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Review of clinical profile and bacterial spectrum and sensitivity patterns of pathogens in febrile neutropenic patients in hematological malignancies: A retrospective analysis from a single center.

BackgroundThe aim of this study was to study clinical profile with bacterial spectrum and susceptibility patterns of pathogens in culture positive febrile neutropenic (FN) patients of hematological malignancies.Materials and methodsWe retrospectively reviewed the medical records of 23 hematological malignancy patients admitted with chemotherapy induced febrile neutropenia with culture positive results, at our institute between June 2011 and December 2011.ResultsA total of 23 patients were studied 12 males and 11 females, with a median age of 35 years. Most common diagnosis was acute leukemia (

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… Lastly for S. aureus main sensitive antibiotics were vancomycin, linezolid and gentamicin and resistant one were penicillin, erythromycin and ciprofloxacin. … commonly isolated gram positive organisms.[ 3 , 6 ] E. coli was the most frequently isolated gram negative pathogen.[ 3 , 7 ] This study shows that C/Su and amikacin may represent current best empirical antibiotics for suspected gram negative infections while for gram positive infections; vancomycin and linezolid …

Nutritionally variant streptococci bacteremia in cancer patients: a retrospective study, 1999-2014.

BackgroundNutritionally variant Streptococci (NVS), Abiotrophia and Granulicatella are implicated in causing endocarditis and blood stream infections more frequently than other sites of infection. Neutropenia and mucositis are the most common predisposing factors for infection with other pathogens in cancer patients. In this study, we investigated the clinical characteristics of NVS bacteremia in cancer patients and identified risk factors and outcomes associated with these infections.Materials and methodsWe retrospectively reviewed all cases of NVS bacteremia occurring from June 1999 to April

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… to complications 6 | 64 | F | NHL | 1 | 7 | Vancomycin, Cefepime | Survived 7 | 86 | M | Bladder cancer | 1 | - | Ampicillin/sulbactam, Levofloxacin | Survived 8 | 39 | F | NHL | 1 | 4 | Piperacillin/tazobactam | Deceased at hospice 9 | 59 | M | Esophageal cancer | 1 | - | Piperacillin/tazobactam, Linezolid … | Deceased due to complications 10 | 49 | M | NHL | 1 | 19 | Cefepime, Vancomycin | Survived 11 | 66 | M | Esophageal cancer | 1 | - | Aztreonam, Linezolid | Survived 12 | 66 | M | AML | 1 | 10 | Piperacillin/tazobactam, Vancomycin | Survived 13 | 80 | M | AML | 1 | 2 | Vancomycin | Survived Figure …

Comorbidities and mortality rate in COVID-19 patients with hematological malignancies: A systematic review and meta-analysis.

IntroductionThe global pandemic of coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It seems that there is an association between blood cancer and an increased risk of severe COVID-19. This study aimed to review the literature reporting the COVID-19 outcomes in patients with hematological malignancies.Material and methodsIn this systematic review and meta-analysis, Pubmed, Embase, and Web of Science databases were searched using the following keywords: COVID-19, SARS-CoV-2, blood cancer, myeloma, lymphoma, and leukemia. All the

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… , meropenem, LPV/r, IFN | Fever, dyspnea, myalgia | Increased: CRP, ferritin, LDH, D‐dimer Decreased: WBC, Hb, PLT, ANC, lymphocyte | Diabetes | Death Song 72 | China | Dec 2019 | Case report | 1 | 78 | F | CLL | None | 5 y | RT‐PCR, CT scans | OTV, cefoperazone, sulbactam, linezolid, mPDRL, oxygen support … | Fatigue, malaise, hyporexia | Increased: WBC, lymphocyte, CRP Decreased: Hb | Hypertension, cardiovascular disease, COPD | Death Li 73 | China | May 2020 | Case report | 1 | 26 | M | B‐cell lymphoma | DA‐EPOCH‐R | NR | RT‐PCR, CT scans | Meropenem, linezolid, AZ, ganciclovir, OTV, ARB | Fever | Decreased …

Empirical antimicrobial treatment in haemato-/oncological patients with neutropenic sepsis.

