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Сексуальная дисфункция и качество жизни в различных возрастных группах у пациентов с множественным склерозом: перспективный перекрестный анализ.

ВВЕДЕНИЕ: Множественный склероз (MS), являющийся наиболее распространенным хроническим неврологическим расстройством у молодых людей, существенно влияет на неврологическую функцию, особенно на автономную нервную систему. Хотя физические симптомы видны, MS также вызывает такие скрытые эффекты, как сексуальная дисфункция. Исследования показывают, что сексуальные расстройства чаще встречаются у пациентов, страдающих НР, по сравнению с другими неврологическими заболеваниями и примерно в пять раз чаще, чем у населения в целом. В ходе этого исследования использовались вопросники по вопросам сексуаль

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… Previous studies recognized erectile and ejaculatory dysfunction as the most common sexual symptoms in men; however, dyspareunia, decreased lubrication, and impaired clitoral erection are prevalent in women [ 1 ]. …

Ocular Manifestations in Hematological Disorders.

Background Ophthalmic manifestations are a common feature in hematological malignancies and may be divided into two groups: those attributable to the disease's infiltration of the eye, and the ocular consequences due to blood abnormalities. This study aims to determine the prevalence of ocular manifestations and their association with the different hematological disease subgroups. Materials and methods We conducted a retrospective and observational study enrolling 137 consecutive patients on active treatment or follow-up for hematological malignancies from January 2016 to January 2020 at the C

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… The three-pronged treatment modalities include decreasing ocular surface inflammation, lubrication and tear preservation, and prevention and control of tear evaporation. Topical lubrification remains the first line of treatment, with the use of tear substitutes supplemented with viscous ointments. …

Belantamab Mafodotin to Treat Multiple Myeloma: A Comprehensive Review of Disease, Drug Efficacy and Side Effects.

Multiple myeloma (MM) is a hematologic malignancy characterized by excessive clonal proliferation of plasma cells. The treatment of multiple myeloma presents a variety of unique challenges due to the complex molecular pathophysiology and incurable status of the disease at this time. Given that MM is the second most common blood cancer with a characteristic and unavoidable relapse/refractory state during the course of the disease, the development of new therapeutic modalities is crucial. Belantamab mafodotin (belamaf, GSK2857916) is a first-in-class therapeutic, indicated for patients who have

Metabolomic Profiling in the Characterization of Degenerative Bone and Joint Diseases.

Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive disease processes. In osteoarthritis, atty acid metabolism has been implicated in disease development, both locally and systemically. Several series of rheumatoid arthritis patients have demonstrated overlapping trends related to histidine and glyceric aci

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… This protein-rich ultrafiltrate from plasma lubricates the articular cartilage-covered surfaces of a joint via non-Newtonian properties and contains both hyaluronic acid and lubricin (protein; proteoglycan 4) for boundary lubrication. …

A Study of Oral Health Parameters and the Properties and Composition of Saliva in Oncological Patients with and without Medication-Related Osteonecrosis of the Jaw Who Take Bisphosphonates.

Background and Objectives: The aim of this study was to examine how the status of the oral cavity, composition and properties of saliva change in oncological patients with and without Medication-Related Osteonecrosis of the Jaw (MRONJ) undergoing bisphosphonate therapy. Materials and Methods: A retrospective case-control study of 49 oncological patients using bisphosphonates (BPs) was conducted. The study population was divided into two groups-Group I consisted of 29 patients with MRONJ and Group II of 20 patients without MRONJ. The control group consisted of 32 persons without oncological his

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… A normal flow of saliva is necessary to ensure the lubrication of oral tissues [ 27 ]. Through its lubricating function, saliva protects the surface of the mucosa and improves oral cavity cleaning [ 23 , 24 , 25 ]. …

Effect of expressive writing on the sexual self-concept in men with multiple sclerosis: a randomized clinical controlled trial.

BACKGROUND: Previous studies have examined the various outcomes of expressive writing intervention in different populations. The purpose of this study was to evaluate the effect of expressive writing on the sexual self-concept of men with multiple sclerosis. METHODS: This parallel randomized controlled clinical trial conducted on 70 men attending an MS clinic in Tehran in 2022. The participants were randomly assigned to expressive writing intervention and control groups. For two weeks, participants in the intervention group disclosed their emotions and expressed their feelings in writing twic

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… Women with MS may experience issues such as loss of libido, impaired orgasm, reduced vaginal lubrication, and decreased genital sensation [ 9 ], while men may face challenges such as erectile dysfunction or diminished sexual desire, that can impact sexual performance [ 10 ]. …

Scaling the side effects: A case of apalutamide-induced ichthyosis.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

A Case Report of Sebaceous Filaments.

