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Chronic Non-cancer Pain Management and Addiction: A Review.

The use of opioids in chronic non-cancer pain (CNCP) has been a fast-rising treatment phenomenon in the last two decades. Though opioids are advocated in various chronic pain management guidelines, their use in chronic non-cancer pain still remains controversial as evidence of this approach is still weak. This paper highlights potential adverse effects associated with opioid use in pain management, including an increase in tolerance, dependence, and addiction outcomes. Nonetheless, opioids have an important place in contemporary CNCP management for selected patients. However, pain management m

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… Furthermore, though some opioids, such as methadone and buprenorphine can also be used to treat pain, the duration of analgesic action associated with them is often shorter compared to the withdrawal and craving symptoms. …

Доклад по делу: Существенное сокращение повреждений и структурные нейронные изменения после лечения ибогина при множественном склерозе.

Множественный склероз (MS) — изнуряющее нейродегенеративное заболевание, характеризующееся демиэлированием и нейронной потерей. Традиционная терапия часто не может остановить прогрессирование заболеваний или обратный неврологический дефицит. Ибогаин, психоактивный алкалоид, был предложен в качестве потенциального нейрогенеративного агента в силу его многогранного фармакологического профиля. Мы представляем два тематических исследования пациентов MS, которые прошли новое лечение ибогином, высветив значительные нейроимации и клинические улучшения. Пациент А продемонстрировал существенное сокраще

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… Although most widely discussed as an aid to mitigating withdrawal and cravings from opioids and other drugs ( 1 – 3 ), ibogaine has recently garnered attention for its potential to alleviate symptoms associated with traumatic brain injury ( 4 ), neuropathic pain ( 5 ), and other neurodegenerative conditions …

Нейробиологические пути, связывающие сексуальные расстройства и Психиатрические расстройства: обзор.

Навязчивое сексуальное расстройство (CSBD) — это новое засекреченное клиническое состояние, характеризующееся постоянной сложностью контроля за сексуальными импульсами, повторяющейся сексуальной активностью, несмотря на неблагоприятные последствия, а также значительным расстройством или ухудшением положения в различных сферах жизни. Этот обзор посвящен изучению клинических и нейробиологических переплетений между СВБД и отдельными психическими расстройствами, включая расстройства настроения и тревоги, расстройства, связанные с дефицитом внимания/гиперактивности, расстройства аутистического спек

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… In the case of CSBD, mesocorticolimbic dopaminergic hyperactivity may amplify the craving for sexual stimuli [ 14 ]. …

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.

BACKGROUND: Nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes. This helps to reduce cravings and withdrawal symptoms, and ease the transition from cigarette smoking to complete abstinence. Although there is high-certainty evidence that NRT is effective for achieving long-term smoking abstinence, it is unclear whether different forms, doses, durations of treatment or timing of use impacts its effects. OBJECTIVES: To determine the effectiveness and safety of different forms, deliveries, doses, durations and schedules of NRT, for achieving long-term smoking cessation. …

Налтрексон для острого управления навязчивыми сексуальными и одержимыми симптомами у пациента с неевроразвитым расстройством.

Навязчивое сексуальное расстройство (CSBD) характеризуется постоянной сложностью контроля за сексуальными желаниями и поведением, связанным с явными расстройствами или расстройствами. Данные, основанные на населении, свидетельствуют о том, что ~8.6% , взрослых американцев испытывают трудности, связанные с борьбой с сексуальными желаниями, чувствами и поведением, в то время как крупные международные исследования в области скрининга показывают, что ~5% ОСББ может подвергаться высокому риску, однако лишь меньшинство обращается за лечением. Диагностическая классификация по-прежнему сопряжена с тру

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… This shared compulsive and reward‐seeking profile may explain why naltrexone, which reduces craving and dampens reinforcement mechanisms, may also benefit individuals with CSBD. …

Alcohol Withdrawal.

AUDIENCE: Emergency medicine residents and medical students on emergency medicine rotations. INTRODUCTION: Alcohol use disorder (AUD) is common in the United States, with an estimated lifetime prevalence of 30%.1 The rate of use is higher among white males, Native Americans, and individuals of low socioeconomic status.1 Alcohol withdrawal symptoms manifest in 50% of individuals who misuse alcohol.1 While life-threatening sequelae of alcohol withdrawal are rare, the syndrome is a common reason for emergency department (ED) presentations. Alcohol withdrawal symptoms range from benign, cravings,…

'You're never pregnant in the same way again': prior early pregnancy loss influences need for health care and support in subsequent pregnancy.

STUDY QUESTION: What are couples' needs for health care and support in a subsequent pregnancy after prior early pregnancy loss (PL) and how do needs change across the pregnancy? SUMMARY ANSWER: Couples described unmet needs for pregnancy care in the first 20 weeks of pregnancy and were more satisfied with the care provided during the remainder of the pregnancy. WHAT IS KNOWN ALREADY: Despite early PL being common (∼25% of pregnancies), there is a paucity of research to guide practice to optimize treatment and support future pregnancies. There has been low priority for the issue in research a

Complementary and alternative therapies in the palliative setting.

