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Molecular Pathogenesis and Diagnostic Imaging of Metastatic Jaw Tumors.

Metastasis is the spread of malignant cells from a primary tumor to distant sites through lymphatics or blood vessels. Malignant lesions metastasizing to the oral and perioral region are a rarity indeed. Malignant lesions could metastasize to both soft tissue of oral cavity and the hard tissues of the jaws and recent meta-analysis showed that metastasis is more common in the jaws than oral soft tissues because of rich vascular supply. The incidence is very low when compared to the incidence of primary oral cancers; nevertheless, one has to include in the diagnostic workup, metastatic malignant

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… visceral organs.[ 21 , 44 ] Earlier studies suggested that tumor-associated macrophages play a crucial role in guiding tumor cells to blood vessels and sites of intravasation (directional cell migration).[ 45 ] Extravasation of the transported tumor cell at predestined site is depended on integrins and ezrin … The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med. 2004;10:182–6. doi: 10.1038/nm982. 47. Paget S. The distribution of secondary growths in cancer of the breast 1889. Cancer Metastasis Rev. 1989;8:98–101. 48. Li F, Tiede B, Massagué J, Kang Y. …

Clinical prognostic implications of EPB41L4A expression in multiple myeloma.

Background: Multiple myeloma (MM) is one of the most common incurable malignancies in malignant plasma cell disease. EPB41L4A is a target gene for the Wnt/β-catenin pathway, which is closely related to the survival of multiple myeloma cells. However, there is currently no research report on the prognostic significance of the EPB41L4A gene in MM. Methods: We studied the biological significance and prognostic significance of EPB41L4A expression in MM by integrating 1956 MM samples from 7 datasets, and explored the relationship between EPB41L4A expression and MM ISS stage, molecular type, therape

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… EPB41L4A ( e rythrocyte p rotein b and 4.1-l ike 4a, also called Nbl4) which is a member of the band FERM (Four-point-one, Ezrin, Radixin, Moesin) protein superfamily were discovered in almost all cellular organism in molecular ecology, especially high expressions in brain, liver, thymus, and peripheral … Abbreviations Multiple myeloma International Myeloma Working Group International Staging System Revised International Classification System autologous stem cell transplantation erythrocyte protein band 4.1-like 4a, also called Nbl4 Four-point-one, Ezrin, Radixin, Moesin Gene Expression Omnibus …

Roles of Microvesicles in Tumor Progression and Clinical Applications.

Microvesicles are extracellular vesicles with diameter ranging from 100 to 1000 nm that are secreted by tumor cells or other cells in the tumor microenvironment. A growing number of studies demonstrate that tumor-derived microvesicles are involved in tumor initiation and progression, as well as drug resistance. In addition, tumor-derived microvesicles carry a variety of immunogenic molecules and inhibit tumor response to immunotherapy; therefore, they can be exploited for use in tumor vaccines. Moreover, because of their high stability, tumor-derived microvesicles extracted from body fluids ca

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… Representative cargos of MVs are shown: P-gp, TF, EGFR, v-SNARE, ARF6, chemokine receptor, IL-6, IL-1β, VAMP-3, Ezrin, CD40, uPA, DNA, microRNA, tTG, EMMPRIN, MMPs, and VEGF. … Representative cargos of MVs are shown: P-gp, TF, EGFR, v-SNARE, ARF6, chemokine receptor, IL-6, IL-1β, VAMP-3, Ezrin, CD40, uPA, DNA, microRNA, tTG, EMMPRIN, MMPs, and VEGF. …

Development of novel gene signatures for the risk stratification of prognosis and diagnostic prediction of osteosarcoma patients using bioinformatics analysis.

BackgroundOsteosarcoma (OS) is a common malignant bone cancer in children and teenagers that originates from osteoblast cells. Although many biomarkers have been reported in OS, they have not improved the prognosis of this disease. This study sought to identify effective biomarkers for the early diagnosis and prognosis of OS using a comprehensive bioinformatics analysis.MethodsOS-associated microRNAs (miRNAs) were screened in the Human microRNA Disease Database (HMDD). The differentially expressed genes (DEGs) related to OS were screened using 3 data sets (GSE16088, GSE36001, and GSE56001) fro

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… Ezrin ( 10 , 11 ) was identified as a diagnostic and prognostic marker in OS. It was up-regulated in high-grade OS patients and points to a worse prognosis. … Mol Med Rep 2015 ; 12 : 1157 - 62 . 10.3892/mmr.2015.3535 25815525 10 Park HR Cabrini RL Araujo ES Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. …

Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis.

