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Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults.

The nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutritional evaluation and follow-up during hematopoietic stem cell transplant are essential. To emphasize the importance of nutritional status and body composition during treatment, as well a

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… The use of cryotherapy with ice chips before melphalan (120 minutes in total for each regimen) was significantly lower in the group that developed dysgeusia. … Univariate and multivariate logistic regression analyses showed that the chemotherapy regimen used, and the presence of oral mucositis were independent risk factors for dysgeusia, while cryotherapy was an independent suppressor. …

Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In c … c, and resistant to therapy. Treatment methods commonly applied in immunocompetent patients such as cryotherapy, curettage, and electrocautery are not generally recommended in patients with severe immunodeficiency as they pose a risk of secondary infection or autoinoculation (6). Additionally, such treatment of multiple lesions is connected with pain and high …

Vertebral Primary Bone Lesions: Review of Management Options.

The assessment and treatment of vertebral primary bone lesions continue to pose a unique yet significant challenge. Indeed, there exists little in the literature in the way of compiling and overviewing the various types of vertebral lesions, which can often have complicated intervention strategies. Given the severe consequences of mismanaged vertebral bone tumors-including the extreme loss of motor function-it is clear that such an overview of spinal lesion care is needed. Thus, in the following paper, we aim to address the assessment of various vertebral primary bone lesions, outlining the re

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… To prevent the recurrence of the vertebral lesion, adjuvant measures like phenol instillation or cryotherapy may be used post-surgically. Small or slow-developing lesions may only require corticoid injections or percutaneous vertebroplasty to eradicate the tumor. … When categorized as a benign aggressive or low-grade malignant bone tumor, cryotherapy with liquid nitrogen is as effective as wide excision [ 44 ]. More effectively than phenol and cement, cryosurgery produces cell necrosis of up to 2 cm from the bone surface [ 45 ]. …

Nutritional Impact of High-Dose Melphalan in Autologous Stem Cell Transplantation.

High-dose melphalan is the standard conditioning treatment for patients undergoing autologous hematopoietic stem cell transplantation for hematological malignancies. Although effective, it often causes significant gastrointestinal side effects, such as mucositis, nausea, vomiting, and diarrhea, which can quickly affect patients' nutrition, hydration, and electrolyte balance, leading to acute malnutrition. This nutritional decline increases the risk of infections, prolongs hospital stays, and can worsen short-term recovery. Routine nutritional assessment and early support are not consistently i

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… Oral cryotherapy has also been shown to reduce the incidence and severity of melphalan-induced oral mucositis and may indirectly help preserve oral intake. …

Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs.

Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enh

Nurses' Perspectives on the Non-Pharmacological Management of Oral Mucositis in Onco-Hematological Care: A Qualitative Content Analysis.

Background/Objectives: Oral mucositis (OM) is a common complication in onco-hematological patients undergoing chemotherapy and hematopoietic stem cell transplantation, negatively affecting comfort, nutrition, and quality of life. Despite existing assessment tools and recommendations, OM management-particularly non-pharmacological approaches-remains inconsistent, and evidence on nurses' perspectives and contextual factors is limited. This study explored nurses' perceptions and experiences regarding non-pharmacological treatments for OM, including educational needs and barriers and facilitators

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… The use of complementary non-pharmacological interventions was limited and largely confined to cryotherapy, he use of ice pops in practice, and mouthwashes. “Ice lollies help relieve the pain a bit.” (P03) 3.5. … The study revealed that the use of non-pharmacological interventions beyond cryotherapy and mouthwashes was limited. …

Use of a newly developed minimally invasive bilateral fixed angle locking system in the treatment of pathological pelvic fractures: a case series.

BACKGROUND: Metastatic bone disease (MBD) and its complications have a significant impact on patients' quality of life. Pathological fractures are a particular problem as they affect patient mobility and pose a high risk of non-union. The pelvis is frequently affected by MBD and its fixation is challenging. We present a case series of three pathological sacral fractures treated with a new minimally invasive bilateral fixed angle locking system. CASE PRESENTATION: Case 1 and 2 suffered a pathological transforaminal sacral fracture without adequate trauma in stage 4 carcinomas (gastric cancer a

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… Typical surgical options for the treatment of MBD include osteosynthesis, endoprosthesis, cryotherapy, radiofrequency ablation and cementoplasty; typical non-surgical options are radiotherapy, embolization, chemotherapy and bisphosphonates/denosumab [ 4 ]. …

Prostate cancer immunotherapy-based strategies: an updated review emphasizing immune checkpoint inhibitors.

Prostate cancer (PC) is one of the most common cancers that is diagnosed in about 10-15% of men in old age. It seems that the current treatments are not effective, and this leads to prostate cancer becoming the second-deadliest cancer. Treatments such as chemotherapy, radiotherapy, androgen deprivation therapy (ADT), and surgery are among these treatments. However, the possibility of disease recurrence after these treatments is high. Therefore, other methods have become necessary, and PC treatment is changing. One of the methods that has received much attention today is immunotherapy. Immunoth

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… Cryotherapy A small pilot study also utilized cryotherapy in combination with pembrolizumab (an anti-PD-1 Antibody). The median progression-free survival was 14 months, with no serious adverse effects ( 214 ). … To date, treatment modalities such as chemotherapy, radiotherapy, cryotherapy, PARP inhibitors, vaccines, ADTs, and several other therapies have been combined with ICIs to inhibit tumor growth in preclinical and clinical trials. …

Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report.

BackgroundAdenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease.Case presentationWe report a case of an 82-year-old white man affected by primary adenoid cystic carcinoma of the trachea, treated with debulking surgery and radiotherapy on the residual disease. A three-dimensional conformal radiation th

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… Palliation can be obtained with several procedures, such as electrocoagulation, cryotherapy, photodynamic therapy, or with stents, above all in cases of severe airway obstruction. Many studies are available in the scientific literature about the employment of radiotherapy in ACC (Table 1 ). …

Current Overview of Treatment for Metastatic Bone Disease.

The number of patients with bone metastasis increases as medical management and surgery improve the overall survival of patients with cancer. Bone metastasis can cause skeletal complications, including bone pain, pathological fractures, spinal cord or nerve root compression, and hypercalcemia. Before initiation of treatment for bone metastasis, it is important to exclude primary bone malignancy, which would require a completely different therapeutic approach. It is essential to select surgical methods considering the patient's prognosis, quality of life, postoperative function, and risk of pos

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… They also recommended local adjuvant therapy, such as phenol and cryotherapy, and radiotherapy after curettage [ 44 ]. … Ablation methods, such as RFA or cryotherapy, are contraindicated if the tumor is within 1 cm of important structures such as the spinal cord, major nerves, and blood vessels [ 174 ]. …

Von Hippel-Lindau Disease: Current Challenges and Future Prospects.

Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominant tumor syndrome usually manifests in young adulthood and predisposes affected patients to the development of benign and malignant tumors of different organ systems mainly including the nervous system and internal organs. A consequent screening and timely preventive treatment of l

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… Laser coagulation or cryotherapy can control the majority of peripheral retinal hemangioblastomas. 62 , 63 Larger tumors can be treated by vitrectomy. 64 Optic disc hemangioblastomas should be monitored without treatment. … Side effects of systemic use were paresthesias and nail petechiae. 157 To conclude; laser photocoagulation, cryotherapy, photodynamic therapy and pars plana vitrectomy seem to remain the gold standard for the treatment of retinal VHL hemangioblastomas. …

Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates.

Since the successful approval of gemtuzumab ozogamicin, antibody-drug conjugates (ADCs) have emerged as a pivotal category of targeted therapies for cancer. Among these ADCs, the use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, which has significantly improved overall therapeutic efficacy against various malignancies. However, increasing clinical observations have raised concerns regarding the potential nervous system toxicity associated with MMAE-based ADCs. Specifically, a higher incidence of peripheral neuropathy has been reported in ADCs inco

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… Moreover, cryotherapy and compression therapy have been reported as effective treatments for paclitaxel-induced peripheral neuropathy with generally well-tolerated and safe. 123 As demonstrated in clinical trials, the use of surgical gloves for compression therapy has shown promise as a potentially safe … Comparison of the efficacy of cryotherapy and compression therapy for preventing nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A prospective self-controlled trial. Breast. 2020;49:219–224. doi: 10.1016/j.breast.2019.12.011. 124. Li Y., Lustberg M.B., Hu S. …

State-of-the-art imaging for diagnosis of metastatic bone disease.

Metastatic bone disease (MBD) is common-it is detected in up to 65-75% of patients with breast or prostate cancer, in over 35% of patients with lung cancer; and almost all patients with symptomatic multiple myeloma have focal lesions or a diffuse bone marrow infiltration. Metastatic bone disease can cause a variety of symptoms and is often associated with a poorer prognosis, with high social and health-care costs. Population-based cohort studies confirm significantly increased health-care utilization costs in patients presenting with cancer with MBD compared with those without MBD. The prolong

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… options may be curative (surgery, chemo-, radiotherapy), locally curative (radiotherapy, ablation), or palliative (radiotherapy, chemotherapy, arterial embolization, stabilization with forms of cementoplasty such as kyphoplasty, and/or vertebroplasty, which can be combined with radiofrequency ablation, cryotherapy … There is therefore a need to explore further the role of minimally invasive and noninvasive image-guided therapies, including targeted MR-guided high-intensity focused ultrasound (MRg—HIFU), microwave/radiofrequency ablation, and cryotherapy. …

Editorial: Cancer therapy: The challenge of handling a double-edged sword.

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… Interestingly, non-pharmacological interventions (mainly cryotherapy, compression therapy, and massage therapy) seemed to be more effective than pharmacological interventions (gabapentin, omega-3 fatty acids, vitamin E and N-acetylcysteine) in the 14 controlled trials that were eligible for the study …

Keyword Index for Volume 107

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… co-morbidity 189, 1175, 1901 conditional power 910 CONFIRM 1044 connexin-26 1963 continual reassessment method 1022 contralateral breast cancer 221 contralateral testicular germ cell tumour 1637 copper 1488 costs 1574 COX-2 inhibitor 707 C-reactive protein 275, 1031 creatine kinase 1797 CRP 1131 cryotherapy …

Gastrointestinal Bleeding Secondary to High-Dose Melphalan Pretreatment in Patients with Multiple Myeloma Was Associated with the Mode of Melphalan Administration.

