Результаты поиска

Regulating effect of Qifu Yin on intestinal microbiota in mice with memory impairment induced by scopolamine hydrobromide.

ETHNOPHARMACOLOGICAL RELEVANCE: Qifu Yin (QFY) originates from "Jingyue Quanshu · Volume 51 · New Fang Bazhen · Buzhen" a work by Zhang Jing … on, presenting a novel perspective on QFY's mechanism in ameliorating myocardial infarction through lipidomics. While this research provides an experimental foundation for the clinical application of QFY, a comprehensive and in-depth analysis of its improvement mechanism remains imperative. AIM OF THE STUDY: To clarify the regulatory mechanism of QFY on int …

Monitoring concentration and lipid signature of plasma extracellular vesicles from HR+ metastatic breast cancer patients under CDK4/6 inhibitors treatment.

Extracellular vesicles (EVs) are cell-derived small membrane structures that transport various molecules. They have emerged as potential circulating biomarkers for monitoring responses to cancer therapies. This study aimed to comprehensively characterize plasma-carried EVs in hormone receptor-positive (HR+) metastatic breast cancer (MBC) patients treated with first-line CDK4/6 inhibitors (iCDK4/6) combined with endocrine therapy. MBC patients were classified into three groups based on their response to therapy: resistant, intermediate or sensitive. In a prospective cohort, we monitored the con

Специальный выпуск "Роль липидов в здравоохранении и болезнях".

Липиды представляют собой гидрофобные биомолекулы, которые, как правило, характеризуются как восковые или масляные и нерастворимые в воде, включающие в себя структурно разнообразную группу, включающую триглицериды, фосфолипиды, воски и стероиды [...].

Совпадение в полном тексте источника
… Advances in analytical technologies, particularly mass spectrometry-based lipidomics [ 11 , 12 ], have uncovered an extraordinary diversity of lipid species [ 13 , 14 , 15 ] and elucidated their functional roles in cellular physiology [ 16 , 17 ]. … Emerging technologies such as precision and spatial lipidomics [ 47 , 48 ], including single-cell lipidomics [ 49 ], are revealing cellular heterogeneity and tissue-specific lipid dynamics. …

Глубинные пространственные омики MLADI-MS, управляемые квантовой каскадной лазерной микроскопией среднего инфракрасного изображения.

В пространственной "omics " высокоуверенные молекулярные идентификации необходимы для исследования сложной биологии и для пространственной биомаркировки. Однако нынешняя масс-спектрометрическая съемка (MSI) на основе пространственной "омики" должна скомпрометировать скорость получения данных и глубину биохимического профилирования. Здесь мы введём быструю, без этикеток квантовую каскадную лазерную микроскопию среднего инфракрасного изображения (QCL-MIR), чтобы направить MSI в высокоинтересные области тканей, такие маленькие, как гломерули почки, культурные многоклеточные сфероидные я

Совпадение в полном тексте источника
… In this work, we develop QCL-MIR imaging-guided MSI workflows and computational tools for spatially resolved deep lipidomics profiling and make them and extensive spatial lipidomics data available as a community resource. … Structure-CCS-relationships based on experimental deep profiling spatial lipidomics data This vast resource of spatial MALDI-MSI and corresponding LC-MS data, both acquired on TIMS-MS platforms, permitted deep inquiries into the (spatial) sulfoglyco- lipidome. …

Using an integrated omics approach to uncover the mechanisms underlying chemotherapy-induced peripheral neuropathy (CIPN).

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect with limited treatment options. The primary challenge in developing therapies is the lack of identified neurotoxic mechanisms. To address this, an integrated omics approach, combining transcriptomics, proteomics, and metabolomics, is essential to map the biological changes underlying the condition. Here, we show how data from these complementary approaches converge on key mechanisms involved in CIPN through a critical summary of animal and human studies. Current research highlights several key drivers of CIPN, such

Совпадение в полном тексте источника
… Beyond injury models, MSI has been applied to characterize the baseline lipidomic composition of peripheral nerves. … Lipidomics, a specialized branch of metabolomics focusing on lipid profiling, has undergone rapid advances due to improvements in high-resolution MS techniques such as LC-MS/MS, shotgun lipidomics, and IMS 106 . …

Lipid metabolism in multiple myeloma: pathogenesis, therapeutic opportunities, and future directions.