Complementary and alternative medicine (CAM) encompasses a wide range of medication, herbal, dietary and physical therapies that are not usually considered within the realm of conventional therapeutics. Approximately two thirds of the Australian population use CAMs and only around half of this number will discuss their use of these products with their doctor. Clinical use is commonly seen in patients with life-limiting illness, often because they experience a high burden of symptoms. However, it is also the case that many of these therapies do not have demonstrated efficacy, particularly for t

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… Animal models of addiction suggest it may also help lessen cravings for alcohol, cannabis, opiates and stimulants. …

Алкоголь и каннабис используют строгость в связи с навязчивым сексуальным поведением и проблематичным использованием порнографии в неклинической выборке: перекрестное исследование.

ВВЕДЕНИЕ: Насильственные сексуальные расстройства и проблематичное использование порнографии (ППП) часто связаны с расстройствами, связанными с потреблением веществ, однако их связи с конкретными веществами в неклинических группах по-прежнему плохо известны. В настоящем исследовании рассматриваются связи между остротой потребления алкоголя и каннабиса и симптомами CSBD и ППУ в неклинической выборке взрослого населения. МЕТОДЫ: В мае-октябре имеющим на то право взрослым было предложено провести анонимное онлайновое обследование 2025. Показатели распространенности потребления алкоголя и каннабис

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… Kraus et al. ( 19 ) suggest that shared neurotransmitter systems may contribute to both compulsive sexual behaviors and substance use disorders, while neuroimaging studies indicate similarities in mechanisms related to craving and attentional processes. …

The Impact of Ketogenic Nutrition on Obesity and Metabolic Health: Mechanisms and Clinical Implications.

The ketogenic diet (KD) has recently gained increasing popularity. This high-fat, adequate-protein, and carbohydrate-poor eating pattern leads to nutritional ketosis. The KD has long been known for its antidiabetic and antiepileptic effects and has been used therapeutically in these contexts. Recently, the KD, due to its effectiveness in inducing weight loss, has also been proposed as a possible approach to treat obesity. Likewise, a KD is currently explored as a supporting element in the treatment of obesity-associated metabolic disorders and certain forms of cancer. Here, we discuss the meta

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… cancer showed that elevated serum BHB may reflect a metabolic environment inhospitable to cancer proliferation. 154 During the 12-week study duration, the KD did not negatively affect quality of life of the patients and improved patients’ physical function end energy expenditure while diminishing food cravings … Favorable effects of a ketogenic diet on physical function, perceived energy, and food cravings in women with ovarian or endometrial cancer: a randomized, controlled trial. Nutrients. 2018;10:1187. 10.3390/nu10091187 156. Cohen CW, Fontaine KR, Arend RC, et al. …

Морфологические изменения в сетчатке при расстройствах, связанных с употреблением алкоголя: систематический обзор и метаанализ исследований с использованием технологии оптической согласованности.

Цель обзора - использование чреонического алкоголя связано с различными структурными и функциональными изменениями в мозге. Скринальная морфология, оцениваемая с помощью оптической последовательности томографии (OCT), неинвазивно выявляет повреждения мозга, связанные с алкоголем, и может быть маркером болезней. 15/ Апрель/2025). Метаанализы случайного воздействия проводились по толщине параметров сетчатки как на диске, так и на макуле: слой волокна сетчатки (RNFL), слой ячеек ганглиона (GCL), внутренний плексиформный слой (IPL), плексиформальный слой с ганглионными клетками (GCIPL), толщина хо

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… This laterality distinction in AUD has also been noted for the pattern of cognitive dysfunction and impulsivity, which is associated with right hemisphere damage, 24 – 25 and for craving, which correlates with left hemispheric dysfunction. 25 This distinction further aligns with the WM–GM distinction …

АКНП 60th Ежегодное совещание: выдержки из плакатов P276 - P550.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Immediate adverse events to intravenous immunoglobulin in pediatric patients with inborn errors of immunity: A longitudinal study with a pre-infusion protocol.

INTRODUCTION: Immunoglobulin represents the main therapy for patients with inborn errors of immunity (IEI) and it is a safe procedure, but adverse events (AEs) can occur with variable frequencies. OBJECTIVE: To evaluate the frequency of immediate AEs to intravenous immunoglobulin (IVIG) regular therapy in a pediatric cohort with IEI after a pre-IVIG infusion protocol. METHODS: This was a longitudinal study from 2011 to 2019 at a tertiary pediatric hospital in Brazil. RESULTS: A total of 1736 infusions were studied in 70 patients with IEI, 46 (65.7%) of whom were males and whose median age w

The Multifaceted Nature of GLP-1: Molecular Mechanisms and Signaling Pathways in Metabolic and Neurodegenerative Diseases.

