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Antibiotic Prophylaxis or Granulocyte-Colony Stimulating Factor Support in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation.

We compare, in this manuscript, antibiotic prophylaxis versus granulocyte-colony stimulating factor (G-CSF) support as anti-infective strategies, in patients with multiple myeloma (MM), undergoing high-dose therapy followed by autologous stem cell transplantation (HDT/ASCT). At our institution, antibiotic prophylaxis after HDT/ASCT in MM was stopped in January 2017 and replaced by G-CSF support in March 2017. Consecutive MM patients who received HDT/ASCT between March 2016 and July 2018 were included in this single-center retrospective analysis. In total, 298 patients and 353 individual cases

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… Patients with prior hepatitis b infection (anti-HBc antibody positive) received antiviral prophylaxis with lamivudine, entecavir, or tenofovir. Detailed information about the anti-infective strategies during the period March 2016 to July 2018 are shown in Table 1 . …

Aptamer: A potential oligonucleotide nanomedicine in the diagnosis and treatment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common cancers with a high mortality rate. Late diagnosis and poor prognosis are still a major drawback since curative therapies such as liver resection and liver transplantation are effective only for an early stage HCC. Development of novel molecular targeting therapies against HCC may provide new options that will improve the efficiency of the diagnosis and the success of the therapy, thus ameliorating the life expectancy of the patients. The aptamer is an oligonucleotide nanomedicine that has high binding affinity and specificity to small a

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… Aptamer-based field-effect biosensor for tenofovir detection. Sci Rep. 2017;7:44409. doi: 10.1038/srep44409. https://doi.org/10.1038/srep44409 . 49. Hou Y, Liu J, Hong M, Li X, Ma Y, Yue Q, Li CZ. …

Case series discussion of cardiac and vascular events following carfilzomib treatment: possible mechanism, screening, and monitoring.

BackgroundCarfilzomib is a selective proteasome inhibitor approved in the United States in 2012 for the treatment of relapsed and refractory multiple myeloma. Although cardiopulmonary and vascular events have been reported infrequently, they can be potentially serious complications, and their incidence and pathophysiology following carfilzomib treatment remain poorly characterized in a real-world patient population.MethodsWe retrospectively reviewed the records of 67 patients with relapsed and/or refractory multiple myeloma treated at our institution.ResultsWe describe 12 patients who experien

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… Case 5: dyspnea and lung disease A 58-year-old Asian American male with IgG kappa MM, DS stage III, and ISS stage II at diagnosis in 2010 had a medical history significant for hepatitis B virus (HepB) infection with clearance of HepB DNA while on maintenance tenofovir. …

The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis.

Although it has long been recognized that inflammation, a consequence of immune-driven processes, significantly impacts bone turnover, the degree of centralization of skeletal and immune functions has begun to be dissected only recently. It is now recognized that formation of osteoclasts, the bone resorbing cells of the body, is centered on the key osteoclastogenic cytokine, receptor activator of NF- κ B ligand (RANKL). Although numerous inflammatory cytokines are now recognized to promote osteoclast formation and skeletal degradation, with just a few exceptions, RANKL is now considered to be

Конвергенция генетики вируса хост и Эпштейн-Барр в множестве склерозов.

Недавние сероэпидемиологические исследования укрепили гипотезу о том, что вирус Эпштейн-Барр (ЭБВ) может быть причиной множественного склероза (МС). С учетом сложности взаимодействия EBV-принимателя различные механизмы могут нести ответственность за патогенез болезни. Кроме того, остается неясным, относится ли это к конкретным заболеваниям. Здесь мы показали, что гены, кодирующие взаимодействие EBV, обогащаются в лоси, связанных с MS, но не с другими заболеваниями и в приоритетных терапевтических целях. Анализ крови MS и транскриптомов мозга подтвердил дисрегулирование связанных с MS EBV интер

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… In this context, the strong effects of Tenofovir prodrugs on EBV lytic DNA replication ( 49 ), along with recent case reports suggesting some clinical efficacy in MS ( 50 ), may represent a concrete opportunity. …

Subject index

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… 219–222 long-term prognosis for renal transplantation and, 903–911 rapidly progressive glomerulonephritis and, 950–955 T cells, in transplant glomerulitis, peritubular capillary C4d deposition and, 1084–1089 Telomere length shortening, chronic inflammation in long-term hemodialysis and, 353–359 Tenofovir-induced …

Renal Involvement in Mixed Cryoglobulinemic Vasculitis: Current Perspectives.