BACKGROUND: Accumulating evidence indicates that miRNAs play an important role in the development of amyotrophic lateral sclerosis (ALS). Most of previous studies on miRNA dysregulation in ALS focused on the alterative expression in ALS animal model or in limited samples from European patients with ALS. In the present study, the miRNA expression profiles were investigated in Chinese ALS patients to explore leukocytes miRNAs as a potential biomarker for the diagnosis of ALS. METHODS: We analyzed the expression profiles of 1733 human mature miRNAs using microarray technology in leukocytes obtai

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… -B., et al. (2014). miR-183 inhibits invasion of gastric cancer by targeting Ezrin. Int. J. Clin. Exp. Pathol. 7, 5582–5594. Cellura E., Spataro R., Taiello A. C., La Bella V. (2012). Factors affecting the diagnostic delay in amyotrophic lateral sclerosis. Clin. Neurol. … Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. Am. J. Pathol. 180, 2440–2451. 10.1016/j.ajpath.2012.02.023 Associated Data Supplementary Materials Click here for additional data file. Click here for additional data file. …

Role of PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints.

Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) induce cytotoxic effects as single agents in tumors characterized by defective repair of DNA double-strand breaks deriving from BRCA1/2 mutations or other abnormalities in genes associated with homologous recombination. Preclinical studies have shown that PARPi-induced DNA damage may affect the tumor immune microenvironment and immune-mediated anti-tumor response through several mechanisms. In particular, increased DNA damage has been shown to induce the activation of type I interferon pathway and up-regulation of PD-L1 expression in cance

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… Moreover, although being able to impair osteosarcoma growth, PARPi have been shown to support its metastatic potential through phosphorylation of the ezrin protein [ 132 ], a cytosolic structural molecule that regulates cell growth and motility [ 133 ]. … This observation is of relevance because a high expression of the ezrin protein has been related to lower overall survival (OS) [ 134 ] and disease progression in patients with ovarian cancer [ 135 ], unveiling a potential mechanism of resistance to PARPi. 2.2. …

The Biogenesis and Functions of piRNAs in Human Diseases.

Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26-30 nt in length and bind to Piwi proteins. These short RNAs were originally discovered in germline cells and are considered as key regulators for germline maintenance. A growing body of evidence has now extended our views into piRNA biological significance showing that they can also regulate gene expression in somatic cells through transposon silencing, epigenetic programming, DNA rearrangements, mRNA turnover, and translational control. Mounting studies have revealed that the dysregulation of piRNAs may caus

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… recent study compared piRNA expression profiles between eight non-small-cell lung cancer (NSCLC) tissue samples and three human bronchial epithelial cell samples. 66 piR-L-163 in NSCLC cells, the top downregulated one, inhibited cell migration and invasion by maintaining the function of phosphorylated ezrin-radixin-moesin … Table 1 piRNAs in Different Diseases and Potential Mechanisms Behind Them Disease | piRNA | Changes | Mechanism | Role | Reference Lung cancer | piR-L-163 | downregulated | bind to 3′ UTR of mTOR mRNA | suppressor | 66 piR-55490 | maintain the function of phospho-ezrin-radaxin-moesin (p-ERM) | 67 Liver …

Эгоистические нейрофармацевтики: открытие кровеносного барьера для лечения следующего поколения.

Блокирование мозга крови (ББД) представляет собой огромную проблему в нейрофармакологии, ограничивая доставку терапевтических агентов в мозг. Экзосомы, нанокарьеры природы, стали многообещающим решением из-за их биосовместимости, низкой иммуногенности и врожденной способности пересекать ББД. Тщательное изучение анатомии и физиологии ББД свидетельствует о сложности доставки неврологических наркотиков и подчеркивает ограниченность традиционных методов. В настоящем обзоре изучается потенциал нейрофармацевтики с экзосомной силой, при этом особое внимание уделяется их структурным и функциональным с

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… Cytoskeletal Proteins Actin, Vimentin, Talin, Ezrin, Tubulin, Cofilin, Moesin Involved in maintaining vesicle integrity and facilitating exosome biogenesis and secretion. … Cytoskeletal Proteins Actin, Vimentin, Talin, Ezrin, Tubulin, Cofilin, Moesin Involved in maintaining vesicle integrity and facilitating exosome biogenesis and secretion. …

Keyword Index for Volume 98

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… negative 1380 ERBB2 1525 ERCC1 1398 ERK1/2 1525 erlotinib 1774 erythropoietin receptor 1059 ethnicity 633 etoposide 693 Europe 1012 everolimus 923 evidence 1944 excision repair cross- complementing gene 1 832 expression 1059 extracolorectal cancer 997 extremity soft tissue sarcoma 1403 Ezrin …

Overview of Ayurveda and Ashwagandha: Bioactive Phytochemicals and Potential Applications to Gliomas.

