systemic risk factors. MATERIALS AND METHODS: This review

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… | | 7700 | | | | | | 12 | | N/R | | 0 | 0 | | 1 | 1 (1) (other implant not immediate | 0 | 0 Longoni et al. ( 2014 ) | 35 mg/week | 4 | 97.25 | 69.01 | | 12 | | | | | 14,790 | 10,495.61 | | | | | | | | | | | 32 | 14.73 | 1 | 4 | 0 | 0 | | 1 | 3 (1) | Levothyroxine sodium, Omeprazole …