Cryoglobulinemia is a rare disorder characterized by the presence of abnormal proteins (cryoglobulins) in the blood that precipitate at low temperatures. It presents with a wide clinical spectrum, from mild symptoms to severe, life-threatening disease. In mixed cryoglobulinemia (MC), vascular damage results from immune complexes-typically monoclonal IgM with rheumatoid factor activity and polyclonal IgG (Type II), or polyclonal/oligoclonal IgM and IgG (Type III). These complexes can obstruct small blood vessels, leading to ischemia and leukocytoclastic vasculitis. Renal involvement occurs in a

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… In HBV-associated cryoglobulinemia, antiviral therapy with nucleoside analogs (Entecavir and Tenofovir) is the first-line treatment for HBV-associated cryoglobulinemia and, as in HCV-related disease, a decrease in viral replication was associated with the laboratory findings of undetectable cryocrit …

Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE).

Chimeric antigen receptor (CAR) T cells are a novel class of anti-cancer therapy in which autologous or allogeneic T cells are engineered to express a CAR targeting a membrane antigen. In Europe, tisagenlecleucel (Kymriah™) is approved for the treatment of refractory/relapsed acute lymphoblastic leukemia in children and young adults as well as relapsed/refractory diffuse large B-cell lymphoma, while axicabtagene ciloleucel (Yescarta™) is approved for the treatment of relapsed/refractory high-grade B-cell lymphoma and primary mediastinal B-cell lymphoma. Both agents are genetically engineered a

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… For patients with a history of hepatitis B infection, prophylaxis with tenofovir is recommended. 66 Medium-term complications and management: day +28 to day +100 Potential toxicities during this period include delayed tumor lysis syndrome, delayed hemophagocytic lympho-histiocytosis/macrophage activation …

CAR T-Cell Terrapy Opveiled: Навигация за пределы ССЗ и ИКАНС для решения проблем, связанных с отсроченными последствиями, и оптимизации стратегий управления.

Цимерическая антигенная рецепторная (КАР) T-клетологическая терапия положила начало эпохе преобразований в регулировании рецидивов/отсутствий гематологической гематологии. Кульминацией интенсивных испытаний второго этапа, направленных на борьбу с повторной/охотничьей лимфомой, включая различные подтипы, такие, как диффузная большая лимфома B-клеток, фолликулярная лимфома и лимфома мантичной клетки, а также многочисленные миелома и острая лимфоболическая лейкемия B-клеток, стало одобрение различных продуктов CAR-T-клеток для этих конкретных указаний Администрацией по вопросам продовольствия и н

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… Monitor viral load every 3–6 months during the first year after discontinuation | Entecavir 0.5 mg po daily | Monitor hepatitis B polymerase chain reaction once per month while on prophylaxis and for 1 year after stopping Consider infectious disease consult Alternative: Tenofovir | Respiratory bacterial …

Infections in Hospitalized Cancer Patients.

Cancer patients are at an increased risk of developing infections that are primarily treatment-driven but may also be malignancy-driven. While cancer treatments such as chemotherapy, radiotherapy, and surgery have been known to improve malignancy morbidity and mortality, they also have the potential to weaken immune defenses and induce periods of severe cytopenia. These adverse effects pave the way for opportunistic infections to complicate a hospitalized cancer patient's clinical course. Understanding the risk each patient inherently has for developing a bacterial, fungal, or viral infection

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… ASCO and IDSA guidelines recommend entecavir or tenofovir as nucleoside reverse transcriptase inhibitors that should be given to patients at risk of reactivation [ 83 ]. …

Nanoparticles Based Therapeutic Approaches in Oncogenic Viral Infections: A Review.