Ayurveda is the traditional medical system of India and has been in use for more than 5000 years. The focus of Ayurveda is to maintain harmony and balance of the three Doshas (Vata, Pitta, Kapha), or life forces, that govern the physiology and health of each individual. Ashwagandha is considered one of the most useful plants in the Ayurvedic system for various illnesses, including cancer. Ethnopharmacological and phytochemical analyses have been elucidating the bioactive compounds in ashwagandha that mediate the anti-cancer effects. The most bioactive compounds appear to be the withanolides, i

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… Three proteins were noted to be downregulated in response to treatment with WiNA 20-1 and WTHN: heterogeneous nuclear ribonucleoprotein K (hnRNP-K), mortalin, and ezrin. hnRNP-K is a multifunctional protein that regulates ERK, MMPs, and VEGF and contributes to cell migration, invasion, and angiogenesis … Three proteins were noted to be downregulated in response to treatment with WiNA 20-1 and WTHN: heterogeneous nuclear ribonucleoprotein K (hnRNP-K), mortalin, and ezrin. hnRNP-K is a multifunctional protein that regulates ERK, MMPs, and VEGF and contributes to cell migration, invasion, and angiogenesis …

Lactylation in health and disease: physiological or pathological?

Lactate is an indispensable substance in various cellular physiological functions and plays regulatory roles in different aspects of energy metabolism and signal transduction. Lactylation (Kla), a key pathway through which lactate exerts its functions, has been identified as a novel posttranslational modification (PTM). Research indicates that Kla is an essential balancing mechanism in a variety of organisms and is involved in many key cellular biological processes through different pathways. Kla is closely related to disease development and represents a potential and important new drug target

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… activity; | PMID: 38155775 METTL16 | K229 | Increase protein activity; | PMID: 37863889 P53 | unknown | Development of enhanced Enz resistance and progression of PCa; | PMID: 38880227 SLC16A1 | unknown | Promoting L-lactate transport through proton junctions in the plasma membrane; | PMID: 38817665 Ezrin … Histone Kla activates the RhoA/ROCK/Ezrin pathway, triggering NF-κB, inflammation, apoptosis, and kidney dysfunction. Multiple Kla sites were identified on Ezrin, with K263 Kla playing a key role in inflammatory metabolic adaptation in renal proximal tubular epithelial cells 169 . …

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination.

The stromal microenvironment regulates mammary gland development and tumorigenesis. In normal mammary glands, the stromal microenvironment encompasses the ducts and contains fibroblasts, the main regulators of branching morphogenesis. Understanding the way fibroblast signaling pathways regulate mammary gland development may offer insights into the mechanisms of breast cancer (BC) biology. In fact, the unregulated mammary fibroblast signaling pathways, associated with alterations in extracellular matrix (ECM) remodeling and branching morphogenesis, drive breast cancer microenvironment (BCM) rem

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… Interestingly, inhibition of Ezrin and CCL5 in MAFs reduces their capability to promote cancer cell migration and invasion in vitro. … Therefore, Ezrin and CCL5 could represent promising targets to prevent the differentiation of BCAFs into a more metastatic phenotype, especially in BRCA1 mutated tumors [ 206 ]. …

Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines.

The availability of metamizole varies greatly around the world. There are countries such as the USA, UK, or Australia where the use of metamizole is completely forbidden, and there are also countries where this drug is available only on prescription (e.g., Greece, Italy, Spain, etc.) and those in which it is sold OTC-over the counter (e.g., most Asian and South American countries). Metamizole, as a drug with a strong analgesic effect, is used as an alternative to other non-steroidal anti-inflammatory drugs, alone or in combination with opioid drugs. Risedronate sodium is a third-generation bis

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… Etiopathogenesis of OSA in dogs and humans is not fully understood, but the most common predisposing factors include micro-injuries, overexpression of COX-2, or disorders in the synthesis of proteins such as ezrin or other proteins belonging to the ERM family. …

Keyword Index for Volume 110

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… , 2569 ERBB2 2985 EREG 648 eribulin mesilate 1497 ERK1/2 1034, 1288 ERR β 2144 ESMO 2640 estimates of effect 1834 ethnic 1322 ethnicity 4, 224, 230, 1433 ex vivo model 2604 expanded access 1721 expression microarray profiling 520 external quality assessment 850 external validation 42 Ezrin …

Резюме

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Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies.