BackgroundMultiple myeloma (MM) is a complex hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. Emerging studies have emphasized the importance of lipid metabolism, which is closely associated with the survival, proliferation, and drug resistance of tumor cells. The hypoxic environment in the bone marrow (BM) contributes to metabolic reprogramming in MM cells, including alterations in metabolite levels, changes in metabolic enzyme activity, and metabolic shifts. Cancer cells possess the ability to adapt their metabolism in order to fulfill their

Совпадение в полном тексте источника
… By seamlessly integrating patients’ genomic, lipidomic, and clinical data, AI can construct highly sophisticated predictive models. For example, machine - learning algorithms can sift through vast amounts of lipidomics data to identify biomarkers associated with treatment responses. … The combined power of lipidomics and AI provides a potent toolkit for biomarker discovery and patient stratification in MM patients. Lipidomics can accurately pinpoint specific lipid metabolites or pathways that are dysregulated in MM. …

Editorial: Autologous and Allogeneic Stem Cell Transplant in Cancer Therapy.

Over the last 10 to 20 years, there have been significant improvements in the fields of both autologous and allogenic transplantation [...].

Диет модернизирует терапевтическое воздействие диметилфумарата, поддерживаемого иммунометаболическим нейтрофильным рецептором HCAR2.

Монометилфумарат (ММФ) и его пронаркодиметилфумарат (ДМП) в настоящее время являются наиболее широко используемыми агентами для лечения множественных склерозов (МС). Однако не все пациенты получают помощь от ДМФ. Мы предположили, что переменная реакция пациентов может быть связана с их питанием. В поддержку этой гипотезы мыши, подвергшиеся экспериментальному аутоиммунальному энцефаломиэлиту (EAE), являющемуся моделью MS, не пользовались лечением DMF при питании богатой лауричной кислотой диетой. В противоположность этому, мыши на нормальном питании чау (NC) и даже мыши на рационе с высоким сод

Совпадение в полном тексте источника
… Lipidomics and metabolomics analyses via LC-MS/MS All experiments used a Dionex Ultimate 3000 UHPLC system coupled to a Q-Exactive Orbitrap mass spectrometer (Thermo Fisher Scientific) equipped with a heated electrospray ionization source. … Fold change analysis and sPLS-DA of lipidomics and metabolomics data were performed using MetaboAnalyst 6.0 ( Xia et al., 2009 ). For the comparison of dietary effects on lipidomics and metabolomics data, p values were adjusted for false discovery rate by the Benjamini-Hochberg procedure. …

Цифровой двойник для неврологических условий: систематический обзор сферы охвата.

Цифровая двойная технология стала многообещающим подходом к развитию точной медицины в сложных болезнях, особенно в неврологии. Цель этого аналитического обзора заключалась в том, чтобы систематически картировать текущую литературу о цифрового двойного применения в неврологических условиях с уделением особого внимания характеристикам исследований, подходам к моделированию, источникам данных и клиническому применению. Всесторонний поиск six базы данных с момента создания по февраль 2026 выявленные 36 - исследования, отвечающие критериям включения. Полученные результаты свидетельствуют о быстром

Совпадение в полном тексте источника
… , Abeta, Tau, MMSE, hippocampal atrophy, lipidomics; N = 20) Biomarker discovery/Disease mechanism understanding 11 lipidomic modules correlated with 11 functional processes in domains of microglia metabolism and neuron energy balance. … functional processes) | Partial mechanistic digital twin | Multiomics data (ADNI: APOE4, Abeta, Tau, MMSE, hippocampal atrophy, lipidomics; N = 20) | Biomarker discovery/Disease mechanism understanding | 11 lipidomic modules correlated with 11 functional processes in domains of microglia metabolism …

Tumor Biology Hides Novel Therapeutic Approaches to Diffuse Large B-Cell Lymphoma: A Narrative Review.