This report details a case of a 16-year-old African American girl who presented with a two-year history of white spicules on her face without associated symptoms, including pruritus or pain. On physical examination, there were many 1-2 mm discreet white to yellow filamentous spicules on the mid and lower face. Histopathology scrapings showed cornified cells and calcification consistent with sebaceous filaments. Sebaceous filaments are a rare condition that presents as white-to-yellow spicules distributed in highly sebaceous areas on the face. It is caused by sebum accumulation and cornified ke

Clinical Practice Guidelines for management of Sexual Disorders in Elderly.

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… Hormone Replacement Therapy (HRT) with estrogen in case of menopausal women as vaginal function, particularly lubrication is determined by them. Hyperprolactinaemia is treated by administration of dopaminergic drugs like bromocriptine. … Saffron (30 mg/day) has been shown to improve sexual function (arousal, lubrication and pain domain) in females with SSRI induced sexual dysfunction. Snacking on pistachio nuts, 100 gm/day for 3 weeks, has been shown to improve erectile dysfunction. …

The Role of Angiogenesis in Haemophilic Arthropathy: Where Do We Stand and Where Are We Going?

Haemophilia is an inherited bleeding disorder that can lead to degenerative joint arthropathy due to recurrent bleeding episodes affecting the musculoskeletal system of the patient. The cause of bleeding can be either traumatic or spontaneous. The pathogenesis of haemophilic arthropathy is unclear as many factors like iron, inflammatory cytokines, and angiogenic factors contribute to this process. Blood into joints can deteriorate the bone to such an extent that the patient experiences pain, reduction of the range of movement, and deformity of the joint, conditions that could have a great impa

Clinical Practice Guideline: Nosebleed (Epistaxis) Executive Summary.

OBJECTIVE: Nosebleed, also known as epistaxis, is a common problem that occurs at some point in at least 60% of people in the United States. While the great majority of nosebleeds are limited in severity and duration, about 6% of people who experience nosebleeds will seek medical attention. For the purposes of this guideline, we define the target patient with a nosebleed as a patient with bleeding from the nostril, nasal cavity, or nasopharynx that is sufficient to warrant medical advice or care. This includes bleeding that is severe, persistent, and/or recurrent, as well as bleeding that impa

Clinical Practice Guideline: Nosebleed (Epistaxis).

OBJECTIVE: Nosebleed, also known as epistaxis, is a common problem that occurs at some point in at least 60% of people in the United States. While the majority of nosebleeds are limited in severity and duration, about 6% of people who experience nosebleeds will seek medical attention. For the purposes of this guideline, we define the target patient with a nosebleed as a patient with bleeding from the nostril, nasal cavity, or nasopharynx that is sufficient to warrant medical advice or care. This includes bleeding that is severe, persistent, and/or recurrent, as well as bleeding that impacts a

Эффективность транскутановой электрической стимуляции нервной системы в случае боли в тазе у женщин: систематический обзор.

Хроническая боль в тазе (КПГ) затрагивает примерно 26 процентов женщин и оказывает значительное воздействие на качество жизни. К числу общих причин относятся дисфункция дисменерреи и тазового пола. Транскутановая электрическая стимуляция нерва (TENS) широко используется для обезболивания в целях предотвращения обезболивания и стимулирования внутреннего опиоида. Цель этого исследования состоит в том, чтобы оценить эффективность ENS в деле реабилитации женщин, страдающих от боли в тазе, с помощью выборочных контролируемых испытаний (РКТ). Систематический поиск проводился в базах данных PubMed и

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… Their results demonstrated significant improvements in sexual function, particularly in the lubrication and pain domains of the FSFI, in the group receiving TENS. …

Uncommon Blepharitis.

Blepharitis is a common chronic inflammatory condition affecting the eyelid margins; the pathophysiology of blepharitis is complex and not fully understood. The disease is anatomically divided into anterior (inflammation of eyelashes) and posterior (meibomian gland dysfunction) types. Diagnosis relies on clinical examination, revealing characteristic features like scurf, vascular changes, and meibomian gland dysfunction. The main goals of blepharitis treatment are symptom relief, recurrence prevention, and complication risk minimization. Treatment options include lid hygiene, topical and syste

Presumptive Prostate Cancer Presenting as Low Back Pain in the Chiropractic Office: Two Cases and Literature Review.

