Результаты поиска

Involvement of Lipids and Lipid Mediators in Inflammation and Atherogenesis.

Atherosclerosis is the pathophysiological basis for major diseases, such as coronary heart disease, cerebral stroke, and peripheral arterial … er of innate immune functions, disorders of which are associated with atherosclerosis. Furthermore, lipids are not only a morphological substrate but also important participants in the development of atherosclerosis. They are involved in the development and resolution of inflammation and mediate vascular cell function.

The interaction of TRPV1 and lipids: Insights into lipid metabolism.

Transient receptor potential vanilloid 1 (TRPV1), a non-selective ligand-gated cation channel with high permeability for Ca2+, has received considerable attention as potential therapeutic target for the treatment of several disorders including pain, inflammation, and hyperlipidemia. In particular, TRPV1 regulates lipid metabolism by mechanisms that are not completely understood. Interestingly, TRPV1 and lipids regulate each other in a reciprocal and complex manner. This review surveyed the recent literature dealing with the role of TRPV1 in the hyperlipidemia-associated metabolic syndrome. Bes…

Analysis of lipid profile in lipid storage myopathy.

Lipid dysmetabolism disease is a condition in which lipids are stored abnormally in organs and tissues throughout the body, causing muscle weakness (myopathy). Usually, the diagnosis of this disease and its characterization goes through dosage of Acyl CoA in plasma accompanied with evidence of droplets of intra-fibrils lipids in the patient muscle biopsy. However, to understand the pathophysiological mechanisms of lipid storage diseases, it is useful to identify the nature of lipids deposited in muscle fiber. In this work fatty acids and triglycerides profile of lipid accumulated in the muscle…

Beyond Fasting Lipids: Nutritional and Clinical Perspectives on Postprandial Triglycerides.

BACKGROUND: Postprandial triglyceride (TG) metabolism represents a dynamic dimension of lipid physiology that complements conventional fasting lipid assessment. Although low-density lipoprotein cholesterol (LDL-C) remains the primary therapeutic target in cardiovascular prevention, residual cardiovascular risk persists in many individuals despite apparently adequate fasting lipid control. Because most individuals spend the majority of their waking hours in a fed state, postprandial TG responses may provide clinically relevant insight into metabolic flexibility, dietary exposure, and the effici

Incretin-based therapies: Effects on plasma lipids and potential mechanisms.

Incretin-based therapies have transformed the treatment of type-2 diabetes and obesity, yet their effects on lipid and lipoprotein metabolism are less appreciated than their glycemic and weight-related actions. This review examines evidence for the effects of glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists on plasma lipids, with emphasis on triglyceride-rich lipoprotein metabolism in fasting and postprandial states. Across clinical studies, the most reproducible lipid-r…

Optical control of carrier-mediated ion transport by photoswitchable lipids.

We report a molecular strategy for precise, reversible, and noninvasive photoregulation of ion-selective membrane transport. Embedding azobenzene-containing photolipids into bilayers enables nanoscale control over the interaction and mobility of small-molecule ion carriers. Photoisomerization alone produces only minor changes in baseline conductance, consistent with the limited influence of small bilayer thickness variations on ion permeability, yet it elicits striking responses in the presence of mobile carriers. A newly designed protonophore exhibits proton-selective currents that increase b…

Prediction, Targeting, and Annotation of Oxidized Lipids Using LPPtiger2 Software.

The epilipidome, a subset of the natural lipidome arising from enzymatic and non-enzymatic lipid modifications, remains largely unexplored. Within this emerging class, oxidized complex lipids have raised considerable interest due to their diverse biological functions, including the modulation of inflammation, cell fate decisions, and the execution of programmed cell death. However, the discovery and annotation of these typically low-abundant yet structurally diverse lipid species present significant analytical challenges, often necessitating advanced bioinformatics tools. Here, we present a co…

Malassezia globosa lipidome: The dynamics of uptake and secreted lipids.

Malassezia globosa plays a crucial role as part of the human skin's mycobiome. However, this yeast has been detected in other niches, such as the gut. Despite being commensal, the pathogenic link in several dermatological conditions, but recently, chronic diseases such as cancer, Crohn's disease, and Parkinson's disease, among others, have been explored. Lipids can be involved in fungal pathogenesis, and this yeast is characterized by a significant lipid metabolic versatility, with a lack of the complex fatty acid synthase (FAS) required for the de novo synthesis of fatty acids, as it relies o…

Distribution and molecular profile of betaine lipids in basidiomycete fungi.

