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The Effectiveness of Guided Imagery on Walking and Balance Dysfunction in Patients With Multiple Sclerosis: A Randomized Controlled Trial.

Background: Multiple sclerosis can cause walking and balance disorders. These complications cause extensive disturbances in the quality of life, independence, and self-care and affect many aspects of their lives. The guided imagery method is a simple, easy, and safe intervention. Methods: A randomized controlled trial was conducted to determine the effect of guided imagery on walking and balance dysfunction in patients with multiple sclerosis in 2023. Sixty-six patients were randomly divided into two intervention and control groups (n = 33). The intervention group listened to the audio file of

Leveraging stories of cardiac amyloidosis patients of African ancestry or descent to support patient-derived data elements for efficient diagnosis and treatment.

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Совпадение в полном тексте источника
… Beyond imagination | amyloidosis foundation. Available at: https://www.amyloidosis.org/node/110 (Accessed: August 9, 2023). Beckwith C., Hereditary ATTR. (2020). Cece’s story, amyloidosis research consortium. Available at: https://arci.org/resource/4747/ (Accessed: August 9, 2023). Benson M. …

Качество жизни снижается у лиц с повторно излучающимся множественным склерозом, которые развиваются независимо от рецидивной активности.

ВВЕДЕНИЕ: Снижение качества жизни (QoL) является одной из первых черт множественного склероза (MS). Воздействие прогресса, независимого от активности рецидива (ИПРА), на QoL мало изучено. ЦЕЛЬ: ОЦЕНКА ВОЗДЕЙСТВИЯ ПИРА на QOL с использованием мер конечных результатов, сообщаемых пациентами (ПРОМ). МЕТОДЫ: В перспективном исследовании 125 Число лиц, которым был поставлен диагноз " повторное образование " MS (PwRRMS) " . 5 годы с: EuroQoL-5-Dimension-3-level (В тыс.EQ-5D-3L), EQ-визуально-аналоговый масштаб (EQ-VAS) и 29-item-MS-Impact-Scale (В тыс.MSIS-29). PwRRMS был дихотомизиро

Определение воздействия методов эмоциональной свободы на сексуальную дисфункцию и самообслуживание женщин, страдающих множественным склерозом.

АИМ: Данное исследование направлено на определение воздействия методов эмоциональной свободы (ЭФТ) на сексуальную дисфункцию и уход за собой у женщин, у которых диагностирован множественный склероз (МС). МЕТОД: Настоящее исследование проводилось с использованием экспериментальной схемы, разработанной до проведения испытаний, включая последующие оценки для оценки устойчивости последствий вмешательства. В выборку входили 16 женщин в возрасте от 19 до 49 лет, которым был поставлен диагноз MS и которые были представлены в неврологическую клинику университетской больницы в Тюркийе в период с октябр

Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life.

Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians. While studies are few, the KCNJ6 gene is a promising target for investigating genetic factors that contribute to pain and analgesia response. This is the first association study on polymorphisms in KCNJ6 and response to methadone for pain management in advanced cancer. Fifty-four adult patients with advanced cancer were recruited across two study sites in a prospective, open lab

Characteristics and Outcomes of Patients with Cancer Pain Placed in an Emergency Department Observation Unit.

Pain remains an undertreated complication of cancer, with poor pain control decreasing patients’ quality of life. Traditionally, patients presenting to an emergency department with pain have only had two dispositions available to them: hospitalization or discharge. A third emerging healthcare environment, the emergency department observation unit (EDOU), affords patients access to a hospital’s resources without hospitalization. To define the role of an EDOU in the management of cancer pain, we conducted a retrospective study analyzing patients placed in an EDOU with uncontrolled cancer pain fo

Barriers to Treg therapy in Europe: From production to regulation.

There has been an increased interest in cell based therapies for a range of medical conditions in the last decade. This explosion in novel therapeutics research has led to the development of legislation specifically focused on cell and gene based therapies. In Europe, the European medicines agency (EMA) designates any medicines for human use which are based on genes, tissues, or cells as advanced therapy medicinal products or advanced therapy medicinal products (ATMPs). In this article we discuss the hurdles to widespread adoption of ATMPs in Europe, with a focus on regulatory T cells (Tregs).