Prostate cancer is a common type of cancer in men and may metastasize to the spine and pelvis, causing back and/or radicular pain that appears to be musculoskeletal. This presents a diagnostic challenge and can be complicated by a lack of routine screening for prostate cancer. In two similar cases, elderly males (ages 78 and 82) with no known history of cancer and no previous prostate-specific antigen screening presented to a chiropractor with chronic, worsening radiating low back pain. In each case, a previous provider obtained radiographs and ascribed symptoms to a non-cancerous etiology (i.

The clinical effectiveness and safety of traditional Chinese medicine uremic clearance granule combined with high-flux hemodialysis in the treatment of uremic pruritus: A protocol for systematic review and meta analysis.

BackgroundSkin pruritus is a common complication in patients with uremia. When the hemodialysis time of patients is extended, and the probability of skin pruritus is greater. Patients often have the symptoms of skin pruritus intolerable, affecting the normal sleep and normal life of patients. The patients with uremic pruritus often constant scratching and pruritus skin, resulting in broken skin, and further symptoms such as infection, and subsequent skin shedding, prurigo nodularis, and other adverse complications, aggravating the patient's condition. Some patients will experience symptoms suc

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… Different treatment strategies are made according to the disease stages and complications. [ 9 , 10 ] At present, Western medicine has limited treatment for the disease, mainly through the optimization of dialysis program, skin hydration and lubrication, physiotherapy and antihistamine drugs, opioid …

Non-invasive detection of corneal sub-basal nerve plexus changes in multiple myeloma patients by confocal laser scanning microscopy.

PURPOSE: Confocal laser scanning microscopy (CLSM) is a non-invasive technique for cellular in vivo imaging of the human cornea. CLSM screening was evaluated for early detection of corneal nerve morphology changes and neuropathogenic events in different stage multiple myeloma (MM) patients. As MM patients show disease as well as therapy-related neuropathological symptoms, CLSM potentially provides a tool for non-invasive early detection of neuropathogenic events. CLSM findings were compared with the severity of peripheral neuropathic (PNP) symptoms. METHODS: The study enrolled 25 MM patients

When to Use Methadone for pain: A Case-Based Approach.

The case studies are written in this article to illustrate how methadone might be used for pain in the Indian context. These cases might be used for discussion in a multidisciplinary team, or for individual study. It is important to understand that pain requires a multidisciplinary approach as opioids will assist only with physical, i.e. neuropathic and nociceptive pain, but not emotional, spiritual, or relational pain or the pain of immobility. The social determinants of pain were included to demonstrate how emotional, relational, and psychological dimensions of pain amplify the physical aspe

Challenges in the Diagnosis and Management of the Miller Fisher Variant of Guillain-Barré Syndrome: A Case Report.

Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome (GBS), characterized by the triad of ophthalmoplegia, ataxia, and areflexia, often following a bacterial or viral illness. This case report presents a 58-year-old Hispanic female patient with a preceding streptococcal pharyngitis who developed symptoms of bilateral facial nerve palsy and lower limb ataxia. Cerebrospinal fluid (CSF) analysis revealed albuminocytologic dissociation and, combined with her presentation of ophthalmoplegia, ataxia, and areflexia, supported the diagnosis of MFS. Magnetic resonance imaging (MRI)

Ocular toxicities associated with anticancer drug therapy in Asian patients: a literature review and practical management recommendations for non-ophthalmologic settings.

BACKGROUND: Ocular toxicities associated with anticancer therapies, including cytotoxic chemotherapy, hormonal agents, molecular targeted therapies, immune checkpoint inhibitors, and antibody-drug conjugates, are increasingly recognized and may substantially impair visual function and quality of life. However, ethnicity-specific data for Asian populations and practical management strategies applicable to non-ophthalmologic settings remain limited. METHODS: A literature review of publications up to December 2025 was conducted using PubMed to identify studies reporting incidence, mechanisms, pr

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… An experimental canine study demonstrated that repeated administration of artificial tears reduced S-1–induced corneal surface injury, suggesting a potential preventive role for lubrication therapy [ 22 ]. … Notably, an exception exists for tisotumab vedotin, for which prospective clinical trials incorporated prophylactic ocular interventions, including lubricating eye drops, steroid eye drops, vasoconstrictor drops, and cooling eye masks, to mitigate corneal and conjunctival toxicities [ 63 ]. …