Neutropenic sepsis in haemato-/oncological patients is a medical emergency, as infections may show a fulminant clinical course. Early differentiation between sepsis and febrile neutropenic response often proves to be challenging. To assess the severity of the illness, different tools, which are discussed in this article, are available. Once the diagnosis has been established, the correct use of early empirical antibiotic and antifungal treatment is key in improving patient survival. Therefore, profound knowledge of local resistance patterns is mandatory and carefully designed antibiotic regime

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… If history of a type IV penicillin allergy (ie, drug exanthema) is present or suspected for the patient in question, alternatively an initial cefepime therapy with escalation to cefepime/linezolid is advisable. … or aztreonam/linezolid, in this order. …

Can Oritavancin Be Used for Treatment and/or Suppressive Antimicrobial Therapy of Bone and Joint Infections Caused by Vancomycin-resistant Enterococcus faecium ?

BACKGROUND: Vancomycin-resistant enterococcus (VRE) infections pose substantial challenges for the treatment and suppression of bone and joi … (48 to 66), 4 of 6 patients were male, and patients had received prior therapy for VRE with either linezolid or daptomycin. Infections were hardware-associated osteomyelitis in 2 of 6 patients, osteomyelitis in 3 of 6, and prosthetic joint infection in 1 of 6. In the suppressive antimicrobial therapy group, the median (range) age was 61 years (25 to 68), a …

[Risk factors and antibiotic use in methicillin-resistant Staphylococcus aureus bacteremia in hospitalized patients at Hacettepe University Adult and Oncology Hospitals (2004-2011) and antimicrobial susceptibilities of the isolates: a nested case-control study].

The aim of this study was to evaluate methicillin-resistant Staphylococcus aureus (MRSA) bacteremia cases who were followed at the Infectiou … the isolates were found to be susceptible to trimethoprim-sulfamethoxazole, VAN, TEC, tigecycline, linezolid and daptomycin. Mortality rates in patients who were infected with MRSA strains exhibiting vancomycin MIC value of ≤ 1.0 µg/ml (n= 49) and with MRSA strains exhibiting MIC > 1.0 µg/ml (n= 50) were 34.6% (17/49) and 60% (30/50), respectively. This di …

[Analysis of epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with perineal and/or hip burns].

Objective: To explore the epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with … , and tetracycline ranged from 14.3% to 57.1%, and the resistance rates of Enterococcus faecalis to linezolid, tigecycline, and vancomycin were all 0. The differences were statistically significant between the two groups in terms of gender, status of complication of hypoproteinaemia, depth of perineal burn, status of non-perineal/hip debridement/skin transp …

Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

The adequate management of central nervous system (CNS) infections requires that antimicrobial agents penetrate the blood-brain barrier (BBB … ed, it achieves higher concentrations in the presence of inflammation and accumulation is possible. Linezolid reaches high CSF concentrations; however, more frequent dosing might be required in infants due to their increased elimination. Metronidazole also has very limited information but it demonstrated favorable results similar to adult data; CSF concentr …

Diabetic Ketoacidosis and Necrotizing Soft Tissue Infection.

AUDIENCE: Emergency medicine (EM) residents at all levels of education and medical students on EM rotation. INTRODUCTION: Diabetes is a chr … cted NSTI are typically polymicrobial and myonecrosis and should be treated with: 1) vancomycin (or linezolid), 2) either piperacillin/tazobactam, ampicillin/sulbactam, or a carbapenem, 3) clindamycin to decrease toxin production.2,4Initial treatment of DKA is isotonic fluids, and insulin therapy should be withheld until serum potassium levels are obtained …

[A multicentric clinical study on clinical characteristics and drug sensitivity of children with pneumococcal meningitis in China].