Utilities measured by rating scale, time trade-off, and standard gamble: review and reference for health care professionals.

Utility is a simple expression of health-related quality of life in individuals with different states of health. A number of studies on utility measurements were conducted and published in the past. We retrieved 164 English-language articles which appeared in 1966 through 1999 for a systematic review. The number of reports has been increasing at an accelerating pace, especially during the past decade. The most widely used method of utility measurement was time trade-off, TTO (40%), followed by rating scale, RS (31%) and standard gamble, SG (29%). The utility of chronic health status was more f

Совпадение в полном тексте источника
… Reasons may include the convenience of access by researchers, quick apprehension of rather difficult concept of utility, and clear imagination of hypothetical clinical situations. … A chronic health status seems to be easier to imagine and assess its utility than acute health status for persons without the disease at issue. A chronic illness lasts for long time and the study subjects can exchange utility values for a given time or gamble their entire life. …

What Defines Quality of Life for Older Patients Diagnosed with Cancer? A Qualitative Study.

The treatment of cancer can have a significant impact on quality of life in older patients and this needs to be taken into account in decision making. However, quality of life can consist of many different components with varying importance between individuals. We set out to assess how older patients with cancer define quality of life and the components that are most significant to them. This was a single-centre, qualitative interview study. Patients aged 70 years or older with cancer were asked to answer open-ended questions: What makes life worthwhile? What does quality of life mean to you?

Guided imagery relaxation in quality of life of patients undergoing hematopoietic stem cell transplantation: a quasi-experiment.

ObjectiveThe aim of this study was to evaluate the effects of the relaxation technique with guided imagery by means of virtual reality on health-related quality of life in patients undergoing hematopoietic stem cell transplantation.MethodsA quasi-experiment conducted in a Bone Marrow Transplantation Service of a public hospital in southern Brazil. From October 2019 to October 2020, forty-two adult participants who underwent transplantation were included, 35 in the intervention group and seven in the control group. A guided imagery intervention, with audio guiding the relaxation associated with

Exploring the rationale, experience and impact of using Cancer Information and Support (CIS) services: an international qualitative study.

PurposeThe aim of this study was to develop an in-depth understanding of the rationale, experiences, evaluation and outcomes of using Cancer Information and Support (CIS) services in Australia, the UK and USA.MethodsSemi-structured interviews were used to gather data between November 2015 and January 2016. Telephone interviews were recorded, de-identified, transcribed and thematically analysed. Ten users from each of three international CIS services (n = 30 in total) were recruited. Participants were eligible for inclusion if they had utilised the CIS in 2015 via telephone contact with a cance

Oncological and functional results of the surgical treatment of vertebral metastases in patients with multiple myeloma".

BACKGROUND: In nearly 30% of patients with myeloma, pathological fractures are found to occur in the spine. If the patients are not treated promptly and satisfactorily, the quality of their lives diminishes. Currently, the standard treatment for metastatic lesions of the spine is radiotherapy, but surgical intervention is becoming more frequent. It is very important to quickly identify metastases and implement surgical treatment before any fracture/s occur. METHODS: Over the period of 2010-2014 in our department, a total of 129 patients were treated for metastatic spinal myeloma. 73 patients

Lumbar Sympathicolysis Attenuates Refractory Chemotherapy-Induced Peripheral Neuropathy in the Lower Extremities: A Prospective, Real-World Study.

PurposeCurrently, there are limited effective treatment strategies available for refractory chemotherapy-induced peripheral neuropathy (CIPN). Lumbar sympathicolysis is a minimally invasive therapy and may offer an option for CIPN. This single-center, prospective, observational study aimed to evaluate the efficacy and safety of CT-guided lumbar sympathicolysis in alleviating multiple symptoms of refractory CIPN in the lower extremities.MethodsThis single-arm study conducted at Henan Cancer Hospital from September 2022 to July 2024,twenty-five patients with refractory CIPN in both lower extremi

Останемся или пойдем? Последние данные о том, что лекарство прекратилось при множественном склерозе.