The aim of this article is to present the current state of knowledge regarding the use of GLP-1 agonists in the treatment of type 2 diabetes, obesity, and other potential clinical indications, including neurodegenerative conditions. The article describes the characteristics of the diseases discussed, with particular emphasis on the pathophysiological mechanisms and the impact of metabolic disorders on the course of the diseases. In addition, the specific role of GLP-1 receptor agonists and their mechanisms of action leading to improved clinical outcomes were discussed, including their impact o

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… A study conducted at an American clinic between 2022 and 2024 by Hendershot [ 121 ] examined the effect of semaglutide on reducing alcohol consumption and alcohol cravings in adults with alcohol use disorder (AUD). … The results suggest that semaglutide reduced the number of drinks consumed during a drinking episode and reduced weekly alcohol cravings. …

Sustained-release naltrexone for opioid dependence.

BACKGROUND: Opioid dependence is a severe and often lifelong disorder with a high risk of overdose and premature death, as well as severe ps … retention in treatment, treatment acceptability and adverse events. Secondary outcomes were opioid craving, recreational use of substances other than opioids, mental health, quality of life and criminal activity. We assessed the risk of bias using the Cochrane risk of bias tool (RoB 1). We combined the results of individual trials through meta-analysis w …

Mindfulness for smoking cessation.

BACKGROUND: Mindfulness-based smoking cessation interventions may aid smoking cessation by teaching individuals to pay attention to, and work mindfully with, negative affective states, cravings, and other symptoms of nicotine withdrawal. Types of mindfulness-based interventions include mindfulness training, which involves training in meditation; acceptance and commitment therapy (ACT); distress tolerance training; and yoga. OBJECTIVES: To assess the efficacy of mindfulness-based interventions for smoking cessation among people who smoke, and whether these interventions have an effect on menta…

Alcohol Misuse in Older Women: A Scoping Review of Correlates, Consequences, Treatment, and Prevention.

BackgroundAlcohol use and alcohol use disorder (AUD) among older women (defined as age 50 and over) have increased substantially in recent years. Compared to men and younger women, older women negotiate biopsychosocial transitions that put them at greater risk of alcohol-related health conditions as they age and are less reliably screened and treated for heavy alcohol use and AUD.ObjectivesThis scoping review represents a critical evaluation of research methodology and findings since 2004 on biopsychosocial correlates and consequences of alcohol misuse (i.e., heavy alcohol use, defined as four

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… . | DSM–5 eliminated legal problems as a criterion and adds alcohol craving as a criterion for an AUD diagnosis. … Women were more likely than men to belong to a class distinguished by symptoms of irresistible cravings, drinking more than intended, and continued use despite consequences. …

Нынешний подход к решению проблемы вторичного недоедания у пациентов с гематологическими отклонениями: рекомендации в отношении консенсуса экспертов Испании.

Для оценки мнений клинических гематологов было проведено обследование на базе Делфи (n = 17) и клинических иммунологов (n = 18) по всей Испании о вторичных иммунодефицитах (СИД) в области лечения онкогематологических пациентов. Там было 100% :: согласие с необходимостью наличия руководящих принципов в отношении лечения иммунодефицита у пациентов, страдающих гематологией; проведение базовой иммунологической оценки у пациентов с хронической лимфоцитной лейкемией (КЛЛ), множественной миеломой (ММ), лимфомой и гематопоиетической трансплантацией стволовых клеток (ХСБТ); и количественная оценка уров

Interventions for smoking cessation in hospitalised patients.

BACKGROUND: In 2020, 32.6% of the world's population used tobacco. Smoking contributes to many illnesses that require hospitalisation. A hospital admission may prompt a quit attempt. Initiating smoking cessation treatment, such as pharmacotherapy and/or counselling, in hospitals may be an effective preventive health strategy. Pharmacotherapies work to reduce withdrawal/craving and counselling provides behavioural skills for quitting smoking. This review updates the evidence on interventions for smoking cessation in hospitalised patients, to understand the most effective smoking cessation treat…

Light Chain (AL) Amyloidosis: The Journey to Diagnosis.

BackgroundLight chain (AL) amyloidosis is a rare, complex disease associated with significant morbidity and mortality. Delays in diagnosis are common and may have detrimental consequences on patients' prognosis. Too little is known regarding the patient journey to diagnosis.ObjectiveThe objective of this study was to describe the patient-reported journey to a correct diagnosis for AL amyloidosis.MethodsUsing a mixed-methods approach, data were collected from clinician (n = 4) and patient (n = 10) interviews and a survey of community-based patients with AL amyloidosis (n = 341). Data were used

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… (Patient 003) “It was things like being a little more tired, and I was suddenly, and I don’t know how this fits in, but I had been a vegetarian or semi-vegetarian for quite some time, and all of a sudden I would have these horrible cravings for meat, and I thought it had something to do with iron, being …