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PROMIS® Health Organization (PHO) 2021 Conference Abstracts.

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Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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… Belury 1 1 Department Human Nutrition, The Ohio State University, Columbus, OH, USA; 2 College of Pharmacy, The Ohio State University, Columbus, OH, USA Background and aims: Cachexia is a common syndrome in advanced cancer patients and significantly impairs quality of life. …

Многомерное профилирование и модели риска, основанные на клиническом развертывании АИ, в МГУС и миеломе.

Моноклональная гаммопатия неопределённого значения (MGUS), храпающая миелома (SMM) и множественная миелома (MM) образуют континуум расстройств плазменных клеток, причем прогрессировать от MGUS до MM трудно предсказать. Нынешние модели стратификации риска, в значительной степени основанные на клинических, лабораторных и цитогенетических маркерах, не отражают молекулярную сложность, лежащую в основе развития заболеваний, что ограничивает их прогнозную точность. Последние достижения в области мультиомики, включая геномику, транскриптомику, протеомику и метаболомику, позволили глубже понять молеку

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… The Ohio State University; 2020. 37. Pirouzbakht M, Hamzeh S, Soleimani H, Samarkhazan. Beyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers. Clin Exp Med. 2025;25(1):355. 38. Sutanto H, et al. …

Recent clinical researches and technological development in TIL therapy.

Tumor-infiltrating lymphocyte (TIL) therapy represents a groundbreaking advancement in the solid cancer treatment, offering new hope to patients and their families with high response rates and long overall survival. TIL therapy involves extracting immune cells from a patient's tumor tissue, expanding them ex vivo, and infusing them back into the patient to target and eliminate cancer cells. This revolutionary approach harnesses the power of the immune system to combat cancers, ushering in a new era of T cell-based therapies along with CAR-T and TCR-therapies. In this comprehensive review, we a

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… |Ohio State University Comprehensive Cancer Center | USA | Phase 1 NCT05607095 | Uveal melanoma, melanoma, metastatic Uveal melanoma, metastatic melanoma | Lifileucel (LN-144) | Memorial Sloan Kettering Cancer Center|Iovance Biotherapeutics, Inc | USA | Phase 1 NCT05573035 | Relapsed/refractory metastatic …

Proceedings 27th Symposium ESVN‐ECVN

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… Green 3 1 Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA 2 Mass Spectrometry and Proteomics Facility, The Ohio State University, Columbus, OH, USA 3 Department of Chemistry, University of Florida, Florida, FL, USA The investigation of the proteins expressed …

The value and effectiveness of geriatric assessments for older adults with cancer: an umbrella review.

PurposeThis umbrella review aimed to summarise and synthesize the evidence on the outcomes reported and used to assess the value and or efficacy of geriatric assessments (GAs) for older adults with cancer.MethodsSix electronic databases, PsycINFO, MEDLINE, Embase, CINAHL, Cochrane Library and Web of Science databases, were searched to identify systematic reviews with or without meta-analyses that described the value or outcomes of GAs for older adults with cancer.ResultsTwenty-six systematic reviews were included, of which six included a meta-analysis of the data. Thirteen associations and or

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… Oncologist (Dayton Ohio). 2012;17:1439–49. 10.1634/theoncologist.2012-0186. 31. Versteeg KS, Konings IR, Lagaay AM, et al. Prediction of treatment-related toxicity and outcome with geriatric assessment in elderly patients with solid malignancies treated with chemotherapy: a systematic review. …

Micro and nanotechnologies: The little formulations that could.

The first publication of micro- and nanotechnology in medicine was in 1798 with the use of the Cowpox virus by Edward Jenner as an attenuated vaccine against Smallpox. Since then, there has been an explosion of micro- and nanotechnologies for medical applications. The breadth of these micro- and nanotechnologies is discussed in this piece, presenting the date of their first report and their latest progression (e.g., clinical trials, FDA approval). This includes successes such as the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines from Pfizer, Moderna, and Janssen (

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… One of the most well‐known NPs, Doxil, had a shortage from 2012 to 2015 after its sole manufacturing plant was shut down. 205 The production requirements of the formulations were only managed at Ben Venue Laboratories in Ohio. 206 To meet the shortage, other PEGylated (Lip‐Dox 206 ) and non‐PEGylated …

The Medicare experience with end-stage renal disease: trends in incidence, prevalence, and survival.