Betaine lipids are non-phosphorus glycerolipids found across diverse organisms, including bacteria, algae, ferns, and certain fungi, and are capable of substituting phospholipids under phosphate deficiency. Their distribution in the Basidiomycota division of fungi remains enigmatic. This study presents the first comprehensive survey of diacylglyceryl-N,N,N-trimethylhomoserine (DGTS) distribution in both natural fruiting bodies and pure cultures of over 150 fungal species. Comparative lipid analysis of fungal mycelium grown on complete versus phosphorus-depleted media revealed that DGTS biosynt…

Lipid ciliology: specialized ciliary membrane lipids in physiology and disease.

Primary cilia are the microtubule-based sensory organelles. The unique lipid makeup of the ciliary membrane strictly controls their signaling ability, to orchestrate tissue formation and homeostasis. Emerging evidence has demonstrated that lipids play important roles in cilia formation and cilia-related signaling, solidifying the previously proposed concept of "lipid ciliology." The ciliary membrane exhibits a highly specialized lipid composition, including enrichment in cholesterol, sphingolipids, and specific phosphoinositides, compared with the surrounding plasma membrane. Recent studies ha…

Extraction and Quantification of Skin Immune Cells and Skin Lipids.

We have recently shown that the immune system, specifically T cells stimulated by the skin-derived cytokine thymic stromal lymphopoietin, ca … the role of sebum in skin immunobiology. Here, we describe a protocol that we developed to extract lipids from mouse fur followed by thin layer chromatography analysis of the various lipid classes. We also describe a protocol to maximally extract immune cells from the skin for flow cytometric analysis, which has previously been limited by low cell numbe …

Beyond lipids: a precision prevention blueprint for China's residual risk.

Despite achieving guideline-recommended lipid levels, patients with atherosclerotic cardiovascular disease (ASCVD) retain substantial residual risk arising from heterogeneous biological pathways, including persistent inflammation and genetically determined atherogenic susceptibility. High-sensitivity C-reactive protein (hs-CRP) provides a pragmatic measure of potentially modifiable inflammatory activity, whereas lipoprotein(a) [Lp(a)] identifies relatively stable, genetically mediated risk that is not adequately captured by standard lipid panels. The 2025 American College of Cardiology Scienti

Stable, micron-scale lipocondensates achieving prolonged circulation without PEGlyated lipids.

Biomolecular condensates are key organizers of cellular biochemistry and are emerging as promising platforms for therapeutic delivery. Howev … diameter), far bigger than conventional liposomes. Functionally, LipCons composed solely of natural lipids display prolonged circulation, achieving an initial half-life of ∼13 hours-over 10× longer than the most structurally comparable lipid-coated condensate system reported to date and rivaling nano-scale PEGylated systems. In fact, at micron-scale, lip …

Beyond Glucose: The Overlooked Role of Lipids in Gestational Diabetes.

AIMS: To examine the role of maternal lipid metabolism before and during pregnancy in the development of gestational diabetes mellitus, and to evaluate its clinical implications for maternal and offspring outcomes. DATA SYNTHESIS: Shifts in lipid metabolism represent key physiologic adaptations of pregnancy, and, when dysregulated, may contribute to the pathogenesis of gestational diabetes. Lipid abnormalities typically precede conception, underscoring a continuum between pre-pregnancy metabolic health and pregnancy outcomes. Low HDL-C, elevated triglycerides, and small dense LDL-C particles

Специальный выпуск "Роль липидов в здравоохранении и болезнях".

Липиды представляют собой гидрофобные биомолекулы, которые, как правило, характеризуются как восковые или масляные и нерастворимые в воде, включающие в себя структурно разнообразную группу, включающую триглицериды, фосфолипиды, воски и стероиды [...].

Совпадение в аннотации оригинала
Lipids are hydrophobic biomolecules, typically characterized as waxy or oily and insoluble in water, encompassing a structurally diverse group that includes triglycerides, phospholipids, waxes, and steroids [...].