Objective: To understand clinical characteristics of children with pneumococcal meningitis (PM) in China and to analyze the drug sensitivity … .000). Streptococcus pneumoniae isolates were completely sensitive to vancomycin (100.0%, 152/152), linezolid (100.0%, 126/126), moxifloxacin (100.0%, 93/93) and ofloxacin (100.0%,41/41); highly sensitive to levofloxacin (99.3%, 142/143) and ertapenem (84.6%, 66/78); moderately sensitive to ceftriaxone (48.4%, 45/93), cefotaxime (40.0%, 44/110) and meropene …

Парастеральный перикардиоцентис для метициллина-сопротивляющегося Стафилокока ауреуса Перикардита, скомпрометированного Абсцессом и Тампонадой.

Перикардит (MRSA) является редким заболеванием и характеризуется высокой заболеваемостью и смертностью. Резюме дела: A 70-year-old Женщина с прошлым медицинским прошлым множеством миэломы, фибрилляциями, циррозом и сердечной анемией с уменьшенной фракцией выброса, покрытой болью в груди и диспной. Бактеремия MRSA из зараженного центрального венозного порта привела к септическому шоку и переднему перикардному абсцессу, что вызвало сердечный тампонад. Срочный парастеральный перикардиоцентез был выполнен, при этом флюифицированные культуры были положительными для МРСА. Несмотря на разрешение тамп

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… At this point, the patient elected for inpatient hospice, where she was switched to oral linezolid for palliation and ultimately died. … Patient elects for inpatient hospice and is discharged on palliative linezolid. Day 30 | Patient dies peacefully. Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose. …

Когда уши болеют больше: отомастоидитные двусторонние краниальные Neurophies в иммунокомпрометированном пациенте.

Отомастоидит — это инфекция и воспаление как отитной среды (мидлушное ухо), так и мастоидной воздушной клетки. Если инфекция проходит мимо среднего уха, чтобы повлиять на прилежащие структуры, то могут быть задействованы мастоидные воздушные элементы. Фунгальный мастоидит очень редкий и почти исключительно наблюдается у иммунокомпромиссированных пациентов. Мы представляем необычный случай типа 2 диабетик с грибковым отомастоидитом, проявляющимся как боль в левом ухе, а также нейропатия левого черепного нерва VII и правого черепного нерва III. Хотя паралич лицевого нерва часто объясняется идиоп

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… He was also treated with linezolid, which was transitioned to doxycycline after two weeks, along with isavuconazole to minimize nephrotoxicity. One month after discharge, the patient’s contralateral right-sided CN III palsy and left otalgia resolved. … Nonetheless, he was treated with both linezolid/doxycycline and isavuconazole to cover both gram-positive and fungal organisms and responded adequately to therapy. …

Exploring Nanoherbal Paraboea leuserensis as a Therapeutic Agent in Traumatic Brain Injury: In Silico, and In Vivo Approaches.

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that causes various infections and exhibits antibiotic resistance and virulence factors, requiring alternative therapies. This study aimed to evaluate the effects of nanocurcumin on gene expression of S. aureus isolates from burn wounds in Iraqi patients, focusing on inhibiting resistance and virulence genes. METHODS: From March 2023 to May 2024, burn wound samples from Iraqi patients yielded 110 S. aureus isolates. Identification was conducted by Gram staining, biochemical assays, and culture techniques. Fifty isola

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… response, using cefoxitin, benzylpenicillin, amoxicillin, amoxicillin/clavulanic acid, ampicillin/sulbactam, piperacillin/tazobactam, cloxacillin, oxacillin, gentamicin, ciprofloxacin, moxifloxacin, norfloxacin, inducible clindamycin resistance, azithromycin, clarithromycin, erythromycin, clindamycin, linezolid … It also revealed that 20% of the isolates were resistant to moxifloxacin, norfloxacin, linezolid, and teicoplanin, while the resistance to vancomycin was 10%. …

TB AND OTHER CHEST INFECTIONS

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… Methods: Patients on linezolid containing regimen over one year period were screened. 34 patients were found to have developed linezolid induced ADRs. They were further studied with above mentioned aims and objectives. … Results: Of the 230 drug resistant TB patients screened, 34 patient developed Linezolid induced ADRs like Peripheral neuropathy, optic neuritis, bicytopenia, blackening of teeth in decreasing frequency. …

[Analysis of distribution and drug resistance of pathogens isolated from 159 patients with catheter-related bloodstream infection in burn intensive care unit].