This article presents a detailed account of the incidence, prevalence, and survival experience of people with end-stage renal disease (ESRD) covered by Medicare. The number of new entrants into the ESRD program has risen since its inception. This increase is greatest for people whose cause of renal failure is primary hypertensive disease or diabetic nephropathy. The program incidence rates for black people is 2.8 times that of white people. Incidence is highest for persons 65 to 69 years of age. Total patient survival is 44 percent 5 years after renal failure onset. Total Medicare enrollment f

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… Hampshire | 871 | 44.0 | 51 | 703 | 30.7 | 44 New Jersey | 7327 | 709.3 | 97 | 5748 | 332.7 | 58 New Mexico | 1212 | 96.7 | 80 | 913 | 54.7 | 60 New York | 17748 | 1457.3 | 82 | 13842 | 665.0 | 48 North Carolina | 5577 | 455.3 | 82 | 3712 | 180.0 | 48 North Dakota | 652 | 33.7 | 52 | 544 | 25.0 | 46 Ohio …

Decoding Waldenström Macroglobulinemia Through Genomics, Epigenomics and Cellular Interactions

Waldenström macroglobulinemia is a rare lymphoplasmacytic malignancy characterized by bone marrow infiltration and monoclonal immunoglobulin M production. Despite its indolent clinical course, the disease exhibits considerable biological complexity driven by recurrent genetic alterations, dysregulated signaling pathways, and a supportive bone marrow microenvironment. The identification of MYD88 and CXCR4 mutations has significantly advanced understanding of disease pathogenesis, clonal evolution, and treatment response. Additional insights from cytogenetic, epigenetic, and microRNA studies hav

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… Ohio 2020 38 849 859 10.1002/stem.3174 PMC7566894 32159901 120. Greenbaum A. Hsu Y.-M.S. Day R.B. Schuettpelz L.G. Christopher M.J. Borgerding J.N. Nagasawa T. Link D.C. …

Clinical Posters From JADPRO Live 2023.

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… JL1106C: Advanced Practice Providers in Oncology Care: Consensus Principles for Clinical Practice Utilization Dori Klemanski, 1 DNP, APRN-CNP, Lindsey Bandini, 2 MPH, Donna Berizzi, 3 DNP, RN, OCN ® , NEA-BC, Elizabeth Souza, 4 MHA, Katie Stehman, 2 PA-C, MMS, Rondeep Brar, 5 MD; 1 Ohio State Univ Wexler …

Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study.

Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived genomic alterations in cell-free DNA in blood are being adopted for multi-cancer early detection in human medicine and are now available for veterinary use. The CANcer Detection in Dogs (CANDiD) study is an international, multi-center clinical study designed to validate the performance of a novel multi-cancer early detection "liquid biopsy" test developed for noninvasive detection and characterization of cancer in dogs using n

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… Animal Hospital, VCA Valley Oak Veterinary Center, City Paws Home Health, Prices Creek Veterinary Services, Carlsbad Animal Hospital, Oceanside Veterinary Hospital, Amici Pet Hospital of Little Italy, Colony Veterinary Hospital, Carriage Hills Animal Hospital, and the Integrated Oncology Service at The Ohio …

Премии победителей и резюме 32nd Ежегодный симпозиум Общества протеинов; Бостон, ОЭТ, июль 9-12, 2018.

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Innovative Peptide Therapeutics in the Pipeline: Transforming Cancer Detection and Treatment.