OBJECTIVE: To analyze the characteristics of gastrointestinal bleeding secondary to high-dose melphalan pretreatment in patients with multiple myeloma. METHODS: Between 1 January 2016 and 31 October 2021, 26 patients with multiple myeloma after autologous peripheral blood hematopoietic stem cell transplantation with high-dose melphalan pretreatment were recruited. They were assigned to either the oral administration group or the intravenous administration group according to the administration modes, or to either the gastrointestinal bleeding group or the nongastrointestinal bleeding group. An

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… Oral cryotherapy is available to alleviate the mucositis caused by high doses of melphalan, with good patient tolerance and easy implementation, which reduces patient pain and improves their quality of life. …

Evaluating Acupuncture for Chemotherapy-Induced Peripheral Neuropathic Pain: A Narrative Review of Clinical Evidence and Mechanistic Perspectives.

BACKGROUND/OBJECTIVES: Despite the high prevalence of chemotherapy-induced peripheral neuropathic pain (CIPNp), its management remains challenging, and reliable preventive strategies are still lacking. Current treatment is largely symptomatic and often provides only modest benefits, as available pharmacological therapies have shown limited and inconsistent efficacy. In this context, acupuncture has been investigated as a non-pharmacological intervention, but the certainty and clinical applicability of the available evidence remain unclear. This critical narrative review examines the clinical e

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… In response to these limitations, increasing attention has been directed toward non-pharmacological and integrative approaches for CIPN, including exercise-based rehabilitation, cryotherapy, neuromodulation, and acupuncture [ 7 , 8 ]. … Cryotherapy and compression techniques, applied during chemotherapy infusion, have been investigated primarily as preventive strategies, particularly in taxane-based regimens. …

Exploring the applicability, combined strategies, and challenges of ablation in hematology based on its characteristics and immunomodulatory mechanisms.

Malignant hematological diseases, such as lymphoma, leukemia, and multiple myeloma, are frequently accompanied by clinical challenges including local progressive lesions, relapsed/refractory conditions, and poor tolerance to standard treatments in special populations. Systemic therapies represented by chemotherapy and targeted therapy have inherent limitations in addressing local tumor burden, relieving organ compression, and being suitable for frail patients. As a minimally invasive local treatment technology, ablation has been widely used in solid tumor therapy due to its advantages of preci

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… Thermal Characterization and Preclinical Feasibility Verification of an Accessible, Carbon Dioxide-Based Cryotherapy System. Bioengineering. Multidisciplinary Digit Publishing Inst. 2024;11:391. 10.3390/bioengineering11040391. 40. Kwak K, Yu B, Lewandowski RJ, Kim D-H. … Changes in interleukin-1β and 6 after hepatic microwave tissue ablation compared with radiofrequency, cryotherapy and surgical resections. Am J Surg Elsevier. 2010;200:500–6. 10.1016/j.amjsurg.2009.12.025. 63. Frenkel N, Poghosyan S, van Wijnbergen JW, Rinkes IB, Kranenburg O, Hagendoorn J. …

Биологические движущие силы инъекции периферальной Neurophy в Множестве миеломы.

Внедрение иммуноводных препаратов (ИМИД), таких, как талидомид, линалидомид и помалидомид, привело к значительному улучшению методов лечения миеломы (ММ). Многие пациенты в настоящее время живут 10 или более лет со своим заболеванием, в результате чего побочные эффекты, связанные с лечением, приобретают все большее значение. Периферальная нейропатия (PN) является общим побочным эффектом терапии IMID, которая оказывает существенное воздействие на качество жизни пациентов, и в настоящее время не имеется никаких профилактических или целевых терапевтических стратегий. В ходе этого обзора изучаются

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… Interventions like cryotherapy, showing promise in other CIPN [ 111 ], have not yet been evaluated, and clinical trials focusing IMiD‐specific PN are notably absent. … Egle , et al., “ Cropsi Study: Efficacy and Safety of Cryotherapy and Cryocompression in the Prevention of Chemotherapy‐Induced Peripheral Neuropathy in Patients With Breast and Gynecological Cancer–A Prospective, Randomized Trial ,” Breast 76 ( 2024 ): 103763 , 10.1016/j.breast.2024.103763 . 38941655 …

Flat Warts (Verrucae Planae) Confined to the Pigment of a Tattoo: A Rare Tattoo-associated Complication.

Tattoos are a form of decorative body art in which pigment dyes of different colors are inoculated into the skin. It is estimated that 15-25 … colored ink (7,8). There are several treatment options for verrucae planae, such as liquid nitrogen cryotherapy, topical 5% fluorouracil, topical 5% imiquimod, 0.025-0.050% tretinoin, 10% salicylic acid, or 10-30% glycolic acid. These treatments have differing success rates. Destructive modalities, such as surgical excision, curetting, or laser ablation may s …