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A scoping review of breakthrough cancer pain: Multidimensional patient needs and influencing factors.

ObjectivesBreakthrough cancer pain (BTcP), a common complication among cancer patients, has been confirmed to have extensive impacts on patients' lives. However, existing research remains fragmented, lacking a systematic theoretical framework to integrate these findings. This scoping review aimed to systematically examine the multidimensional needs and influencing factors of BTcP patients based on Kolcaba's Comfort Theory, construct a conceptual mapping of BTcP needs and influences, and explore the theoretical foundations and practical pathways of related interventions.MethodsUsing a scoping r

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management.

Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine

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… To some extent, the lack of “First in Class” or “Me-Only” pain killers manifested the frustration of current drug discovery model ( Csermely et al., 2005 ; Kinch and Griesenauer, 2019 ; Ebied et al., 2020 ; Mullard, 2021 ). …

Engineering precision nanoparticles for drug delivery.

In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers - systemic, microenvironmental and cellular - that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… One study suggested that frustration associated with targeted therapy–associated acneiform rash is greater than that experienced with eczematous dermatitis and acne vulgaris ( Joshi et al., 2010 ). …

Сердечно-сосудистые заболевания

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Heterogeneous tissue-specific macrophages orchestrate metastatic organotropism of breast cancer: implications for promising therapeutics.

Compelling evidences have manifested that breast cancer cells prefer to metastasize to certain distant organs, including brain, lung, bone and liver. According to the canonical "seed and soil" theory, this prominent biological behavior, termed as metastatic organotropism, involves intricate interactions between breast cancer cells (the "seeds") and specific residents in the tumor microenvironment (the "soil"), initiating from pre-metastatic niche formation to metastatic outgrowth. Recently, multifaceted heterogeneity of tissue-specific macrophages (TSMs) and their roles played in organotropic

2021 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Las Vegas, Nevada, 31 August–3 September 2021: Video Loops

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Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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The Clinical Application of Ozonetherapy

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Abstracts 12th PCNE working conference 'Partnering for better patient outcomes: challenges and opportunities 3-6 February 2021, University of Basel, Switzerland (was held online).

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… However, residents seemed to have some frustrations towards GPs, and carers indicated to regularly ask questions about the resident’s medication. Additionally, both groups gave examples of negative experiences concerning the resident’s medication and changes therein. …

37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017

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… 3)Information and Support Needs: Many felt uncertain and uninformed about what was happening creating feelings of anger, frustration and confusion. Seeking information was important for relatives to help both try to make sense of what happened and exonerate feelings of guilt and self-blame. …

Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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Targeting MDM2, RAS, and PCNA for cancer targeted therapy: pan-cancer approaches vs. cancer-specific strategies.

Cancer therapy and cancer drug discovery and development have been historically focused on specific cancers (tissue/organ of origin). However, with advances in molecular biology and multi-omics of cancer, there is a trend to develop pan-cancer therapeutic modalities. In targeted therapy, pan-cancer strategies target common molecular alterations across different cancer types and specific cancer strategies are tailored to the unique biological characteristics of individual tumor types. Each approach offers distinct advantages and limitations, and understanding these differences is critical in th

Более широкие соображения в отношении интеграции медицинских и стоматологических данных

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Angioprevention of Urologic Cancers by Plant-Derived Foods.

The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to

Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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… Some PCPs described a reluctance to initiate an eConsult because of difficulty with technical aspects of the program, frustration with slower-than-promised responses from consultants, or concern about how and when to communicate with patients regarding a consultant’s recommendations. … Participants expressed frustration as to lack of clarity regarding how to implement SCN, and despite this barrier, pulled together to creatively implement SCNs best adapted to meet local needs. …

Резюме, представленные на 32nd Ежегодная конференция Международного общества по изучению качества жизни.

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Advances in improving cancer immunotherapy with nanotechnology: from smart nanoparticles to synergistic combination strategies.

Cancer immunotherapy has substantially advanced cancer treatment, achieving durable responses in select malignancies. However, its widespread application is limited by significant challenges: low efficacy in many solid tumors, severe side effects, and immune evasion facilitated by the tumor microenvironment (TME). Nanotechnology offers a promising approach to address these obstacles. By employing nanoparticles (NPs), we can precisely deliver therapeutics to tumor sites, ensure controlled release to minimize side effects, and amplify the immune response, thereby substantially boosting the effec

UEG Week 2017 Oral Presentations

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