Cancer remains a leading global health burden, profoundly affecting patient survival and quality of life. Current treatments-including chemotherapy, radiotherapy, immunotherapy, and surgery-are often limited by toxicity or insufficient specificity. Conventional chemotherapy, for instance, indiscriminately attacks rapidly dividing cells, causing severe side effects. In contrast, peptide-based therapeutics offer a paradigm shift, combining high tumour-targeting precision with minimal off-target effects. Their low immunogenicity, multi-pathway modulation capabilities, and adaptability for diagnos

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… Ohio State University Comprehensive Cancer Center BZLF1 Peptide Vaccine (OSU-2131) with QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants. 2024. [(accessed on 10 July 2025)]. …

Lipocalin 2-not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials.

Lipocalin 2 (Lcn2), also known as neutrophil gelatinase-associated lipocalin, is an innate immune protein encoded by the LCN2 gene. In this study, we investigated various roles and functions of Lcn2 characterized in a systems-based format and evaluated its therapeutic potentials and clinical relevance for diagnosis and prognosis. An additional systematic presentation was presented for 70 ongoing clinical trials utilizing Lcn2 in the diagnostic and prognostic setting as a key outcome measure. With trials being conducted through December 2030, Lcn2 will become all the more relevant given its ass

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… Weiler Hospital, Bronx, NY, USA NCT03782610 | 675 | Other; NIH | Observational | Observational model: cohort; time perspective: prospective | Dec 2025 | Nationwide Children's Hospital Main Campus Neonatal Intensive Care Unit, Columbus, OH, USA; Nationwide Children's Neonatal Intensive Care Unit at The Ohio …

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps.

Leishmaniasis is a neglected tropical disease endemic primarily to low- and middle-income countries, for which there has been inadequate development of affordable, safe, and efficacious therapies. Clinical manifestations of leishmaniasis range from self-healing skin lesions to lethal visceral infection with chances of relapse. Although treatments are available, secondary effects limit their use outside the clinic and negatively impact the quality of life of patients in endemic areas. Other non-medicinal treatments, such as thermotherapies, are limited to use in patients with cutaneous leishman

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… Disclosure The US Food and Drug Administration and Ohio State Innovation Foundation report a patent 17-786,129 pending to Gennova Biopharmaceuticals. The authors report no other conflict of interest in this work. References 1. CDC. DPDx – Leishmaniasis:23. …

Pharmacist-led interventions in hematological malignancies: a systematic review of clinical, process and economic outcomes.

BackgroundPharmacist-led interventions are increasingly integrated into hematology-oncology care to address complex pharmacotherapy and medication safety challenges. However, their impact within hematological malignancies has not been comprehensively synthesized across clinical, process-related, and economic domains.MethodsA systematic review was conducted to evaluate pharmacist-led interventions in patients with hematological malignancies across inpatient and outpatient settings. Thirty-three studies were included. Owing to substantial heterogeneity in study design, interventions, and outcome

Abstracts From JADPRO Live 2019: Washington State Convention Center • Seattle • October 24-27.

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… Approaches: In June 2016, the lymphoma providers at the Ohio State James Cancer Hospital recognized substance use as a problem, leading to poor outcomes, and a multidisciplinary workgroup was formed focusing on strategies/interventions to improve outcomes. …

Электронные постеры

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Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016-2022).

Fluorine is characterized by high electronegativity and small atomic size, which provide this molecule with the unique property of augmenting the potency, selectivity, metabolic stability, and pharmacokinetics of drugs. Fluorine (F) substitution has been extensively explored in drug research as a means of improving biological activity and enhancing chemical or metabolic stability. Selective F substitution onto a therapeutic or diagnostic drug candidate can enhance several pharmacokinetic and physicochemical properties such as metabolic stability and membrane permeation. The increased binding a

Hyaluronic Acid as a Modern Approach in Anticancer Therapy-Review.

Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to embryonic development, healing, inflammation, and cancerogenesis. This review summarizes new research on the metabolism and interactions of HA with its binding proteins, known as hyaladherins (CD44, RHAMM), revealing the molecular basis for its distinct biological function in the development of cancer. The presence of HA on the surface of tumor cells is a sign of an adverse prognosis. The involvement of HA in malignancy h