Решение прекратить лечение пациентов с множественным склерозом (PwMS) в целях изменения заболеваний является критической клинической проблемой. Исторически DMT были прекращены из-за побочных эффектов, ограничений на лечение или перехода к вторичному прогрессивному MS. Вместе с тем достижения в области лечения MS, в частности высокоэффективные DMT (HE-DMT) и расширение знаний о курсах лечения заболеваний и фенотипах, привели к более индивидуализированным подходам к лечению и привели к обсуждению вопроса о запланированном прекращении DMT. В настоящем обзоре рассматриваются текущие данные о прекр

Интеграция паллиативного ухода в многообразное лечение миеломы: оптимизация качества жизни по всему спектру болезней.

Множественная миелома (ММ) создает значительные проблемы из-за ее сложного симптоматологического и изменяющегося ландшафта лечения. Несмотря на то, что терапевтический прогресс позволил улучшить показатели выживания, комплексное управление ММ требует удовлетворения многочисленных физических и психосоциальных потребностей пациентов. Паллиативный уход (ПХ) предлагает комплексный подход к лечению симптомов и поддержке ухода на физическом, психологическом и духовном уровнях; однако его роль в ММ по-прежнему недостаточно изучена. МЕТОДЫ: В этом ретроспективном исследовании с одним центром рассматри

Role of radiofrequency ablation and cement injection for pain control in patients with spinal metastasis.

BackgroundThe study aimed to investigate the effects and reliability of simultaneous vertebroplasty and radiofrequency ablation or radiofrequency ablation applied alone for pain control in patients with painful spine metastasis, and to investigate the effect of preventing tumor spread in long-term follow-up.MethodsPatients with painful vertebrae metastasis in the Afyonkarahisar Health Sciences University, Medical Faculty, Hospital Neurosurgery Clinic between 01.01.2015 and 01.06.2020 were recruited. They were divided into groups according to the surgical procedures applied. Group 1 included 26

INvestigational Vertebroplasty Efficacy and Safety Trial (INVEST): a randomized controlled trial of percutaneous vertebroplasty.

BACKGROUND: The treatment of painful osteoporotic vertebral compression fractures has historically been limited to several weeks of bed rest, anti-inflammatory and analgesic medications, calcitonin injections, or external bracing. Percutaneous vertebroplasty (the injection of bone cement into the fractured vertebral body) is a relatively new procedure used to treat these fractures. There is increasing interest to examine the efficacy and safety of percutaneous vertebroplasty and to study the possibility of a placebo effect or whether the pain relief is from local anesthetics placed directly on

Является ли лекарственные средства на основе каннабиса полезным средством для нейрофической боли? Систематический обзор.

Нейропотическая боль - это хроническое расстройство, которое возникает из-за повреждения или неисправности нервов. Гиперчувствительность к стимуляторам, также известным как гиперальгезия, может вызвать у человека боль от неболезненных стимулов, называемых аллодинией. Лекарства на основе каннабиса (МД) могут обеспечить новые варианты лечения нейропатической боли. Был проведен обзор соответствующих исследований для оценки эффективности мер укрепления доверия в лечении нейропатической боли. С января проводились систематические обыски научной литературы 2003 по декабрь 2024 с использованием Web of

Guideline "diagnosis and non interventional therapy of neuropathic pain" of the German Society of Neurology (deutsche Gesellschaft für Neurologie).

2019 the DGN (Deutsche Gesellschaft für Neurology) published a new guideline on the diagnosis and non-interventional therapy of neuropathic pain of any etiology excluding trigeminal neuralgia and CRPS (complex regional pain syndrome). Neuropathic pain occurs after lesion or damage of the somatosensory system. Besides clinical examination several diagnostic procedures are recommended to assess the function of nociceptive A-delta and C-Fibers (skin biopsy, quantitative sensory testing, Laser-evoked potentials, Pain-evoked potentials, corneal confocal microscopy, axon reflex testing). First line

Developing role of B cells in the pathogenesis and treatment of chronic GVHD.

Chronic graft-versus-host disease (cGVHD) is a major complication affecting the long-term survival of patients after allogeneic haematopoietic stem cell transplantation. The mechanism of cGVHD is unclear, and while previous studies have primarily focused on T cells, the role of B cells in the pathogenesis of cGVHD has been less reported. However, current studies on cGVHD are increasingly focused on the important role of B cells. In this review, we will introduce the newest studies and examine the role of B cells in cGVHD in detail with respect to the following aspects: altered B cell subpopula