Objective: To analyze the distribution and drug resistance of pathogens isolated from patients with catheter-related bloodstream infection ( … istance rates of MRSA to most antibiotics were higher than those of MSSA. MRSA was not resistant to linezolid, vancomycin, teicoplanin, sulfamethoxazole, or tigecycline. The resistance rates of MRSA to clindamycin and erythromycin were 7.9% and 62.0%, respectively, and those to the other antibiotics were higher than 91.5%. Except for the complete resistance …

Group A Streptococcus Meningitis, United States, 1997-2022.

Group A Streptococcus (GAS) causes a variety of diseases in humans but is not widely appreciated as a cause of meningitis. During 1997-2022, ten sites participating in the Active Bacterial Core Surveillance network in the United States identified GAS meningitis cases. We calculated annual incidence and case-fatality rates (CFRs) for 320 of those cases and determined antimicrobial resistance by whole-genome sequencing. Annual incidence of GAS meningitis ranged from 0.02 to 0.07 cases/100,000 persons. Children <1 year of age had the highest average annual incidence, 0.23 cases/100,000 children.

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… We did not detect β-lactam, linezolid, or vancomycin resistance among available isolates. Of the 21 clindamycin-resistant isolates, 8 (38.1%) were emm 92 and 4 (19.1%) were emm 12 type; all emm 92 isolates were part of the same ST82 lineage. … The poor diffusion of clindamycin over the meningeal membranes is an additional challenge and has led to recommendations to use high-dose clindamycin or linezolid as an adjunctive antibiotic ( 37 , 38 ). …

Abstracts of the ICARE 2024 78th SIAARTI National Congress

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Novel recombinant endolysin ointment with broad antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from wounds and burns.

The major problem in the management of burn wounds is infections. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major cau … t results, all S. aureus isolates were identified as sensitive against vancomycin, ceftaroline, and linezolid. Results shows one lysogenic bacteriophage and three distinct lytic specific S. aureus bacteriophage were isolated from sewage. For each of the three samples, a single contig was possible to be obtained. Sample BP-SA2 had the best coverage, and the …

[Analysis of distribution and drug resistance of pathogens from the wounds of 1 310 thermal burn patients].

Objective: To analyze the distribution and drug resistance of pathogens from the wounds of thermal burn patients, so as to provide reliable … as below 31.00% in each year. (5) From 2012 to 2017, Staphylococcus aureus resistant to vancomycin, linezolid, or teicoplanin was not detected; the drug-resistant rates of MRSA to penicillin G, oxacillin, gentamicin, rifampicin, tetracycline, ciprofloxacin, ofloxacin, and levofloxacin were above or equal to 80.0% in each year; the drug-resistant rates of St …

Outcomes and microbiological patterns of bacteremia in chemotherapy-related febrile neutropenia at a tertiary facility in Kenya.

IntroductionFebrile neutropenia (FN) is a major cause of mortality and morbidity in patients with malignancy post-chmotherapy. Current guidelines for managing FN recommend starting empiric antibiotic therapy (EAT) promptly. The choice of antibiotic is based on the patient's condition, local data on common microorganisms isolated, and their resistance patterns. Of note, there is a growing trend of isolating multi-drug-resistant gram-negative bacteria in these patients. In sub-Saharan Africa, there are insufficient data on the mortality rates of FN. There is also a lack of local epidemiologic da

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… One of the Enterococci species was vancomycin-susceptible and the other was vancomycin-resistant but susceptible to linezolid. The Streptococci were penicillin-susceptible. There were two cases of fungemia with Candida auris. … Of the two Enterococci isolated, one was vancomycin-susceptible and the other was vancomycin-resistant but linezolid-sensitive. The most common EAT of choice was carbapenems at 85.6% (77) of FN episodes. …