Diffuse large B-cell lymphoma (DLBCL) is a malignancy of immense biological and clinical heterogeneity. Based on the transcriptomic or genomic approach, several different classification schemes have evolved over the years to subdivide DLBCL into clinically (prognostically) relevant subsets, but each leaves unclassified samples. Herein, we outline the DLBCL tumor biology behind the actual and potential drug targets and address the challenges and drawbacks coupled with their (potential) use. Therapeutic modalities are discussed, including small-molecule inhibitors, naked antibodies, antibody-dru

An Individualized Exercise Intervention for People with Multiple Myeloma-Study Protocol of a Randomized Waitlist-Controlled Trial.

People with multiple myeloma (MM) are second only to people with lung cancer for the poorest reported health-related quality of life (HRQoL) of all cancer types. Whether exercise can improve HRQoL in MM, where bone pain and lesions are common, requires investigation. This trial aims to evaluate the efficacy of an exercise intervention compared with control on HRQoL in people with MM. Following baseline testing, people with MM (n = 60) will be randomized to an exercise (EX) or waitlist control (WT) group. EX will complete 12-weeks of supervised (24 sessions) and unsupervised (12 sessions) indiv

Совпадение в полном тексте источника
… Metabolomic and Lipidomic Analyses Untargeted metabolomic and targeted plasma lipidomic profiles will be determined using liquid chromatography-coupled tandem mass spectroscopy analysis [ 89 , 90 ]. … Metabolomics and lipidomics data will be evaluated using multivariate statistics, including principal component analysis and sparse partial least squares discriminant analysis. …

Small molecule metabolites: discovery of biomarkers and therapeutic targets.

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject's phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has b

Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma.

Multiple myeloma (MM), the second most common hematologic cancer, is caused by accumulation of aberrant plasma cells in the bone marrow. Its molecular causes are not fully understood and its great heterogeneity among patients complicates therapeutic decision-making. In the past decades, development of new therapies and drugs have significantly improved survival of MM patients. However, resistance to drugs and relapse remain the most common causes of mortality and are the major challenges to overcome. The advent of high throughput omics technologies capable of analyzing big amount of clinical a

Совпадение в полном тексте источника
… Lipidomics Lipids are not only crucial components of cell membranes and energy reservoirs, they also play important roles in physiological processes and participate in signaling pathways. … Hence, the study of MM lipidome emerges as a relevant source of potential biomarkers that could help predict the evolution of the disease and the response to treatment. …

Sphingolipid metabolism and hematologic disorders: current understanding and future directions.

Sphingolipids are not only key structural components of cell membranes but also serve as important signaling molecules, and their metabolic homeostasis is essential for the maintenance of cellular functions. In recent years, with the advancement of technologies such as metabolomics, studies have revealed that sphingolipid metabolic abnormalities are extensively involved in the occurrence and development of various hematological disorders, including immune thrombocytopenia, myeloproliferative neoplasms, graft-versus-host disease, hereditary hematological diseases, and hematologic malignancies.

Совпадение в полном тексте источника
… Similarly, in chronic lymphocytic leukemia (CLL), untargeted metabolomics and lipidomics analyses have revealed distinct signatures of sphingolipid dysregulation associated with aggressive CLL and poor survival outcomes ( Nguyen Van Long et al., 2023 ). … This necessitates the integration of multi-omics data, such as metabolomics, lipidomics, and transcriptomics, to map the patient-specific metabolic landscape. …

Metabolomic Profiling in the Characterization of Degenerative Bone and Joint Diseases.

Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive disease processes. In osteoarthritis, atty acid metabolism has been implicated in disease development, both locally and systemically. Several series of rheumatoid arthritis patients have demonstrated overlapping trends related to histidine and glyceric aci

Последствия злоупотребления наркотиками для путей ферроптоза: потенциальные терапевтические цели для расстройств, связанных с потреблением психоактивных веществ.

Серьезными проблемами в области здравоохранения во всем мире, особенно в развитых странах, по-прежнему являются расстройства, связанные с потреблением психоактивных веществ. Для ОСВ характерна устойчивая нейроинфламмация и синаптическая дисфункция мозга. Несмотря на десятилетия интенсивного расследования, детальные механизмы, лежащие в основе ВСГ, по-прежнему остаются иллюзорными. Ферроптоз — это высокорегулируемый процесс смерти клеток, на который сильно влияют метаболизм железа, пероксидация липидов, производство реактивных видов кислорода (РОС) и антиоксидантные системы. Он был связан с мно

Нейродегенеративные биомаркеры при множественном склерозе: на стыке между исследованиями и клинической практикой.

Множественный склероз (MS) — хроническое аутоиммунное расстройство, характеризующееся воспалением, обезвоживанием и нейродегенерацией в центральной нервной системе (CNS). Хотя подстрекательские компоненты MS были тщательно изучены, прогрессивный нейродегенеративный аспект по-прежнему является одним из важнейших факторов, способствующих долгосрочной инвалидности. Поэтому выявление и проверка биомаркеров, связанных с нейродегенеративными процессами, имеют важнейшее значение для улучшения диагностики, прогнозирования и мониторинга лечения. В рамках этого обзора изучаются цереброспинные жидкости (

Ferroptosis, lipid metabolism, and genetic regulation in postoperative rehabilitation of elderly hip fractures: from molecular mechanisms to clinical translation.

BACKGROUND: Elderly hip fracture represents a major global public health challenge, with postoperative rehabilitation involving complex molecular mechanisms and metabolic networks. Beyond osteoporotic fractures, pathological hip fractures caused by tumor bone metastasis constitute a non-negligible proportion in elderly patients, with molecular pathological mechanisms significantly different from osteoporotic fractures. Recent research has confirmed that ferroptosis (iron-dependent regulated cell death) and lipid metabolism dysregulation are key links in fracture healing and functional recovery

Совпадение в полном тексте источника
… Lipidomics provides powerful tools for comprehensive evaluation of lipid metabolism, simultaneously quantifying hundreds of lipid molecules through mass spectrometry ( Tabassum et al., 2021 ). … Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases. Cell. Mol. Life Sci. 78 (6), 2565–2584. 10.1007/s00018-020-03715-45 Tanaka T., Shen J., Abecasis G. R., Kisialiou A., Ordovas J. M., Guralnik J. M., et al. (2009). …

Exploring the evolving role of apolipoproteins in oncology: global trends and emerging frontiers.

BackgroundMetabolic reprogramming, especially lipid metabolism, is crucial in cancer progression and treatment resistance. Apolipoproteins are crucial targets for research as they regulate autophagy, oxidative stress, and chemoresistance. A systematic bibliometric and bioinformatics approach is necessary to identify trends and elucidate the molecular mechanisms linking apolipoproteins to cancer.MethodsA systematic bibliometric analysis was conducted using the Web of Science Core Collection and PubMed. VOSviewer, CiteSpace, and the Bibliometrix R package were employed to analyze and visualize c

Sending the Signal to Bone: How Tumor-Derived EVs Orchestrate Pre-Metastatic Niche Formation and Skeletal Colonization.

Bone is a preferred site for disseminated tumor cells, yet the molecular mechanisms that prepare the skeletal microenvironment for metastatic colonization are only beginning to be understood. At the heart of this process are extracellular vesicles (EVs), nano-sized, lipid-encapsulated particles secreted by cancer cells and stromal components. This review consolidates current findings that position EVs as key architects of the bone-metastatic niche. We detail the biogenesis of EVs and their organotropic distribution, focusing on how integrin patterns and bone-specific ligands guide vesicle homi