The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational tumor that evolves in the mesothelium layer of the pleural cavities (inner lining- visceral pleura and outer lining- parietal pleura), peritoneum, pericardium, and tunica vaginalis and is highly resistant to standard treatments. In mesothelioma, the predominant pattern of lesions is a loss of genes that limit tumour growth. Despite the worldwide ban on the manufacture and supply of asbestos, the prevalence of mesothelioma continues to increase. Mesothelioma presents and behaves in a variety of ways, making dia

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… Merlin is an Ezrin/radixin/moesine family protein encoded by NF2. From Drosophila to mammals, Merlin acts as an upstream regulator of the Hippo signaling cascade ( 17 ). … Inhibition of the hippo pathway in mesothelioma fibroblasts Moesin-ezrin-radixin-like protein (Merlin) has a genetic mutation that leads to neurofibromatosis type 2 (NF2). Merlin is a component of the ring 4.1 group of cytoskeletal linkage proteins ( Figure 1 ). …

Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy.

The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is a critical signaling network governing cellular functions such as immune responses, proliferation, and apoptosis. Dysregulation of this pathway is strongly implicated in cancer progression. This review explores the therapeutic potential of natural products, including Curcumin, Resveratrol, Apigenin, and Epigallocatechin Gallate (EGCG), as modulators of the JAK/STAT pathway. These phytochemicals exhibit anticancer activity by inhibiting JAK/STAT phosphorylation, blocking STAT dimerization, and interfering wi

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… The FERM (four-point one ezrin radixin, moesin) domain is formed by the combination of one-half of the JH4 domain, JH5, JH6, and JH7. The fundamental role of the FERM domain is to facilitate the interaction between JAK kinases and the intracellular Box 1 region of cytokine receptors. … Breakpoint cluster region/abelson murine leukemia Cancer-Associated Fibroblasts Cyclooxygenase DNA-binding domain Deoxyribonucleic acid Endometrial cancer Epigallocatechin gallate Epidermal growth factor receptor Extracellular signal-regulated kinase Esophageal squamous cell cancer Four-point One Ezrin …

Highlighting recent achievements to advance more effective cancer immunotherapy.

From 17 to 19th October 2024, the XXI Italian Network for Bio-Immunotherapy of Tumors Meeting (NIBIT) took place in Palermo, in the marvelous historical location of Teatro Politeama, under the auspices of the Italian Association of Medical Oncology (AIOM), Italian Association of Cancer Research (AIRC), Fondazione Pezcoller, Italian Alliance against Cancer (ACC), Italian Lymphoma Foundation (FIL), Grazia Focacci Foundation and Melagioco Foundation. The conference covered a spectrum of topics ranging from target discovery to therapeutic advances in immuno-oncology, bringing world-renowned expert

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… TF was found to regulate TGFβ receptor (TGFBR) surface expression, phosphorylation, and endocytosis by interacting with Ezrin and stabilizing its dimerization, thereby affecting plasma membrane tension. …

Antioxidant and Antiproliferation Activities of Lemon Verbena (Aloysia citrodora): An In Vitro and In Vivo Study.

Aloysia citrodora (Verbenaceae) is traditionally used to treat various diseases, including bronchitis, insomnia, anxiety, digestive, and heart problems. In this study, this plant's antioxidant and anti-proliferation effects were evaluated. In addition to volatiles extraction, different solvent extracts were prepared. The GC-MS, LC-MS analysis and the Foline-Ciocalteu (F-C) method were used to investigate the phytochemical components of the plant. MTT assay was used to measure the antiproliferative ability for each extract. Antioxidant activity was determined using the 2,2-diphenylpicrylhydrazy

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… Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells BMC Cancer 2011 11 527 10.1186/1471-2407-11-527 22204275 PMC3260329 105. Zhang D.Y. Wu J. Ye F. Xue L. Jiang S. Yi J. Zhang W. Wei H. Sung M. Wang W. …

Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis.

HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV (PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life, and there is currently no effective treatment for it. The development of HIV-NCI is complex and is mediated, in part, by the entry of HIV-infected mature monocytes into the central nervous system (CNS). Once in the CNS, these cells release inflammatory mediators that lead to neuroinflammation, and subsequent neuronal damage. Infected monocytes may infect other CNS cells as well as differentiate into macrophages,

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… ICAM-3 is an adhesion molecule that can interact with LFA-1 extracellularly or ezrin/radixin/moesin intracellularly, contributing to tumor metastasis ( 62 ). CD151, a tetraspanin, interacts with integrins promoting cell matrix adhesion ( 63 ). …