Nanotechnology has revolutionized biomedical research by providing novel strategies for the prevention, diagnosis, and treatment of oncogenic viral infections. Nanoparticles, possessing tunable physicochemical properties, enable targeted drug delivery, enhance vaccine efficacy, and facilitate advanced viral diagnostics, addressing key limitations of conventional therapies. Oncogenic viruses contribute substantially to the global burden of cancer through persistent infections and are influenced by environmental and lifestyle factors. The objective of this review is to synthesize and critically

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… AuNPs coated with sulfated ended ligand [ 140 ] ˂20 2 Human CD4+CD25+.CD127low Carboxilan dendrimers Cytoprotection a ** ˂20 MT4, MMT, primary human astrocytes Carboxilan dendrimers conguted with RNA decoy [ 114 ] Latency breaking a ** 0 10±3 MT4, MMT, primary human astrocytes Fe3O4 NP loaded with tenofovir … ended ligand | [ 140 ] ˂20 | 2 | Human CD4+CD25+.CD127low | Carboxilan dendrimers Cytoprotection a ** | ˂20 | | MT4, MMT, primary human astrocytes | Carboxilan dendrimers conguted with RNA decoy | [ 114 ] Latency breaking a ** | 0 | 10±3 | MT4, MMT, primary human astrocytes | Fe3O4 NP loaded with tenofovir …

SARS-CoV-2 drug resistance and therapeutic approaches.

In light of the transition of COVID-19 from a pandemic to an endemic phase, there is still a dire need to address challenges associated with drug resistance, particularly among immunocompromised and high-risk populations. This review explores the current state of research on SARS-CoV-2 drug resistance and underscores the ongoing need for effective therapeutic strategies. It critically evaluates existing knowledge on resistance mechanisms and therapeutic options, aiming to consolidate information and highlight areas for future research. By examining the complex interactions between the virus an

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… Additionally, tenofovir and emtricitabine have been found to reduce viral titers in non-hospitalized patients [ 185 ]. Despite the initial promise, many other drugs were later revoked by the FDA due to failure in clinical trials or toxicity concerns. …

Potential drug development and therapeutic approaches for clinical intervention in COVID-19.

While the vaccination is now available to many countries and will slowly dissipate to others, effective therapeutics for COVID-19 is still illusive. The SARS-CoV-2 pandemic has posed an unprecedented challenge to researchers, scientists, and clinicians and affected the wellbeing of millions of people worldwide. Since the beginning of the pandemic, a multitude of existing anti-viral, antibiotic, antimalarial, and anticancer drugs have been tested, and some have shown potency in the treatment and management of COVID-19, albeit others failed to leave any positive impact and a few also became cont

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… Elfiky et al. used molecular docking simulations to study interactions between SARS-CoV-2 RdRp and anti-viral drugs (Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir), and reported that these drugs showed promising results against SARS-CoV-2 [92] . … Ribavirin, remdesivir, sofosbuvir, galidesivir, and tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): a molecular docking study. Life Sci. 2020;253 doi: 10.1016/j.lfs.2020.117592. 93. Buonaguro L., Tagliamonte M., Tornesello M.L., Buonaguro F.M. …

[XVIII Митинг после ECTRIMS: Обзор новых разработок, представленных на Конгресс ECTRIMS 2025 (Часть I)]

18-е издание совещания Европейского комитета по лечению и исследованию множественной скlerоза (ECTRIMS) прошло 17-18 октября 2025 года в Мадриде, объединив испанских нейрологов, специализирующихся на множественной склерозе (МС), которые представили наиболее значимые достижения, обсуждённые на конгрессе ECTRIMS несколько дней ранее в Барселоне. Целью собрания было обобщить последние достижения в патогенезе, новые критерии диагностики и биомаркеры МС. Эта статья является первой частью двухчастной серии (I и II), которая обзором последних данных о транспортировке клеток в центральную нервную сист

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… De especial interés son los estudios con tenofovir alafenamida fumarato (TAF), que inhibe la replicación lítica del VEB, cuyos resultados se esperan pronto [ 12 ]. …

Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential.

Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide sequences in humans. Telomeres preserve chromosomal stability and genomic integrity. Telomere length shortens with every cell division in somatic cells, eventually resulting in replicative senescence once telomere length becomes critically short. Telomere shortening can be overcome by telomerase enzyme activity that is undetectable in somatic cells, while being active in germline cells, stem cells, and immune cells. Telomeres are bound by a shelterin complex that regulates telomere lengthening as well as protects t

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… Different Types or Classes of Telomerase Inhibitors | Name of Drugs or Agents | Mechanism of Their Action | Identification Methods | Outcomes and Safety Profile | References Nucleoside analogs | AZT, stavudine, tenofovir, didanosine and abacavir 6-thio-dG, 5-MeCITP | Incorporate into telomeric DNA to … Examples include zidovudine (Azidothymidine or AZT), stavudine, tenofovir, didanosine, and abacavir [ 183 , 184 ]. However, the major disadvantage is high in vivo toxicity and lack of efficacy in preclinical cancer models. …

Osteoimmunopathology in HIV/AIDS: A Translational Evidence-Based Perspective.

Infection with the human immunodeficiency virus-1 (HIV) and the resulting acquired immune deficiency syndrome (AIDS) alter not only cellular immune regulation but also the bone metabolism. Since cellular immunity and bone metabolism are intimately intertwined in the osteoimmune network, it is to be expected that bone metabolism is also affected in patients with HIV/AIDS. The concerted evidence points convincingly toward impaired activity of osteoblasts and increased activity of osteoclasts in patients with HIV/AIDS, leading to a significant increase in the prevalence of osteoporosis. Research

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… 1.08 ( P < .0001), gender (male), OR : 2.23; CI 95 = 1.77–2.8 ( P < .0001), cachexia and wasting syndrome), OR : 1.14; CI 95 = 1.11–1.17 ( P < .0001), duration of treatment with protease inhibitor (PI), (OR : 1.18; CI 95 = 1.12–1.24 ( P < .0001), or with antiviral reverse transcriptase inhibitor (ART, tenofovir …

The role of CD38 in HIV infection.

The widely-expressed molecule CD38 is a single-stranded type II transmembrane glycoprotein that is mainly involved in regulating the differentiation and activation state of the cell. CD38 has broad and complex functions, including enzymatic activity, intercellular signal transduction, cell activation, cytokine production, receptor function and adhesion activity, and it plays an important role in the physiological and pathological processes of many diseases. Many studies have shown that CD38 is related to the occurrence and development of HIV infection, and CD38 may regulate its progression thr

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… Dynamics of immune reconstitution and activation markers in HIV+ treatment-naïve patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine. PLoS One. 2013; 8(12):e83514. 63. Lederman MM. Immune restoration and CD4+ T-cell function with antiretroviral therapies. …

Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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A review of feline infectious peritonitis virus infection.

Feline infectious peritonitis (FIP) is an infectious disease characterized by non-specific laboratory changes and clinical signs. Clinical symptoms include anorexia, jaundice, fever, and weight loss. Moreover, some lesions are found in the digestive and respiratory systems. FIP, whose virulence varies, cannot be distinguished using several diagnostic methods. Moreover, feline coronaviruses (FCoVs) can be classified into two serotypes based on differences in their amino acid sequences, spike (S) protein sequences, and antibody (Ab) neutralization. There are two pathotypes, namely those caused b

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… When interferon-α is combined with antiviral medications, such as tenofovir, entecavir, and ribavirin, it can effectively combat hepatitis B and/or C virus infections. However, reliance solely on this approach seldom yields success. …

Rational drug repositioning for coronavirus-associated diseases using directional mapping and side-effect inference.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen of coronavirus disease 2019 (COVID-19), has infected hundreds of millions of people and caused millions of deaths. Looking for valid druggable targets with minimal side effects for the treatment of COVID-19 remains critical. After discovering host genes from multiscale omics data, we developed an end-to-end network method to investigate drug-host gene(s)-coronavirus (CoV) paths and the mechanism of action between the drug and the host factor in a directional network. We also inspected the potential side effect of the ca

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… Ribavirin, remdesivir, sofosbuvir, galidesivir, and tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): a molecular docking study Life Sci. 253 2020 117592 10.1016/j.lfs.2020.117592 32222463 PMC7102646 Fiscon G. Conte F. Farina L. Paci P. …